{"id":"https://openalex.org/W3212966227","doi":"https://doi.org/10.1002/1878-0261.13135","title":"RASSF1A independence and early galectin\u20101 upregulation in PIK3CA\u2010induced hepatocarcinogenesis: new therapeutic venues","display_name":"RASSF1A independence and early galectin\u20101 upregulation in PIK3CA\u2010induced hepatocarcinogenesis: new therapeutic venues","publication_year":2021,"publication_date":"2021-11-08","ids":{"openalex":"https://openalex.org/W3212966227","doi":"https://doi.org/10.1002/1878-0261.13135","mag":"3212966227","pmid":"https://pubmed.ncbi.nlm.nih.gov/34748271","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8895452"},"language":"en","primary_location":{"id":"doi:10.1002/1878-0261.13135","doi":"https://doi.org/10.1002/1878-0261.13135","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1878-0261.13135","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.13135","source":{"id":"https://openalex.org/S80282989","display_name":"Molecular Oncology","issn_l":"1574-7891","issn":["1574-7891","1878-0261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.13135","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032305524","display_name":"Alexander Scheiter","orcid":"https://orcid.org/0000-0001-6734-261X","observed_orcids":["https://orcid.org/0000-0001-6734-261X"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Alexander Scheiter","raw_affiliation_strings":["Institute of Pathology, University of Regensburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6734-261X","affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088301199","display_name":"Katja Evert","orcid":"https://orcid.org/0000-0003-0984-5563","observed_orcids":["https://orcid.org/0000-0003-0984-5563"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katja Evert","raw_affiliation_strings":["Institute of Pathology, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009310519","display_name":"Lucas E. Reibenspies","orcid":"https://orcid.org/0000-0002-0459-7516","observed_orcids":["https://orcid.org/0000-0002-0459-7516"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lucas Reibenspies","raw_affiliation_strings":["Institute of Pathology, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047006975","display_name":"Antonio Cigliano","orcid":"https://orcid.org/0000-0002-6408-3613","observed_orcids":["https://orcid.org/0000-0002-6408-3613"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Antonio Cigliano","raw_affiliation_strings":["Institute of Pathology, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039173563","display_name":"Katharina Annweiler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Annweiler","raw_affiliation_strings":["Institute of Pathology, University Medicine of Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medicine of Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058235612","display_name":"Karolina M\u00fcller","orcid":"https://orcid.org/0000-0001-5241-2945","observed_orcids":["https://orcid.org/0000-0001-5241-2945"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karolina M\u00fcller","raw_affiliation_strings":["Center for Clinical Studies, University Hospital Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Studies, University Hospital Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038674964","display_name":"Laura\u2010Maria\u2010Giovanna P\u00f6hmerer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura\u2010Maria\u2010Giovanna P\u00f6hmerer","raw_affiliation_strings":["Institute of Pathology, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101059748","display_name":"Hongwei Xu","orcid":"https://orcid.org/0009-0000-9490-7196","observed_orcids":["https://orcid.org/0009-0000-9490-7196"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Hongwei Xu","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA","Department of Liver Surgery, Center of Liver Transplantation, West China Hospital of Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Liver Surgery, Center of Liver Transplantation, West China Hospital of Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071191729","display_name":"Guofei Cui","orcid":"https://orcid.org/0009-0005-5624-0403","observed_orcids":["https://orcid.org/0009-0005-5624-0403"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guofei Cui","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040462236","display_name":"Timo Itzel","orcid":"https://orcid.org/0009-0002-8075-6643","observed_orcids":["https://orcid.org/0009-0002-8075-6643"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Timo Itzel","raw_affiliation_strings":["Division of Hepatology, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatology, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048941967","display_name":"Silvia Materna\u2010Reichelt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silvia Materna\u2010Reichelt","raw_affiliation_strings":["Division of Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany","institution_ids":["https://openalex.org/I4210111966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000424435","display_name":"Andrea