{"id":"https://openalex.org/W3214934124","doi":"https://doi.org/10.1016/j.biopha.2021.112426","title":"Membrane model as key tool in the study of glutathione-s-transferase mediated anticancer drug resistance","display_name":"Membrane model as key tool in the study of glutathione-s-transferase mediated anticancer drug resistance","publication_year":2021,"publication_date":"2021-11-30","ids":{"openalex":"https://openalex.org/W3214934124","doi":"https://doi.org/10.1016/j.biopha.2021.112426","mag":"3214934124","pmid":"https://pubmed.ncbi.nlm.nih.gov/34861633"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2021.112426","doi":"https://doi.org/10.1016/j.biopha.2021.112426","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2021.112426","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.biopha.2021.112426","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070491441","display_name":"Elsa M. Mater\u00f3n","orcid":"https://orcid.org/0000-0002-3382-1193","observed_orcids":["https://orcid.org/0000-0002-3382-1193"]},"institutions":[{"id":"https://openalex.org/I177909021","display_name":"Universidade Federal de S\u00e3o Carlos","ror":"https://ror.org/00qdc6m37","country_code":"BR","type":"education","lineage":["https://openalex.org/I177909021"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405267372","display_name":"Instituto de F\u00edsica de S\u00e3o Carlos","ror":"https://ror.org/02f1crb75","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Elsa M. Mater\u00f3n","raw_affiliation_strings":["Chemistry Department, Federal University of S\u00e3o Carlos, CP 676, S\u00e3o Carlos 13565-905, S\u00e3o Paulo, Brazil; S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil. Electronic address: elsa_materon@yahoo.com","Chemistry Department, Federal University of S\u00e3o Carlos, CP 676, S\u00e3o Carlos 13565-905, S\u00e3o Paulo, Brazil","S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Federal University of S\u00e3o Carlos, CP 676, S\u00e3o Carlos 13565-905, S\u00e3o Paulo, Brazil; S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil. Electronic address: elsa_materon@yahoo.com","institution_ids":["https://openalex.org/I177909021","https://openalex.org/I17974374","https://openalex.org/I4405267372"]},{"raw_affiliation_string":"Chemistry Department, Federal University of S\u00e3o Carlos, CP 676, S\u00e3o Carlos 13565-905, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I177909021"]},{"raw_affiliation_string":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025642299","display_name":"Fl\u00e1vio M. Shimizu","orcid":"https://orcid.org/0000-0002-4833-9893","observed_orcids":["https://orcid.org/0000-0002-4833-9893"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]},{"id":"https://openalex.org/I4405267372","display_name":"Instituto de F\u00edsica de S\u00e3o Carlos","ror":"https://ror.org/02f1crb75","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Flavio M. Shimizu","raw_affiliation_strings":["S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil; Department of Applied Physics, \"Gleb Wataghin\" Institute of Physics (IFGW), University of Campinas (UNICAMP), Campinas, SP 13083-859, Brazil. Electronic address: fshimizu@unicamp.br","Department of Applied Physics, \"Gleb Wataghin\" Institute of Physics (IFGW), University of Campinas (UNICAMP), Campinas, SP 13083-859, Brazil","S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil; Department of Applied Physics, \"Gleb Wataghin\" Institute of Physics (IFGW), University of Campinas (UNICAMP), Campinas, SP 13083-859, Brazil. Electronic address: fshimizu@unicamp.br","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I181391015","https://openalex.org/I4405267372"]},{"raw_affiliation_string":"Department of Applied Physics, \"Gleb Wataghin\" Institute of Physics (IFGW), University of Campinas (UNICAMP), Campinas, SP 13083-859, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013637942","display_name":"Kevin Figueiredo dos Santos","orcid":"https://orcid.org/0000-0002-7800-0209","observed_orcids":["https://orcid.org/0000-0002-7800-0209"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405267372","display_name":"Instituto de F\u00edsica de S\u00e3o Carlos","ror":"https://ror.org/02f1crb75","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Kevin Figueiredo dos Santos","raw_affiliation_strings":["S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014092483","display_name":"Gustavo Freitas do Nascimento","orcid":"https://orcid.org/0000-0001-5362-9441","observed_orcids":["https://orcid.org/0000-0001-5362-9441"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405267372","display_name":"Instituto de F\u00edsica de S\u00e3o Carlos","ror":"https://ror.org/02f1crb75","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gustavo F. Nascimento","raw_affiliation_strings":["S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070907273","display_name":"Vanan\u00e9lia P.N. Geraldo","orcid":"https://orcid.org/0000-0003-2773-324X","observed_orcids":["https://orcid.org/0000-0003-2773-324X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405267372","display_name":"Instituto de F\u00edsica de S\u00e3o