{"id":"https://openalex.org/W3213069997","doi":"https://doi.org/10.1182/blood-2021-148281","title":"Correlative Biological Studies Related to the Response, Peak and Persistence of ARI0002h, an Academic BCMA-Directed CAR-T Cell, with Fractionated Initial Infusion and Booster Dose for Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)","display_name":"Correlative Biological Studies Related to the Response, Peak and Persistence of ARI0002h, an Academic BCMA-Directed CAR-T Cell, with Fractionated Initial Infusion and Booster Dose for Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)","publication_year":2021,"publication_date":"2021-11-05","ids":{"openalex":"https://openalex.org/W3213069997","doi":"https://doi.org/10.1182/blood-2021-148281","mag":"3213069997"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2021-148281","doi":"https://doi.org/10.1182/blood-2021-148281","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-148281","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052822911","display_name":"Aina Oliver\u2010Cald\u00e9s","orcid":"https://orcid.org/0000-0002-7921-5420","observed_orcids":["https://orcid.org/0000-0002-7921-5420"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aina Oliver-Cald\u00e9s","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030098094","display_name":"Marta Espa\u00f1ol\u2010Rego","orcid":"https://orcid.org/0000-0001-5497-2276","observed_orcids":["https://orcid.org/0000-0001-5497-2276"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Espa\u00f1ol-Rego","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090362608","display_name":"Aintzane Zabaleta","orcid":"https://orcid.org/0000-0003-3474-3040","observed_orcids":["https://orcid.org/0000-0003-3474-3040"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aintzane Zabaleta","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210158561","https://openalex.org/I4392738196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034667545","display_name":"Susana Inog\u00e9s","orcid":"https://orcid.org/0000-0002-9370-8416","observed_orcids":["https://orcid.org/0000-0002-9370-8416"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Susana Inog\u00e9s","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210158561","https://openalex.org/I4392738196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022553370","display_name":"Ascensi\u00f3n L\u00f3pez-D\u00edaz de Cerio","orcid":"https://orcid.org/0000-0002-7837-135X","observed_orcids":["https://orcid.org/0000-0002-7837-135X"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ascensi\u00f3n L\u00f3pez-Diaz de Cerio","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210158561","https://openalex.org/I4392738196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046022528","display_name":"Ver\u00f3nica Gonz\u00e1lez\u2010Calle","orcid":"https://orcid.org/0000-0002-5493-6707","observed_orcids":["https://orcid.org/0000-0002-5493-6707"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210134045","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca","ror":"https://ror.org/03em6xj44","country_code":"ES","type":"facility","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034","https://openalex.org/I4210134045"]},{"id":"https://openalex.org/I4210138819","display_name":"Centro de Investigaci\u00f3n del C\u00e1ncer","ror":"https://ror.org/04rxrdv16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210138819"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Veronica Gonzalez-Calle","raw_affiliation_strings":["Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigaci\u00f3n del Cancer (IBMCC-USAL, CSIC), Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigaci\u00f3n del Cancer (IBMCC-USAL, CSIC), Salamanca, Spain","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4210134045","https://openalex.org/I4210138819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058537512","display_name":"Valent\u00edn Caba\u00f1as","orcid":"https://orcid.org/0000-0002-6248-2549","observed_orcids":["https://orcid.org/0000-0002-6248-2549"]},"institutions":[{"id":"https://openalex.org/I4210146619","display_name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria","ror":"https://ror.org/053j10c72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210146619"]},{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]},{"id":"https://openalex.org/I80180929","display_name":"Universidad