{"id":"https://openalex.org/W3213082308","doi":"https://doi.org/10.23736/s0393-3660.20.04399-5","title":"Large cell neuroendocrine tumor of the gastrointestinal tract with concurrent tubular adenomas","display_name":"Large cell neuroendocrine tumor of the gastrointestinal tract with concurrent tubular adenomas","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W3213082308","doi":"https://doi.org/10.23736/s0393-3660.20.04399-5","mag":"3213082308"},"language":"en","primary_location":{"id":"doi:10.23736/s0393-3660.20.04399-5","doi":"https://doi.org/10.23736/s0393-3660.20.04399-5","is_oa":false,"landing_page_url":"https://doi.org/10.23736/s0393-3660.20.04399-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210206598","display_name":"Gazzetta Medica Italiana Archivio per le Scienze Mediche","issn_l":"0016-5670","issn":["0016-5670","0393-3660","1827-1812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800528","host_organization_name":"Edizioni Minerva Medica","host_organization_lineage":["https://openalex.org/P4320800528"],"host_organization_lineage_names":["Edizioni Minerva Medica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gazzetta Medica Italiana Archivio per le Scienze Mediche","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067954224","display_name":"Inayat Gill","orcid":"https://orcid.org/0000-0001-5972-700X","observed_orcids":["https://orcid.org/0000-0001-5972-700X"]},"institutions":[{"id":"https://openalex.org/I2799370151","display_name":"Beaumont Health","ror":"https://ror.org/05g2hd893","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799370151","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Inayat GILL","raw_affiliation_strings":["Department of Internal Medicine, Beaumont Health, Royal Oak, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Beaumont Health, Royal Oak, MI, USA","institution_ids":["https://openalex.org/I2799370151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042564128","display_name":"Christienne Shams","orcid":"https://orcid.org/0000-0003-3707-2457","observed_orcids":["https://orcid.org/0000-0003-3707-2457"]},"institutions":[{"id":"https://openalex.org/I2799370151","display_name":"Beaumont Health","ror":"https://ror.org/05g2hd893","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799370151","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christienne SHAMS","raw_affiliation_strings":["Department of Internal Medicine, Beaumont Health, Royal Oak, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Beaumont Health, Royal Oak, MI, USA","institution_ids":["https://openalex.org/I2799370151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022917418","display_name":"Elisa Quiroz","orcid":"https://orcid.org/0000-0002-5241-063X","observed_orcids":["https://orcid.org/0000-0002-5241-063X"]},"institutions":[{"id":"https://openalex.org/I2802091096","display_name":"Scripps Mercy Hospital","ror":"https://ror.org/04k4h9k07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I2802091096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisa QUIROZ","raw_affiliation_strings":["Division of Hematology and Oncology, Department of Internal Medicine, Scripps Mercy Hospital, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, Department of Internal Medicine, Scripps Mercy Hospital, San Diego, CA, USA","institution_ids":["https://openalex.org/I2802091096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110030536","display_name":"Subhashree Mallika Krishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799370151","display_name":"Beaumont Health","ror":"https://ror.org/05g2hd893","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799370151","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subhashree M. KRISHNAN","raw_affiliation_strings":["Department of Pathology, Beaumont Health, Royal Oak, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beaumont Health, Royal Oak, MI, USA","institution_ids":["https://openalex.org/I2799370151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074982900","display_name":"Susanna S. Gaikazian","orcid":"https://orcid.org/0000-0002-0456-196X","observed_orcids":["https://orcid.org/0000-0002-0456-196X"]},"institutions":[{"id":"https://openalex.org/I2799370151","display_name":"Beaumont Health","ror":"https://ror.org/05g2hd893","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799370151","https://openalex.org/I4392738273"]},{"id":"https://openalex.org/I4210128757","display_name":"Corewell Health William Beaumont University Hospital","ror":"https://ror.org/03artm726","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128757","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanna GAIKAZIAN","raw_affiliation_strings":["Division of Hematology and Oncology, Department of Internal Medicine, Beaumont Health, Royal Oak, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, Department of Internal Medicine, Beaumont Health, Royal Oak, MI, USA","institution_ids":["https://openalex.org/I2799370151","https://openalex.org/I4210128757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067954224"],"corresponding_institution_ids":["https://openalex.org/I2799370151"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"180","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/large-cell-neuroendocrine-carcinoma","display_name":"large cell neuroendocrine carcinoma","score":1.0},{"id":"https://openalex.org/keywords/tubular-adenoma","display_name":"tubular adenoma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/gastrointestinal-neuroendocrine-tumors","display_name":"gastrointestinal neuroendocrine tumors","score":0.753000020980835},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/spinal-metastases","display_name":"spinal