{"id":"https://openalex.org/W3211825907","doi":"https://doi.org/10.1007/s12325-021-01978-2","title":"Long-Term Safety and Clinical Outcomes with Insulin Degludec/Insulin Aspart Treatment in Japanese Patients with Diabetes: A Real-World, Prospective, Observational Study","display_name":"Long-Term Safety and Clinical Outcomes with Insulin Degludec/Insulin Aspart Treatment in Japanese Patients with Diabetes: A Real-World, Prospective, Observational Study","publication_year":2021,"publication_date":"2021-11-20","ids":{"openalex":"https://openalex.org/W3211825907","doi":"https://doi.org/10.1007/s12325-021-01978-2","mag":"3211825907","pmid":"https://pubmed.ncbi.nlm.nih.gov/34800283","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8799571"},"language":"en","primary_location":{"id":"doi:10.1007/s12325-021-01978-2","doi":"https://doi.org/10.1007/s12325-021-01978-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12325-021-01978-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12325-021-01978-2.pdf","source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12325-021-01978-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046158507","display_name":"Takuyuki Katabami","orcid":"https://orcid.org/0000-0002-0396-8645","observed_orcids":["https://orcid.org/0000-0002-0396-8645"]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]},{"id":"https://openalex.org/I4210098866","display_name":"Yokohama City Seibu Hospital","ror":"https://ror.org/013y4v758","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210098866"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takuyuki Katabami","raw_affiliation_strings":["Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine Yokohama City Seibu Hospital, 1197-1, Yasashicho, Asahi-Ku, Yokohama, Kanagawa, 241-0811, Japan. t2kataba@marianna-u.ac.jp","Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine Yokohama City Seibu Hospital, 1197\u20131, Yasashicho, Asahi-Ku, Yokohama, Kanagawa, 241-0811, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine Yokohama City Seibu Hospital, 1197-1, Yasashicho, Asahi-Ku, Yokohama, Kanagawa, 241-0811, Japan. t2kataba@marianna-u.ac.jp","institution_ids":["https://openalex.org/I163917720","https://openalex.org/I4210098866"]},{"raw_affiliation_string":"Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine Yokohama City Seibu Hospital, 1197\u20131, Yasashicho, Asahi-Ku, Yokohama, Kanagawa, 241-0811, Japan","institution_ids":["https://openalex.org/I163917720","https://openalex.org/I4210098866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112265548","display_name":"Kirsten Thorup Eriksen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kirsten T. Eriksen","raw_affiliation_strings":["Novo Nordisk A/S, S\u00f8borg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023015579","display_name":"Yuiko Yamamoto","orcid":"https://orcid.org/0000-0003-2673-6238","observed_orcids":["https://orcid.org/0000-0003-2673-6238"]},"institutions":[{"id":"https://openalex.org/I4405265707","display_name":"Novo Nordisk Pharma Ltd. (Japan)","ror":"https://ror.org/05gzvb546","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265707"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuiko Yamamoto","raw_affiliation_strings":["Novo Nordisk Pharma Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Pharma Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I4405265707"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038812890","display_name":"Yasushi Ishigaki","orcid":"https://orcid.org/0000-0003-2479-5752","observed_orcids":["https://orcid.org/0000-0003-2479-5752"]},"institutions":[{"id":"https://openalex.org/I180680657","display_name":"Iwate Medical University","ror":"https://ror.org/04cybtr86","country_code":"JP","type":"education","lineage":["https://openalex.org/I180680657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Ishigaki","raw_affiliation_strings":["Division of Diabetes, Metabolism and Endocrinology, Iwate Medical University, Morioka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Diabetes, Metabolism and Endocrinology, Iwate Medical