Coluccio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrea Coluccio","raw_affiliation_strings":["Division of Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany","institution_ids":["https://openalex.org/I4210111966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069270945","display_name":"Kamran Honarnejad","orcid":"https://orcid.org/0000-0001-7122-0615","observed_orcids":["https://orcid.org/0000-0001-7122-0615"]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kamran Honarnejad","raw_affiliation_strings":["Division of Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, Regensburg, Germany","institution_ids":["https://openalex.org/I4210111966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089643041","display_name":"Andreas Teufel","orcid":"https://orcid.org/0000-0001-7953-8927","observed_orcids":["https://orcid.org/0000-0001-7953-8927"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Teufel","raw_affiliation_strings":["Division of Hepatology, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatology, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033363764","display_name":"Christoph Brochhausen","orcid":"https://orcid.org/0000-0002-6761-0247","observed_orcids":["https://orcid.org/0000-0002-6761-0247","https://orcid.org/0000-0002-2530-1075"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Brochhausen","raw_affiliation_strings":["Institute of Pathology, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038182004","display_name":"Frank Dombrowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Dombrowski","raw_affiliation_strings":["Institute of Pathology, University Medicine of Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medicine of Greifswald, Germany","institution_ids":["https://openalex.org/I2799318839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363101","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-9588-0164","observed_orcids":["https://orcid.org/0000-0002-9588-0164"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022582588","display_name":"Matthias Evert","orcid":"https://orcid.org/0009-0001-8412-9682","observed_orcids":["https://orcid.org/0009-0001-8412-9682"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Evert","raw_affiliation_strings":["Institute of Pathology, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091038323","display_name":"Diego Francesco Calvisi","orcid":"https://orcid.org/0000-0002-6038-8567","observed_orcids":["https://orcid.org/0000-0002-6038-8567"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Diego F. Calvisi","raw_affiliation_strings":["Institute of Pathology, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062134753","display_name":"Kirsten Utpatel","orcid":"https://orcid.org/0000-0001-8615-9677","observed_orcids":["https://orcid.org/0000-0001-8615-9677"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kirsten Utpatel","raw_affiliation_strings":["Institute of Pathology, University of Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5032305524"],"corresponding_institution_ids":["https://openalex.org/I60668342"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":{"value":3094,"currency":"EUR","value_usd":3336},"fwci":1.0013,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.73805006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"5","first_page":"1091","last_page":"1118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.18469999730587006,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0794999971985817,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/rassf1a","display_name":"RASSF1A","score":0.8740000128746033},{"id":"https://openalex.org/keywords/galectin-1","display_name":"galectin-1","score":0.953000009059906},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.7850000262260437},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase-1","display_name":"stearoyl-CoA desaturase 1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.7699999809265137},{"id":"https://openalex.org/keywords/hydrodynamic-tail-vein-injection","display_name":"hydrodynamic tail vein injection","score":0.628000020980835},{"id":"https://openalex.org/keywords/synergistic-cytotoxicity","display_name":"synergistic cytotoxicity","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7355217933654785},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6981475949287415},{"id":"https://openalex.org/C2779314089","wikidata":"https://www.wikidata.org/wiki/Q18026830","display_name":"HCCS","level":3,"score":0.6390504240989685},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6262404918670654},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6162664294242859},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5669129490852356},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.51127028465271},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4519892632961273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45085659623146057},{"id":"https://openalex.org/C2781465904","wikidata":"https://www.wikidata.org/wiki/Q14887700","display_name":"P110\u03b1","level":4,"score":0.4255131483078003