{"id":"https://openalex.org/W3213618232","doi":"https://doi.org/10.21203/rs.2.13701/v1","title":"Validation of EORTC, CUETO and EAU risk stratification in prediction of recurrence, progression and death of patients with initially non-muscle invasive bladder cancer (NMIBC): a cohort analysis with systematic review.","display_name":"Validation of EORTC, CUETO and EAU risk stratification in prediction of recurrence, progression and death of patients with initially non-muscle invasive bladder cancer (NMIBC): a cohort analysis with systematic review.","publication_year":2019,"publication_date":"2019-08-31","ids":{"openalex":"https://openalex.org/W3213618232","doi":"https://doi.org/10.21203/rs.2.13701/v1","mag":"3213618232"},"language":"en","primary_location":{"id":"doi:10.21203/rs.2.13701/v1","doi":"https://doi.org/10.21203/rs.2.13701/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.13701/v1","pdf_url":"https://www.researchsquare.com/article/rs-4406/v1.pdf?c=1631841396000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W3213618232"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-4406/v1.pdf?c=1631841396000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136183427","display_name":"Mateusz W\u0142adys\u0142aw Jobczyk","orcid":"https://orcid.org/0000-0001-8615-5940","observed_orcids":["https://orcid.org/0000-0001-8615-5940"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Mateusz Jobczyk","raw_affiliation_strings":["Uniwersytet Medyczny w Lodzi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniwersytet Medyczny w Lodzi","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015231262","display_name":"Konrad Stawiski","orcid":"https://orcid.org/0000-0002-6550-3384","observed_orcids":["https://orcid.org/0000-0002-6550-3384"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Konrad Stawiski","raw_affiliation_strings":["Medical University of Lodz"],"raw_orcid":"https://orcid.org/0000-0002-6550-3384","affiliations":[{"raw_affiliation_string":"Medical University of Lodz","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046777203","display_name":"Wojciech M Fendler","orcid":"https://orcid.org/0000-0002-5083-9168","observed_orcids":["https://orcid.org/0000-0002-5083-9168"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wojciech Fendler","raw_affiliation_strings":["Dana Farber Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana Farber Cancer Institute","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000801699","display_name":"Waldemar R\u00f3\u017ca\u0144ski","orcid":"https://orcid.org/0000-0001-6272-5355","observed_orcids":["https://orcid.org/0000-0001-6272-5355"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Waldemar R\u00f3\u017ca\u0144ski","raw_affiliation_strings":["Uniwersytet Medyczny w Lodzi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uniwersytet Medyczny w Lodzi","institution_ids":["https://openalex.org/I4210122071"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015231262"],"corresponding_institution_ids":["https://openalex.org/I4210122071"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-muscle-invasive-bladder-cancer","display_name":"non-muscle-invasive bladder cancer","score":0.9300000071525574},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cancer-recurrence-prediction","display_name":"tumor recurrence prediction","score":0.6809999942779541},{"id":"https://openalex.org/keywords/tumor-progression-prediction","display_name":"tumor progression prediction","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.5820000171661377},{"id":"https://openalex.org/keywords/risk-score-validation","display_name":"risk score validation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.7179999947547913},{"id":"https://openalex.org/keywords/bladder-cancer-recurrence","display_name":"bladder cancer recurrence","score":0.3499999940395355},{"id":"https://openalex.org/keywords/bladder-cancer-progression","display_name":"bladder cancer progression","score":0.8579999804496765},{"id":"https://openalex.org/keywords/bladder-cancer-mortality","display_name":"bladder cancer mortality","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.821976900100708},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.7791955471038818},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6568506956100464},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5882896184921265},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5463770031929016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4263278841972351},{"id":"https://openalex.org/C192943249","wikidata":"https://www.wikidata.org/wiki/Q1893382","display_name":"Stratification (seeds)","level":5,"score":0.42252978682518005},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3989224433898926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0671108067035675},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C3527866","wikidata":"https://www.wikidata.org/wiki/Q162267","display_name":"Dormancy","level":3,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C88548481","wikidata":"https://www.wikidata.org/wiki/Q2397491","display_name":"Seed dormancy","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.2.13701/v1","doi":"https://doi.org/10.21203/rs.2.13701/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.13701/v1","pdf_url":"https://www.researchsquare.com/article/rs-4406/v1.pdf?c=1631841396000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.2.13701/v1","doi":"https://doi.org/10.21203/rs.2.13701/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.13701/v1","pdf_url":"https://www.researchsquare.com/article/rs-4406/v1.pdf?c=1631841396000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3213618232.pdf","grobid_xml":"https://content.openalex.org/works/W3213618232.