{"id":"https://openalex.org/W3214242580","doi":"https://doi.org/10.1182/blood-2021-147108","title":"Results of an International, Multi-Centre, Retrospective Study to Describe Treatment Pathways, Outcomes and Resource Use in Patients with Multiple Myeloma in Emerging Markets (INTEGRATE)","display_name":"Results of an International, Multi-Centre, Retrospective Study to Describe Treatment Pathways, Outcomes and Resource Use in Patients with Multiple Myeloma in Emerging Markets (INTEGRATE)","publication_year":2021,"publication_date":"2021-11-05","ids":{"openalex":"https://openalex.org/W3214242580","doi":"https://doi.org/10.1182/blood-2021-147108","mag":"3214242580"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2021-147108","doi":"https://doi.org/10.1182/blood-2021-147108","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-147108","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100353399","display_name":"Kihyun K\u0131m","orcid":"https://orcid.org/0000-0002-5878-8895","observed_orcids":["https://orcid.org/0000-0002-5878-8895"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kihyun Kim","raw_affiliation_strings":["Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan Univ. Sch. of Med. Samsung Medical Center, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan Univ. Sch. of Med. Samsung Medical Center, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068099446","display_name":"Natalia Paola Schutz","orcid":"https://orcid.org/0000-0002-1167-7186","observed_orcids":["https://orcid.org/0000-0002-1167-7186"]},"institutions":[{"id":"https://openalex.org/I2802359038","display_name":"Hospital Italiano de Buenos Aires","ror":"https://ror.org/00bq4rw46","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I2802359038"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Natalia Paola Schutz","raw_affiliation_strings":["Hospital Italiano de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Italiano de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2802359038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030170547","display_name":"Su\u2010Peng Yeh","orcid":"https://orcid.org/0000-0001-6981-8677","observed_orcids":["https://orcid.org/0000-0001-6981-8677"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Su-Peng Yeh","raw_affiliation_strings":["China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061201808","display_name":"Estelle R. Verburgh","orcid":"https://orcid.org/0000-0003-4657-7318","observed_orcids":["https://orcid.org/0000-0003-4657-7318"]},"institutions":[{"id":"https://openalex.org/I2802258008","display_name":"Groote Schuur Hospital","ror":"https://ror.org/00c879s84","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I1307091933","https://openalex.org/I2802258008"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Estelle Verburgh","raw_affiliation_strings":["Groote Schuur Hospital, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groote Schuur Hospital, Cape Town, South Africa","institution_ids":["https://openalex.org/I2802258008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109053603","display_name":"Fahad Z. Alsharif","orcid":"https://orcid.org/0000-0003-2209-2914","observed_orcids":["https://orcid.org/0000-0003-2209-2914"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Fahad Alsharif","raw_affiliation_strings":["Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769267","display_name":"Wen-Ming Chen","orcid":"https://orcid.org/0000-0001-9070-9280","observed_orcids":["https://orcid.org/0000-0001-9070-9280"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenming Chen","raw_affiliation_strings":["Beijing Chao-Yang Hospital of Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Chao-Yang Hospital of Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077189736","display_name":"Tatiana A. Mitina","orcid":"https://orcid.org/0000-0001-7493-0030","observed_orcids":["https://orcid.org/0000-0001-7493-0030"]},"institutions":[{"id":"https://openalex.org/I4210115129","display_name":"Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky","ror":"https://ror.org/0233m9s16","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210115129"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatiana Mitina","raw_affiliation_strings":["Moscow Regional Research and Clinical Institute (\"MONIKI\"), Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moscow Regional Research and Clinical Institute (\"MONIKI\"), Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210115129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066282840","display_name":"Wee Joo Chng","orcid":"https://orcid.org/0000-0003-2578-8335","observed_orcids":["https://orcid.org/0000-0003-2578-8335"]},"institutions":[{"id":"https://openalex.org/I4210103786","display_name":"National University Cancer Institute, Singapore","ror":"https://ror.org/025yypj46","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210103786","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wee-Joo Chng","raw_affiliation_strings":["National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore","institution_ids":["https://openalex.org/I4210103786","https://openalex.org/I4210150261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053761444","display_name":"Cathy H. Wu","orcid":"https://orcid.org/0000-0001-6379-8601","observed_orcids":["https://orcid.org/0000-0001-6379-8601","https://orcid.org/0000-0001-8594-303X"]},"institutions":[{"id":"https://openalex.org/I4210098530","display_name":"Takeda (Singapore)","ror":"https://ror.org/00dzggj72","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210098530","https://openalex.org/I44892455"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Cathy Wu","raw_affiliation_strings":["Takeda Pharmaceuticals International AG - Singapore Branch, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceuticals International AG - Singapore Branch, Singapore, Singapore","institution_ids":["https://openalex.org/I4210098530"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098530","display_name":"Takeda (Singapore)","ror":"https://ror.org/00dzggj72","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210098530","https://openalex.org/I44892455"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Hui Wan","raw_affiliation_strings":["Takeda Pharmaceuticals International AG - Singapore Branch, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceuticals International AG - Singapore Branch, Singapore, Singapore","institution_ids":["https://openalex.org/I4210098530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112458111","display_name":"Zhongwen Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Zhongwen Huang","raw_affiliation_strings":["Takeda R&D Data Science Institute, Takeda Pharmaceuticals International Co., Cambridge,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda R&D Data Science Institute, Takeda Pharmaceuticals International Co., Cambridge,","institution_ids":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080776694","display_name":"Meral Beksa\u00e7","orcid":"https://orcid.org/0000-0003-1797-8657","observed_orcids":["https://orcid.org/0000-0003-1797-8657"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Meral Beksac","raw_affiliation_strings":["Department of Hematology, Ankara University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]}],"institutions":[],"countries_distinct_count":11,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"Supplement 1","first_page":"3045","last_page":"3045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/newly-diagnosed-multiple-myeloma","display_name":"newly diagnosed multiple myeloma","score":0.8849999904632568},{"id":"https://openalex.org/keywords/relapsed-refractory-multiple-myeloma","display_name":"relapsed/refractory multiple myeloma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/treatment-pathways","display_name":"treatment pathways","score":0.9290000200271606},{"id":"https://openalex.org/keywords/time-to-next-treatment","display_name":"time to next treatment","score":0.8360000252723694},{"id":"https://openalex.org/keywords/healthcare-resource-utilization","display_name":"healthcare resource utilization","score":0.6790000200271606},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.5640000104904175},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.5460000038146973},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/emerging-markets","display_name":"emerging markets","score":0.4350000023841858},{"id":"https://openalex.org/keywords/real-world-data","display_name":"real-world data","score":0.7839999794960022},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.3790000081062317},{"id":"https://openalex.org/keywords/treatment-lines","display_name":"treatment lines","score":0.4000000059604645},{"id":"https://openalex.org/keywords/health-care-costs","display_name":"health care