{"id":"https://openalex.org/W3214799576","doi":"https://doi.org/10.1093/rheumatology/keab874","title":"Chondroprotective effects of CDK4/6 inhibition via enhanced ubiquitin-dependent degradation of JUN in synovial fibroblasts","display_name":"Chondroprotective effects of CDK4/6 inhibition via enhanced ubiquitin-dependent degradation of JUN in synovial fibroblasts","publication_year":2021,"publication_date":"2021-11-19","ids":{"openalex":"https://openalex.org/W3214799576","doi":"https://doi.org/10.1093/rheumatology/keab874","mag":"3214799576","pmid":"https://pubmed.ncbi.nlm.nih.gov/34849618","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9348617"},"language":"en","primary_location":{"id":"doi:10.1093/rheumatology/keab874","doi":"https://doi.org/10.1093/rheumatology/keab874","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rheumatology/keab874","pdf_url":"https://academic.oup.com/rheumatology/article-pdf/61/8/3427/45226640/keab874.pdf","source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/rheumatology/article-pdf/61/8/3427/45226640/keab874.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063740905","display_name":"Tadashi Hosoya","orcid":"https://orcid.org/0000-0001-5177-6413","observed_orcids":["https://orcid.org/0000-0001-5177-6413"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Hosoya","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5177-6413","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101953914","display_name":"Tetsuya Saito","orcid":"https://orcid.org/0000-0001-5356-9477","observed_orcids":["https://orcid.org/0000-0001-5356-9477"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Saito","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroyuki Baba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Baba","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084627679","display_name":"Nao Tanaka","orcid":"https://orcid.org/0000-0002-2085-4682","observed_orcids":["https://orcid.org/0000-0002-2085-4682"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nao Tanaka","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667584","display_name":"Seiji Noda","orcid":"https://orcid.org/0000-0003-0268-8446","observed_orcids":["https://orcid.org/0000-0003-0268-8446"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Noda","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066637227","display_name":"Youji Komiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Youji Komiya","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yasuhiro Tagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Tagawa","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102897621","display_name":"Akio Yamamoto","orcid":"https://orcid.org/0000-0002-2866-6571","observed_orcids":["https://orcid.org/0000-0002-2866-6571"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Yamamoto","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033989320","display_name":"Fumitaka Mizoguchi","orcid":"https://orcid.org/0000-0002-3956-7122","observed_orcids":["https://orcid.org/0000-0002-3956-7122"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumitaka Mizoguchi","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3956-7122","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052024446","display_name":"Kimito Kawahata","orcid":"https://orcid.org/0000-0002-4359-9987","observed_orcids":["https://orcid.org/0000-0002-4359-9987"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kimito Kawahata","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110765658","display_name":"Nobuyuki Miyasaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Miyasaka","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013526431","display_name":"Hitoshi Kohsaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Kohsaka","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016009056","display_name":"Shinsuke Yasuda","orcid":"https://orcid.org/0000-0001-6171-2077","observed_orcids":["https://orcid.org/0000-0001-6171-2077"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shinsuke Yasuda","raw_affiliation_strings":["Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016009056"],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":{"value":2817,"currency":"GBP","value_usd":4225},"apc_paid":{"value":2817,"currency":"GBP","value_usd":4225},"fwci":1.7188,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.8275304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"61","issue":"8","first_page":"3427","last_page":"3438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.6801999807357788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.6801999807357788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.3034999966621399,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk4-6-inhibition","display_name":"CDK4/6 