{"id":"https://openalex.org/W3213068937","doi":"https://doi.org/10.1016/j.jddst.2021.102857","title":"In vitro optimization, characterization and anti-tumor evaluation against colorectal cancer of a novel 5-fluorouracil oral nanosuspension using soy protein, polysaccharides-protein complexation, and in-situ gel formation","display_name":"In vitro optimization, characterization and anti-tumor evaluation against colorectal cancer of a novel 5-fluorouracil oral nanosuspension using soy protein, polysaccharides-protein complexation, and in-situ gel formation","publication_year":2021,"publication_date":"2021-11-06","ids":{"openalex":"https://openalex.org/W3213068937","doi":"https://doi.org/10.1016/j.jddst.2021.102857","mag":"3213068937"},"language":"en","primary_location":{"id":"doi:10.1016/j.jddst.2021.102857","doi":"https://doi.org/10.1016/j.jddst.2021.102857","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jddst.2021.102857","pdf_url":null,"source":{"id":"https://openalex.org/S97205441","display_name":"Journal of Drug Delivery Science and Technology","issn_l":"1773-2247","issn":["1773-2247","2588-8943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068365581","display_name":"Samaa Abdullah","orcid":"https://orcid.org/0000-0001-5245-6489","observed_orcids":["https://orcid.org/0000-0001-5245-6489"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Samaa Abdullah","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sahar El Hadad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]},{"id":"https://openalex.org/I4210134127","display_name":"Vacsera (Egypt)","ror":"https://ror.org/03nh6bz87","country_code":"EG","type":"company","lineage":["https://openalex.org/I4210134127"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Sahar El Hadad","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia","Research Center of Genetic Engineering and Bioinformatics, VACSERA, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]},{"raw_affiliation_string":"Research Center of Genetic Engineering and Bioinformatics, VACSERA, Cairo, Egypt","institution_ids":["https://openalex.org/I4210134127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062892129","display_name":"Alia Aldahlawi","orcid":"https://orcid.org/0000-0001-9599-050X","observed_orcids":["https://orcid.org/0000-0001-9599-050X"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Alia Aldahlawi","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia","Immunology Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]},{"raw_affiliation_string":"Immunology Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068365581"],"corresponding_institution_ids":["https://openalex.org/I185163786"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":1.4174,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.75703542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"67","issue":null,"first_page":"102857","last_page":"102857"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5824999809265137,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.5824999809265137,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":1.0},{"id":"https://openalex.org/keywords/soy-protein","display_name":"soy protein","score":0.7710000276565552},{"id":"https://openalex.org/keywords/solid-dispersion","display_name":"solid dispersion","score":0.675000011920929},{"id":"https://openalex.org/keywords/sodium-alginate","display_name":"sodium alginate","score":0.9459999799728394},{"id":"https://openalex.org/keywords/in-situ-gelation","display_name":"in situ gelation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8240000009536743},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/colon-specific-drug-delivery","display_name":"colon-targeted drug delivery","score":0.7070000171661377},{"id":"https://openalex.org/keywords/nanoparticle-formation","display_name":"nanoparticle formation","score":0.6050000190734863},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.5969749689102173},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5079959034919739},{"id":"https://openalex.org/C2777014122","wikidata":"https://www.wikidata.org/wiki/Q7571993","display_name":"Soy protein","level":2,"score":0.505620002746582},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4878968894481659},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.47881776094436646},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47539815306663513},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.45507705211639404},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.44670921564102173},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.43600142002105713},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.4182928502559662},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4092106819152832},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2447832226753235},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.221381276845932},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1615334153175354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14204978942871094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1307877004146576},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jddst.2021.102857","doi":"https://doi.org/10.1016/j.jddst.2021.102857","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jddst.2021.102857","pdf_url":null,"source":{"id":"https://openalex.org/S97205441","display_name":"Journal of Drug Delivery Science and Technology","issn_l":"1773-2247","issn":["1773-2247","2588-8943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery Science and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322322","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W161399351","https://openalex.org/W620044983","https://openalex.org/W1462714624","https://openalex.org/W1549826455","https://openalex.org/W1970173773","https://openalex.org/W1970998758","https://openalex.org/W1999644763","https://openalex.org/W2005913110","https://openalex.org/W2012267280","https://openalex.org/W2034659394","https://openalex.org/W2048320838","https://openalex.org/W2050272724","https://openalex.org/W2061119124","https://openalex.org/W2063625135","https://openalex.org/W2068083571","https://openalex.org/W2086534626","https://openalex.org/W2088044343","https://openalex.org/W2088506915","https://openalex.org/W2094331027","https://openalex.org/W2112466262","https://openalex.org/W2130392703","https://openalex.org/W2144957370","https://openalex.org/W2157498028","https://openalex.org/W2174957215","https://openalex.org/W2184214697","https://openalex.org/W2466490295","https://openalex.org/W2534162752","https://openalex.org/W2727109679","https://openalex.org/W2766367919","https://openalex.org/W2806432392","https://openalex.org/W2895004762","https://openalex.org/W2913288756","https://openalex.org/W2999281449","https://openalex.org/W3007802718","https://openalex.org/W3031851776","https://openalex.org/W3042641582","https://openalex.org/W3043696061","https://openalex.org/W3145236092","https://openalex.org/W6606577469","https://openalex.org/W6685860058"],"related_works":["https://openalex.org/W4200386398","https://openalex.org/W4205664266","https://openalex.org/W3115456909","https://openalex.org/W7219528665","https://openalex.org/W1964872366","https://openalex.org/W3216303639","https://openalex.org/W1982759704","https://openalex.org/W3024951634","https://openalex.org/W4385154629","https://openalex.org/W4220980159"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2021-11-22T00:00:00"}