{"id":"https://openalex.org/W3213263267","doi":"https://doi.org/10.31031/gmr.2021.06.000628","title":"Advances into the Epigenetic Regulation by DNA Methylation in Non-Alcoholic Fatty Liver Disease","display_name":"Advances into the Epigenetic Regulation by DNA Methylation in Non-Alcoholic Fatty Liver Disease","publication_year":2021,"publication_date":"2021-08-12","ids":{"openalex":"https://openalex.org/W3213263267","doi":"https://doi.org/10.31031/gmr.2021.06.000628","mag":"3213263267"},"language":"en","primary_location":{"id":"doi:10.31031/gmr.2021.06.000628","doi":"https://doi.org/10.31031/gmr.2021.06.000628","is_oa":true,"landing_page_url":"https://doi.org/10.31031/gmr.2021.06.000628","pdf_url":"http://crimsonpublishers.com/gmr/pdf/GMR.000628.pdf","source":{"id":"https://openalex.org/S4210196348","display_name":"Gastroenterology \u00a0Medicine\u00a0&\u00a0Research","issn_l":"2637-7632","issn":["2637-7632"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology:\u00a0Medicine\u00a0&amp;\u00a0Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://crimsonpublishers.com/gmr/pdf/GMR.000628.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029159339","display_name":"Teresa Rubio\u2010Tom\u00e1s","orcid":"https://orcid.org/0000-0002-5331-4244","observed_orcids":["https://orcid.org/0000-0002-5331-4244"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES","GR"],"is_corresponding":true,"raw_author_name":"Teresa Rubio- Tom\u00e1s","raw_affiliation_strings":["Institute for Biomedical Research August Pi and Sunyer (IDIBAPS), Spain","School of Medicine, University of Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Research August Pi and Sunyer (IDIBAPS), Spain","institution_ids":["https://openalex.org/I4210160192"]},{"raw_affiliation_string":"School of Medicine, University of Crete, Greece","institution_ids":["https://openalex.org/I142617266"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029159339"],"corresponding_institution_ids":["https://openalex.org/I142617266","https://openalex.org/I4210160192"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12883113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.39500001072883606,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/steatohepatitis","display_name":"steatohepatitis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/high-calorie-diet","display_name":"hypercaloric diet","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sedentary-lifestyle","display_name":"sedentary lifestyle","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8511187434196472},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7780776023864746},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.7552654147148132},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.6163156032562256},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5237781405448914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4660336375236511},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42767494916915894},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3502258062362671},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33821821212768555},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.33716005086898804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3179900050163269},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2613154649734497},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25347915291786194},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11997413635253906},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31031/gmr.2021.06.000628","doi":"https://doi.org/10.31031/gmr.2021.06.000628","is_oa":true,"landing_page_url":"https://doi.org/10.31031/gmr.2021.06.000628","pdf_url":"http://crimsonpublishers.com/gmr/pdf/GMR.000628.pdf","source":{"id":"https://openalex.org/S4210196348","display_name":"Gastroenterology \u00a0Medicine\u00a0&\u00a0Research","issn_l":"2637-7632","issn":["2637-7632"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology:\u00a0Medicine\u00a0&amp;\u00a0Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31031/gmr.2021.06.000628","doi":"https://doi.org/10.31031/gmr.2021.06.000628","is_oa":true,"landing_page_url":"https://doi.org/10.31031/gmr.2021.06.000628","pdf_url":"http://crimsonpublishers.com/gmr/pdf/GMR.000628.pdf","source":{"id":"https://openalex.org/S4210196348","display_name":"Gastroenterology \u00a0Medicine\u00a0&\u00a0Research","issn_l":"2637-7632","issn":["2637-7632"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology:\u00a0Medicine\u00a0&amp;\u00a0Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3213263267.pdf","grobid_xml":"https://content.openalex.org/works/W3213263267.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2988307436","https://openalex.org/W3013910762","https://openalex.org/W3017465316","https://openalex.org/W3042464564","https://openalex.org/W3047493724","https://openalex.org/W3089492519","https://openalex.org/W3093349278","https://openalex.org/W3096106003","https://openalex.org/W3103030515","https://openalex.org/W3109831279","https://openalex.org/W3124551966","https://openalex.org/W3139220903","https://openalex.org/W3140501752","https://openalex.org/W3163776584","https://openalex.org/W3165340773","https://openalex.org/W3170608429","https://openalex.org/W4211246989","https://openalex.org/W4213176465","https://openalex.org/W4241398143"],"related_works":["https://openalex.org/W2041466968","https://openalex.org/W2356530513","https://openalex.org/W2787375028","https://openalex.org/W4303615074","https://openalex.org/W2015315045","https://openalex.org/W2886939951","https://openalex.org/W4400554407","https://openalex.org/W4386759785","https://openalex.org/W3083078688","https://openalex.org/W4320006529"],"abstract_inverted_index":{"The":[0],"incidence":[1],"of":[2,22,37,51,70,91],"Non-Alcoholic":[3],"Fatty":[4],"Liver":[5],"(NAFLD)":[6],"and":[7,27,58,98,101,106],"its":[8],"complications":[9],"is":[10],"increasing":[11],"worldwide,":[12],"due":[13],"to":[14,19,47,53],"different":[15],"factors,":[16],"but":[17],"especially":[18],"the":[20,35,49,68,71,82,87],"increase":[21,33],"hypercaloric":[23],"diets,":[24],"sedentary":[25],"lifestyle":[26],"obesity,":[28],"as":[29,31],"well":[30],"an":[32,94],"in":[34,40,61],"percentage":[36],"aged":[38],"populations":[39],"Western":[41],"countries.Many":[42],"efforts":[43],"are":[44],"being":[45],"done":[46],"understand":[48],"pathogenesis":[50],"NAFLD":[52,99],"stop":[54],"this":[55,73],"global":[56],"pandemic":[57],"many":[59],"alterations":[60],"epigenetic":[62,96],"mechanisms":[63],"have":[64],"been":[65],"detected":[66],"during":[67],"course":[69],"disease.In":[72],"mini-review":[74],"I":[75],"will":[76],"focus":[77],"on":[78],"recent":[79],"articles":[80],"(from":[81],"last":[83],"year)":[84],"that":[85],"explore":[86],"link":[88],"between":[89],"deregulation":[90],"DNA":[92],"methylation,":[93],"important":[95],"mechanism,":[97],"development":[100],"progression":[102],"towards":[103],"steatohepatitis,":[104],"cirrhosis":[105],"liver":[107],"cancer.":[108]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-11-22T00:00:00"}
