{"id":"https://openalex.org/W3214928623","doi":"https://doi.org/10.3390/ph14111180","title":"Physicochemical and Biological Characterization of rhC1INH Expressed in CHO Cells","display_name":"Physicochemical and Biological Characterization of rhC1INH Expressed in CHO Cells","publication_year":2021,"publication_date":"2021-11-19","ids":{"openalex":"https://openalex.org/W3214928623","doi":"https://doi.org/10.3390/ph14111180","mag":"3214928623","pmid":"https://pubmed.ncbi.nlm.nih.gov/34832963","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8621594"},"language":"en","primary_location":{"id":"doi:10.3390/ph14111180","doi":"https://doi.org/10.3390/ph14111180","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph14111180","pdf_url":"https://www.mdpi.com/1424-8247/14/11/1180/pdf?version=1637310456","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8247/14/11/1180/pdf?version=1637310456","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103170746","display_name":"\u0415. \u0412. \u0417\u0443\u0431\u0430\u0440\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-6178-0050","observed_orcids":["https://orcid.org/0000-0002-6178-0050"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Ekaterina Zubareva","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":"https://orcid.org/0000-0002-6178-0050","affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051886303","display_name":"Maksim B. Degterev","orcid":"https://orcid.org/0000-0002-5541-5575","observed_orcids":["https://orcid.org/0000-0002-5541-5575"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maksim Degterev","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":"https://orcid.org/0000-0002-5541-5575","affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037234015","display_name":"A. A. Kazarov","orcid":"https://orcid.org/0000-0003-0682-6113","observed_orcids":["https://orcid.org/0000-0003-0682-6113"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander Kazarov","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":"https://orcid.org/0000-0003-0682-6113","affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113898913","display_name":"M. V. Zhilyaeva","orcid":"https://orcid.org/0000-0002-9880-1724","observed_orcids":["https://orcid.org/0000-0002-9880-1724"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maria Zhiliaeva","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9880-1724","affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036157102","display_name":"K. V. Ulyanova","orcid":"https://orcid.org/0000-0002-3793-7978","observed_orcids":["https://orcid.org/0000-0002-3793-7978"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ksenia Ulyanova","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":"https://orcid.org/0000-0002-3793-7978","affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061715729","display_name":"\u0412. \u041c. \u0421\u0438\u043c\u043e\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0002-0879-5595","observed_orcids":["https://orcid.org/0000-0002-0879-5595"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir Simonov","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060029889","display_name":"Ivan V. Lyagoskin","orcid":"https://orcid.org/0000-0002-9058-1106","observed_orcids":["https://orcid.org/0000-0002-9058-1106"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ivan Lyagoskin","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9058-1106","affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007311973","display_name":"Maksim Smolov","orcid":"https://orcid.org/0000-0003-2935-7655","observed_orcids":["https://orcid.org/0000-0003-2935-7655"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maksim Smolov","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":"https://orcid.org/0000-0003-2935-7655","affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069279069","display_name":"Madina Iskakova","orcid":"https://orcid.org/0000-0001-9527-8176","observed_orcids":["https://orcid.org/0000-0001-9527-8176"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Madina Iskakova","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":"https://orcid.org/0000-0001-9527-8176","affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067769784","display_name":"Anna M. Azarova","orcid":"https://orcid.org/0000-0002-2901-732X","observed_orcids":["https://orcid.org/0000-0002-2901-732X"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Anna Azarova","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047632675","display_name":"Rahim R. Shukurov","orcid":"https://orcid.org/0000-0002-6532-7835","observed_orcids":["https://orcid.org/0000-0002-6532-7835"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Rahim Shukurov","raw_affiliation_strings":["JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia"],"raw_orcid":"https://orcid.org/0000-0002-6532-7835","affiliations":[{"raw_affiliation_string":"JSC \u201cGENERIUM\u201d, 14, Vladimirskaya Street, Volginskiy 601125, Vladimir Region, Russia","institution_ids":["https://openalex.org/I4405272539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047632675","https://openalex.org/A5067769784","https://openalex.org/A5103170746"],"corresponding_institution_ids":["https://openalex.org/I4405272539"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1944},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1944},"fwci":0.3237,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52771698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"11","first_page":"1180","last_page":"1180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.9259999990463257},{"id":"https://openalex.org/keywords/hereditary-angioedema","display_name":"hereditary angioedema","score":0.949999988079071},{"id":"https://openalex.org/keywords/acquired-angioedema","display_name":"acquired angioedema","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cho-cell-expression","display_name":"CHO cell expression","score":0.9409999847412109},{"id":"https://openalex.org/keywords/berinert","display_name":"Berinert","score":0.7649999856948853},{"id":"https://openalex.org/keywords/protein-characterization","display_name":"protein characterization","score":0.5260000228881836},{"id":"https://openalex.org/keywords/peptide-mapping","display_name":"peptide mapping","score":0.5759999752044678},{"id":"https://openalex.org/keywords/therapeutic-proteins","display_name":"therapeutic