metastases","score":0.9070000052452087},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.902999997138977},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":1.0},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.7360000014305115},{"id":"https://openalex.org/keywords/chromogranin","display_name":"chromogranin","score":0.871999979019165},{"id":"https://openalex.org/keywords/synaptophysin","display_name":"synaptophysin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hospice-care","display_name":"hospice care","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8622426986694336},{"id":"https://openalex.org/C2777209535","wikidata":"https://www.wikidata.org/wiki/Q14864388","display_name":"Synaptophysin","level":3,"score":0.6707032918930054},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.482725590467453},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4687657058238983},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.4474669098854065},{"id":"https://openalex.org/C77231918","wikidata":"https://www.wikidata.org/wiki/Q3698322","display_name":"Chromogranin A","level":3,"score":0.4428633153438568},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.41718292236328125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4146703779697418},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4029628336429596},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39824509620666504},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3860468864440918},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.36497050523757935},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.12839937210083008},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11174759268760681}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23736/s0393-3660.20.04399-5","doi":"https://doi.org/10.23736/s0393-3660.20.04399-5","is_oa":false,"landing_page_url":"https://doi.org/10.23736/s0393-3660.20.04399-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210206598","display_name":"Gazzetta Medica Italiana Archivio per le Scienze Mediche","issn_l":"0016-5670","issn":["0016-5670","0393-3660","1827-1812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800528","host_organization_name":"Edizioni Minerva Medica","host_organization_lineage":["https://openalex.org/P4320800528"],"host_organization_lineage_names":["Edizioni Minerva Medica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gazzetta Medica Italiana Archivio per le Scienze Mediche","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1438504881","https://openalex.org/W1967330410","https://openalex.org/W1987025782","https://openalex.org/W1988370994","https://openalex.org/W2022519725","https://openalex.org/W2093720483","https://openalex.org/W2094551615","https://openalex.org/W2128704816","https://openalex.org/W2155635879","https://openalex.org/W2162247675","https://openalex.org/W2327235090","https://openalex.org/W2472836691","https://openalex.org/W2501193934","https://openalex.org/W2561175458","https://openalex.org/W2587181899","https://openalex.org/W2755554950"],"related_works":["https://openalex.org/W4399925640","https://openalex.org/W2972603591","https://openalex.org/W4205621633","https://openalex.org/W2162247675","https://openalex.org/W2068622143","https://openalex.org/W4415539833","https://openalex.org/W2587181899","https://openalex.org/W4387734211","https://openalex.org/W2093399967","https://openalex.org/W6980687266"],"abstract_inverted_index":{"Large":[0],"cell":[1],"neuroendocrine":[2],"carcinomas":[3],"(LCNECs)":[4],"are":[5],"rare,":[6],"aggressive":[7,164],"tumors,":[8],"often":[9],"diagnosed":[10],"in":[11,30,84,145],"advanced":[12],"stages":[13],"due":[14],"to":[15,140,161,168],"early":[16],"metastasis.":[17],"The":[18,92,148],"concurrent":[19],"presentation":[20],"of":[21,39,150,159],"both":[22],"LCNEC":[23,106,151],"and":[24,47,71,80,100,114,127,131,143,152],"tubular":[25,90,153],"adenomas":[26],"has":[27],"been":[28],"reported":[29],"only":[31],"a":[32,37,59,78,123,132,177],"few":[33],"cases.":[34],"We":[35],"present":[36],"case":[38],"56-year-old":[40],"male":[41],"who":[42],"presented":[43],"with":[44,68,88,105,112],"abdominal":[45],"discomfort":[46],"dyspepsia":[48],"for":[49,97,118,156],"several":[50],"months.":[51,120],"A":[52,74],"CT":[53,134],"scan":[54],"done":[55],"on":[56],"admission":[57],"revealed":[58],"3.7\u00d71.7":[60],"cm":[61],"colonic":[62],"mass":[63,83],"at":[64,122],"the":[65,85,169,172],"splenic":[66],"flexure":[67],"multiple":[69,89],"liver":[70],"vertebral":[72],"lesions.":[73],"subsequent":[75],"colonoscopy":[76],"showed":[77,135],"fungating":[79],"partially":[81],"obstructing":[82],"transverse":[86],"colon":[87],"adenomas.":[91],"immunohistochemical":[93],"profile":[94],"was":[95],"positive":[96],"chromogranin,":[98],"synaptophysin":[99],"60%":[101],"Ki-67":[102],"activity":[103],"consistent":[104],"diagnosis.":[107],"Patient":[108,138],"received":[109],"adjuvant":[110],"chemotherapy":[111],"Carboplatin":[113],"Etoposide,":[115],"achieving":[116],"remission":[117],"8":[119],"However,":[121],"follow-up":[124],"appointment,":[125],"renal":[126],"hepatic":[128],"function":[129],"worsened,":[130],"repeat":[133],"disease":[136],"progression.":[137],"decided":[139],"forego":[141],"treatment":[142,160],"enrolled":[144],"hospice":[146],"care.":[147],"coexistence":[149],"adenoma":[154],"allowed":[155],"prompt":[157],"initiation":[158],"treat":[162],"this":[163],"tumor,":[165],"also":[166],"leading":[167],"postulation":[170],"that":[171],"two":[173],"lesions":[174],"might":[175],"share":[176],"common":[178],"origin.":[179]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-11-22T00:00:00"}
