{"id":"https://openalex.org/W3211960368","doi":"https://doi.org/10.1016/j.phrs.2021.105928","title":"Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human studies","display_name":"Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human studies","publication_year":2021,"publication_date":"2021-11-17","ids":{"openalex":"https://openalex.org/W3211960368","doi":"https://doi.org/10.1016/j.phrs.2021.105928","mag":"3211960368","pmid":"https://pubmed.ncbi.nlm.nih.gov/34800625"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2021.105928","doi":"https://doi.org/10.1016/j.phrs.2021.105928","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2021.105928","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048524738","display_name":"Antonia Sophocleous","orcid":"https://orcid.org/0000-0003-0854-1429","observed_orcids":["https://orcid.org/0000-0003-0854-1429"]},"institutions":[{"id":"https://openalex.org/I201118511","display_name":"European University Cyprus","ror":"https://ror.org/04xp48827","country_code":"CY","type":"education","lineage":["https://openalex.org/I201118511"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Antonia Sophocleous","raw_affiliation_strings":["Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenes Street, 1516, Nicosia, Cyprus"],"raw_orcid":"https://orcid.org/0000-0003-0854-1429","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenes Street, 1516, Nicosia, Cyprus","institution_ids":["https://openalex.org/I201118511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070483471","display_name":"Michael Yiallourides","orcid":"https://orcid.org/0000-0002-2085-5239","observed_orcids":["https://orcid.org/0000-0002-2085-5239"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Yiallourides","raw_affiliation_strings":["Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001293500","display_name":"F. Zeng","orcid":"https://orcid.org/0000-0001-9235-0750","observed_orcids":["https://orcid.org/0000-0001-9235-0750"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Feier Zeng","raw_affiliation_strings":["Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015145279","display_name":"Pantelis Pantelas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pantelis Pantelas","raw_affiliation_strings":["Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013364514","display_name":"Eleni Stylianou","orcid":"https://orcid.org/0000-0001-7454-2775","observed_orcids":["https://orcid.org/0000-0001-7454-2775"]},"institutions":[{"id":"https://openalex.org/I201118511","display_name":"European University Cyprus","ror":"https://ror.org/04xp48827","country_code":"CY","type":"education","lineage":["https://openalex.org/I201118511"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Eleni Stylianou","raw_affiliation_strings":["Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenes Street, 1516, Nicosia, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenes Street, 1516, Nicosia, Cyprus","institution_ids":["https://openalex.org/I201118511"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Boya Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Boya Li","raw_affiliation_strings":["Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032945320","display_name":"Giovana Carrasco","orcid":"https://orcid.org/0000-0002-0382-4334","observed_orcids":["https://orcid.org/0000-0002-0382-4334"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giovana Carrasco","raw_affiliation_strings":["Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK"],"raw_orcid":"https://orcid.org/0000-0002-0382-4334","affiliations":[{"raw_affiliation_string":"Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082454972","display_name":"Aymen I. Idris","orcid":"https://orcid.org/0000-0003-4327-5306","observed_orcids":["https://orcid.org/0000-0003-4327-5306"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Aymen I. Idris","raw_affiliation_strings":["Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK. Electronic address: aymen.idris@sheffield.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK. Electronic address: aymen.idris@sheffield.ac.uk","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082454972"],"corresponding_institution_ids":["https://openalex.org/I91136226"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.1582,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.19878296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"175","issue":null,"first_page":"105928","last_page":"105928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cannabinoid-receptors","display_name":"cannabinoid receptors","score":0.921999990940094},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cb2-receptor","display_name":"CB2 receptor","score":1.0},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.902999997138977},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.6700000166893005},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5559999942779541},{"id":"https://openalex.org/keywords/hu-308","display_name":"HU-308","score":0.8519999980926514},{"id":"https://openalex.org/keywords/am251","display_name":"AM251","score":0.8169999718666077},{"id":"https://openalex.org/keywords/am630","display_name":"AM630","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":0.8090000152587891},{"id":"https://openalex.org/keywords/peak-bone-mass","display_name":"peak bone mass","score":0.6629999876022339},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6327646970748901},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5981357097625732},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5859642028808594},{"id":"https://openalex.org/C2910065304","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid Receptor Agonists","level":5,"score":0.516486644744873},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41910016536712646},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.4176005721092224},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.4162573218345642},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.3000276982784271}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phrs.2021.105928","doi":"https://doi.org/10.1016/j.phrs.2021.105928","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2021.105928","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:34800625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34800625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320332","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1762617857","https://openalex.org/W1905238978","https://openalex.org/W1964020207","https://openalex.org/W1975424968","https://openalex.org/W1977352773","https://openalex.org/W1990210398","https://openalex.org/W1994594771","https://openalex.org/W1994829213","https://openalex.org/W1998996442","https://openalex.org/W2001057761","https://openalex.org/W2003338312","https://openalex.org/W2005501262","https://openalex.org/W2020825180","https://openalex.org/W2025958964","https://openalex.org/W2029918787","https://openalex.org/W2030261305","https://openalex.org/W2039644514","https://openalex.org/W2048832437","https://openalex.org/W2058571677","https://openalex.org/W2059988860","https://openalex.org/W2066638828","https://openalex.org/W2067181191","https://openalex.org/W2071897837","https://openalex.org/W2087674201","https://openalex.org/W2089465877","https://openalex.org/W2096913171","https://openalex.org/W2100450635","https://openalex.org/W2119826244","https://openalex.org/W2122487138","https://openalex.org/W2123907272","https://openalex.org/W2136160086","https://openalex.org/W2140202777","https://openalex.org/W2146727923","https://openalex.org/W2148069788","https://openalex.org/W2149211697","https://openalex.org/W2150475621","https://openalex.org/W2162109499","https://openalex.org/W2163310458","https://openalex.org/W2165884167","https://openalex.org/W2208613608","https://openalex.org/W2225480602","https://openalex.org/W2281792021","https://openalex.org/W2338741450","https://openalex.org/W2405045429","https://openalex.org/W2415678656","https://openalex.org/W2511255409","https://openalex.org/W2534549165","https://openalex.org/W2591992106","https://openalex.org/W2593646375","https://openalex.org/W2611336486","https://openalex.org/W2776516641","https://openalex.org/W2784327403","https://openalex.org/W2893274576","https://openalex.org/W2905830350","https://openalex.org/W2909923904","https://openalex.org/W2939948833","https://openalex.org/W2944436744","https://openalex.org/W2947951130","https://openalex.org/W2957281478","https://openalex.org/W2978795816","https://openalex.org/W2980777424","https://openalex.org/W2984434907","https://openalex.org/W2991792334","https://openalex.org/W3004701357","https://openalex.org/W3005607082","https://openalex.org/W3006093312","https://openalex.org/W3014357871","https://openalex.org/W3016253367","https://openalex.org/W3089027668","https://openalex.org/W6651220480","https://openalex.org/W6660647707","https://openalex.org/W6681814854","https://openalex.org/W6682114920","https://openalex.org/W6713907624"],"related_works":["https://openalex.org/W1997389495","https://openalex.org/W161203191","https://openalex.org/W2086287710","https://openalex.org/W1994829213","https://openalex.org/W2160814688","https://openalex.org/W2036963690","https://openalex.org/W2215002952","https://openalex.org/W1905238978","https://openalex.org/W2155296417","https://openalex.org/W2067181191"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-22T00:00:00"}