costs","score":0.34299999475479126},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.3479999899864197},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6835711002349854},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5684474110603333},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5183754563331604},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.46143031120300293},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4393214285373688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42101356387138367},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3429073095321655},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3243526518344879},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2021-147108","doi":"https://doi.org/10.1182/blood-2021-147108","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-147108","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2989331680","https://openalex.org/W4409450552","https://openalex.org/W2808748371","https://openalex.org/W2559685064","https://openalex.org/W2779429666","https://openalex.org/W4405054549","https://openalex.org/W4405049811","https://openalex.org/W4285744760","https://openalex.org/W7093123108","https://openalex.org/W2966812112"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Multiple":[2],"myeloma":[3],"(MM)":[4],"is":[5,18,36,68,521],"a":[6,154,211,255,475,621],"progressive,":[7],"rarely":[8],"curable,":[9],"B-cell":[10],"malignancy":[11],"(McCachren":[12],"et":[13,28,39,43,563,567,582,589,614],"al.":[14,29,40,44,564,568,583,590,615],"2021).":[15],"The":[16,105,168,267,313,374,384,617],"incidence":[17],"increasing,":[19],"with":[20,61,87,389,512],"the":[21,76,111,145,233,246,299,306,345,348,422,439,449,465,500,516,522,528,541,560,571,586,599,625,633],"greatest":[22],"acceleration":[23],"in":[24,59,63,206,216,293,381,515,545,557,719,733],"emerging":[25,34,64,535],"markets":[26,536],"(Cowan":[27],"2016).":[30],"Optimal":[31],"management":[32,529,639],"amidst":[33],"treatments":[35,542,644],"challenging":[37],"(Bruno":[38,588],"2020;":[41,565],"Mohty":[42],"2020).":[45,591],"This":[46],"study":[47,74,525,619],"aimed":[48],"to":[49,109,113,526,555,609,635,645],"obtain":[50],"real-world":[51,524,572],"data":[52,219],"on":[53,316,351,551,642,673,739,752,765,778,791,804],"treatment,":[54],"toxicity":[55],"and":[56,99,142,161,187,192,210,264,288,333,366,410,438,464,499,559,585,627,631,638],"healthcare":[57],"utilization":[58],"patients":[60,83,149,180,202,225,235,250,279,301,388,428,455],"MM":[62,531],"markets.":[65],"Methods:":[66],"INTEGRATE":[67,520,618],"an":[69,674,740,753,766,779,792,805],"international,":[70],"multi-center,":[71],"retrospective,":[72],"observational":[73],"of":[75,79,120,134,232,427,454,502,530,540,596,603,629,648,677,743,756,769,782,795,808],"medical":[77],"records":[78,124],"alive":[80],"or":[81,91,165,432,459,506,679,745,758,771,784,797,810],"deceased":[82],"aged":[84],"\u226518":[85],"years":[86,175,274],"newly":[88],"diagnosed":[89],"(NDMM)":[90],"relapsed/refractory":[92,307],"(RRMM)":[93],"disease":[94,433],"between":[95,624],"1":[96,651],"January":[97],"2010":[98],"31":[100],"December":[101],"2011":[102],"(Figure":[103,419],"1).":[104],"primary":[106],"objective":[107],"was":[108,173,272,319,354,391,443,469],"describe":[110,527],"time":[112,315,350,550],"next":[114],"treatment":[115,437,463,597,630],"(TTNT)":[116],"at":[117,127,171,270,305,330,338,363,371,399,407,416,486],"each":[118],"line":[119,332,340,365,409,418],"therapy.":[121,649],"Results:":[122],"Patient":[123],"were":[125,150,159,193,222,241,251,260,510],"screened":[126],"45":[128],"centers":[129],"across":[130,532],"Argentina,":[131],"China,":[132],"Republic":[133],"Korea,":[135],"Russia,":[136],"Saudi":[137],"Arabia,":[138],"South":[139],"Africa,":[140],"Taiwan":[141],"Turkey.":[143],"In":[144,245,344,421,448,474,592],"NDMM":[146,342,390,424,451,494,517],"group":[147,248],"(N=1,511),":[148],"followed":[151,252],"up":[152,253],"for":[153,243,254,303,341,387,493],"median":[155,256,314,349,385,594],"56.9":[156],"months,":[157,258],"50.6%":[158],"male":[160],"predominantly":[162],"White":[163,263],"(50.2%)":[164],"Asian":[166,479],"(37.9%).":[167],"mean":[169,268],"age":[170,269],"diagnosis":[172,271,487],"59.6":[174],"(range":[176,275],"24.4-97.3":[177],"years).":[178,277],"Most":[179,278],"(51.4%)":[181],"had":[182,189,203,213,281,285,290,429,456],"immunoglobulin":[183],"G":[184],"(IgG)":[185],"myeloma,":[186,283],"32.0%":[188],"IgG":[190,282,286