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40670549869537354},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3713398575782776},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27639880776405334},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24119603633880615},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.1882632076740265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10703501105308533},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08046895265579224}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1002/1878-0261.13135","doi":"https://doi.org/10.1002/1878-0261.13135","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1878-0261.13135","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.13135","source":{"id":"https://openalex.org/S80282989","display_name":"Molecular Oncology","issn_l":"1574-7891","issn":["1574-7891","1878-0261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oncology","raw_type":"journal-article"},{"id":"doi:10.1101/2021.06.15.448477","doi":"https://doi.org/10.1101/2021.06.15.448477","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.06.15.448477","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/06/15/2021.06.15.448477.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8895452","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8895452","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Oncol","raw_type":"Text"},{"id":"pmid:34748271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34748271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular oncology","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:46063","doi":null,"is_oa":false,"landing_page_url":"http://orcid.org/0000-0003-0984-5563>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:db2315a1864e41beaeb3a952e323cea0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/db2315a1864e41beaeb3a952e323cea0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Oncology, Vol 16, Iss 5, Pp 1091-1118 (2022)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt5633v319","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/5633v319","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Oncology, vol 16, iss 5","raw_type":"article"},{"id":"pmh:oai:fraunhofer.de:N-647468","doi":null,"is_oa":true,"landing_page_url":"http://publica.fraunhofer.de/documents/N-647468.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400801","display_name":"Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer ITEM","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniss.it:11388/288195","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11388/288195","pdf_url":null,"source":{"id":"https://openalex.org/S4306401147","display_name":"UnissResearch (Universit\u00e0 degli Studi di Sassari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I159650629","host_organization_name":"University of Sassari","host_organization_lineage":["https://openalex.org/I159650629"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/415697","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/415697","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/443257","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/443257","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"paper"},{"id":"doi:10.5283/epub.46063","doi":"https://doi.org/10.5283/epub.46063","is_oa":true,"landing_page_url":"https://doi.org/10.5283/epub.46063","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1002/1878-0261.13135","doi":"https://doi.org/10.1002/1878-0261.13135","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1878-0261.13135","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.13135","source":{"id":"https://openalex.org/S80282989","display_name":"Molecular Oncology","issn_l":"1574-7891","issn":["1574-7891","1878-0261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3212966227.pdf","grobid_xml":"https://content.openalex.org/works/W3212966227.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W74841586","https://openalex.org/W142804060","https://openalex.org/W1541898988","https://openalex.org/W1560020441","https://openalex.org/W1601583906","https://openalex.org/W1603787733","https://openalex.org/W1968038516","https://openalex.org/W1969957411","https://openalex.org/W1979189995","https://openalex.org/W1986581033","https://openalex.org/W1986657600","https://openalex.org/W1988314411","https://openalex.org/W1990392530","https://openalex.org/W1991961196","https://openalex.org/W1992477322","https://openalex.org/W2007353819","https://openalex.org/W2009886463","https://openalex.org/W2014533420","https://openalex.org/W2017352677","https://openalex.org/W2020173286","https://openalex.org/W2050474151","https://openalex.org/W2060901213","https://openalex.org/W2061609609","https://openalex.org/W2063569450","https://openalex.org/W2065402899","https://openalex.org/W2067224679","https://openalex.org/W2070732456","https://openalex.org/W2072054880","https://openalex.org/W2073270386","https://openalex.org/W2074648434","https://openalex.org/W2080560721","https://openalex.org/W2082634075","https://openalex.org/W2087106096","https://openalex.org