{"id":"https://openalex.org/W3212944154","doi":"https://doi.org/10.1007/s10482-021-01683-8","title":"Addition of proteinase K during the culture alter the physiology of Bacillus thuringiensis culture and the cry1Ac, nprX, nprA, and spo0A gene transcription","display_name":"Addition of proteinase K during the culture alter the physiology of Bacillus thuringiensis culture and the cry1Ac, nprX, nprA, and spo0A gene transcription","publication_year":2021,"publication_date":"2021-11-19","ids":{"openalex":"https://openalex.org/W3212944154","doi":"https://doi.org/10.1007/s10482-021-01683-8","mag":"3212944154","pmid":"https://pubmed.ncbi.nlm.nih.gov/34797466"},"language":"en","primary_location":{"id":"doi:10.1007/s10482-021-01683-8","doi":"https://doi.org/10.1007/s10482-021-01683-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10482-021-01683-8","pdf_url":null,"source":{"id":"https://openalex.org/S192712274","display_name":"Antonie van Leeuwenhoek","issn_l":"0003-6072","issn":["0003-6072","1572-9699"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antonie van Leeuwenhoek","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018297431","display_name":"Miguel \u00c1ngel Pe\u00f1a-Rico","orcid":"https://orcid.org/0000-0001-8275-6044","observed_orcids":["https://orcid.org/0000-0001-8275-6044"]},"institutions":[{"id":"https://openalex.org/I4210098721","display_name":"Universidad del Papaloapan","ror":"https://ror.org/012wxwj57","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210098721"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Miguel A. Pe\u00f1a-Rico","raw_affiliation_strings":["Instituto de Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico"],"raw_orcid":"https://orcid.org/0000-0001-8275-6044","affiliations":[{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico","institution_ids":["https://openalex.org/I4210098721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006559819","display_name":"Humberto Rafael Bravo-Delgado","orcid":"https://orcid.org/0000-0002-9996-2861","observed_orcids":["https://orcid.org/0000-0002-9996-2861"]},"institutions":[{"id":"https://openalex.org/I4210098721","display_name":"Universidad del Papaloapan","ror":"https://ror.org/012wxwj57","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210098721"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Humberto R. Bravo-D","raw_affiliation_strings":["Divisi\u00f3n de Estudios de Posgrado, Doctorado en Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisi\u00f3n de Estudios de Posgrado, Doctorado en Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico","institution_ids":["https://openalex.org/I4210098721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020085434","display_name":"Crisanto Roldan-Sabino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098721","display_name":"Universidad del Papaloapan","ror":"https://ror.org/012wxwj57","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210098721"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Crisanto Roldan-Sabino","raw_affiliation_strings":["Ingenier\u00eda en Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ingenier\u00eda en Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico","institution_ids":["https://openalex.org/I4210098721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024527427","display_name":"Karla Viridiana Castro-Cerritos","orcid":"https://orcid.org/0000-0002-4292-1356","observed_orcids":["https://orcid.org/0000-0002-4292-1356"]},"institutions":[{"id":"https://openalex.org/I4210098721","display_name":"Universidad del Papaloapan","ror":"https://ror.org/012wxwj57","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210098721"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Karla V. Castro-Cerritos","raw_affiliation_strings":["Instituto de Qu\u00edmica Aplicada, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico"],"raw_orcid":"https://orcid.org/0000-0002-4292-1356","affiliations":[{"raw_affiliation_string":"Instituto de Qu\u00edmica Aplicada, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico","institution_ids":["https://openalex.org/I4210098721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089587551","display_name":"Ariana Arlene Huerta\u2010Heredia","orcid":"https://orcid.org/0000-0003-4182-1529","observed_orcids":["https://orcid.org/0000-0003-4182-1529"]},"institutions":[{"id":"https://openalex.org/I4210098721","display_name":"Universidad del Papaloapan","ror":"https://ror.org/012wxwj57","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210098721"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ariana Huerta-Heredia","raw_affiliation_strings":["CONACyT-UNPA, Instituto de Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico","Instituto de Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico"],"raw_orcid":"https://orcid.org/0000-0003-4182-1529","affiliations":[{"raw_affiliation_string":"CONACyT-UNPA, Instituto de Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico","institution_ids":["https://openalex.org/I4210098721"]},{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico","institution_ids":["https://openalex.org/I4210098721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027285273","display_name":"Ana Karin Navarro-Mtz","orcid":"https://orcid.org/0000-0003-4124-5533","observed_orcids":["https://orcid.org/0000-0003-4124-5533"]},"institutions":[{"id":"https://openalex.org/I4210098721","display_name":"Universidad del Papaloapan","ror":"https://ror.org/012wxwj57","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210098721"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"A. Karin Navarro-Mtz","raw_affiliation_strings":["Instituto de Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico. anavarro@unpa.edu.mx","Instituto de Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico"],"raw_orcid":"https://orcid.org/0000-0003-4124-5533","affiliations":[{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico. anavarro@unpa.edu.mx","institution_ids":["https://openalex.org/I4210098721"]},{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda, Universidad del Papaloapan, Circuito Central 200, Parque Industrial, 