de Murcia","ror":"https://ror.org/03p3aeb86","country_code":"ES","type":"education","lineage":["https://openalex.org/I80180929"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Valentin Caba\u00f1as","raw_affiliation_strings":["Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. IMIB-Arrixaca. University of Murcia, Murcia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. IMIB-Arrixaca. University of Murcia, Murcia, Spain","institution_ids":["https://openalex.org/I4210146619","https://openalex.org/I4210150677","https://openalex.org/I80180929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068807291","display_name":"Beatriz Mart\u00edn-Antonio","orcid":"https://orcid.org/0000-0003-0612-2693","observed_orcids":["https://orcid.org/0000-0003-0612-2693"]},"institutions":[{"id":"https://openalex.org/I4405264755","display_name":"Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/02whsjy88","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210129357","https://openalex.org/I4405264755"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Martin-Antonio","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jimenez Diaz, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jimenez Diaz, Madrid, Spain","institution_ids":["https://openalex.org/I4405264755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079200899","display_name":"Lorena P\u00e9rez-Amill","orcid":"https://orcid.org/0000-0003-0674-4660","observed_orcids":["https://orcid.org/0000-0003-0674-4660"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lorena P\u00e9rez-Amill","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002035508","display_name":"Juan Luis Reguera","orcid":"https://orcid.org/0009-0009-6408-1747","observed_orcids":["https://orcid.org/0009-0009-6408-1747"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Luis Reguera","raw_affiliation_strings":["Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), University of Sevilla, Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), University of Sevilla, Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I4210158561","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001784933","display_name":"Juan R. Rodr\u00edguez-Madoz","orcid":"https://orcid.org/0000-0003-4327-1866","observed_orcids":["https://orcid.org/0000-0003-4327-1866"]},"institutions":[{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Roberto Rodriguez-Madoz","raw_affiliation_strings":["Hemato-Oncology Program, CIMA Universidad de Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemato-Oncology Program, CIMA Universidad de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4392738196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080959881","display_name":"Paula Rodr\u00edguez\u2010Otero","orcid":"https://orcid.org/0000-0001-5236-7785","observed_orcids":["https://orcid.org/0000-0001-5236-7785"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paula Rodr\u00edguez-Otero","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210158561","https://openalex.org/I4392738196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080119173","display_name":"Daniel Ben\u00edtez\u2010Ribas","orcid":"https://orcid.org/0000-0002-2346-5324","observed_orcids":["https://orcid.org/0000-0002-2346-5324"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Daniel Ben\u00edtez-Ribas","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064282591","display_name":"Mari-Pau Mena","orcid":"https://orcid.org/0000-0001-9248-5997","observed_orcids":["https://orcid.org/0000-0001-9248-5997"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mari-Pau Mena","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048211632","display_name":"Marta Lasa","orcid":"https://orcid.org/0000-0002-2981-162X","observed_orcids":["https://orcid.org/0000-0002-2981-162X"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Lasa","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210158561","https://openalex.org/I4392738196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028420062","display_name":"Luis Gerardo Rodr\u00edguez\u2010Lobato","orcid":"https://orcid.org/0000-0001-5694-0921","observed_orcids":["https://orcid.org/0000-0001-5694-0921"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Gerardo