{"id":"https://openalex.org/W3211997209","doi":"https://doi.org/10.3390/cancers13225788","title":"Melanoma Immunotherapy and Precision Medicine in the Era of Tumor Micro-Tissue Engineering: Where Are We Now and Where Are We Going?","display_name":"Melanoma Immunotherapy and Precision Medicine in the Era of Tumor Micro-Tissue Engineering: Where Are We Now and Where Are We Going?","publication_year":2021,"publication_date":"2021-11-18","ids":{"openalex":"https://openalex.org/W3211997209","doi":"https://doi.org/10.3390/cancers13225788","mag":"3211997209","pmid":"https://pubmed.ncbi.nlm.nih.gov/34830940","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8616100"},"language":"en","primary_location":{"id":"doi:10.3390/cancers13225788","doi":"https://doi.org/10.3390/cancers13225788","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13225788","pdf_url":"https://www.mdpi.com/2072-6694/13/22/5788/pdf?version=1637236241","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3211997209"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/13/22/5788/pdf?version=1637236241","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026726962","display_name":"Francesca Varrone","orcid":"https://orcid.org/0000-0003-1820-5955","observed_orcids":["https://orcid.org/0000-0003-1820-5955"]},"institutions":[{"id":"https://openalex.org/I4210149054","display_name":"IRBM","ror":"https://ror.org/03ndq5j60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210149054"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Varrone","raw_affiliation_strings":["IRBM S.p.A., Via Pontina Km 30,600, I-00071 Pomezia, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1820-5955","affiliations":[{"raw_affiliation_string":"IRBM S.p.A., Via Pontina Km 30,600, I-00071 Pomezia, Italy","institution_ids":["https://openalex.org/I4210149054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039350857","display_name":"Luigi Mandrich","orcid":"https://orcid.org/0000-0002-0025-9544","observed_orcids":["https://orcid.org/0000-0002-0025-9544"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4405253368","display_name":"Consiglio Nazionale delle Ricerche - Istituto di Ricerca sugli Ecosistemi Terrestri","ror":"https://ror.org/00keh9s20","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4405253368"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Mandrich","raw_affiliation_strings":["Research Institute on Terrestrial Ecosystem\u2014IRET-CNR Via Pietro Castellino 111, I-80131 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0025-9544","affiliations":[{"raw_affiliation_string":"Research Institute on Terrestrial Ecosystem\u2014IRET-CNR Via Pietro Castellino 111, I-80131 Naples, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4405253368"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028654545","display_name":"Emilia Caputo","orcid":"https://orcid.org/0000-0002-6485-8802","observed_orcids":["https://orcid.org/0000-0002-6485-8802"]},"institutions":[{"id":"https://openalex.org/I4210137461","display_name":"Institute of Genetics and Biophysics","ror":"https://ror.org/04hadk112","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Emilia Caputo","raw_affiliation_strings":["Institute of Genetics and Biophysics\u2014IGB-CNR, \u201cA. Buzzati-Traverso\u201d, Via Pietro Castellino 111, I-80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics and Biophysics\u2014IGB-CNR, \u201cA. Buzzati-Traverso\u201d, Via Pietro Castellino 111, I-80131 Naples, Italy","institution_ids":["https://openalex.org/I4210137461"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028654545"],"corresponding_institution_ids":["https://openalex.org/I4210137461"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":0.1837,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.18930906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"13","issue":"22","first_page":"5788","last_page":"5788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8080000281333923},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.777999997138977},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9810000061988831},{"id":"https://openalex.org/keywords/adaptive-resistance","display_name":"adaptive resistance","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tumor-plasticity","display_name":"tumor plasticity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ex-vivo-evaluation","display_name":"ex vivo