{"id":"https://openalex.org/W3211925192","doi":"https://doi.org/10.1136/jitc-2021-sitc2021.096","title":"96 The impact of radiographic tumor thickness on the complexity of the tumor immune microenvironment in malignant pleural mesothelioma","display_name":"96 The impact of radiographic tumor thickness on the complexity of the tumor immune microenvironment in malignant pleural mesothelioma","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W3211925192","doi":"https://doi.org/10.1136/jitc-2021-sitc2021.096","mag":"3211925192"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2021-sitc2021.096","doi":"https://doi.org/10.1136/jitc-2021-sitc2021.096","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2021-sitc2021.096","pdf_url":"https://jitc.bmj.com/content/jitc/9/Suppl_2/A105.full.pdf","source":{"id":"https://openalex.org/S4363604233","display_name":"Regular and Young Investigator Award Abstracts","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jitc.bmj.com/content/jitc/9/Suppl_2/A105.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076321493","display_name":"Katarzyna J. Tomczak","orcid":"https://orcid.org/0000-0003-0553-8056","observed_orcids":["https://orcid.org/0000-0003-0553-8056"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katarzyna Tomczak","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030468200","display_name":"Jacqueline Oliva","orcid":"https://orcid.org/0000-0001-9334-2066","observed_orcids":["https://orcid.org/0000-0001-9334-2066"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Liszeth Oliva","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061975225","display_name":"Nicolas Zhou","orcid":"https://orcid.org/0000-0002-8340-9113","observed_orcids":["https://orcid.org/0000-0002-8340-9113"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas Zhou","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005462090","display_name":"Carlos Ramos-Galarza","orcid":"https://orcid.org/0000-0001-5614-1994","observed_orcids":["https://orcid.org/0000-0001-5614-1994"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Ramos","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037608325","display_name":"Nathaniel Deboeve","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel Deboeve","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017168441","display_name":"Hope A. Feldman","orcid":"https://orcid.org/0000-0002-0425-3465","observed_orcids":["https://orcid.org/0000-0002-0425-3465"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hope Feldman","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006353545","display_name":"Percy P. Lee","orcid":"https://orcid.org/0000-0001-6004-840X","observed_orcids":["https://orcid.org/0000-0001-6004-840X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Percy Lee","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063378671","display_name":"Chad D. Strange","orcid":"https://orcid.org/0000-0002-8675-3956","observed_orcids":["https://orcid.org/0000-0002-8675-3956"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad Strange","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074792755","display_name":"Annikka Weissferdt","orcid":"https://orcid.org/0000-0002-9510-0818","observed_orcids":["https://orcid.org/0000-0002-9510-0818"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annikka Weissferdt","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082839000","display_name":"David C. Rice","orcid":"https://orcid.org/0000-0002-7422-1522","observed_orcids":["https://orcid.org/0000-0002-7422-1522"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Rice","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057175032","display_name":"Reza John Mehran","orcid":"https://orcid.org/0000-0002-2557-2000","observed_orcids":["https://orcid.org/0000-0002-2557-2000"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reza Mehran","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100358178","display_name":"Jianjun J. Zhang","orcid":"https://orcid.org/0000-0001-7872-3477","observed_orcids":["https://orcid.org/0000-0001-7872-3477"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianjun Zhang","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057281549","display_name":"Anne S. Tsao","orcid":"https://orcid.org/0000-0003-0505-6639","observed_orcids":["https://orcid.org/0000-0003-0505-6639"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Tsao","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060288261","display_name":"Boris Sepesi","orcid":"https://orcid.org/0000-0003-1442-611X","observed_orcids":["https://orcid.org/0000-0003-1442-611X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris Sepesi","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050132330","display_name":"Cara Haymaker","orcid":"https://orcid.org/0000-0002-1317-9287","observed_orcids":["https://orcid.org/0000-0002-1317-9287"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cara