{"id":"https://openalex.org/W3213027475","doi":"https://doi.org/10.1038/s41467-021-26861-0","title":"Epromoters function as a hub to recruit key transcription factors required for the inflammatory response","display_name":"Epromoters function as a hub to recruit key transcription factors required for the inflammatory response","publication_year":2021,"publication_date":"2021-11-18","ids":{"openalex":"https://openalex.org/W3213027475","doi":"https://doi.org/10.1038/s41467-021-26861-0","mag":"3213027475","pmid":"https://pubmed.ncbi.nlm.nih.gov/34795220","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8602369"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-021-26861-0","doi":"https://doi.org/10.1038/s41467-021-26861-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-26861-0","pdf_url":"https://www.nature.com/articles/s41467-021-26861-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-021-26861-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025574366","display_name":"David Santiago\u2010Algarra","orcid":"https://orcid.org/0000-0003-4697-7047","observed_orcids":["https://orcid.org/0000-0003-4697-7047"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Santiago-Algarra","raw_affiliation_strings":["Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-4697-7047","affiliations":[{"raw_affiliation_string":"Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008381398","display_name":"Charbel Souaid","orcid":"https://orcid.org/0000-0002-2495-1308","observed_orcids":["https://orcid.org/0000-0002-2495-1308"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Charbel Souaid","raw_affiliation_strings":["Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071080377","display_name":"Himanshu Narayan Singh","orcid":"https://orcid.org/0000-0003-4111-5165","observed_orcids":["https://orcid.org/0000-0003-4111-5165"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Himanshu Singh","raw_affiliation_strings":["Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-4111-5165","affiliations":[{"raw_affiliation_string":"Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081746158","display_name":"Lan T.M. Dao","orcid":"https://orcid.org/0000-0001-6071-3342","observed_orcids":["https://orcid.org/0000-0001-6071-3342"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"id":"https://openalex.org/I4405276886","display_name":"Vinmec Research Institute of Stem Cell and Gene Technology","ror":"https://ror.org/00nn14q45","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4210142044","https://openalex.org/I4405276886"]},{"id":"https://openalex.org/I4405276989","display_name":"Vinmec Healthcare System","ror":"https://ror.org/012rvtf75","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989"]}],"countries":["FR","VN"],"is_corresponding":false,"raw_author_name":"Lan T. M. Dao","raw_affiliation_strings":["Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France","Vinmec Research Institute of Stem cell and Gene technology, Vinmec Healthcare System, Hanoi, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France","institution_ids":["https://openalex.org/I4210095243"]},{"raw_affiliation_string":"Vinmec Research Institute of Stem cell and Gene technology, Vinmec Healthcare System, Hanoi, Vietnam","institution_ids":["https://openalex.org/I4405276886","https://openalex.org/I4405276989"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Saadat Hussain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Saadat Hussain","raw_affiliation_strings":["Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060491883","display_name":"Alejandra Medina-Rivera","orcid":"https://orcid.org/0000-0002-7912-2718","observed_orcids":["https://orcid.org/0000-0002-7912-2718"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alejandra Medina-Rivera","raw_affiliation_strings":["Laboratorio Internacional de Investigaci\u00f3n sobre el Genoma Humano, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Juriquilla, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Internacional de Investigaci\u00f3n sobre el Genoma Humano, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Juriquilla, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076843722","display_name":"Lucia Ramirez-Navarro","orcid":"https://orcid.org/0000-0003-2194-2438","observed_orcids":["https://orcid.org/0000-0003-2194-2438"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Lucia Ramirez-Navarro","raw_affiliation_strings":["Laboratorio Internacional de Investigaci\u00f3n sobre el Genoma Humano, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Juriquilla, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-2194-2438","affiliations":[{"raw_affiliation_string":"Laboratorio Internacional de Investigaci\u00f3n sobre el Genoma