Rodr\u00edguez-Lobato","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109447684","display_name":"Azucena Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Azucena Gonz\u00e1lez","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015898454","display_name":"Laura Rosi\u00f1ol","orcid":"https://orcid.org/0000-0002-2534-9239","observed_orcids":["https://orcid.org/0000-0002-2534-9239"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Rosinol","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071364391","display_name":"Jose Maria Moraleda","orcid":"https://orcid.org/0000-0001-9080-1466","observed_orcids":["https://orcid.org/0000-0001-9080-1466"]},"institutions":[{"id":"https://openalex.org/I4210146619","display_name":"Instituto Murciano de Investigaci\u00f3n Biosanitaria","ror":"https://ror.org/053j10c72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210146619"]},{"id":"https://openalex.org/I4210150677","display_name":"Hospital Universitario Virgen de la Arrixaca","ror":"https://ror.org/058thx797","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210150677"]},{"id":"https://openalex.org/I80180929","display_name":"Universidad de Murcia","ror":"https://ror.org/03p3aeb86","country_code":"ES","type":"education","lineage":["https://openalex.org/I80180929"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Maria Moraleda","raw_affiliation_strings":["Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. IMIB-Arrixaca. University of Murcia, Murcia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednico Universitario Virgen de la Arrixaca. IMIB-Arrixaca. University of Murcia, Murcia, Spain","institution_ids":["https://openalex.org/I4210146619","https://openalex.org/I4210150677","https://openalex.org/I80180929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016030888","display_name":"Felipe Pr\u00f3sper","orcid":"https://orcid.org/0000-0001-6115-8790","observed_orcids":["https://orcid.org/0000-0001-6115-8790","https://orcid.org/0000-0002-3274-2450"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Felipe Pr\u00f3sper","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210158561","https://openalex.org/I4392738196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012535366","display_name":"\u00c1lvaro Urbano-Ispiz\u00faa","orcid":"https://orcid.org/0000-0002-7529-9399","observed_orcids":["https://orcid.org/0000-0002-7529-9399"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1lvaro Urbano-Ispizua","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029159537","display_name":"Mar\u00eda\u2010Victoria Mateos","orcid":"https://orcid.org/0000-0003-2390-1218","observed_orcids":["https://orcid.org/0000-0003-2390-1218"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210134045","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca","ror":"https://ror.org/03em6xj44","country_code":"ES","type":"facility","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034","https://openalex.org/I4210134045"]},{"id":"https://openalex.org/I4210138819","display_name":"Centro de Investigaci\u00f3n del C\u00e1ncer","ror":"https://ror.org/04rxrdv16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210138819"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria-Victoria Mateos","raw_affiliation_strings":["Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigaci\u00f3n del Cancer (IBMCC-USAL, CSIC), Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigaci\u00f3n del Cancer (IBMCC-USAL, CSIC), Salamanca, Spain","institution_ids":["https://openalex.org/I184999862","https://openalex.org/I4210134045","https://openalex.org/I4210138819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063848310","display_name":"Manel Juan","orcid":"https://orcid.org/0000-0002-3064-1648","observed_orcids":["https://orcid.org/0000-0002-3064-1648"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manel Juan","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057189669","display_name":"Bruno Paiva","orcid":"https://orcid.org/0000-0003-1977-3815","observed_orcids":["https://orcid.org/0000-0003-1977-3815","https://orcid.org/0000-0002-0128-8849"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Bruno Paiva","raw_affiliation_strings":["Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBERONC Pamplona, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003","https://openalex.org/I4210158561","https://openalex.org/I4392738196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027974177","display_name":"Mariona Pascal","orcid":"https://orcid.org/0000-0003-0549-9720","observed_orcids":["https://orcid.org/0000-0003-0549-9720"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mariona Pascal","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039525330","display_name":"Carlos Fern\u00e1ndez de Larrea","orcid":"https://orcid.org/0000-0003-4930-9255","observed_orcids":["https://orcid.org/0000-0003-4930-9255"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Fernandez de Larrea","raw_affiliation_strings":["Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednic de Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"Supplement 1","first_page":"552","last_page":"552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.04809999838471413,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapsed-refractory-multiple-myeloma","display_name":"relapsed/refractory multiple myeloma","score":0.9010000228881836},{"id":"https://openalex.org/keywords/booster-vaccination","display_name":"booster vaccination","score":0.8460000157356262},{"id":"https://openalex.org/keywords/4-1bb-costimulation","display_name":"4-1BB costimulation","score":0.875},{"id":"https://openalex.org/keywords/car-t-cell-persistence","display_name":"CAR T cell persistence","score":0.675000011920929},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.8339999914169312},{"id":"https://openalex.org/keywords/soluble-bcma","display_name":"soluble BCMA","score":0.7990000247955322},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2776738589","wikidata":"https://www.wikidata.org/wiki/Q618446","display_name":"Apheresis","level":3,"score":0.6776844263076782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.571421205997467},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5040118098258972},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.4230317771434784},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3806132674217224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.354488730430603},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.33718180656433105},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3324069082736969},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14608711004257202},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.13811790943145752},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.12959781289100647}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2021-148281","doi":"https://doi.org/10.1182/blood-2021-148281","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-148281","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3213973183","https://openalex.org/W4283376773","https://openalex.org/W4389233343","https://openalex.org/W4399480956","https://openalex.org/W4382933451","https://openalex.org/W4392640248","https://openalex.org/W7108444762","https://openalex.org/W7133348651","https://openalex.org/W4405126083","https://openalex.org/W7108477053"],"abstract_inverted_index":{"Abstract":[0],"B":[1],"ackground:":[2],"ARI0002h":[3,111,196,321,416,675],"is":[4,26,677],"an":[5,756,776,892,904,920,932,944,956,973,988,1000,1012,1026],"academic":[6],"autologous":[7,323],"CAR":[8,120],"T-cell":[9,189,356],"product":[10,125],"with":[11,37,74,175,275,279,289,312,339,364,431,448,467,482,512,530,533,536,616],"a":[12,17,93,206,235,290,313,449,478,483,518,592,646,652],"4-1BB":[13],"co-stimulatory":[14],"domain":[15],"and":[16,105,116,137,152,165,181,191,215,233,254,287,376,396,433,438,461,552,575,601,606,614,679,691,720,788,1038,1049],"humanized":[18],"single":[19],"chain":[20],"variable":[21],"fragment":[22],"targeting":[23],"BCMA,":[24],"which":[25,308,701],"being":[27],"tested":[28,548],"in":[29,83,92,122,199,334,352,358,382,390,405,446,487,497,508,520,525,544,640,693],"the":[30,71,100,123,335,353,359,394,546,570,659,662],"CARTBCMA-HCB-01":[31],"clinical":[32],"trial":[33],"for":[34,188,259,412,577],"patients":[35],"(pts)":[36],"RRMM":[38],"(NCT04309981).":[39],"A":[40,56,330,368],"fractionated":[41],"infusion":[42,202,208,690],"of":[43,59,81,195,294,320,341,371,442,452,472,489,500,555,594,622,683,689,699,759,779,895