68301, Tuxtepec, Oaxaca, M\u00e9xico","institution_ids":["https://openalex.org/I4210098721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027285273"],"corresponding_institution_ids":["https://openalex.org/I4210098721"],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":null,"fwci":0.0699,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.26379927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"115","issue":"1","first_page":"89","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.8159000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.8159000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11436","display_name":"Entomopathogenic Microorganisms in Pest Control","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-thuringiensis","display_name":"Bacillus thuringiensis","score":1.0},{"id":"https://openalex.org/keywords/proteinase-k","display_name":"proteinase K","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cry1ac","display_name":"Cry1Ac","score":0.718999981880188},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.6620000004768372},{"id":"https://openalex.org/keywords/spo0a","display_name":"Spo0A","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bacterial-growth-kinetics","display_name":"bacterial growth kinetics","score":0.6269999742507935},{"id":"https://openalex.org/keywords/sporulation","display_name":"sporulation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/bioinsecticide-production","display_name":"bioinsecticide production","score":0.7160000205039978},{"id":"https://openalex.org/keywords/culture-medium-supplementation","display_name":"culture medium supplementation","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2779035793","wikidata":"https://www.wikidata.org/wiki/Q310467","display_name":"Bacillus thuringiensis","level":3,"score":0.8848817944526672},{"id":"https://openalex.org/C2781151318","wikidata":"https://www.wikidata.org/wiki/Q16953059","display_name":"Cry1Ac","level":5,"score":0.7874737977981567},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5869631171226501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.561604380607605},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5066898465156555},{"id":"https://openalex.org/C2776870249","wikidata":"https://www.wikidata.org/wiki/Q149128","display_name":"Bacilli","level":3,"score":0.4574429988861084},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4508589506149292},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4089128077030182},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3574577867984772},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.346244215965271},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3433641195297241},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3336948752403259},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23258990049362183},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.15606531500816345},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14800727367401123},{"id":"https://openalex.org/C122172344","wikidata":"https://www.wikidata.org/wiki/Q1503477","display_name":"Genetically modified crops","level":4,"score":0.09900197386741638}],"mesh":[{"descriptor_ui":"D001413","descriptor_name":"Bacillus thuringiensis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006460","descriptor_name":"Hemolysin Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019286","descriptor_name":"Endopeptidase K","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10482-021-01683-8","doi":"https://doi.org/10.1007/s10482-021-01683-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10482-021-01683-8","pdf_url":null,"source":{"id":"https://openalex.org/S192712274","display_name":"Antonie van Leeuwenhoek","issn_l":"0003-6072","issn":["0003-6072","1572-9699"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antonie van Leeuwenhoek","raw_type":"journal-article"},{"id":"pmid:34797466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34797466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antonie van Leeuwenhoek","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G516944714","display_name":null,"funder_award_id":"CB-2015/258587","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G8279405064","display_name":null,"funder_award_id":"CB-2008-105057","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"}],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W230311150","https://openalex.org/W1577836495","https://openalex.org/W1602108077","https://openalex.org/W1622787619","https://openalex.org/W1942644614","https://openalex.org/W1971711059","https://openalex.org/W1972128570","https://openalex.org/W1983549218","https://openalex.org/W1985879705","https://openalex.org/W1992502576","https://openalex.org/W1993386415","https://openalex.org/W2007679399","https://openalex.org/W2008632935","https://openalex.org/W2024712383","https://openalex.org/W2036439094","https://openalex.org/W2037158460","https://openalex.org/W2043709991","https://openalex.org/W2065237822","https://openalex.org/W2073126811","https://openalex.org/W2079513009","https://openalex.org/W2089784866","https://openalex.org/W2106479897","https://openalex.org/W2107310931","https://openalex.org/W2107983142","https://openalex.org/W2110840717","https://openalex.org/W2128154405","https://openalex.org/W2128701714","https://openalex.org/W2148979040","https://openalex.org/W2157817029","https://openalex.org/W2164312870","https://openalex.org/W2168055071","https://openalex.org/W2202482316","https://openalex.org/W2212786547","https://openalex.org/W2267592432","https://openalex.org/W2314405806","https://openalex.org/W2329536003","https://openalex.org/W2340004383","https://openalex.org/W2395770123","https://openalex.org/W2395924285","https://openalex.org/W2398211034","https://openalex.org/W2399985563","https://openalex.org/W2406094470","https://openalex.org/W2416550605","https://openalex.org/W2482894601","https://openalex.org/W2544917152","https://openalex.org/W2622556140","https://openalex.org/W2754384888","https://openalex.org/W2774762476","https://openalex.org/W2800391015","https://openalex.org/W2913929675","https://openalex.org/W2925351423","https://openalex.org/W2942161050","https://openalex.org/W3003399395","https://openalex.org/W4252076820"],"related_works":["https://openalex.org/W2007679399","https://openalex.org/W1966034636","https://openalex.org/W2107983142","https://openalex.org/W2167443890","https://openalex.org/W2414608974","https://openalex.org/W4411346446","https://openalex.org/W1989679853","https://openalex.org/W2793673913","https://openalex.org/W1985879705","https://openalex.org/W7099278383"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-22T00:00:00"}