Humano, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Juriquilla, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072613924","display_name":"Jaime Abraham Castro-Mondragon","orcid":"https://orcid.org/0000-0003-4069-357X","observed_orcids":["https://orcid.org/0000-0003-4069-357X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR","NO"],"is_corresponding":false,"raw_author_name":"Jaime A. Castro-Mondragon","raw_affiliation_strings":["Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318, Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0003-4069-357X","affiliations":[{"raw_affiliation_string":"Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, 0318, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073395698","display_name":"Nori Sadouni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nori Sadouni","raw_affiliation_strings":["Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guillaume Charbonnier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Charbonnier","raw_affiliation_strings":["Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091488339","display_name":"Salvatore Spicuglia","orcid":"https://orcid.org/0000-0002-8101-7108","observed_orcids":["https://orcid.org/0000-0002-8101-7108"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Salvatore Spicuglia","raw_affiliation_strings":["Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France. salvatore.spicuglia@inserm.fr","Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France. salvatore.spicuglia@inserm.fr","Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-8101-7108","affiliations":[{"raw_affiliation_string":"Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France. salvatore.spicuglia@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Equipe Labellis\u00e9e Ligue Contre le Cancer, Paris, France. salvatore.spicuglia@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210095243"]},{"raw_affiliation_string":"Aix-Marseille University, INSERM, TAGC, UMR 1090, Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5091488339"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210095243","https://openalex.org/I4210112918"],"apc_list":{"value":5560,"currency":"USD","value_usd":5560},"apc_paid":{"value":4530,"currency":"EUR","value_usd":4885},"fwci":1.6818,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.85793162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"6660","last_page":"6660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.5950000286102295},{"id":"https://openalex.org/keywords/enhancer-promoter-interactions","display_name":"enhancer-promoter interactions","score":0.44999998807907104},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.6869999766349792},{"id":"https://openalex.org/keywords/interferon-response-genes","display_name":"interferon response genes","score":0.6869999766349792},{"id":"https://openalex.org/keywords/irf-transcription-factors","display_name":"IRF transcription factors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/gene-induction","display_name":"gene induction","score":0.527999997138977},{"id":"https://openalex.org/keywords/lps-stimulated-macrophages","display_name":"LPS-stimulated macrophages","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gene-regulatory-elements","display_name":"gene regulatory elements","score":0.46399998664855957},{"id":"https://openalex.org/keywords/transcription-factor-recruitment","display_name":"transcription factor recruitment","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.8658832907676697},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.7120538949966431},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.6476308703422546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6298588514328003},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6043460369110107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6013034582138062},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5797547698020935},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5467218160629272},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.471016526222229},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.450148344039917},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44315865635871887},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.4424339532852173},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.44167420268058777},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.42897215485572815},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36120277643203735},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050795","descriptor_name":"STAT2 