{"id":"https://openalex.org/W3213716658","doi":"https://doi.org/10.1016/j.jtho.2021.10.022","title":"Tumor Junction Burden and Antigen Presentation as Predictors of Survival in Mesothelioma Treated With Immune Checkpoint Inhibitors","display_name":"Tumor Junction Burden and Antigen Presentation as Predictors of Survival in Mesothelioma Treated With Immune Checkpoint Inhibitors","publication_year":2021,"publication_date":"2021-11-17","ids":{"openalex":"https://openalex.org/W3213716658","doi":"https://doi.org/10.1016/j.jtho.2021.10.022","mag":"3213716658","pmid":"https://pubmed.ncbi.nlm.nih.gov/34800701","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8882146"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtho.2021.10.022","doi":"https://doi.org/10.1016/j.jtho.2021.10.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2021.10.022","pdf_url":"http://www.jto.org/article/S1556086421033190/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jto.org/article/S1556086421033190/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070480124","display_name":"Farhad Kosari","orcid":"https://orcid.org/0000-0003-0321-164X","observed_orcids":["https://orcid.org/0000-0003-0321-164X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farhad Kosari","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019445512","display_name":"Maria Disselhorst","orcid":"https://orcid.org/0000-0003-3532-4155","observed_orcids":["https://orcid.org/0000-0003-3532-4155"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maria Disselhorst","raw_affiliation_strings":["Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473205","display_name":"Jun Yin","orcid":"https://orcid.org/0000-0003-3242-9664","observed_orcids":["https://orcid.org/0000-0003-3242-9664"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Yin","raw_affiliation_strings":["Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108726564","display_name":"Tobias Peikert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tobias Peikert","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089609616","display_name":"Julia B.M. Udell","orcid":"https://orcid.org/0000-0003-3225-733X","observed_orcids":["https://orcid.org/0000-0003-3225-733X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Udell","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051491336","display_name":"Sarah H. Johnson","orcid":"https://orcid.org/0000-0001-7412-5322","observed_orcids":["https://orcid.org/0000-0001-7412-5322"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Johnson","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077968996","display_name":"James B. Smadbeck","orcid":"https://orcid.org/0000-0002-8902-0950","observed_orcids":["https://orcid.org/0000-0002-8902-0950"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Smadbeck","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011416122","display_name":"Stephen J. Murphy","orcid":"https://orcid.org/0000-0002-8630-5897","observed_orcids":["https://orcid.org/0000-0002-8630-5897"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Murphy","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112616379","display_name":"Alexa McCune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa McCune","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005641583","display_name":"Giannoula Karagouga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giannoula Karagouga","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078137308","display_name":"Aakash P. Desai","orcid":"https://orcid.org/0000-0002-2943-3817","observed_orcids":["https://orcid.org/0000-0002-2943-3817"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aakash Desai","raw_affiliation_strings":["Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008709154","display_name":"Janet L. Schaefer-Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Schaefer-Klein","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018257387","display_name":"Mitesh J. Borad","orcid":"https://orcid.org/0000-0003-2700-2658","observed_orcids":["https://orcid.org/0000-0003-2700-2658"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitesh J. Borad","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota; Department of Medical Oncology, Mayo Clinic, Phoenix, Arizona","Department of Medical Oncology, Mayo Clinic, Phoenix, Arizona","Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota; Department of Medical Oncology, Mayo Clinic, Phoenix, Arizona","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Phoenix, Arizona","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082725102","display_name":"John C. Cheville","orcid":"https://orcid.org/0000-0002-8202-6268","observed_orcids":["https://orcid.org/0000-0002-8202-6268"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Cheville","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021419381","display_name":"George