inhibition","score":0.9430000185966492},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.6909999847412109},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.9580000042915344},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chondroprotection","display_name":"chondroprotection","score":0.984000027179718},{"id":"https://openalex.org/keywords/ubiquitin-mediated-degradation","display_name":"ubiquitin-mediated proteolysis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cytokine-cytokine-receptor-interaction","display_name":"cytokine-cytokine receptor interaction","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cartilage-destruction","display_name":"cartilage destruction","score":0.6800000071525574},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7787781357765198},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6076056361198425},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.5793053507804871},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4310370683670044},{"id":"https://openalex.org/C2777652487","wikidata":"https://www.wikidata.org/wiki/Q575064","display_name":"Synovial membrane","level":3,"score":0.4254959225654602},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39914682507514954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25348997116088867},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.21040832996368408},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16690242290496826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06391438841819763},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06359511613845825},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051358","descriptor_name":"Cyclin-Dependent Kinase 4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051361","descriptor_name":"Cyclin-Dependent Kinase 6","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/rheumatology/keab874","doi":"https://doi.org/10.1093/rheumatology/keab874","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rheumatology/keab874","pdf_url":"https://academic.oup.com/rheumatology/article-pdf/61/8/3427/45226640/keab874.pdf","source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},{"id":"pmid:34849618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34849618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9348617","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9348617/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology (Oxford)","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:07523:0007478928","doi":null,"is_oa":true,"landing_page_url":"https://marianna-u.repo.nii.ac.jp/records/2004284","pdf_url":"https://marianna-u.repo.nii.ac.jp/record/2004284/files/keab874.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rheumatology","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1093/rheumatology/keab874","doi":"https://doi.org/10.1093/rheumatology/keab874","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rheumatology/keab874","pdf_url":"https://academic.oup.com/rheumatology/article-pdf/61/8/3427/45226640/keab874.pdf","source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1857844953","display_name":"Targeting synovial fibroblasts for the treatment of rheumatoid arthritis by CDK4/6 inhibition","funder_award_id":"19K17884","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G18613197","display_name":"Pathological contribution of RA risk loci to the disease progression and the therapeutic response","funder_award_id":"15K20976","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2991450934","display_name":"\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u95a2\u9023\u7dda\u7dad\u82bd\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u898f\u6cbb\u7642\u6226\u7565\u306e\u958b\u767a","funder_award_id":"21ek0410061h0003","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6904115150","display_name":"The novel anti-inflammatory drug development complementing with glucocorticoid","funder_award_id":"21K08472","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7460985278","display_name":null,"funder_award_id":"2020A15","funder_id":"https://openalex.org/F4320310756","funder_display_name":"Japan Research Foundation for Clinical Pharmacology"}],"funders":[{"id":"https://openalex.org/F4320310756","display_name":"Japan Research Foundation for Clinical Pharmacology","ror":"https://ror.org/02900by63"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3214799576.pdf","grobid_xml":"https://content.openalex.org/works/W3214799576.