evaluation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8080000281333923},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7460134029388428},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7438329458236694},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.679583728313446},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.6631388664245605},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6121688485145569},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5662520527839661},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.535058319568634},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4887089729309082},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.468203604221344},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4585217833518982},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4399411976337433},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32076770067214966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24501937627792358},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1894720196723938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1736447811126709},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers13225788","doi":"https://doi.org/10.3390/cancers13225788","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13225788","pdf_url":"https://www.mdpi.com/2072-6694/13/22/5788/pdf?version=1637236241","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:34830940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34830940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8616100","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8616100/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/cancers13225788","doi":"https://doi.org/10.3390/cancers13225788","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13225788","pdf_url":"https://www.mdpi.com/2072-6694/13/22/5788/pdf?version=1637236241","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1464101492","display_name":null,"funder_award_id":"FESR 2014-2020","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G185273301","display_name":null,"funder_award_id":"PO FESR 2014\u20132020 \u201cSATIN\u201d","funder_id":"https://openalex.org/F4320322218","funder_display_name":"Regione Campania"},{"id":"https://openalex.org/G1859629608","display_name":null,"funder_award_id":"FESR 2014","funder_id":"https://openalex.org/F4320322218","funder_display_name":"Regione Campania"},{"id":"https://openalex.org/G1888088267","display_name":null,"funder_award_id":"2014-2020\u2019","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3770228856","display_name":null,"funder_award_id":"PO FESR 2014\u20132020","funder_id":"https://openalex.org/F4320322218","funder_display_name":"Regione Campania"},{"id":"https://openalex.org/G76646173","display_name":null,"funder_award_id":"FESR 2014 2020","funder_id":"https://openalex.org/F4320322218","funder_display_name":"Regione Campania"},{"id":"https://openalex.org/G8227698777","display_name":null,"funder_award_id":"PO FESR 2014-2020","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320322218","display_name":"Regione Campania","ror":"https://ror.org/02kg21794"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3211997209.pdf","grobid_xml":"https://content.openalex.org/works/W3211997209.grobid-xml"},"referenced_works_count":159,"referenced_works":["https://openalex.org/W230810425","https://openalex.org/W614733133","https://openalex.org/W1545177819","https://openalex.org/W1628071823","https://openalex.org/W1741548448","https://openalex.org/W1930083721","https://openalex.org/W1964847767","https://openalex.org/W1965498876","https://openalex.org/W1967135832","https://openalex.org/W1967304777","https://openalex.org/W1970393647","https://openalex.org/W1975629518","https://openalex.org/W1981421409","https://openalex.org/W1985528986","https://openalex.org/W1985925139","https://openalex.org/W1990757263","https://openalex.org/W1991383456","https://openalex.org/W1997546490","https://openalex.org/W2008118174","https://openalex.org/W2008878539","https://openalex.org/W2013520568","https://openalex.org/W2016193552","https://openalex.org/W2019097500","https://openalex.org/W2020469453","https://openalex.org/W2023075736","https://openalex.org/W2026813843","https://openalex.org/W2026878412","https://openalex.org/W2028295154","https://openalex.org/W2028415754","https://openalex.org/W2034036012","https://openalex.org/W2034464870","https://openalex.org/W2039146285","https://openalex.org/W2039252207","https://openalex.org/W2040610114","https://openalex.org/W2045072263","https://openalex.org/W2050752490","https://openalex.org/W2052005627","https://openalex.org/W2060469376","https://openalex.org/W2072569544","https://openalex.org/W2078701991","https://openalex.org/W2083870593","https://openalex.org/W2089158037","https://openalex.org/W2099545798","https://openalex.org/W2103489164","https://openalex.org/W2104885590","https://openalex.org/W2107429737","https://openalex.org/W2110729724","https://openalex.org/W2113082145","https://openalex.org/W2115226530","https://openalex.org/W2115914792","https://openalex.org/W2119036906","https://openalex.org/W2119792393","https://openalex.org/W2121833147","https://openalex.org/W2128366974","https://openalex.org/W2129091609","https://openalex.org/W2133075384","https://openalex.org/W2139788242","https://openalex.org/W2142541223","https://openalex.org/W2143463252","https://openalex.org/W2149441684","https://openalex.org/W2149668671","https://openalex.org/W2155390826","https://openalex.org/W2159537800","https://openalex.org/W2159855032","https://openalex.org/W2163755473","https://openalex.org/W2166226087","https://openalex.org/W2166662937","https://openalex.org/W2168631000","https://openalex.org/W2169083371","https://openalex.org/W2172