{"id":"https://openalex.org/W3213337246","doi":"https://doi.org/10.1378/chest.124.5.2033","title":"Steroids and Drotrecogin Alfa (Activated) for Severe Sepsis","display_name":"Steroids and Drotrecogin Alfa (Activated) for Severe Sepsis","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W3213337246","doi":"https://doi.org/10.1378/chest.124.5.2033","mag":"3213337246","pmid":"https://pubmed.ncbi.nlm.nih.gov/14605088"},"language":"en","primary_location":{"id":"doi:10.1378/chest.124.5.2033","doi":"https://doi.org/10.1378/chest.124.5.2033","is_oa":false,"landing_page_url":"https://doi.org/10.1378/chest.124.5.2033","pdf_url":null,"source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016896001","display_name":"Jay S. Steingrub","orcid":"https://orcid.org/0000-0002-6019-6725","observed_orcids":["https://orcid.org/0000-0002-6019-6725"]},"institutions":[{"id":"https://openalex.org/I1338449461","display_name":"Baystate Medical Center","ror":"https://ror.org/01q2nz307","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1338449461"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jay S. Steingrub","raw_affiliation_strings":["Baystate Medical Center Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baystate Medical Center Springfield, MA","institution_ids":["https://openalex.org/I1338449461"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016896001"],"corresponding_institution_ids":["https://openalex.org/I1338449461"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46802983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"5","first_page":"2033","last_page":"2033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-sepsis","display_name":"severe sepsis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8740000128746033},{"id":"https://openalex.org/keywords/drotrecogin-alfa","display_name":"drotrecogin alfa","score":0.9229999780654907},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9269999861717224},{"id":"https://openalex.org/keywords/relative-adrenal-insufficiency","display_name":"relative adrenal insufficiency","score":0.9229999780654907},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.7160000205039978},{"id":"https://openalex.org/keywords/sepsis-mortality","display_name":"sepsis mortality","score":0.6449999809265137},{"id":"https://openalex.org/keywords/adrenal-insufficiency-diagnosis","display_name":"adrenal insufficiency diagnosis","score":0.5180000066757202},{"id":"https://openalex.org/keywords/sepsis-treatment-guidelines","display_name":"sepsis treatment guidelines","score":0.47699999809265137},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9082390666007996},{"id":"https://openalex.org/C2778129406","wikidata":"https://www.wikidata.org/wiki/Q2507454","display_name":"Adrenal insufficiency","level":2,"score":0.8462653160095215},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.825263261795044},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7158939838409424},{"id":"https://openalex.org/C2778005785","wikidata":"https://www.wikidata.org/wiki/Q412888","display_name":"Drotrecogin alfa","level":5,"score":0.5630952715873718},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.5414329767227173},{"id":"https://openalex.org/C2776899810","wikidata":"https://www.wikidata.org/wiki/Q2697578","display_name":"Fludrocortisone","level":3,"score":0.4644937813282013},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43472304940223694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37247467041015625},{"id":"https://openalex.org/C2994086866","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Severe sepsis","level":4,"score":0.1652125120162964}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1378/chest.124.5.2033","doi":"https://doi.org/10.1378/chest.124.5.2033","is_oa":false,"landing_page_url":"https://doi.org/10.1378/chest.124.5.2033","pdf_url":null,"source":{"id":"https://openalex.org/S76900504","display_name":"CHEST Journal","issn_l":"0012-3692","issn":["0012-3692","1931-3543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"journal-article"},{"id":"pmid:14605088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14605088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chest","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1992311120","https://openalex.org/W2042268246","https://openalex.org/W2126756111","https://openalex.org/W2322121630","https://openalex.org/W2550507245"],"related_works":["https://openalex.org/W4237620082","https://openalex.org/W2122453141","https://openalex.org/W2063006068","https://openalex.org/W2092297166","https://openalex.org/W2132697836","https://openalex.org/W1996823736","https://openalex.org/W2031857661","https://openalex.org/W2989374275","https://openalex.org/W2130036521","https://openalex.org/W2100985823"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-22T00:00:00"}