{"id":"https://openalex.org/W3213767185","doi":"https://doi.org/10.1158/1538-7445.panca21-po-094","title":"Abstract PO-094: G\u03b113 loss in KPC mouse model promotes well-differentiated pancreatic tumors that are susceptible to mTOR inhibition","display_name":"Abstract PO-094: G\u03b113 loss in KPC mouse model promotes well-differentiated pancreatic tumors that are susceptible to mTOR inhibition","publication_year":2021,"publication_date":"2021-11-15","ids":{"openalex":"https://openalex.org/W3213767185","doi":"https://doi.org/10.1158/1538-7445.panca21-po-094","mag":"3213767185"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca21-po-094","doi":"https://doi.org/10.1158/1538-7445.panca21-po-094","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca21-po-094","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020129454","display_name":"Mario A. Shields","orcid":"https://orcid.org/0000-0002-3562-9875","observed_orcids":["https://orcid.org/0000-0002-3562-9875"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario A. Shields","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059353717","display_name":"Christina Spaulding","orcid":"https://orcid.org/0009-0004-3658-421X","observed_orcids":["https://orcid.org/0009-0004-3658-421X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Spaulding","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047335558","display_name":"Mahmoud G. Khalafalla","orcid":"https://orcid.org/0000-0002-7171-8162","observed_orcids":["https://orcid.org/0000-0002-7171-8162"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmoud G. Khalafalla","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039554820","display_name":"Thao D. Pham","orcid":"https://orcid.org/0000-0001-7547-0945","observed_orcids":["https://orcid.org/0000-0001-7547-0945"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thao N. D. Pham","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001372566","display_name":"Hidayatullah G. Munshi","orcid":"https://orcid.org/0000-0002-9552-0775","observed_orcids":["https://orcid.org/0000-0002-9552-0775"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hidayatullah G. Munshi","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"81","issue":"22_Supplement","first_page":"PO","last_page":"094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galpha13","display_name":"G\u03b113","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8939999938011169},{"id":"https://openalex.org/keywords/kpc-mouse-model","display_name":"KPC mouse model","score":0.9570000171661377},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.7900000214576721},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-suppressor-function","display_name":"tumor suppressor function","score":0.6600000262260437},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7866964340209961},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7430795431137085},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.662940502166748},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6208362579345703},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5960292816162109},{"id":"https://openalex.org/C2777996000","wikidata":"https://www.wikidata.org/wiki/Q7130412","display_name":"Pancreatic tumor","level":4,"score":0.5705369710922241},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.551638126373291},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5461183786392212},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.4927978813648224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4814995527267456},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.479621022939682},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.44862300157546997},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2573416531085968},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.198906809091568},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.08129939436912537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05553478002548218},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca21-po-094","doi":"https://doi.org/10.1158/1538-7445.panca21-po-094","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca21-po-094","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4214751040","https://openalex.org/W4284693898","https://openalex.org/W4309108364","https://openalex.org/W3103739244","https://openalex.org/W4409821279","https://openalex.org/W3006665307","https://openalex.org/W1981681375","https://openalex.org/W2104246332","https://openalex.org/W1971486310","https://openalex.org/W2335158147"],"abstract_inverted_index":{"Abstract":[0],"G\u03b113":[1,8,33,52,62,82,106,146,164,197],"transduces":[2],"signals":[3],"from":[4,126],"G":[5],"protein-coupled":[6],"receptors.":[7],"is":[9],"pro-tumorigenic":[10],"in":[11,22,34,40,53,60,64,84,108,165,172,199],"epithelial":[12],"cancer":[13,94,122],"cell":[14,55,123],"lines,":[15],"which":[16,132],"contrasts":[17],"with":[18,98,138,144],"its":[19],"tumor-suppressive":[20,170],"function":[21],"transgenic":[23,42,88,173],"mouse":[24,43,68,89,111,174,201],"models":[25,175],"of":[26,32,51,70,91,163,176,216],"lymphomas.":[27],"We":[28],"investigated":[29],"the":[30,65,85,109,217],"role":[31,162,171],"pancreatic":[35,54,71,93,121,142,166,178,205],"tumor":[36,58,72,77,100],"development":[37,78],"and":[38,102,117,154],"progression":[39],"a":[41,160,169],"model.":[44],"Here":[45],"we":[46],"show":[47],"that":[48,207],"while":[49],"loss":[50,63,83,107,198],"lines":[56,124],"decreases":[57],"growth":[59],"vivo,":[61],"Kras-driven":[66],"(KC)":[67],"model":[69,90,112,202],"initiation":[73],"does":[74],"not":[75],"affect":[76],"or":[79],"survival.":[80,104],"Instead,":[81],"Kras/Tp53":[86],"(KPC)":[87],"advanced":[92,177],"promotes":[95,203],"well-differentiated":[96,130,204],"tumors":[97,206],"increased":[99,150],"burden":[101],"reduced":[103],"Mechanistically,":[105],"KPC":[110,200],"enhances":[113],"E-cadherin-mediated":[114],"cell-cell":[115],"junctions":[116],"mTOR":[118,136,155,211],"signaling.":[119,156],"G\u03b113-deficient":[120],"derived":[125],"these":[127],"mice":[128],"form":[129],"tumors,":[131],"are":[133,208],"susceptible":[134,209],"to":[135,210],"inhibition":[137,212],"rapamycin.":[139],"Importantly,":[140],"human":[141],"cancers":[143],"low":[145],"expression":[147,153],"also":[148],"exhibit":[149],"E-cadherin":[151],"protein":[152],"This":[157],"work":[158],"establishes":[159],"context-dependent":[161],"tumorigenesis,":[167],"demonstrating":[168],"cancer.":[179],"Citation":[180],"Format:":[181],"Mario":[182],"A.":[183],"Shields,":[184],"Christina":[185],"Spaulding,":[186],"Mahmoud":[187],"G.":[188,195],"Khalafalla,":[189],"Thao":[190],"N.":[191],"D.":[192],"Pham,":[193],"Hidayatullah":[194],"Munshi.":[196],"[abstract].":[213],"In:":[214],"Proceedings":[215],"AACR":[218],"Virtual":[219],"Special":[220],"Conference":[221],"on":[222],"Pancreatic":[223],"Cancer;":[224],"2021":[225],"Sep":[226],"29-30.":[227],"Philadelphia":[228],"(PA):":[229],"AACR;":[230],"Cancer":[231],"Res":[232],"2021;81(22":[233],"Suppl):Abstract":[234],"nr":[235],"PO-094.":[236]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2021-11-22T00:00:00"}