,907,923,935,947,959,976,991,1003,1015,1029],"3x10":[44,60],"6":[45,61,154,434],"CAR+":[46,62,443],"cells":[47,163,325,408,418,445,634],"(ARI0002h)/kg":[48],"(10/30/60%)":[49],"was":[50,64,197,209,217,224,237,326,337,349,380,495,506,523,572,655],"administered":[51],"after":[52,70,139,201,213,528,644,687,696,713],"lymphodepletion":[53],"regimen":[54],"(LR).":[55],"second":[57,207,314],"dose":[58,649],"cells/kg":[63],"planned":[65],"starting":[66],"at":[67,135,147,149,153,231,245,269,281,303,409,423,539,550,565,591,598,603,630,637,650],"4":[68],"months":[69,155],"first":[72,304],"dose,":[73,481],"or":[75,761,781,897,909,925,937,949,961,978,993,1005,1017,1031],"without":[76],"LR":[77,494,704],"according":[78],"to":[79,107,157,229,669,709,724],"persistence":[80,451,463],"CAR-T":[82,384,407,417,633],"peripheral":[84],"blood":[85],"(PB).":[86],"Clinical":[87,253],"results":[88,402],"have":[89,558],"been":[90],"submitted":[91],"separate":[94],"abstract":[95],"(#147188);":[96],"here":[97],"we":[98],"present":[99],"correlative":[101],"biological":[102],"studies":[103],"performed":[104],"related":[106],"disease":[108,168],"response.":[109,469,534],"Methods:":[110],"production":[112,676],"data":[113,256],"were":[114,133,145,186,243,257,271,285,300,403,586,589,608,635],"obtained":[115,134,146,286,302,717],"analyzed,":[117],"including":[118],"%":[119,318],"transduction":[121,319],"final":[124],"(FP)":[126],"by":[127,170,203,226,459],"flow":[128,173],"cytometry":[129],"(FC).":[130],"PB":[131,200,398,421,462],"samples":[132,144,183,549],"inclusion":[136,270,540],"sequentially":[138],"infusion.":[140],"Bone":[141],"marrow":[142],"(BM)":[143],"inclusion,":[148],"d28,":[150,410],"d100":[151,246],"(m),":[156],"evaluate":[158],"BCMA":[159,222,263,612,617],"expression":[160,379],"on":[161,184,249,265,322,755,775,891,903,919,931,943,955,972,987,999,1011,1025],"plasma":[162],"(PCs)":[164],"minimal":[166],"residual":[167],"(MRD)":[169],"next":[171],"generation":[172],"(NGF)":[174],"10":[176,488,502],"-6":[177],"sensitivity.":[178],"Apheresis,":[179],"FP,":[180],"PB/BM":[182],"d28":[185,232,397,551],"analyzed":[187],"subpopulations":[190,357],"surface":[192],"markers.":[193],"Persistence":[194],"evaluated":[198,244],"PCR.":[204],"If":[205],"administered,":[210],"CART":[211,485,513,684],"detection":[212],"3":[214,432],"7d":[216,426],"also":[218,692],"checked.":[219],"Plasmatic":[220],"soluble":[221],"(sBCMA)":[223],"determined":[225],"ELISA":[227],"prior":[228],"infusion,":[230],"if":[234],"relapse":[236],"observed.":[238,656],"Human":[239],"anti-human":[240],"antibodies":[241],"(HAHAs)":[242],"(using":[247],"FC":[248],"transduced":[250],"HEK":[251],"cells).":[252],"response":[255,280,344,365,663,666],"collected":[258],"analysis.":[260],"Results:":[261],"Mean":[262],"molecules/cell":[264],"malignant":[266],"BM":[267,406,571],"PC":[268],"1306":[272],"(SD":[273,328],"\u00b1889)":[274],"non-significant":[276],"(NS)":[277],"correlation":[278],"d100.":[282,553],"Thirty-three":[283],"apheresis":[284,336],"transduced,":[288],"median":[291,450],"manufacturing":[292],"time":[293],"11d":[295],"(range":[296,425,454],"9-14).":[297],"All":[298],"FP":[299,360,395],"successfully":[301],"attempt":[305],"but":[306,643],"one,":[307],"could":[309],"be":[310,707,725],"produced":[311],"apheresis.":[315],"The":[316,681],"mean":[317],"T":[324,444],"56%":[327],"\u00b125).":[329],"higher":[331],"CD4/CD8":[332],"ratio":[333],"correlated":[338],"achievement":[340],"stringent":[342],"complete":[343],"(sCR)":[345],"(p=0.003);":[346],"this":[347,641],"association":[348,532],"not":[350,362,465,706],"observed":[351,381,404,507,524],"FP.":[354],"Moreover,":[355],"did":[361,464],"correlate":[363,466],"(Figure":[366,414,515],"1A).":[367],"significant":[369],"increase":[370],"PD-1":[372,389],"(p=0.0001),":[373,392],"TIGIT":[374],"(p=0.037)":[375],"LAG3":[377,413],"(p=0.003)":[378],"CD4":[383],"cells,":[385],"as":[386,388],"well":[387],"CD8":[391],"between":[393],"paired":[399],"samples;":[400],"similar":[401],"except":[411],"1B).":[415],"showed":[419],"maximum":[420],"expansion":[422,486,514,654,685,712],"14d":[424,688],"-":[427,913],"5m).":[428],"Among":[429],"pts":[430,475,510,527,557,561,626,695],"m":[435],"follow-up,":[436],"54%":[437],"24%":[439],"had":[440,562,627],"evidence":[441],