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-021-26861-0","doi":"https://doi.org/10.1038/s41467-021-26861-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-26861-0","pdf_url":"https://www.nature.com/articles/s41467-021-26861-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8602369","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8602369","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:34795220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34795220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03513051v1","doi":null,"is_oa":true,"landing_page_url":"https://amu.hal.science/hal-03513051","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-26861-0⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26861-0","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-021-26861-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2a838a6dac1c4a42aac0c04facbcf0f8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2a838a6dac1c4a42aac0c04facbcf0f8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-021-26861-0","doi":"https://doi.org/10.1038/s41467-021-26861-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-021-26861-0","pdf_url":"https://www.nature.com/articles/s41467-021-26861-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1512583955","display_name":"INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE","funder_award_id":"ANR-11-IDEX-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1742243815","display_name":null,"funder_award_id":"ANR11IDEX000102","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2483067034","display_name":"Organisation et mont\u00e9e en puissance d'une Infrastructure Nationale de G\u00e9nomique","funder_award_id":"ANR-10-INBS-0009","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3263520876","display_name":"Molecular basis of human enhanceropathies","funder_award_id":"860002","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4181824923","display_name":"Dissection of coordinated stress responses by novel promoter elements with enhancer activity","funder_award_id":"ANR-18-CE12-0019","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4656594441","display_name":null,"funder_award_id":"ANR18","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4866930200","display_name":null,"funder_award_id":"ANR-11-IDEX","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5029280039","display_name":null,"funder_award_id":"PLBIO018-031 INCA_12619","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"},{"id":"https://openalex.org/G541215150","display_name":null,"funder_award_id":"ANR-11-IDEX-0001-02","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G572841159","display_name":null,"funder_award_id":"ANR 11-IDEX-0001-02","funder_id":"https://openalex.org/F4320309911","funder_display_name":"Aix-Marseille Universit\u00e9"},{"id":"https://openalex.org/G61842821","display_name":"Identification & analysis of genomic silencer elements","funder_award_id":"ANR-17-CE12-0035","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6803667113","display_name":null,"funder_award_id":"ANR-17","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7633708271","display_name":null,"funder_award_id":"ANR-11-IDEX-0001","funder_id":"https://openalex.org/F4320309911","funder_display_name":"Aix-Marseille Universit\u00e9"},{"id":"https://openalex.org/G782245399","display_name":null,"funder_award_id":"IDEX-0001-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8333144378","display_name":null,"funder_award_id":"M17S02","funder_id":"https://openalex.org/F4320324492","funder_display_name":"Asociaci\u00f3n Nacional de Universidades e Instituciones de Educaci\u00f3n Superior"},{"id":"https://openalex.org/G8485337361","display_name":null,"funder_award_id":"291235","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320309911","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320323401","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"},{"id":"https://openalex.org/F4320323775","display_name":"Cancerop\u00f4le PACA","ror":"https://ror.org/01mwvah42"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"},{"id":"https://openalex.org/F4320324477","display_name":"Fondation Bettencourt Schueller","ror":"https://ror.org/02p3abx23"},{"id":"https://openalex.org/F4320324492","display_name":"Asociaci\u00f3n Nacional de Universidades e Instituciones de Educaci\u00f3n Superior","ror":"https://ror.org/00tpx5s27"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3213027475.pdf","grobid_xml":"https://content.openalex.org/works/W3213027475.