Vasmatzis","orcid":"https://orcid.org/0000-0002-3401-3497","observed_orcids":["https://orcid.org/0000-0002-3401-3497"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Vasmatzis","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Baas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paul Baas","raw_affiliation_strings":["Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071440718","display_name":"Aaron Scott Mansfield","orcid":"https://orcid.org/0000-0002-9483-6903","observed_orcids":["https://orcid.org/0000-0002-9483-6903"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aaron S. Mansfield","raw_affiliation_strings":["Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota. Electronic address: mansfield.aaron@mayo.edu","Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota","Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota. Electronic address: mansfield.aaron@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Precision Cancer Therapeutics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071440718"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":2.2694,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.89246139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"17","issue":"3","first_page":"446","last_page":"454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0560000017285347,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-pleural-mesothelioma","display_name":"malignant pleural mesothelioma","score":0.9179999828338623},{"id":"https://openalex.org/keywords/chromosomal-rearrangements","display_name":"chromosomal rearrangements","score":0.9259999990463257},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.9020000100135803},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.8610000014305115},{"id":"https://openalex.org/keywords/antigen-processing-and-presentation","display_name":"antigen processing and presentation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.890999972820282},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":1.0},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6700000166893005},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8199999928474426},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9497083425521851},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.745939314365387},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.5830222964286804},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5313423871994019},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5223240256309509},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.4837755858898163},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.4618614614009857},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4549417793750763},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3981667160987854},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3648180067539215},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3389977812767029},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1638353168964386},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.12601640820503235},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09521663188934326}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086002","descriptor_name":"Mesothelioma, Malignant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.jtho.2021.10.022","doi":"https://doi.org/10.1016/j.jtho.2021.10.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2021.10.022","pdf_url":"http://www.jto.org/article/S1556086421033190/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},{"id":"pmid:34800701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34800701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8882146","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8882146","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Thorac Oncol","raw_type":"Text"},{"id":"pmh:oai:alma.31UKB_LEU:9940745003502711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/3565043","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/3565043/1?col=81522199330002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Thoracic Oncology, Vol. 17, no. 3, p. 446-454","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3565043","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/3565043","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Thoracic Oncology, 17(3), 446 - 454. ELSEVIER SCIENCE INC","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3565043","doi":null,"is_oa":true,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/S1556086421033190?via%3Dihub","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1016/j.jtho.2021.10.022","doi":"https://doi.org/10.1016/j.jtho.2021.10.