"PB,":[447],"4m":[453],"2-not":[455],"reached).":[456],"Expansion":[457],"levels":[458],"PCR":[460],"MM":[468],"22":[470,584],"out":[471],"27":[473,560,623],"eligible":[474],"(81%)":[476],"received":[477],"2":[479,607,647],"nd":[480,648],"subsequent":[484,547],"20":[490],"(50%)":[491],"evaluable":[492,625],"pts;":[493],"readministered":[496],"only":[498],"30%":[499],"these":[501,556],"pts.":[503],"B-cell":[504,521],"aplasia":[505],"all":[509,545],"concurring":[511],"1C).":[516],"Also,":[517],"decline":[519],"counts":[522],"some":[526,694],"reinfusion,":[529,697],"no":[531],"Patients":[535],"detectable":[537],"sBCMA":[538,542],"became":[541],"negative":[543,590],"None":[554],"relapsed.":[559],"MRD":[563,578,609],"assessed":[564],"day":[566,631,638],"+100.":[567],"In":[568],"3,":[569],"severely":[573],"hemodiluted":[574],"inadequate":[576],"testing.":[579],"Of":[580],"24":[581],"MRD-evaluable":[582],"pts,":[583],"(92%)":[585],"MRD-negative":[587],"(59%":[588],"sensitivity":[593],"1x10":[595,599,604],"-6,":[596],"36%":[597],"-5":[600],"5%":[602],"-4),":[605],"positive":[610,613,628],"(one":[611],"another":[615],"undetermined":[618],"result).":[619],"Only":[620],"1":[621,728],"(4%)":[624],"HAHAs":[629],"100.":[632],"undetectable":[636],"70":[639],"patient,":[642],"receiving":[645],"m4":[651],"short-lasted":[653],"Despite":[657],"that,":[658],"patient":[660],"deepened":[661],"from":[664],"partial":[665],"(PR)":[667],"(d100)":[668],"very":[670],"good":[671],"PR":[672],"(m6).":[673],"Conclusion:":[674],"fast":[678],"feasible.":[680],"peak":[682],"occurs":[686],"regardless":[698],"LR,":[700],"suggests":[702],"that":[703],"may":[705],"mandatory":[708],"allow":[710],"further":[711],"booster":[714],"dose.":[715],"Responses":[716],"are":[718],"deep":[719],"construct":[721],"immunogenicity":[722],"seems":[723],"low.":[726],"Figure":[727,729],"1.":[730],"Disclosures":[731],"Gonzalez-Calle:":[732],"BMS,":[733],"Janssen,":[734,747,768,785,1037,1045],"Amgen:":[735,872,952,1068],"Honoraria.":[736,745,790],"Caba\u00f1as:":[737],"Sanofi:":[738,798,984,1039,1078],"Honoraria;":[739,742,766,828,880,882,965,967,983,1021,1051,1063],"BMS:":[740,1073],"Consultancy,":[741,744,811,819,827,830,838,847,1069,1074,1081],"Janssen:":[743,860,881,1008,1080],"Reguera:":[746],"Kite/Gilead,":[748],"Novartis:":[749,753,829],"Speakers":[750],"Bureau;":[751],"BMS-Celgene,":[752],"Membership":[754,774,890,902,918,930,942,954,971,986,998,1010,1024],"entity's":[757,777,893,905,921,933,945,957,974,989,1001,1013,1027],"Board":[758,778,894,906,922,934,946,958,975,990,1002,1014,1028],"Directors":[760,780,896,908,924,936,948,960,977,992,1004,1016,1030],"advisory":[762,782,898,910,926,938,950,962,979,994,1006,1018,1032],"committees.":[763,783,1033],"Rodr\u00edguez-Otero:":[764],"Regeneron:":[765,996],"Celgene-BMS,":[767],"Amgen,":[769,1042],"Sanofi,":[770,1055],"GSK,":[771],"Oncopeptides:":[772,964,1022],"Honoraria,":[773,812,820,831,839,848,884,889,901,917,929,941,953,970,985,997,1009,1023,1065,1070,1075,1082],"Rosinol:":[784],"Celgene,":[786,1052],"Amgen":[787],"Takeda:":[789,818,940,1050,1056,1064],"Moraleda:":[791],"Pfizer:":[792,900],"Other:":[793,799,805,813,821,832,840,849,855,861,867,873],"Educational":[794,800,806,814,822,833,841,850,856,862,868,874],"Grants,":[795,801,807,815,823,834,842,851,857,863,869,875],"Research":[796,802,808,816,824,835,843,852,858,864,870,876,885,1057,1066,1071,1076,1083],"Funding;":[797,803,809,817,825,836,844,853,859,865,871,1067,1072,1077],"MSD:":[804],"ROCHE:":[810],"Sandoz:":[826],"Gilead:":[837],"Jazz":[845],"Pharmaceuticals:":[846],"NovoNordisk:":[854],"Celgene:":[866],"Funding.":[877,886,1058,1084],"Pr\u00f3sper:":[878],"Oryzon:":[879],"BMS-Celgene:":[883],"Mateos:":[887],"Roche:":[888],"committees;":[899,911,927,939,951,963,980,995,1007,1019],"Celgene":[912],"Bristol":[914],"Myers":[915],"Squibb:":[916],"Sea-Gen:":[928],"GSK:":[966,1062],"Adaptive":[968],"Biotechnologies:":[969],"Bluebird":[981],"bio:":[982],"AbbVie:":[1020],"Paiva:":[1034],"Bristol-Myers":[1035,1043],"Squibb-Celgene,":[1036,1044],"Consultancy;":[1040,1079],"Adaptive,":[1041],"Kite":[1046],"Pharma,":[1047],"Sanofi":[1048],"EngMab,":[1053],"Roche,":[1054],"Fernandez":[1059],"de":[1060],"Larrea:":[1061]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-11-22T00:00:00"}