{"id":"https://openalex.org/W3211908597","doi":"https://doi.org/10.1016/j.jos.2021.09.010","title":"Oxidative stress as a critical factor might involve in intervertebral disc degeneration via regulating NOXs/FOXOs","display_name":"Oxidative stress as a critical factor might involve in intervertebral disc degeneration via regulating NOXs/FOXOs","publication_year":2021,"publication_date":"2021-11-09","ids":{"openalex":"https://openalex.org/W3211908597","doi":"https://doi.org/10.1016/j.jos.2021.09.010","mag":"3211908597","pmid":"https://pubmed.ncbi.nlm.nih.gov/34772597"},"language":"en","primary_location":{"id":"doi:10.1016/j.jos.2021.09.010","doi":"https://doi.org/10.1016/j.jos.2021.09.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jos.2021.09.010","pdf_url":null,"source":{"id":"https://openalex.org/S170674194","display_name":"Journal of Orthopaedic Science","issn_l":"0949-2658","issn":["0949-2658","1436-2023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002054454","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0002-7121-8563","observed_orcids":["https://orcid.org/0000-0002-7121-8563"]},"institutions":[{"id":"https://openalex.org/I4210090868","display_name":"Second Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00a98yf63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090868"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi Liu","raw_affiliation_strings":["Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China. Electronic address: liuqi@i.smu.edu.cn","Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China. Electronic address: liuqi@i.smu.edu.cn","institution_ids":["https://openalex.org/I4210090868"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China","institution_ids":["https://openalex.org/I4210090868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101136391","display_name":"Zhang\u2010Bin Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090868","display_name":"Second Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00a98yf63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhangbin Tan","raw_affiliation_strings":["Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou Medical University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangzhou Medical University, China","institution_ids":["https://openalex.org/I4210090868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052548967","display_name":"Chuhai Xie","orcid":"https://orcid.org/0000-0001-5991-2555","observed_orcids":["https://orcid.org/0000-0001-5991-2555","https://orcid.org/0000-0002-0076-740X"]},"institutions":[{"id":"https://openalex.org/I4210090868","display_name":"Second Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00a98yf63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuhai Xie","raw_affiliation_strings":["Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China","institution_ids":["https://openalex.org/I4210090868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103020556","display_name":"Ling Long","orcid":"https://orcid.org/0000-0002-5786-0189","observed_orcids":["https://orcid.org/0000-0002-5786-0189"]},"institutions":[{"id":"https://openalex.org/I4210090868","display_name":"Second Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00a98yf63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Ling","raw_affiliation_strings":["Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China","institution_ids":["https://openalex.org/I4210090868"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090668587","display_name":"Hailan Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090868","display_name":"Second Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00a98yf63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090868"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hailan Hu","raw_affiliation_strings":["Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China. Electronic address: Lanhu75@163.com","Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China. Electronic address: Lanhu75@163.com","institution_ids":["https://openalex.org/I4210090868"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, The Second Affiliated Hospital of Guangzhou Medical University, China","institution_ids":["https://openalex.org/I4210090868"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002054454","https://openalex.org/A5090668587"],"corresponding_institution_ids":["https://openalex.org/I4210090868"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.7154,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.84519637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"28","issue":"1","first_page":"105","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11518","display_name":"Cervical and Thoracic Myelopathy","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8569999933242798},{"id":"https://openalex.org/keywords/foxo-transcription-factors","display_name":"FOXO transcription factors","score":0.8389999866485596},{"id":"https://openalex.org/keywords/nox2","display_name":"NOX2","score":0.8519999980926514},{"id":"https://openalex.org/keywords/nox4","display_name":"NOX4","score":1.0},{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.8920000195503235},{"id":"https://openalex.org/keywords/foxo4","display_name":"FOXO4","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nucleus-pulposus-cells","display_name":"nucleus pulposus cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8679999709129333},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.9259999990463257},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":1.0},{"id":"https://openalex.org/keywords/aggrecan","display_name":"aggrecan","score":0.9509999752044678},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-13","display_name":"matrix metalloproteinase-13","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tert-butyl-hydroperoxide","display_name":"tert-butyl hydroperoxide","score":0.8330000042915344},{"id":"https://openalex.org/keywords/discogenic-pain","display_name":"discogenic pain","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.672181248664856},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.5640888810157776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5597354173660278},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.48327118158340454},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3867347240447998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34491628408432007},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.313964307308197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24672487378120422},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24644529819488525}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jos.2021.09.010","doi":"https://doi.org/10.1016/j.jos.2021.09.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jos.2021.09.010","pdf_url":null,"source":{"id":"https://openalex.org/S170674194","display_name":"Journal of Orthopaedic Science","issn_l":"0949-2658","issn":["0949-2658","1436-2023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Science","raw_type":"journal-article"},{"id":"pmid:34772597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34772597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","score":0.5899999737739563,"id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1820314031","https://openalex.org/W1995045618","https://openalex.org/W2013713556","https://openalex.org/W2020430412","https://openalex.org/W2033797333","https://openalex.org/W2039594564","https://openalex.org/W2042226041","https://openalex.org/W2057247058","https://openalex.org/W2075216923","https://openalex.org/W2082852887","https://openalex.org/W2092798278","https://openalex.org/W2099364141","https://openalex.org/W2106453911","https://openalex.org/W2107871413","https://openalex.org/W2108344016","https://openalex.org/W2134588430","https://openalex.org/W2139585666","https://openalex.org/W2166016039","https://openalex.org/W2281598305","https://openalex.org/W2332850050","https://openalex.org/W2407196167","https://openalex.org/W2475240424","https://openalex.org/W2567953676","https://openalex.org/W2605403816","https://openalex.org/W2756951902","https://openalex.org/W2767930720","https://openalex.org/W2914698736","https://openalex.org/W2960644669","https://openalex.org/W2963841843","https://openalex.org/W2986619224","https://openalex.org/W3008309297","https://openalex.org/W3157947766","https://openalex.org/W6745772955"],"related_works":["https://openalex.org/W2331522529","https://openalex.org/W2780946525","https://openalex.org/W2944451398","https://openalex.org/W2349938184","https://openalex.org/W2374825565","https://openalex.org/W2954869541","https://openalex.org/W4315650986","https://openalex.org/W2160539187","https://openalex.org/W4310774141","https://openalex.org/W4293177554"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}