proteins","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.918339192867279},{"id":"https://openalex.org/C2777788586","wikidata":"https://www.wikidata.org/wiki/Q2096745","display_name":"Hereditary angioedema","level":2,"score":0.700888991355896},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6212023496627808},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.5241004228591919},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.4959357678890228},{"id":"https://openalex.org/C2777261171","wikidata":"https://www.wikidata.org/wiki/Q418750","display_name":"Esterase","level":3,"score":0.49024373292922974},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4414021074771881},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43057823181152344},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4207318425178528},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.42069071531295776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34682774543762207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.318947970867157},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28535717725753784},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28521251678466797},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1214790940284729},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.10863667726516724},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07994407415390015}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/ph14111180","doi":"https://doi.org/10.3390/ph14111180","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph14111180","pdf_url":"https://www.mdpi.com/1424-8247/14/11/1180/pdf?version=1637310456","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},{"id":"pmid:34832963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34832963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8621594","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8621594/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b7adc867c7b4424d92943805cd97fb6c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b7adc867c7b4424d92943805cd97fb6c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, Vol 14, Iss 11, p 1180 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ph14111180","doi":"https://doi.org/10.3390/ph14111180","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph14111180","pdf_url":"https://www.mdpi.com/1424-8247/14/11/1180/pdf?version=1637310456","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3214928623.pdf","grobid_xml":"https://content.openalex.org/works/W3214928623.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W31554181","https://openalex.org/W50187013","https://openalex.org/W276947371","https://openalex.org/W1497280552","https://openalex.org/W1499625106","https://openalex.org/W1503132859","https://openalex.org/W1570484367","https://openalex.org/W1929229765","https://openalex.org/W1976484683","https://openalex.org/W1988606065","https://openalex.org/W1993241932","https://openalex.org/W1996868603","https://openalex.org/W2013180631","https://openalex.org/W2030899178","https://openalex.org/W2036140802","https://openalex.org/W2070783401","https://openalex.org/W2074367238","https://openalex.org/W2074704061","https://openalex.org/W2084691973","https://openalex.org/W2087926948","https://openalex.org/W2104017463","https://openalex.org/W2143122186","https://openalex.org/W2143841063","https://openalex.org/W2145155283","https://openalex.org/W2146519969","https://openalex.org/W2170327826","https://openalex.org/W2281597363","https://openalex.org/W2286655015","https://openalex.org/W2326601291","https://openalex.org/W2334348545","https://openalex.org/W2774393512","https://openalex.org/W2787783783","https://openalex.org/W2902165711","https://openalex.org/W3129093809","https://openalex.org/W4243661403"],"related_works":["https://openalex.org/W1985125466","https://openalex.org/W2143841063","https://openalex.org/W2066489014","https://openalex.org/W2118717586","https://openalex.org/W645710337","https://openalex.org/W1499625106","https://openalex.org/W2129909942","https://openalex.org/W2901279005","https://openalex.org/W2550572533","https://openalex.org/W1995850355"],"abstract_inverted_index":{"The":[0,32,93,122],"disfunction":[1],"or":[2,14,46],"deficiency":[3],"of":[4,40,64,82,97,108,128,152,158],"the":[5,26,38,59,80,87,153,159,180],"C1":[6,69,163],"esterase":[7,70,164],"inhibitor":[8,71,165],"(C1INH)":[9],"is":[10],"associated":[11],"with":[12,104,135,161,192],"hereditary":[13,83],"acquired":[15],"angioedema":[16,84],"(HAE/AAE),":[17],"a":[18,65,102,105,186],"rare":[19],"life-threatening":[20],"condition":[21],"characterized":[22],"by":[23,116],"swelling":[24],"in":[25,141],"skin,":[27],"respiratory":[28],"and":[29,61,91,124,148],"gastrointestinal":[30],"tracts.":[31],"current":[33],"treatment":[34,81],"options":[35],"may":[36],"carry":[37],"risks":[39],"either":[41],"viral":[42],"infection":[43],"(plasma-derived":[44],"Berinert\u00ae)":[45],"immune":[47],"reaction":[48],"(human":[49],"recombinant":[50,67],"C1INH":[51],"from":[52,73,130,166],"rabbit":[53],"milk,":[54],"Ruconest\u00ae).":[55],"This":[56],"study":[57],"describes":[58],"physicochemical":[60],"biological":[62],"characterization":[63],"novel":[66,181],"human":[68,162],"(rhC1INH)":[72],"Chinese":[74],"hamster":[75],"ovary":[76],"(CHO)":[77],"cells":[78,132],"for":[79,190],"compared":[85],"to":[86,177],"marketed":[88],"products":[89],"Berinert\u00ae":[90],"Ruconest\u00ae.":[92],"mass":[94,107,146],"spectrometry":[95],"results":[96],"total":[98],"deglycosylated":[99],"rhC1INH":[100,129,160,182],"revealed":[101],"protein":[103],"molecular":[106],"52,846":[109],"Da.":[110],"Almost":[111],"full":[112],"sequence":[113],"coverage":[114],"(98.6%)":[115],"nanoLC-MS/MS":[117],"peptide":[118],"mapping":[119],"was":[120],"achieved.":[121],"purity":[123],"C1s":[125],"inhibitory":[126,171],"activity":[127,155],"CHO":[131],"are":[133],"comparable":[134],"Ruconest\u00ae,":[136],"although":[137],"we":[138],"found":[139],"differences":[140],"charge":[142],"isoforms":[143],"distribution,":[144],"intact":[145],"values,":[147],"N-glycans":[149],"profile.":[150],"Comparison":[151],"specific":[154],"(IC50":[156],"value)":[157],"blood":[167],"serum":[168],"showed":[169],"similar":[170],"properties.":[172],"These":[173],"data":[174],"allow":[175],"us":[176],"conclude":[178],"that":[179],"molecule":[183],"could":[184],"become":[185],"potential":[187],"therapeutic":[188],"option":[189],"patients":[191],"HAE/AAE.":[193]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-06T00:00:00"}