Haymaker","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A105","last_page":"A105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-pleural-mesothelioma","display_name":"malignant pleural mesothelioma","score":1.0},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9750000238418579},{"id":"https://openalex.org/keywords/treg-expansion","display_name":"Treg expansion","score":0.3930000066757202},{"id":"https://openalex.org/keywords/ifn-gamma-response","display_name":"IFN-gamma response","score":0.7789999842643738},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.5099999904632568},{"id":"https://openalex.org/keywords/ox40","display_name":"OX40","score":0.7089999914169312},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.5860000252723694},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.875},{"id":"https://openalex.org/keywords/tigit","display_name":"TIGIT","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.4050000011920929},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.5910000205039978},{"id":"https://openalex.org/keywords/asbestos","display_name":"asbestos","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7249833941459656},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.695846676826477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5140239000320435},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49829745292663574},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.45361825823783875},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4415775239467621},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.41100212931632996},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3905330300331116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32831889390945435},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32359009981155396},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3224514126777649},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24167534708976746}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2021-sitc2021.096","doi":"https://doi.org/10.1136/jitc-2021-sitc2021.096","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2021-sitc2021.096","pdf_url":"https://jitc.bmj.com/content/jitc/9/Suppl_2/A105.full.pdf","source":{"id":"https://openalex.org/S4363604233","display_name":"Regular and Young Investigator Award Abstracts","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2021-sitc2021.096","doi":"https://doi.org/10.1136/jitc-2021-sitc2021.096","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2021-sitc2021.096","pdf_url":"https://jitc.bmj.com/content/jitc/9/Suppl_2/A105.full.pdf","source":{"id":"https://openalex.org/S4363604233","display_name":"Regular and Young Investigator Award Abstracts","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5400000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3211925192.pdf","grobid_xml":"https://content.openalex.org/works/W3211925192.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2117542219","https://openalex.org/W2559224373","https://openalex.org/W2604593814","https://openalex.org/W2989931780"],"related_works":["https://openalex.org/W4281721122","https://openalex.org/W3090862993","https://openalex.org/W3164913908","https://openalex.org/W3175991011","https://openalex.org/W4286515530","https://openalex.org/W2981345867","https://openalex.org/W2570728510","https://openalex.org/W3043470854","https://openalex.org/W4387571323","https://openalex.org/W2791898765"],"abstract_inverted_index":{"Background":[0],"Malignant":[1,411],"pleural":[2,412,509],"mesothelioma":[3,441,455],"(MPM)":[4],"is":[5,24,66,336],"a":[6,44,131,213,290,293,313,346],"rare":[7],"and":[8,20,30,181,218,227,235,244,283,289,352,376,419,462,505],"aggressive":[9],"cancer":[10],"associated":[11,47,253],"with":[12,16,48,136,254,292,323],"exposure":[13],"to":[14,71,82,85,90,269,370,373,387],"asbestos":[15,470],"limited":[17],"treatment":[18,27,34,96],"strategies":[19,385],"poor":[21],"prognosis.1":[22],"There":[23],"no":[25],"curative":[26],"for":[28,134,170,207,232,237,382],"MPM,":[29],"patients":[31],"follow":[32],"standard":[33],"options.2,3":[35],"Radiographic":[36],"tumor":[37,64,77,116,197],"thickness":[38,117,499],"(TT)":[39],"has":[40],"recently":[41],"emerged":[42],"as":[43,130,310],"surrogate":[45],"marker":[46],"overall":[49],"survival,4":[50],"however,":[51],"the":[52,57,60,76,83,92,114,144,204,216,274,350,360,380,388,457,463,522],"influence":[53],"of":[54,59,75,87,94,118,186,215,362,454,497,524],"TT":[55,84,129,217,325,351],"on":[56,113,379,392,416,500],"complexity":[58],"immune":[61,78,137,140,205,220,263,295,341,353,357],"component":[62],"within":[63],"microenvironment":[65,79],"unknown.":[67],"Our":[68],"aim":[69],"was":[70,110,146,155,188,251,301,320,519],"perform":[72],"comprehensive":[73],"profiling":[74,153,179,258,335,342],"(TIME)":[80],"relative":[81,386],"understand":[86],"