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1482964233","https://openalex.org/W1970430170","https://openalex.org/W1983134858","https://openalex.org/W1989590412","https://openalex.org/W1999574084","https://openalex.org/W2005832407","https://openalex.org/W2014574284","https://openalex.org/W2016098919","https://openalex.org/W2035036601","https://openalex.org/W2035636765","https://openalex.org/W2045528511","https://openalex.org/W2049904360","https://openalex.org/W2050175251","https://openalex.org/W2053043355","https://openalex.org/W2061974695","https://openalex.org/W2067427748","https://openalex.org/W2069691728","https://openalex.org/W2074438676","https://openalex.org/W2081102173","https://openalex.org/W2085807801","https://openalex.org/W2094872845","https://openalex.org/W2107018762","https://openalex.org/W2117810266","https://openalex.org/W2124006755","https://openalex.org/W2128952811","https://openalex.org/W2131167295","https://openalex.org/W2132141505","https://openalex.org/W2134943518","https://openalex.org/W2146516445","https://openalex.org/W2152600133","https://openalex.org/W2162609478","https://openalex.org/W2163463767","https://openalex.org/W2186095447","https://openalex.org/W2552099557","https://openalex.org/W2559838741","https://openalex.org/W2804716665","https://openalex.org/W2896846857","https://openalex.org/W2900310474","https://openalex.org/W2937686488","https://openalex.org/W2945336635","https://openalex.org/W2945883683","https://openalex.org/W2951940744","https://openalex.org/W3022414345","https://openalex.org/W3038115149","https://openalex.org/W3097602692","https://openalex.org/W3122644557","https://openalex.org/W3132814443","https://openalex.org/W3134191307","https://openalex.org/W4211054359"],"related_works":["https://openalex.org/W4416904198","https://openalex.org/W4406934287","https://openalex.org/W7157531630","https://openalex.org/W2050175251","https://openalex.org/W2086437890","https://openalex.org/W2154971969","https://openalex.org/W1559664759","https://openalex.org/W1934823782","https://openalex.org/W4413835481","https://openalex.org/W1969702741"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Targeting":[1],"synovial":[2],"fibroblasts":[3],"(SF)":[4],"using":[5,49,62],"a":[6,15,63],"cyclin-dependent":[7],"kinase":[8],"(CDK)":[9],"4/6":[10,42],"inhibitor":[11],"(CDKI)":[12],"could":[13,224],"be":[14,226],"potent":[16],"therapy":[17],"for":[18],"RA":[19,231],"via":[20,203],"inhibition":[21,193,212],"of":[22,35,83,123,132,167,188,199,207,213],"proliferation":[23],"and":[24,69,78,112,128,134,173,236],"MMP-3":[25,113],"production.":[26],"This":[27],"study":[28],"was":[29,47,88,97,180,194],"designed":[30],"to":[31,86,99,126,233],"elucidate":[32],"the":[33,121,130,138,165,177,197,204,210],"mechanism":[34,187],"chondroprotective":[36,189,235],"effects":[37,59,190],"on":[38],"SFs":[39],"by":[40,54,104,151,191,196],"CDK":[41],"inhibition.":[43],"METHODS:":[44],"CDK4/6":[45,145,192,214],"activity":[46,202],"inhibited":[48,129],"CDKI":[50,105,108,119],"treatment":[51],"or":[52],"enhanced":[53],"adenoviral":[55],"gene":[56,101],"transduction.":[57],"Chondroprotective":[58],"were":[60,72,162],"evaluated":[61,73],"collagen-induced":[64],"arthritis":[65],"model":[66],"(CIA).":[67],"Gene":[68],"protein":[70],"expression":[71],"with":[74,90,164,230],"quantitative":[75],"PCR,":[76],"ELISA":[77],"Western":[79],"blotting.":[80],"The":[81,154,186],"binding":[82,122,140],"nuclear":[84],"extracts":[85],"DNA":[87,127],"assessed":[89],"an":[91],"electrophoresis":[92],"mobility":[93],"shift":[94],"assay.":[95],"RNA-Seq":[96,155],"performed":[98],"identify":[100],"sets":[102],"affected":[103],"treatment.":[106],"RESULTS:":[107],"attenuated":[109],"cartilage":[110],"destruction":[111],"production":[114,131],"in":[115,142,182,220,228],"CIA.":[116],"In":[117],"RASFs,":[118],"impaired":[120,205],"AP-1":[124,139,178,200],"components":[125],"MMP-1":[133],"MMP-3,":[135],"which":[136,161],"contain":[137],"sequence":[141],"their":[143],"promoter.":[144],"protected":[146],"JUN":[147],"from":[148],"proteasome-dependent":[149],"degradation":[150],"inhibiting":[152],"ubiquitination.":[153],"analysis":[156],"identified":[157],"CDKI-sensitive":[158],"inflammatory":[159],"genes,":[160,169],"associated":[163],"pathway":[166],"RA-associated":[168],"cytokine-cytokine":[170],"receptor":[171],"interaction":[172],"IL-17":[174],"signalling.":[175],"Notably,":[176],"motif":[179],"enriched":[181],"these":[183],"genes.":[184],"CONCLUSION:":[185],"achieved":[195],"attenuation":[198],"transcriptional":[201],"stability":[206],"JUN.":[208],"Because":[209],"pharmacologic":[211],"has":[215],"been":[216],"established":[217],"as":[218],"tolerable":[219],"cancer":[221],"treatment,":[222],"it":[223],"also":[225],"beneficial":[227],"patients":[229],"due":[232],"its":[234],"anti-inflammatory":[237],"effects.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-06T00:00:00"}