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1572827793","https://openalex.org/W1964434551","https://openalex.org/W2002045993","https://openalex.org/W2017306423","https://openalex.org/W2030797236","https://openalex.org/W2034786233","https://openalex.org/W2048275270","https://openalex.org/W2052562958","https://openalex.org/W2056056862","https://openalex.org/W2064352891","https://openalex.org/W2085603070","https://openalex.org/W2112619240","https://openalex.org/W2114706063","https://openalex.org/W2116299167","https://openalex.org/W2129535457","https://openalex.org/W2152455106","https://openalex.org/W2158847780","https://openalex.org/W2270022169","https://openalex.org/W2324549245","https://openalex.org/W2330070351","https://openalex.org/W2513058828","https://openalex.org/W2520212019","https://openalex.org/W2571074190","https://openalex.org/W2606371808","https://openalex.org/W2760139092","https://openalex.org/W2889600917","https://openalex.org/W2892152642","https://openalex.org/W2901439945","https://openalex.org/W2905491316","https://openalex.org/W2916183155","https://openalex.org/W2939216217"],"related_works":["https://openalex.org/W3013725287","https://openalex.org/W4307166768","https://openalex.org/W4394739740","https://openalex.org/W2052562958","https://openalex.org/W3038529433","https://openalex.org/W4285217515","https://openalex.org/W4285606368","https://openalex.org/W4395684463","https://openalex.org/W3214915225","https://openalex.org/W2949282823"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"To":[2],"validate":[3],"and":[4,14,23,62,85,95,154,194,213,221,236,245],"summarize":[5],"current":[6],"evidence":[7,180],"about":[8,219],"the":[9,45,227,231,242],"reliability":[10],"of":[11,20,25,36,49,103,129,223,233],"EORTC,":[12,211],"CUETO":[13,114,155,171,195,212],"EAU":[15,124,149,186,201,214],"risk":[16,54,111,121,125,208],"stratification":[17],"in":[18,56,160,199],"prediction":[19,130],"recurrence,":[21],"progression":[22,120,198,222,246],"death":[24],"patients":[26,38,134,203],"with":[27,39,52,136],"initially":[28],"non-muscle-invasive":[29],"bladder":[30],"cancer":[31],"(NMIBC).Methods:":[32],"Retrospective":[33],"cohort":[34],"analysis":[35,68],"322":[37],"newly":[40],"diagnosed":[41],"NMIBC.":[42],"We":[43],"assessed":[44],"concordance":[46],"(Harrell's":[47],"c-index)":[48],"our":[50,77],"results":[51],"calculated":[53],"scores":[55],"Cox":[57],"proportional":[58],"hazard":[59],"regression":[60],"models":[61],"utilized":[63],"receiver":[64],"operating":[65],"characteristic":[66],"curve":[67],"(area":[69],"under":[70],"curve;":[71],"AUCROC).":[72],"Lastly,":[73],"to":[74,91,98,116,148],"further":[75],"confirm":[76],"observations":[78],"we":[79],"conducted":[80],"a":[81],"systematic":[82],"reviewResults:":[83],"1-year":[84,109,119],"5-year":[86],"c-indices":[87],"ranged":[88,105],"from":[89,96,106],"0.55":[90],"0.66":[92],"for":[93,100,108,118,133,190,230],"recurrence":[94,110,161,220,244],"0.72":[97],"0.82":[99,117],"progression.":[101,192],"AUCROC":[102],"predictions":[104,218],"0.46":[107],"based":[112,122],"on":[113,123],"groups":[115,209],"groups.":[126],"The":[127,205],"accuracy":[128],"was":[131,146,177],"lower":[132],"treated":[135],"BCG":[137],"maintenance":[138],"immunotherapy.":[139],"EORTC":[140,163,193,240],"model":[141,159,164],"(overall":[142],"c-index":[143],"c=0.64;":[144],"95%CI:0.61-0.68)":[145],"superior":[147],"(p=0.035;":[150],"0.62;":[151],"95%CI:":[152],"0.59-0.66)":[153],"(p<0.001;":[156],"c=0.53;":[157],"95%CI:0.50-0.56)":[158],"prediction.":[162,247],"(c=0.82;":[165],"95%CI:0.77-0.86)":[166],"also":[167],"performed":[168,183],"better":[169,184],"than":[170,185],"(p=0.008;":[172],"c=0.73;":[173],"95%CI:0.66-0.81)":[174],"but":[175],"there":[176],"no":[178],"sufficient":[179],"that":[181],"it":[182],"(p=0.572;":[187],"c=0.81;":[188],"95%CI:0.77-0.84)":[189],"predicting":[191],"comparably":[196],"predicted":[197],"BCG-treated":[200],"high-risk":[202],"(p=0.48).Conclusions:":[204],"division":[206],"into":[207],"by":[210],"offered":[215],"moderately":[216],"accurate":[217,237],"NMIBC,":[224],"which":[225],"emphasizes":[226],"urgent":[228],"need":[229],"development":[232],"more":[234],"personalized":[235],"predictive":[238],"tool.":[239],"provided":[241],"best":[243]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2021-11-22T00:00:00"}