],"kappa":[191],"staged":[194],"using":[195],"International":[196],"Staging":[197],"System":[198],"criteria":[199],"(49.6%).":[200],"Many":[201],"bone":[204,291,482],"lesions":[205,292],"1-3":[207],"sites":[208],"(43.3%)":[209],"majority":[212],"no":[214,489],"fluorescence":[215],"situ":[217],"hybridization":[218],"reported.":[220],"There":[221],"481":[223],"(31.8%)":[224],"who":[226,236],"underwent":[227,311],"frontline":[228,492],"stem-cell":[229],"transplantation":[230],"(SCT),":[231],"987":[234],"did":[237],"not,":[238],"121":[239],"(12.3%)":[240],"eligible":[242,302],"transplant.":[244],"RRMM":[247,346],"(N=621),":[249],"62.2":[257],"50.1%":[259],"male,":[261],"57.0%":[262],"32.2%":[265],"Asian.":[266],"57.9":[273],"17.7-86.4":[276],"(52.5%)":[280],"33.5%":[284],"kappa,":[287],"44.1%":[289],"more":[294],"than":[295,576],"three":[296],"sites.":[297],"Of":[298],"144":[300],"SCT":[304,450,490],"diagnosis,":[308],"98":[309],"(68.1%)":[310],"transplantation.":[312],"first-line":[317,352,377,436,462],"therapy":[318,353,552,604],"6.0":[320,359,367],"months":[321,327,335,356,360,368,393,403,412],"(interquartile":[322],"range":[323],"[IQR]":[324],"3.7-10.4),":[325],"6.4":[326],"(IQR":[328,336,357,361,369],"3.2-11.9)":[329],"second":[331,364,408],"6.6":[334],"3.3-9.6)":[337],"third":[339,372,417],"patients.":[343,518],"group,":[347],"5.7":[355],"3.5-9.0),":[358],"3.3-9.5)":[362],"3.1-10.9)":[370],"line.":[373],"most":[375],"common":[376],"therapies":[378],"are":[379,605],"shown":[380],"Table":[382],"1.":[383,653],"TTNT":[386,514,626],"39.5":[392],"(95%":[394,404,413,445,471],"confidence":[395],"interval":[396],"[CI]":[397],"37.6-42.6)":[398],"first":[400,600],"line,":[401],"33.9":[402],"CI":[405,414,446,472],"28.8-37.0)":[406],"20.9":[411],"17.1-27.1)":[415],"2).":[420],"non-SCT":[423],"subgroup,":[425,452],"44%":[426],"documented":[430,457],"relapse":[431,458],"progression":[434,460],"after":[435,461],"5-year":[440,466],"OS":[441,467,573],"rate":[442,468],"64.6%":[444],"61.2-67.9).":[447],"43.2%":[453],"73.5%":[470],"69.1-77.4).":[473],"risk":[476],"factor":[477],"analysis,":[478],"ethnicity":[480],"(p<0.001),":[481,488],"marrow":[483],"plasma":[484],"cells":[485],"performed":[491],"(p=0.001),":[495],"ISS":[496],"stage":[497],"II/III":[498],"presence":[501],"either":[503],"t(4;14),":[504],"t(14;16)":[505],"del":[507],"17p13":[508],"(p=0.022)":[509],"associated":[511],"shorter":[513],"Conclusions:":[519],"largest":[523],"these":[533,546],"eight":[534],"that":[537,610],"remains":[538],"reflective":[539],"currently":[543],"available":[544,643],"countries.":[547],"We":[548],"found":[549],"not":[553],"dissimilar":[554],"cohorts":[556],"Europe":[558],"US":[561,587],"(Mohty":[562],"Hari":[566],"2018)":[569],"although":[570],"appears":[574],"longer":[575],"previous":[577],"reports":[578],"from":[579],"Japan":[580],"(Akizuki":[581],"2020)":[584],"addition,":[593],"duration":[595,628],"during":[598],"3":[601],"lines":[602,647],"also":[606],"very":[607],"similar":[608],"reported":[611],"by":[612],"Kwee":[613],"2016.":[616],"highlights":[620],"wide":[622],"variation":[623],"has":[632],"potential":[634],"inform":[636],"screening":[637],"decisions":[640],"based":[641],"maximize":[646],"Figure":[650,652],"Disclosures":[654],"Kim:":[655],"Janssen,":[656],"BMS:":[657,737],"Research":[658,685,699,705,710],"Funding.":[659,711],"Schutz:":[660],"Takeda:":[661,670,707,713,723,727,802],"Honoraria;":[662,666,688,690,692,694,696,708],"Johnson":[663,701],"&":[664,702],"Johnson:":[665,703],"Sanofi:":[667,691,763],"Honoraria.":[668],"Mitina:":[669],"Honoraria,":[671,684,698,704],"Membership":[672,738,751,764,777,790,803],"entity's":[675,741,754,767,780,793,806],"Board":[676,742,755,768,781,794,807],"Directors":[678,744,757,770,783,796,809],"advisory":[680,746,759,772,785,798,811],"committees.":[681],"Chng:":[682],"Novartis:":[683],"Funding;":[686,700,706],"Antengene:":[687],"Pfizer:":[689],"AbbVie:":[693],"Amgen:":[695,776],"BMS/Celgene:":[697],"Aslan:":[709],"Wu:":[712],"Current":[714,716,724,728,730],"Employment,":[715,729],"equity":[717,731],"holder":[718,732],"publicly-traded":[720,734],"company.":[721,735],"Wan:":[722],"Employment.":[725],"Huang:":[726],"Beksac:":[736],"committees,":[747,760,773,786,799,812],"Speakers":[748,761,774,787,800,813],"Bureau;":[749,762,775,788,801],"Janssen:":[750],"Oncopeptides:":[789],"Bureau.":[814]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-11-22T00:00:00"}