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2021.10.022","pdf_url":"http://www.jto.org/article/S1556086421033190/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8866517381","display_name":"Blood-based biomarker of therapeutic efficacy for mesothelioma","funder_award_id":"R21CA251923","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000866180","display_name":"Mayo Clinic Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA015083","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320306769","display_name":"Mesothelioma Applied Research Foundation","ror":"https://ror.org/01d0tvs72"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320315143","display_name":"Mark Foundation For Cancer Research","ror":"https://ror.org/00v7th354"},{"id":"https://openalex.org/F4320317235","display_name":"BeiGene","ror":"https://ror.org/012v2c923"},{"id":"https://openalex.org/F4320317866","display_name":"Verily Life Sciences","ror":"https://ror.org/047305x76"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3213716658.pdf","grobid_xml":"https://content.openalex.org/works/W3213716658.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1618234550","https://openalex.org/W2102804556","https://openalex.org/W2117538040","https://openalex.org/W2125600615","https://openalex.org/W2134513968","https://openalex.org/W2139266962","https://openalex.org/W2152061559","https://openalex.org/W2167810957","https://openalex.org/W2291531085","https://openalex.org/W2346108121","https://openalex.org/W2622499649","https://openalex.org/W2725858612","https://openalex.org/W2772104082","https://openalex.org/W2808133785","https://openalex.org/W2897299514","https://openalex.org/W2897816153","https://openalex.org/W2904883738","https://openalex.org/W2908887190","https://openalex.org/W2920270836","https://openalex.org/W2921778637","https://openalex.org/W2938148515","https://openalex.org/W2961780602","https://openalex.org/W2977339506","https://openalex.org/W3007317932","https://openalex.org/W3012668557","https://openalex.org/W3083986479","https://openalex.org/W3122627530","https://openalex.org/W3136653115","https://openalex.org/W3137911777","https://openalex.org/W3197979465","https://openalex.org/W3207665479","https://openalex.org/W6677714999"],"related_works":["https://openalex.org/W3206084260","https://openalex.org/W4388045104","https://openalex.org/W2897816153","https://openalex.org/W3213692109","https://openalex.org/W4318302223","https://openalex.org/W3112147447","https://openalex.org/W2810593745","https://openalex.org/W7038311693","https://openalex.org/W2527596856","https://openalex.org/W4379599269"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,167],"favorable":[2],"outcomes":[3],"with":[4,24,48,53,76,83,109,129,182,199,223],"immunotherapy":[5],"for":[6,134,247],"mesothelioma":[7,35,59,224],"were":[8,67,90,113,146],"somewhat":[9],"unexpected":[10],"because":[11],"this":[12],"tumor":[13,17,143,183],"has":[14,21],"a":[15,218],"low":[16],"mutation":[18],"burden":[19,185],"which":[20],"been":[22],"associated":[23,47],"benefit":[25,133],"in":[26,34,50,81,136,217],"other":[27],"cancers.":[28],"Because":[29],"chromosomal":[30,98],"rearrangements":[31,99],"are":[32,46],"common":[33],"and":[36,87,100,103,130,159,163,172,186,237],"have":[37],"neoantigenic":[38],"potential,":[39],"we":[40,151],"sought":[41],"to":[42,92,126],"determine":[43],"whether":[44],"they":[45],"survival":[49,111,198,216],"patients":[51,70,128,222],"treated":[52],"immunotherapy.":[54],"METHODS:":[55],"Pleural":[56],"biopsies":[57],"of":[58,65,121,149,169,174,189,208,215,221,234],"after":[60],"at":[61],"least":[62],"one":[63],"line":[64],"therapy":[66],"obtained":[68],"from":[69,97],"(n":[71],"=":[72],"44)":[73],"before":[74],"treatment":[75],"nivolumab":[77],"alone":[78],"(NCT29908324)":[79],"or":[80,196],"combination":[82],"ipilimumab":[84],"(NCT30660511).":[85],"RNA":[86],"whole-genome":[88],"sequencing":[89],"performed":[91],"identify":[93],"the":[94,156,203],"junctions":[95],"resulting":[96],"antigen":[101,161,170,238],"processing":[102,162,171],"presentation":[104,164,173,239],"gene":[105,165,177,240],"set":[106,178,241],"expression.":[107],"Associations":[108],"overall":[110],"(OS)":[112],"estimated":[114],"using":[115],"Cox":[116],"models.":[117],"An":[118],"OS":[119],"cutoff":[120],"1.5":[122],"years":[123],"was":[124,187,212],"used":[125],"distinguish":[127],"without":[131],"durable":[132],"use":[135],"receiving":[137,204],"operating":[138,205],"characteristic":[139,206],"curves.":[140],"RESULTS:":[141],"Although":[142],"junction":[144,157,184],"burdens":[145,158],"not":[147,213,227],"predictive":[148,188,214],"OS,":[150],"identified":[152],"significant":[153],"interactions":[154],"between":[155],"multiple":[160],"sets.":[166],"\"regulation":[168],"peptide":[175],"antigen\"":[176],"revealed":[179],"an":[180,200],"interaction":[181,192,211],"OS.":[190],"This":[191,210],"also":[193],"predicted":[194],"1.5-year":[195],"greater":[197],"area":[201],"under":[202],"curve":[207],"0.83.":[209],"separate":[219],"cohort":[220],"who":[225],"did":[226],"receive":[228],"immune":[229,248],"checkpoint":[230,249],"inhibitors.":[231,250],"CONCLUSIONS:":[232],"Analysis":[233],"structural":[235],"variants":[236],"expression":[242],"may":[243],"facilitate":[244],"patient":[245],"selection":[246]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-22T00:00:00"}