972495","https://openalex.org/W2193922054","https://openalex.org/W2266683146","https://openalex.org/W2299181842","https://openalex.org/W2311770845","https://openalex.org/W2311999172","https://openalex.org/W2332292689","https://openalex.org/W2336567344","https://openalex.org/W2437591938","https://openalex.org/W2512899508","https://openalex.org/W2549131319","https://openalex.org/W2550597146","https://openalex.org/W2552754421","https://openalex.org/W2569342357","https://openalex.org/W2572174216","https://openalex.org/W2596760231","https://openalex.org/W2600430749","https://openalex.org/W2615171435","https://openalex.org/W2619288770","https://openalex.org/W2621895366","https://openalex.org/W2742209106","https://openalex.org/W2765099905","https://openalex.org/W2765161542","https://openalex.org/W2766123339","https://openalex.org/W2767533179","https://openalex.org/W2770898760","https://openalex.org/W2775782830","https://openalex.org/W2776354711","https://openalex.org/W2782630985","https://openalex.org/W2785091318","https://openalex.org/W2795353688","https://openalex.org/W2797866384","https://openalex.org/W2800187340","https://openalex.org/W2803362743","https://openalex.org/W2804258553","https://openalex.org/W2804653411","https://openalex.org/W2808705013","https://openalex.org/W2809687260","https://openalex.org/W2884607428","https://openalex.org/W2886399358","https://openalex.org/W2886498337","https://openalex.org/W2889431912","https://openalex.org/W2890614017","https://openalex.org/W2894237619","https://openalex.org/W2895240612","https://openalex.org/W2896045928","https://openalex.org/W2898830231","https://openalex.org/W2905447079","https://openalex.org/W2911334107","https://openalex.org/W2912898814","https://openalex.org/W2913484031","https://openalex.org/W2916992870","https://openalex.org/W2918152867","https://openalex.org/W2920917911","https://openalex.org/W2930340127","https://openalex.org/W2950669324","https://openalex.org/W2953517953","https://openalex.org/W2960523686","https://openalex.org/W2963803700","https://openalex.org/W2965075335","https://openalex.org/W2966710588","https://openalex.org/W2978972173","https://openalex.org/W2981934952","https://openalex.org/W2983138989","https://openalex.org/W2991447034","https://openalex.org/W2995499586","https://openalex.org/W2997979341","https://openalex.org/W3000183488","https://openalex.org/W3003394374","https://openalex.org/W3005121071","https://openalex.org/W3011214157","https://openalex.org/W3012088984","https://openalex.org/W3012897894","https://openalex.org/W3017374234","https://openalex.org/W3031508706","https://openalex.org/W3031763493","https://openalex.org/W3042416076","https://openalex.org/W3043025818","https://openalex.org/W3085521743","https://openalex.org/W3094081991","https://openalex.org/W3107037282","https://openalex.org/W3108312067","https://openalex.org/W3118571953","https://openalex.org/W3128059610","https://openalex.org/W3134610064","https://openalex.org/W3143174477","https://openalex.org/W3181676144","https://openalex.org/W3207004752","https://openalex.org/W4211002736","https://openalex.org/W7095721368"],"related_works":["https://openalex.org/W4400135507","https://openalex.org/W3091934903","https://openalex.org/W3189793199","https://openalex.org/W4404017962","https://openalex.org/W2807275256","https://openalex.org/W6969225547","https://openalex.org/W4389545992","https://openalex.org/W7213459465","https://openalex.org/W4412515981","https://openalex.org/W2890270801"],"abstract_inverted_index":{"Malignant":[0],"melanoma":[1,106],"still":[2],"remains":[3],"a":[4],"cancer":[5,54],"with":[6],"very":[7],"poor":[8],"survival":[9],"rates,":[10],"although":[11],"it":[12,113],"is":[13],"at":[14],"the":[15,38,68,72,79,83,93,115,125],"forefront":[16],"of":[17,71,85,95,117,127],"personalized":[18],"medicine.":[19],"Most":[20],"patients":[21],"show":[22],"partial":[23],"responses":[24],"and":[25,57,87,90],"disease":[26],"progressed":[27],"due":[28],"to":[29,37,43,103],"adaptative":[30],"resistance":[31],"mechanisms,":[32],"preventing":[33],"long-lasting":[34],"clinical":[35],"benefits":[36],"current":[39],"treatments.":[40],"The":[41],"response":[42],"therapies":[44],"can":[45],"be":[46],"shaped":[47],"by":[48,61],"not":[49],"only":[50],"taking":[51],"into":[52],"account":[53],"cell":[55],"heterogeneity":[56],"plasticity,":[58],"but":[59],"also":[60],"its":[62,110],"structural":[63],"context":[64],"as":[65,67,121,123],"well":[66,122],"cellular":[69],"component":[70],"tumor":[73,96],"microenvironment":[74],"(TME).":[75],"Here,":[76],"we":[77],"review":[78],"recent":[80],"development":[81,116],"in":[82,92,109,114,124],"field":[84],"immunotherapy":[86],"target-based":[88],"therapy":[89],"how,":[91],"era":[94],"micro-tissue":[97],"engineering,":[98],"ex-vivo":[99],"assays":[100],"could":[101],"help":[102],"enhance":[104],"our":[105],"biology":[107],"knowledge":[108],"complexity,":[111],"translating":[112],"successful":[118],"therapeutic":[119,128],"strategies,":[120],"prediction":[126],"benefits.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-11-22T00:00:00"}