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W1549155795","https://openalex.org/W1691389541","https://openalex.org/W1973062929","https://openalex.org/W1973796285","https://openalex.org/W1979594866","https://openalex.org/W2003171404","https://openalex.org/W2014677321","https://openalex.org/W2017398449","https://openalex.org/W2029492292","https://openalex.org/W2045157045","https://openalex.org/W2049898530","https://openalex.org/W2056103949","https://openalex.org/W2065006553","https://openalex.org/W2066053649","https://openalex.org/W2076198632","https://openalex.org/W2077874719","https://openalex.org/W2078844752","https://openalex.org/W2091533196","https://openalex.org/W2091688007","https://openalex.org/W2117131162","https://openalex.org/W2123404806","https://openalex.org/W2124343649","https://openalex.org/W2130807694","https://openalex.org/W2130832456","https://openalex.org/W2133402546","https://openalex.org/W2136430672","https://openalex.org/W2145782793","https://openalex.org/W2152308094","https://openalex.org/W2153142861","https://openalex.org/W2158789637","https://openalex.org/W2166617377","https://openalex.org/W2174701321","https://openalex.org/W2179438025","https://openalex.org/W2254864826","https://openalex.org/W2262252422","https://openalex.org/W2414961378","https://openalex.org/W2424483111","https://openalex.org/W2430004575","https://openalex.org/W2461222159","https://openalex.org/W2531690106","https://openalex.org/W2540381357","https://openalex.org/W2553838260","https://openalex.org/W2554495435","https://openalex.org/W2557087167","https://openalex.org/W2580178967","https://openalex.org/W2581702729","https://openalex.org/W2581818460","https://openalex.org/W2595963502","https://openalex.org/W2606434976","https://openalex.org/W2620165518","https://openalex.org/W2621774891","https://openalex.org/W2628869990","https://openalex.org/W2729547379","https://openalex.org/W2737388023","https://openalex.org/W2772841828","https://openalex.org/W2778151539","https://openalex.org/W2781867702","https://openalex.org/W2786141666","https://openalex.org/W2786204582","https://openalex.org/W2800914998","https://openalex.org/W2801850745","https://openalex.org/W2804802143","https://openalex.org/W2808479265","https://openalex.org/W2883005025","https://openalex.org/W2884681204","https://openalex.org/W2886398566","https://openalex.org/W2886894187","https://openalex.org/W2890893954","https://openalex.org/W2892647771","https://openalex.org/W2903823332","https://openalex.org/W2912028596","https://openalex.org/W2912623135","https://openalex.org/W2921983621","https://openalex.org/W2950772037","https://openalex.org/W2955816935","https://openalex.org/W2955994579","https://openalex.org/W2979343233","https://openalex.org/W2986951699","https://openalex.org/W2988716798","https://openalex.org/W2991331878","https://openalex.org/W2995995832","https://openalex.org/W3007581139","https://openalex.org/W3011428043","https://openalex.org/W3011916641","https://openalex.org/W3037538172","https://openalex.org/W6968811952","https://openalex.org/W6999243349"],"related_works":["https://openalex.org/W6999883192","https://openalex.org/W7149527040","https://openalex.org/W7161550879","https://openalex.org/W7118078007","https://openalex.org/W2398004178","https://openalex.org/W2005656449","https://openalex.org/W2612829549","https://openalex.org/W2024791006","https://openalex.org/W2808261619","https://openalex.org/W163631356"],"abstract_inverted_index":{"Gene":[0],"expression":[1],"is":[2],"controlled":[3],"by":[4],"the":[5,47,54,64,93,102,112,118,134,145],"involvement":[6,113],"of":[7,22,49,66,78,104,114,120,141],"gene-proximal":[8],"(promoters)":[9],"and":[10,32,86,95,99,110],"distal":[11,34],"(enhancers)":[12],"regulatory":[13,89],"elements.":[14],"Our":[15,123],"previous":[16],"results":[17],"demonstrated":[18],"that":[19,40,76,87,126],"a":[20,43,58,130],"subset":[21],"gene":[23,35,51,142],"promoters,":[24],"termed":[25],"Epromoters,":[26],"work":[27],"as":[28,129],"bona":[29],"fide":[30],"enhancers":[31],"regulate":[33,101],"expression.":[36],"Here,":[37],"we":[38,62,108],"hypothesized":[39],"Epromoters":[41,67,85,127],"play":[42],"key":[44,135],"role":[45],"in":[46,68,117],"coordination":[48],"rapid":[50],"induction":[52],"during":[53,144],"inflammatory":[55,146],"response.":[56,147],"Using":[57],"high-throughput":[59],"reporter":[60],"assay":[61],"explored":[63],"function":[65,128],"response":[69],"to":[70],"type":[71],"I":[72],"interferon.":[73],"We":[74],"find":[75],"clusters":[77,116,143],"IFNa-induced":[79],"genes":[80],"are":[81],"frequently":[82],"associated":[83],"with":[84],"these":[88],"elements":[90],"preferentially":[91],"recruit":[92],"STAT1/2":[94],"IRF":[96],"transcription":[97],"factors":[98],"distally":[100],"activation":[103],"interferon-response":[105],"genes.":[106],"Consistently,":[107],"identified":[109],"validated":[111],"Epromoter-containing":[115],"regulation":[119,140],"LPS-stimulated":[121],"macrophages.":[122],"findings":[124],"suggest":[125],"local":[131],"hub":[132],"recruiting":[133],"TFs":[136],"required":[137],"for":[138],"coordinated":[139]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-11-22T00:00:00"}