{"id":"https://openalex.org/W3213068978","doi":"https://doi.org/10.21608/ejh.2021.94120.1559","title":"Resveratrol antiaging impact on bone marrow-derived mesenchymal stem cells in a duration-dependent manner.","display_name":"Resveratrol antiaging impact on bone marrow-derived mesenchymal stem cells in a duration-dependent manner.","publication_year":2021,"publication_date":"2021-11-07","ids":{"openalex":"https://openalex.org/W3213068978","doi":"https://doi.org/10.21608/ejh.2021.94120.1559","mag":"3213068978"},"language":"en","primary_location":{"id":"doi:10.21608/ejh.2021.94120.1559","doi":"https://doi.org/10.21608/ejh.2021.94120.1559","is_oa":true,"landing_page_url":"https://doi.org/10.21608/ejh.2021.94120.1559","pdf_url":null,"source":{"id":"https://openalex.org/S4210178592","display_name":"The Egyptian Journal of Histology","issn_l":"1110-0559","issn":["1110-0559","2090-2417"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Journal of Histology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21608/ejh.2021.94120.1559","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085782041","display_name":"Heba M. Saad Eldien","orcid":"https://orcid.org/0009-0007-9418-905X","observed_orcids":["https://orcid.org/0009-0007-9418-905X","https://orcid.org/0000-0003-0661-3783"]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Heba Saad Eldien","raw_affiliation_strings":["Histology and cell biology - Faculty of Medicine- Assiut University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histology and cell biology - Faculty of Medicine- Assiut University","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001742223","display_name":"Nashwa Mostafa","orcid":"https://orcid.org/0000-0001-8761-909X","observed_orcids":["https://orcid.org/0000-0001-8761-909X"]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nashwa Mostafa","raw_affiliation_strings":["Assiut university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assiut university","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102931730","display_name":"Douaa M. Sayed","orcid":"https://orcid.org/0000-0002-4083-3942","observed_orcids":["https://orcid.org/0000-0002-4083-3942"]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Douaa Sayed","raw_affiliation_strings":["Clinical pathology , SECI, Assiut university , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical pathology , SECI, Assiut university , Egypt","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083270053","display_name":"Shima Gafar Mansor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Shima Mansor","raw_affiliation_strings":["clinical pathology department, SECI, Assiut University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"clinical pathology department, SECI, Assiut University","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055706311","display_name":"Fatma Elewa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Fatma Elewa","raw_affiliation_strings":["Histology and cell biology - Faculty of Medicine- Assiut University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histology and cell biology - Faculty of Medicine- Assiut University","institution_ids":["https://openalex.org/I91041137"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051056823","display_name":"Fatma Y. Meligy","orcid":"https://orcid.org/0000-0002-6372-8731","observed_orcids":["https://orcid.org/0000-0002-6372-8731"]},"institutions":[{"id":"https://openalex.org/I91041137","display_name":"Assiut University","ror":"https://ror.org/01jaj8n65","country_code":"EG","type":"education","lineage":["https://openalex.org/I91041137"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Fatma Meligy","raw_affiliation_strings":["Histology department Assiut university Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histology department Assiut university Egypt","institution_ids":["https://openalex.org/I91041137"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085782041"],"corresponding_institution_ids":["https://openalex.org/I91041137"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"0","issue":"0","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.5414999723434448,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.5414999723434448,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.45509999990463257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/bone-marrow-derived-mesenchymal-stem-cells","display_name":"bone marrow-derived mesenchymal stem cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/stem-cell-aging","display_name":"stem cell aging","score":0.8109999895095825},{"id":"https://openalex.org/keywords/anti-aging","display_name":"anti-aging","score":0.6430000066757202},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/colony-forming-units","display_name":"colony-forming units","score":0.7179999947547913},{"id":"https://openalex.org/keywords/dna-index","display_name":"DNA index","score":0.7279999852180481},{"id":"https://openalex.org/keywords/bubr1","display_name":"BubR1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cd90","display_name":"CD90","score":0.5230000019073486},{"id":"https://openalex.org/keywords/genetic-stability","display_name":"genetic stability","score":0.671999990940094},{"id":"https://openalex.org/keywords/duration-dependent-effects","display_name":"duration-dependent effects","score":0.6510000228881836},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8489015102386475},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.8449980020523071},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6554490923881531},{"id":"https://openalex.org/C112758219","wikidata":"https://www.wikidata.org/wiki/Q16038819","display_name":"Duration (music)","level":2,"score":0.6231932640075684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4236263632774353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23684188723564148},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2099016308784485},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19376415014266968},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.045793890953063965},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21608/ejh.2021.94120.1559","doi":"https://doi.org/10.21608/ejh.2021.94120.1559","is_oa":true,"landing_page_url":"https://doi.org/10.21608/ejh.2021.94120.1559","pdf_url":null,"source":{"id":"https://openalex.org/S4210178592","display_name":"The Egyptian Journal of Histology","issn_l":"1110-0559","issn":["1110-0559","2090-2417"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Journal of Histology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:75f289784f1a4a9d9e4676038979d536","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/75f289784f1a4a9d9e4676038979d536","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Egyptian Journal of Histology, Vol 46, Iss 1, Pp 335-354 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21608/ejh.2021.94120.1559","doi":"https://doi.org/10.21608/ejh.2021.94120.1559","is_oa":true,"landing_page_url":"https://doi.org/10.21608/ejh.2021.94120.1559","pdf_url":null,"source":{"id":"https://openalex.org/S4210178592","display_name":"The Egyptian Journal of Histology","issn_l":"1110-0559","issn":["1110-0559","2090-2417"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Journal of Histology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404093924","https://openalex.org/W3002174642","https://openalex.org/W2980813799","https://openalex.org/W2889806630","https://openalex.org/W2794398446","https://openalex.org/W2917730055","https://openalex.org/W2067437059","https://openalex.org/W2945023359","https://openalex.org/W4283161465","https://openalex.org/W3001142947"],"abstract_inverted_index":{"Background:":[0],"Aging":[1],"is":[2,15],"a":[3,16,47,52,132],"natural":[4],"life":[5],"event":[6],"associated":[7],"with":[8,21,36,51],"progressive":[9],"cellular":[10],"and":[11,64,163,179,199,230,259],"biological":[12,29],"dysfunction.":[13],"It":[14,250],"cumulative":[17],"process":[18],"that":[19],"ends":[20],"impairment":[22],"of":[23,27,61,95,111,134,182,239],"the":[24,28,59,107],"general":[25],"function":[26],"system.":[30],"Stem":[31],"cells":[32,35,85],"are":[33],"unique":[34],"behavioral":[37],"diversity":[38],"making":[39],"them":[40],"intriguing":[41],"candidates":[42],"for":[43,154,160,167],"regenerative":[44],"therapy.Resveratrol":[45],"[RSV],":[46],"nonflavonoid":[48],"polyphenol":[49],"phytoalexin":[50],"stilbene":[53],"structure,":[54],"was":[55,66,116,123,177],"first":[56],"extracted":[57],"from":[58,88],"root":[60],"white":[62],"hellebore,":[63],"it":[65],"widely":[67],"used":[68],"in":[69,138,215,265],"traditional":[70],"Chinese":[71],"medicine.":[72],"Materials":[73],"And":[74],"Methods:":[75],"We":[76,211],"achieved":[77],"our":[78],"study":[79],"on":[80,245,247],"bone":[81],"marrow-derived":[82],"mesenchymal":[83],"stem":[84],"[BM-MSCs]":[86],"derived":[87],"15-month":[89],"aged":[90,248],"rats.":[91],"A":[92],"total":[93],"number":[94],"40":[96],"female":[97],"rats":[98],"weighting":[99],"[200-300g].":[100],"All":[101],"animal":[102,120],"procedures":[103],"were":[104,143,172,185,208],"approved":[105],"by":[106,202],"Institutional":[108],"Ethics":[109],"Committee":[110],"Assiut":[112],"University.":[113],"Every":[114],"attempt":[115],"made":[117],"to":[118],"minimize":[119],"affliction.":[121],"Resveratrol":[122,241],"given":[124],"orally":[125],"[through":[126],"an":[127],"intragastric":[128],"tube]":[129],"daily":[130],"at":[131],"dose":[133],"2.5":[135],"mg/kg":[136],"diluted":[137],"0.5ml":[139],"phosphate":[140],"buffer":[141],"salineAnimals":[142],"subdivided":[144],"into":[145],"four":[146],"equal":[147],"subgroups;":[148],"[A]":[149],"control,":[150],"[B]":[151],"received":[152,158,165],"resveratrol":[153,159,166],"one":[155,168],"week,":[156],"[C]":[157],"two":[161,237],"weeks,":[162],"[D]":[164],"month.":[169],"Morphological":[170],"changes":[171],"tracked,":[173],"surface":[174],"marker":[175,226],"expression":[176],"measured,":[178],"various":[180],"parameters":[181,263],"proliferation":[183,219],"kinetics":[184],"used;":[186],"colony-forming":[187],"unit":[188],"[CFU],":[189],"population":[190],"doubling":[191],"time":[192],"[PDT]":[193],"\"3\u2010[4,5\u2010Dimethylthiazol\u20102\u2010yl]\u20102,5\u2010diphenyltetrazolium":[194],"bromide":[195],"[MTT]\",":[196],"\"DNA":[197],"index\"":[198],"budding":[200],"uninhibited":[201],"benzimidazole-related":[203],"1.":[204],"[BubR1]":[205],"immunocytochemical":[206,233],"staining":[207,234],"implemented.":[209],"Results:":[210],"reached":[212],"significant":[213],"results":[214],"improving":[216],"morphological":[217],"changes,":[218],"kinetic":[220],"parameters,":[221],"immunophenotypic":[222],"flowcytometric":[223],"CD":[224],"90":[225],"expression,":[227],"DNA":[228],"index,":[229],"anti":[231],"BubR1antibody":[232],"even":[235],"after":[236],"weeks":[238],"treatment.Conclusions:":[240],"had":[242],"flourishing":[243],"effects":[244],"MSC":[246,261],"cells.":[249],"promoted":[251],"growth,":[252],"proliferation,":[253],"improved":[254,260],"viability,":[255],"established":[256],"genetic":[257],"stability,":[258],"aging":[262],"documented":[264],"marked":[266],"duration-dependent":[267],"patterns.":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-11-22T00:00:00"}