this":[88],"relationship":[89,214,348],"guide":[91],"design":[93,381],"novel":[95,384],"strategies.":[97],"Methods":[98],"Tumor":[99,160],"specimens":[100],"(n=29)":[101],"were":[102,168],"obtained":[103],"from":[104],"surgically":[105],"managed":[106],"MPM":[107,366],"patients.":[108],"Analysis":[109],"performed":[111],"based":[112,331,391],"median":[115],"80mm,":[119],"which":[120],"defined":[121],"thick":[122,208,270,363],"vs":[123],"thin":[124,210,266,365],"groups.":[125],"Additional":[126],"analysis":[127],"used":[128],"continuous":[132],"variable":[133],"correlations":[135],"features.":[138],"The":[139],"cell":[141,177,334],"composition":[142],"in":[143,203,246,265,312,439,456,460,507],"TIME":[145],"determined":[147,189],"by":[148,173,273,304,521],"flow":[149],"cytometry":[150,199],"(n=23).":[151],"Transcriptomic":[152],"(n=20)":[154],"assessed":[156],"using":[157,190],"Nanostring":[158],"nCounter":[159],"Signaling":[161],"360":[162],"panel.":[163],"Expanded":[164,328],"tumor-infiltrating":[165],"lymphocytes":[166],"(TIL)":[167],"utilized":[169],"further":[171],"characterization":[172],"10x":[174],"Genomics":[175],"single":[176,333],"RNA-seq":[178],"(n=8)":[180],"cytotoxicity":[182],"assays":[183],"(n=18).":[184],"Level":[185],"significance":[187],"unpaired":[191],"non-parametric":[192],"statistical":[193],"test.":[194],"Results":[195],"Fresh":[196],"tissue":[198],"showed":[200,317],"substantial":[201],"differences":[202],"profiles":[206],"versus":[209,364],"tumors,":[211],"highlighting":[212],"its":[219],"composition.":[221],"Thin":[222],"tumors":[223,267,271,367],"contained":[224],"more":[225],"Tregs,":[226],"higher":[228],"OX40":[229],"expression":[230,250,257],"(p=0.081":[231],"non-Treg":[233],"CD4+":[234],"p<0.05":[236],"CD8+":[238],"T":[239],"cells),":[240],"CTLA4,":[241],"LAG3,":[242],"TIGIT":[243],"Ki67":[245],"TIL,":[247],"while":[248],"PD-1":[249],"not":[252,302],"TT.":[255,306,393],"Gene":[256],"suggested":[259],"an":[260,414],"impaired":[261],"adaptive":[262],"response":[264,319],"compared":[268],"characterized":[272],"exhausted":[275],"CD8":[276],"score":[277,281,287,297],"(p=0.0252),":[278],"T-cell":[279],"co-stimulation":[280],"(p=0.0387)":[282],"TNF":[284],"superfamily":[285],"member":[286],"(p=0.0159)":[288],"subset":[291],"myeloid":[294],"evasion":[296],"(p=0.0387).":[298],"TIL":[299,308,329],"expansion":[300],"impacted":[303],"baseline":[305,324],"However,":[307],"cytotoxicity,":[309],"measured":[311],"redirected":[314],"lysis":[315],"assay,":[316],"IFN-gamma":[318],"negatively":[321],"correlated":[322],"(p=0.023,":[326],"R2=0.28).":[327],"clustering":[330],"upon":[332],"underway.":[337],"Conclusions":[338],"Utilizing":[339],"multi-platform":[340],"approaches,":[343],"we":[344],"observed":[345],"distinct":[347],"between":[349],"signatures.":[354],"Understanding":[355],"underlying":[356],"signatures":[358],"underpinning":[359],"biology":[361],"provides":[368],"insights":[369],"potential":[371],"responsiveness":[372],"immune-based":[374],"therapies":[375],"may":[377],"inform":[378],"future":[383],"disease":[389],"extent":[390],"References":[394],"Bibby":[395],"AC,":[396],"Tsim":[397],"S,":[398,428,487],"Kanellakis":[399],"N,":[400,447],"Ball":[401],"H,":[402],"Talbot":[403],"DC,":[404],"Blyth":[405],"KG,":[406],"Maskell":[407],"NA,":[408],"Psallidas":[409],"I.":[410],"mesothelioma:":[413],"update":[415],"investigation,":[417],"diagnosis":[418],"treatment.":[420],"Eur":[421,511],"Respir":[422,512],"Rev":[423],"2016;25(142):472\u201386.":[424],"Faig":[425],"J,":[426],"Howard":[427],"Levine":[429],"EA,":[430],"Casselman":[431],"G,":[432],"Hesdorffer":[433],"M,":[434,450,479],"Ohar":[435],"JA.":[436],"Changing":[437],"pattern":[438],"malignant":[440,508],"survival.":[442],"Transl":[443,472],"Oncol":[444],"2015;8(1):35\u20139.":[445],"Alpert":[446],"van":[448],"Gerwen":[449],"Taioli":[451],"E.":[452],"Epidemiology":[453],"21st":[458],"century":[459],"Europe":[461],"United":[464],"States,":[465],"40":[466],"years":[467],"after":[468,502],"restricted/banned":[469],"use.":[471],"Lung":[473],"Cancer":[474,528],"R":[475],"2020;9:S28-S38.":[476],"de":[477],"Perrot":[478],"Dong":[480],"Z,":[481],"Bradbury":[482],"P,":[483],"Patsios":[484],"D,":[485],"Keshavjee":[486],"Leighl":[488],"NB,":[489],"Hope":[490],"A,":[491],"Feld":[492],"R,":[493],"Cho":[494],"J.":[495],"Impact":[496],"tumour":[498],"survival":[501],"radical":[503],"radiation":[504],"surgery":[506],"mesothelioma.":[510],"J":[513],"2017;49(3).":[514],"Ethics":[515],"Approval":[516],"This":[517],"study":[518],"approved":[520],"University":[523],"Texas":[525],"MD":[526],"Anderson":[527],"Center\u2018s":[529],"IRB;":[530],"approval":[531],"number":[532],"LAB08-0380;":[533],"participants":[534],"gave":[535],"informed":[536],"consent":[537],"before":[538],"taking":[539],"part.":[540]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2021-11-22T00:00:00"}