/W2088291227","https://openalex.org/W2088293068","https://openalex.org/W2097365930","https://openalex.org/W2103562758","https://openalex.org/W2103986437","https://openalex.org/W2110065044","https://openalex.org/W2117832286","https://openalex.org/W2121273843","https://openalex.org/W2121496304","https://openalex.org/W2125681624","https://openalex.org/W2127248987","https://openalex.org/W2128635872","https://openalex.org/W2129172946","https://openalex.org/W2130410032","https://openalex.org/W2134362016","https://openalex.org/W2135784953","https://openalex.org/W2140673952","https://openalex.org/W2140701693","https://openalex.org/W2144117510","https://openalex.org/W2146512944","https://openalex.org/W2147342855","https://openalex.org/W2149639441","https://openalex.org/W2153464229","https://openalex.org/W2155385652","https://openalex.org/W2156003764","https://openalex.org/W2158356057","https://openalex.org/W2158378236","https://openalex.org/W2195725578","https://openalex.org/W2204895915","https://openalex.org/W2287943396","https://openalex.org/W2288929640","https://openalex.org/W2291174954","https://openalex.org/W2301486587","https://openalex.org/W2303102647","https://openalex.org/W2320147764","https://openalex.org/W2320453739","https://openalex.org/W2340909115","https://openalex.org/W2344129824","https://openalex.org/W2523687917","https://openalex.org/W2552972153","https://openalex.org/W2604527271","https://openalex.org/W2606995202","https://openalex.org/W2616761213","https://openalex.org/W2625559053","https://openalex.org/W2767231608","https://openalex.org/W2788684488","https://openalex.org/W2794944537","https://openalex.org/W2802611182","https://openalex.org/W2897219865","https://openalex.org/W2945564879","https://openalex.org/W2946173685","https://openalex.org/W2949088233","https://openalex.org/W2976035920","https://openalex.org/W2979374144","https://openalex.org/W2984955289","https://openalex.org/W2992052961","https://openalex.org/W2999304916","https://openalex.org/W3013656414","https://openalex.org/W3015344913","https://openalex.org/W3025022288","https://openalex.org/W3035765335","https://openalex.org/W3036019667","https://openalex.org/W3082635810","https://openalex.org/W3118255846","https://openalex.org/W3118914594"],"related_works":["https://openalex.org/W4210556097","https://openalex.org/W2204895915","https://openalex.org/W2312365518","https://openalex.org/W3141970979","https://openalex.org/W2026140947","https://openalex.org/W1539996646","https://openalex.org/W2415511421","https://openalex.org/W2618417601","https://openalex.org/W2049468996","https://openalex.org/W2903508110"],"abstract_inverted_index":{"Aberrant":[0],"activation":[1,39,64],"of":[2,16,21,46,62,72,83,101,115,128,150],"the":[3,47,81,158],"phosphoinositide":[4],"3\u2010kinase":[5],"(PI3K)/AKT/mTOR":[6],"and":[7,65,86,132,144,157],"Ras/mitogen\u2010activated":[8],"protein":[9,53],"kinase":[10],"(MAPK)":[11],"pathways":[12],"is":[13,40],"a":[14,19,58,123,148],"hallmark":[15],"hepatocarcinogenesis.":[17],"In":[18],"subset":[20],"hepatocellular":[22],"carcinomas":[23],"(HCCs),":[24],"PI3K/AKT/mTOR":[25],"signaling":[26],"dysregulation":[27],"depends":[28],"on":[29],"phosphatidylinositol\u20104,5\u2010bisphosphate":[30],"3\u2010kinase,":[31],"catalytic":[32],"subunit":[33],"alpha":[34],"(PIK3CA)":[35],"mutations,":[36],"while":[37],"RAS/MAPK":[38],"partly":[41],"attributed":[42],"to":[43,80,109],"promoter":[44],"methylation":[45],"tumor":[48],"suppressor":[49],"Ras":[50],"association":[51],"domain\u2010containing":[52],"1":[54],"(RASSF1A).":[55],"To":[56],"evaluate":[57],"possible":[59],"cocarcinogenic":[60],"effect":[61],"PIK3CA":[63,73,103,155],"RASSF1A":[66,84,116],"knockout,":[67],"plasmids":[68],"expressing":[69],"oncogenic":[70],"forms":[71],"(E545K":[74],"or":[75,105],"H1047R":[76,106],"mutants)":[77],"were":[78],"delivered":[79],"liver":[82],"knockout":[85],"wild\u2010type":[87],"mice":[88,113],"by":[89],"hydrodynamic":[90],"tail":[91],"vein":[92],"injection":[93],"combined":[94],"with":[95,126,154],"sleeping":[96],"beauty\u2010mediated":[97],"somatic":[98],"integration.":[99],"Transfection":[100],"either":[102],"E545K":[104],"mutants":[107],"sufficed":[108],"induce":[110],"HCCs":[111],"in":[112,141,163,166],"irrespective":[114],"mutational":[117],"background.":[118],"The":[119],"related":[120],"tumors":[121],"displayed":[122],"lipogenic":[124],"phenotype":[125],"upregulation":[127],"fatty":[129],"acid":[130],"synthase":[131],"stearoyl\u2010CoA":[133],"desaturase\u20101":[134],"(SCD1).":[135],"Galectin\u20101,":[136],"which":[137],"was":[138],"commonly":[139],"upregulated":[140],"preneoplastic":[142],"lesions":[143],"tumors,":[145],"emerged":[146],"as":[147],"regulator":[149],"SCD1.":[151],"Co\u2010inhibitory":[152],"treatment":[153],"inhibitors":[156],"galectin\u20101":[159],"inhibitor":[160],"OTX008":[161],"resulted":[162],"synergistic":[164],"cytotoxicity":[165],"human":[167],"HCC":[168],"cell":[169],"lines,":[170],"suggesting":[171],"novel":[172],"therapeutic":[173],"venues.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-11-22T00:00:00"}
