{"id":"https://openalex.org/W3213236367","doi":"https://doi.org/10.1016/j.eclinm.2021.101185","title":"Safety, tolerability, pharmacokinetics, and pharmacodynamics of the glucokinase activator PB-201 and its effects on the glucose excursion profile in drug-na\u00efve Chinese patients with type 2 diabetes: a randomised controlled, crossover, single-centre phase 1 trial","display_name":"Safety, tolerability, pharmacokinetics, and pharmacodynamics of the glucokinase activator PB-201 and its effects on the glucose excursion profile in drug-na\u00efve Chinese patients with type 2 diabetes: a randomised controlled, crossover, single-centre phase 1 trial","publication_year":2021,"publication_date":"2021-11-05","ids":{"openalex":"https://openalex.org/W3213236367","doi":"https://doi.org/10.1016/j.eclinm.2021.101185","mag":"3213236367","pmid":"https://pubmed.ncbi.nlm.nih.gov/34805810","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8585621"},"language":"en","primary_location":{"id":"doi:10.1016/j.eclinm.2021.101185","doi":"https://doi.org/10.1016/j.eclinm.2021.101185","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.eclinm.2021.101185","pdf_url":null,"source":{"id":"https://openalex.org/S2898347799","display_name":"EClinicalMedicine","issn_l":"2589-5370","issn":["2589-5370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eClinicalMedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.eclinm.2021.101185","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100761788","display_name":"Dongyang Liu","orcid":"https://orcid.org/0000-0002-0608-8192","observed_orcids":["https://orcid.org/0000-0002-0608-8192"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongyang Liu","raw_affiliation_strings":["Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075127923","display_name":"Ying Du","orcid":"https://orcid.org/0000-0001-6767-0402","observed_orcids":["https://orcid.org/0000-0001-6767-0402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Du","raw_affiliation_strings":["PegBio Co., Ltd, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PegBio Co., Ltd, Suzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078533342","display_name":"Xueting Yao","orcid":"https://orcid.org/0000-0003-1624-2189","observed_orcids":["https://orcid.org/0000-0003-1624-2189"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueting Yao","raw_affiliation_strings":["Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072639267","display_name":"Yudong Wei","orcid":"https://orcid.org/0000-0001-5241-8941","observed_orcids":["https://orcid.org/0000-0001-5241-8941"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yudong Wei","raw_affiliation_strings":["Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101919302","display_name":"Jixiang Zhu","orcid":"https://orcid.org/0000-0002-7898-7672","observed_orcids":["https://orcid.org/0000-0002-7898-7672"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jixiang Zhu","raw_affiliation_strings":["Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101673628","display_name":"Cheng Cui","orcid":"https://orcid.org/0000-0001-6446-0127","observed_orcids":["https://orcid.org/0000-0001-6446-0127"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Cui","raw_affiliation_strings":["Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062819400","display_name":"Hong Zhou","orcid":"https://orcid.org/0000-0002-5580-6744","observed_orcids":["https://orcid.org/0000-0002-5580-6744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Zhou","raw_affiliation_strings":["PegBio Co., Ltd, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PegBio Co., Ltd, Suzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012410312","display_name":"Min Xu","orcid":"https://orcid.org/0000-0002-3113-8382","observed_orcids":["https://orcid.org/0000-0002-3113-8382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Xu","raw_affiliation_strings":["PegBio Co., Ltd, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PegBio Co., Ltd, Suzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360523","display_name":"Haiyan Li","orcid":"https://orcid.org/0000-0002-8286-2813","observed_orcids":["https://orcid.org/0000-0002-8286-2813"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haiyan Li","raw_affiliation_strings":["Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Clinical Trial Center, Peking University Third Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015002294","display_name":"Linong Ji","orcid":"https://orcid.org/0000-0002-3262-2168","observed_orcids":["https://orcid.org/0000-0002-3262-2168","https://orcid.org/0000-0003-1305-1598","https://orcid.org/0009-0001-6222-2915","https://orcid.org/0000-0002-2088-9690"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linong