Carlos","ror":"https://ror.org/02f1crb75","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vanan\u00e9lia P.N. Geraldo","raw_affiliation_strings":["S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103492205","display_name":"Osvaldo N. Oliveira","orcid":"https://orcid.org/0000-0002-5399-5860","observed_orcids":["https://orcid.org/0000-0002-5399-5860"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405267372","display_name":"Instituto de F\u00edsica de S\u00e3o Carlos","ror":"https://ror.org/02f1crb75","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Osvaldo N. Oliveira Jr","raw_affiliation_strings":["S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil. Electronic address: chu@ifsc.usp.br","S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil. Electronic address: chu@ifsc.usp.br","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]},{"raw_affiliation_string":"S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, P.O Box 369, 13560-970 S\u00e3o Carlos, SP, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405267372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024422131","display_name":"Ronaldo C. Faria","orcid":"https://orcid.org/0000-0003-1094-9597","observed_orcids":["https://orcid.org/0000-0003-1094-9597"]},"institutions":[{"id":"https://openalex.org/I177909021","display_name":"Universidade Federal de S\u00e3o Carlos","ror":"https://ror.org/00qdc6m37","country_code":"BR","type":"education","lineage":["https://openalex.org/I177909021"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Ronaldo C. Faria","raw_affiliation_strings":["Chemistry Department, Federal University of S\u00e3o Carlos, CP 676, S\u00e3o Carlos 13565-905, S\u00e3o Paulo, Brazil. Electronic address: rcfaria@ufscar.br","Chemistry Department, Federal University of S\u00e3o Carlos, CP 676, S\u00e3o Carlos 13565-905, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Federal University of S\u00e3o Carlos, CP 676, S\u00e3o Carlos 13565-905, S\u00e3o Paulo, Brazil. Electronic address: rcfaria@ufscar.br","institution_ids":["https://openalex.org/I177909021"]},{"raw_affiliation_string":"Chemistry Department, Federal University of S\u00e3o Carlos, CP 676, S\u00e3o Carlos 13565-905, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I177909021"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024422131","https://openalex.org/A5025642299","https://openalex.org/A5070491441","https://openalex.org/A5103492205"],"corresponding_institution_ids":["https://openalex.org/I177909021","https://openalex.org/I17974374","https://openalex.org/I181391015","https://openalex.org/I4405267372"],"apc_list":{"value":2660,"currency":"USD","value_usd":2660},"apc_paid":{"value":2660,"currency":"USD","value_usd":2660},"fwci":0.3504,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.48542507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"145","issue":null,"first_page":"112426","last_page":"112426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.2101999968290329,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.7730000019073486},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":1.0},{"id":"https://openalex.org/keywords/langmuir-monolayers","display_name":"Langmuir monolayers","score":0.9399999976158142},{"id":"https://openalex.org/keywords/membrane-elasticity","display_name":"membrane elasticity","score":0.44999998807907104},{"id":"https://openalex.org/keywords/drug-membrane-interactions","display_name":"drug-membrane interactions","score":0.8510000109672546},{"id":"https://openalex.org/keywords/drug-inactivation","display_name":"drug inactivation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tumor-cell-membrane","display_name":"tumor cell membrane","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.8177275657653809},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6888229846954346},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6542143821716309},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.643462061882019},{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.5875063538551331},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5132770538330078},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.5055739879608154},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4248139262199402},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4232121706008911},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41535916924476624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16394653916358948},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16267690062522888},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12345069646835327},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10649380087852478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08371025323867798}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.biopha.2021.112426","doi":"https://doi.org/10.1016/j.biopha.2021.112426","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2021.112426","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:34861633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34861633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"},{"id":"pmh:oai:https://www.repositorio.unicamp.br/:1236724","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12733/2986","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio da Produ\u00e7\u00e3o Cient\u00edfica e Intelectual da Unicamp","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:701448312fe243b2a86a9e1461e926e1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/701448312fe243b2a86a9e1461e926e1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112426- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2021.112426","doi":"https://doi.org/10.1016/j.biopha.2021.112426","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2021.112426","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1749530852","display_name":null,"funder_award_id":"2016/00991\u20135","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G26566168","display_name":null,"funder_award_id":"2018-22214-6","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G2755372766","display_name":null,"funder_award_id":"2012/15543\u20137","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G908242994","display_name":"Development of simple electrochemical methods for the detection of biomarkers for the diagnosis of diseases","funder_award_id":"17/24053-7","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1530729903","https://openalex.org/W1543790510","https://openalex.org/W1809579453","https://openalex.org/W1984543805","https://openalex.org/W1985977793","https://openalex.org/W1988113635","https://openalex.org/W2004778565","https://openalex.org/W2005172769","https://openalex.org/W2013485244","https://openalex.org/W2016483610","https://openalex.org/W2019510578","https://openalex.org/W2021381932","https://openalex.org/W2024907000","https://openalex.org/W2025859967","https://openalex.org/W2029501044","https://openalex.org/W2030738887","https://openalex.org/W2032481395","https://openalex.org/W2035717191","https://openalex.org/W2037678485","https://openalex.org/W2070986221","https://openalex.org/W2091528050","https://openalex.org/W2106327881","https://openalex.org/W2127478207","https://openalex.org/W2138835636","https://openalex.org/W2148562484","https://openalex.org/W2155199761","https://openalex.org/W2163182699","https://openalex.org/W2317055602","https://openalex.org/W2344795635","https://openalex.org/W2581593863","https://openalex.org/W2594622216","https://openalex.org/W2791136219","https://openalex.org/W2897014076","https://openalex.org/W2902401199","https://openalex.org/W2913295467","https://openalex.org/W2921487259","https://openalex.org/W2937766145","https://openalex.org/W2949451864","https://openalex.org/W2953702348","https://openalex.org/W2968818285","https://openalex.org/W2980550198","https://openalex.org/W2995987179","https://openalex.org/W3012390511","https://openalex.org/W3013419261","https://openalex.org/W3026003230","https://openalex.org/W3042359089","https://openalex.org/W3047662296","https://openalex.org/W3062807705","https://openalex.org/W3088818596","https://openalex.org/W3120949185","https://openalex.org/W3155828254"],"related_works":["https://openalex.org/W115963311","https://openalex.org/W7097587431","https://openalex.org/W2111989254","https://openalex.org/W2061997406","https://openalex.org/W47752513","https://openalex.org/W2129415908","https://openalex.org/W2089072592","https://openalex.org/W2155199761","https://openalex.org/W2031072909","https://openalex.org/W1797274307"],"abstract_inverted_index":{"Glutathione-s-transferase":[0],"is":[1,111],"believed":[2],"to":[3,9,114,127,141,144],"be":[4],"involved":[5],"in":[6],"the":[7,15,18,47,65,93,116,121,128,131],"resistance":[8],"chemotherapeutic":[10],"drugs,":[11],"which":[12],"depends":[13],"on":[14,92],"interaction":[16,45,109],"with":[17,46],"cell":[19,40],"membranes.":[20],"In":[21],"this":[22],"study,":[23],"we":[24],"employed":[25],"Langmuir":[26],"monolayers":[27],"of":[28,31,67,108,130,133],"a":[29],"mixture":[30],"phospholipids":[32],"and":[33,42,52,60,63,78,135,139,146],"cholesterol":[34],"(MIX)":[35],"as":[36],"models":[37],"for":[38,101],"tumor":[39],"membranes":[41],"investigated":[43],"their":[44],"anticancer":[48],"drugs":[49],"cisplatin":[50],"(CDDP)":[51],"doxorubicin":[53],"(DOX).":[54],"We":[55],"found":[56],"that":[57,110],"both":[58],"DOX":[59,89,134],"CDDP":[61,91,136],"expand":[62],"affect":[64],"elasticity":[66],"MIX":[68],"monolayers,":[69,103],"but":[70],"these":[71],"effects":[72],"are":[73,83,86],"hindered":[74],"when":[75],"glutathione-s-transferase":[76],"(GST)":[77],"its":[79],"cofactor":[80],"glutathione":[81],"(GSH)":[82],"incorporated.":[84],"Changes":[85],"induced":[87],"by":[88,137],"or":[90],"polarization-modulated":[94],"infrared":[95],"reflection":[96],"absorption":[97],"spectroscopy":[98],"(PM-IRRAS)":[99],"data":[100],"MIX/GST/GSH":[102],"thus":[104],"denoting":[105],"some":[106],"degree":[107],"not":[112],"sufficient":[113],"alter":[115],"monolayer":[117],"mechanical":[118],"properties.":[119],"Overall,":[120],"results":[122],"presented":[123],"here":[124],"give":[125],"support":[126],"hypothesis":[129],"inactivation":[132],"GST":[138],"point":[140],"possible":[142],"directions":[143],"detect":[145],"fight":[147],"drug":[148],"resistance.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-12-06T00:00:00"}