University, Morioka, Japan","institution_ids":["https://openalex.org/I180680657"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5046158507"],"corresponding_institution_ids":["https://openalex.org/I163917720","https://openalex.org/I4210098866"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":0.6848,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.65527667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"39","issue":"1","first_page":"544","last_page":"561"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.09099999815225601,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10508","display_name":"Patient Safety and Medication Errors","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-degludec-insulin-aspart","display_name":"IDegAsp","score":0.9760000109672546},{"id":"https://openalex.org/keywords/long-acting-insulin-analogues","display_name":"long-acting insulin analogues","score":0.6769999861717224},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8640000224113464},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9490000009536743},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.621999979019165},{"id":"https://openalex.org/keywords/severe-hypoglycemia","display_name":"severe hypoglycemia","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.7940000295639038},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.878000020980835},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7279999852180481},{"id":"https://openalex.org/keywords/post-marketing-surveillance","display_name":"post-marketing surveillance","score":0.7620000243186951},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.8320000171661377},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.4749999940395355},{"id":"https://openalex.org/keywords/safety-profile","display_name":"safety profile","score":0.40700000524520874},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.367000013589859},{"id":"https://openalex.org/keywords/serious-adverse-events","display_name":"serious adverse events","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.930349588394165},{"id":"https://openalex.org/C2779908123","wikidata":"https://www.wikidata.org/wiki/Q2754775","display_name":"Insulin aspart","level":4,"score":0.7452982664108276},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.66306471824646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6547755002975464},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6410285234451294},{"id":"https://openalex.org/C2775927303","wikidata":"https://www.wikidata.org/wiki/Q16252338","display_name":"Insulin degludec","level":5,"score":0.5639685392379761},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5541735887527466},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5529977679252625},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.48205313086509705},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.47522786259651184},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.43537890911102295},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3490411639213562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2456510066986084},{"id":"https://openalex.org/C2779920387","wikidata":"https://www.wikidata.org/wiki/Q417317","display_name":"Insulin glargine","level":4,"score":0.19672808051109314}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049528","descriptor_name":"Insulin, Long-Acting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061267","descriptor_name":"Insulin Aspart","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s12325-021-01978-2","doi":"https://doi.org/10.1007/s12325-021-01978-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12325-021-01978-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12325-021-01978-2.pdf","source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},{"id":"pmid:34800283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34800283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8799571","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8799571/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s12325-021-01978-2","doi":"https://doi.org/10.1007/s12325-021-01978-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12325-021-01978-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12325-021-01978-2.pdf","source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320333876","display_name":"Novo Nordisk Pharma","ror":"https://ror.org/05gzvb546"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3211825907.pdf","grobid_xml":"https://content.openalex.org/works/W3211825907.