Ji","raw_affiliation_strings":["Department of Endocrinology, Peking University People's Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Peking University People's Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210124809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015002294","https://openalex.org/A5100360523"],"corresponding_institution_ids":["https://openalex.org/I4210124809","https://openalex.org/I4210141942"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.7121,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.82905409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":null,"first_page":"101185","last_page":"101185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucokinase-activators","display_name":"glucokinase activators","score":0.9549999833106995},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glycemic-excursions","display_name":"glycemic excursions","score":0.7419999837875366},{"id":"https://openalex.org/keywords/time-in-range","display_name":"time in range","score":0.847000002861023},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.7210000157356262},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.6620000004768372},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.6140000224113464},{"id":"https://openalex.org/keywords/drug-naive-patients","display_name":"drug-naive patients","score":0.75},{"id":"https://openalex.org/keywords/continuous-glucose-monitoring","display_name":"continuous glucose monitoring","score":0.7210000157356262},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8119999766349792},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.35600000619888306},{"id":"https://openalex.org/keywords/drug-induced-pancreatitis","display_name":"drug-induced pancreatitis","score":0.578000009059906},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9363828897476196},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7119850516319275},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5889616012573242},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5652511715888977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.523561418056488},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.519404411315918},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5051787495613098},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5004854202270508},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4913844168186188},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4684940278530121},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.44824063777923584},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4138692319393158},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3470503091812134},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3034146726131439},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2703201174736023},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.eclinm.2021.101185","doi":"https://doi.org/10.1016/j.eclinm.2021.101185","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.eclinm.2021.101185","pdf_url":null,"source":{"id":"https://openalex.org/S2898347799","display_name":"EClinicalMedicine","issn_l":"2589-5370","issn":["2589-5370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eClinicalMedicine","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.3894909","doi":"https://doi.org/10.2139/ssrn.3894909","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3894909","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8585621","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8585621/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8585621/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EClinicalMedicine","raw_type":"Text"},{"id":"pmid:34805810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34805810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EClinicalMedicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.eclinm.2021.101185","doi":"https://doi.org/10.1016/j.eclinm.2021.101185","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.eclinm.2021.101185","pdf_url":null,"source":{"id":"https://openalex.org/S2898347799","display_name":"EClinicalMedicine","issn_l":"2589-5370","issn":["2589-5370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eClinicalMedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3213236367.pdf","grobid_xml":"https://content.openalex.org/works/W3213236367.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1602648506","https://openalex.org/W1972051717","https://openalex.org/W1973375291","https://openalex.org/W1984207232","https://openalex.org/W2005561360","https://openalex.org/W2012459235","https://openalex.org/W2014190569","https://openalex.org/W2036709932","https://openalex.org/W2049033217","https://openalex.org/W2087515768","https://openalex.org/W2134293572","https://openalex.org/W2136788080","https://openalex.org/W2142051176","https://openalex.org/W2153041556","https://openalex.org/W2160834915","https://openalex.org/W2176469395","https://openalex.org/W2296239131","https://openalex.org/W2509560015","https://openalex.org/W2789367612","https://openalex.org/W2801191096","https://openalex.org/W2906596531","https://openalex.org/W2909977372","https://openalex.org/W2910274134","https://openalex.org/W2921967571","https://openalex.org/W2948261890","https://openalex.org/W2981441462","https://openalex.org/W3042208359","https://openalex.org/W3091490928","https://openalex.org/W3096753335","https://openalex.org/W3131165749","https://openalex.org/W4200161106","https://openalex.org/W4200358162","https://openalex.org/W4235701932","https://openalex.org/W4246340431"],"related_works":["https://openalex.org/W3195237219","https://openalex.org/W3176394421","https://openalex.org/W4307623949","https://openalex.org/W4388823226","https://openalex.org/W3096753335","https://openalex.org/W2801191096","https://openalex.org/W3213814064","https://openalex.org/W3014908823","https://openalex.org/W4210644868","https://openalex.org/W3091490928"],"abstract_inverted_index":{"Background":[0],"PB-201,":[1],"a":[2,67,135],"partial,":[3],"pancreas/liver-dual":[4],"glucokinase":[5],"activator,":[6],"showed":[7,134],"good":[8],"tolerance":[9],"and":[10,24,91,103,125,145,156,170,181,192,237,242],"glycaemic":[11],"effects":[12,236],"in":[13,26,43,142,162,254],"multinational":[14],"studies.":[15],"This":[16],"study":[17],"determined":[18],"its":[19],"optimal":[20,230],"dose,":[21,231],"safety,":[22],"pharmacokinetics,":[23],"pharmacodynamics":[25],"Chinese":[27],"patients":[28,53,92,130,199,209],"with":[29,54,173,212],"type":[30,56],"2":[31,57],"diabetes.":[32],"Methods":[33],"In":[34,71],"this":[35],"double-blind,":[36],"randomised,":[37],"four-period,":[38],"crossover,":[39],"phase":[40],"1":[41],"trial":[42],"China,":[44],"conducted":[45],"at":[46,153],"the":[47,112,143,229],"Peking":[48],"University":[49],"Third":[50],"Hospital,":[51],"adult":[52],"drug-naive":[55],"diabetes":[58],"were":[59,93,101,131,206],"randomised":[60],"(1:1:1:1)":[61],"to":[62,95,110],"four":[63],"sequence":[64],"groups":[65],"using":[66],"computer-generated":[68],"randomisation":[69],"table.":[70],"each":[72],"period,":[73],"they":[74],"received":[75],"oral":[76],"placebo":[77,178],"or":[78,82,217],"PB-201":[79,133,152,221,249],"(50+50,":[80],"100+50,":[81,155],"100+100":[83,157],"mg":[84,158,223,251],"split":[85],"doses)":[86],"for":[87],"7":[88],"days.":[89],"Investigators":[90],"masked":[94],"treatment":[96],"assignment.":[97],"The":[98],"primary":[99],"endpoints":[100],"safety":[102],"pharmacokinetics.":[104],"Continuous":[105],"glucose":[106,113,214],"monitoring":[107],"was":[108],"used":[109],"delineate":[111],"excursion":[114],"profile.":[115],"Trial":[116],"registration":[117],"number:":[118],"NCT03973515.":[119],"Findings":[120],"Between":[121],"August":[122],"27,":[123],"2019":[124],"December":[126],"19,":[127],"2019,":[128],"16":[129],"randomised.":[132],"dose-proportional":[136],"pharmacokinetic":[137],"profile":[138],"without":[139],"apparent":[140],"accumulation":[141],"body":[144],"induced":[146],"dose-dependent":[147],"lowering":[148],"of":[149,240,248],"blood":[150],"glucose.":[151],"50+50,":[154],"increased":[159],"mean":[160],"time":[161],"range":[163],"(49\u00b7210%":[164],"[standard":[165],"deviation":[166],"27],":[167],"56\u00b7130%":[168],"[25],":[169],"63\u00b7330%":[171],"[20]":[172],"three":[174],"doses,":[175],"respectively)":[176],"versus":[177],"(49\u00b7380%":[179],"[27])":[180],"reduced":[182],"estimated":[183],"glycated":[184],"haemoglobin":[185],"from":[186],"baseline":[187],"(\u22120\u00b75445%":[188],"[1\u00b7654],":[189],"\u22121\u00b7063%":[190],"[1\u00b7236],":[191],"\u22121\u00b7888%":[193],"[1\u00b7381]":[194],"vs":[195],"\u22120\u00b7581%":[196],"[1\u00b7200]).":[197],"Fifteen":[198],"(93\u00b78%)":[200],"had":[201,210],"treatment-emergent":[202],"adverse":[203],"events,":[204],"which":[205,232],"mild.":[207],"No":[208],"hypoglycaemia":[211,241],"venous/capillary":[213],"<3\u00b79":[215],"mmol/L":[216],"nocturnal":[218],"hypoglycaemia.":[219],"Interpretation":[220],"100":[222,250],"twice":[224,252],"daily":[225,253],"is":[226,257],"identified":[227],"as":[228],"shows":[233],"promising":[234],"glucose-lowering":[235],"low":[238],"risks":[239],"other":[243],"side":[244],"effects.":[245],"Further":[246],"investigation":[247],"confirmatory":[255],"trials":[256],"warranted.":[258],"Funding":[259],"PegBio.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-11-22T00:00:00"}