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1964959186","https://openalex.org/W1978130556","https://openalex.org/W2035760642","https://openalex.org/W2056526409","https://openalex.org/W2156138170","https://openalex.org/W2166393441","https://openalex.org/W2174239862","https://openalex.org/W2204150768","https://openalex.org/W2291194535","https://openalex.org/W2332567887","https://openalex.org/W2337646370","https://openalex.org/W2525044952","https://openalex.org/W2532403559","https://openalex.org/W2765159569","https://openalex.org/W2789732774","https://openalex.org/W2794676804","https://openalex.org/W2972869264","https://openalex.org/W3127077340","https://openalex.org/W6749756432"],"related_works":["https://openalex.org/W4200320010","https://openalex.org/W4416096820","https://openalex.org/W3127077340","https://openalex.org/W2330756642","https://openalex.org/W4385972188","https://openalex.org/W4281680162","https://openalex.org/W2809175415","https://openalex.org/W4308314784","https://openalex.org/W2313662993","https://openalex.org/W4283458401"],"abstract_inverted_index":{"Insulin":[0],"degludec/insulin":[1],"aspart":[2],"(IDegAsp)":[3],"provides":[4],"effective":[5],"glycaemic":[6,297],"control":[7,298],"with":[8,16,32,48,136,141,146,276,288,295],"an":[9],"acceptable":[10],"safety":[11,28,88,94,291],"profile":[12],"in":[13,18,34,63,92,105,116,156,190,205,219,236,281],"Japanese":[14,36,46,274],"patients":[15,47,124,158,192,208,238,275],"diabetes":[17,49,148],"randomised":[19],"clinical":[20,30,64,283],"trials.":[21],"This":[22],"post-marketing":[23],"surveillance":[24],"study":[25,44],"assessed":[26,91],"long-term":[27],"and":[29,84,111,217,257,264,293],"outcomes":[31],"IDegAsp":[33,57,280],"a":[35,164],"real-world":[37,282],"setting.":[38],"Multicentre,":[39],"prospective,":[40],"observational,":[41],"open-label,":[42],"single-arm":[43],"of":[45,72,160,170,174,207,231,279],"requiring":[50],"insulin":[51],"therapy,":[52],"who":[53],"had":[54],"switched":[55],"to":[56,251],"at":[58,163],"their":[59],"treating":[60],"physician\u2019s":[61],"discretion":[62],"practice.":[65],"One":[66],"year":[67,253],"after":[68,299],"initiating":[69],"IDegAsp,":[70],"incidence":[71],"adverse":[73,80],"events":[74,189,230],"(AEs":[75],"[primary":[76],"endpoint]),":[77],"serious":[78],"AEs,":[79],"drug":[81],"reactions":[82],"(ADRs),":[83],"severe":[85,232],"hypoglycaemia":[86,233],"(secondary":[87],"endpoints)":[89],"were":[90,101,125,154,234],"the":[93,117,161,184],"analysis":[95,119],"set":[96,120],"(SAS).":[97],"Secondary":[98],"effectiveness":[99,118],"endpoints":[100],"change":[102],"from":[103,249],"baseline":[104,250],"glycated":[106],"haemoglobin":[107],"(HbA":[108],"1c":[109,263],")":[110],"fasting":[112],"plasma":[113],"glucose":[114],"(FPG)":[115],"(EAS).":[121],"Overall,":[122],"1321":[123],"included":[126],"(SAS,":[127],"n":[128,132],"=":[129,133],"1321;":[130],"EAS,":[131],"1285);":[134],"4.2%":[135,206],"type":[137,142],"1":[138,252,300],"diabetes,":[139,144,277],"95.2%":[140],"2":[143],"0.7%":[145],"other/unknown":[147],"type.":[149],"In":[150,273],"total,":[151],"204":[152],"AEs":[153,203],"reported":[155,235],"132":[157],"(10.0%":[159],"SAS),":[162],"rate":[165,194,240],"[95%":[166,195,210,222,241],"confidence":[167],"interval":[168],"(CI)]":[169],"16.2":[171],"events/100":[172,198,213,244],"patient-years":[173],"exposure":[175],"(PYE)":[176],"[14.0;":[177],"18.4].":[178],"By":[179],"preferred":[180],"term,":[181],"\u2018hypoglycaemia\u2019":[182],"was":[183,254,285],"most":[185],"frequent":[186],"AE":[187],"(45":[188],"31":[191],"[2.3%];":[193],"CI]":[196,211,223,242],"3.6":[197],"PYE":[199,214,226,245],"[2.5;":[200],"4.6]).":[201],"Serious":[202],"occurred":[204],"(rate":[209,221],"5.7":[212],"[4.4;":[215],"7.0]),":[216],"ADRs":[218],"3.1%":[220],"4.6":[224],"reactions/100":[225],"[3.4;":[227],"5.8]).":[228],"Six":[229],"five":[237],"(0.4%;":[239],"0.5":[243],"[0.1;":[246],"0.9]).":[247],"Change":[248],"\u2212":[255,258],"0.51%":[256],"32.1":[259],"mg/dL":[260],"for":[261,271],"HbA":[262],"FPG,":[265],"respectively":[266],"(":[267],"P":[268],"<":[269],"0.0001":[270],"both).":[272],"initiation":[278],"practice":[284],"well":[286],"tolerated,":[287],"no":[289],"new":[290],"signals,":[292],"associated":[294],"improved":[296],"year.":[301],"ClinicalTrials.gov":[302],"identifier,":[303],"NCT02821052.":[304]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-11-22T00:00:00"}