{"id":"https://openalex.org/W3211813232","doi":"https://doi.org/10.1016/j.jbc.2021.101429","title":"The anti-M\u00fcllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor","display_name":"The anti-M\u00fcllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor","publication_year":2021,"publication_date":"2021-11-19","ids":{"openalex":"https://openalex.org/W3211813232","doi":"https://doi.org/10.1016/j.jbc.2021.101429","mag":"3211813232","pmid":"https://pubmed.ncbi.nlm.nih.gov/34801555","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8801479"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbc.2021.101429","doi":"https://doi.org/10.1016/j.jbc.2021.101429","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2021.101429","pdf_url":"http://www.jbc.org/article/S0021925821012382/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.jbc.org/article/S0021925821012382/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044747824","display_name":"Richard L. Cate","orcid":"https://orcid.org/0009-0003-2530-7498","observed_orcids":["https://orcid.org/0009-0003-2530-7498"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard L. Cate","raw_affiliation_strings":["Department of Chemistry, Boston University, Boston, Massachusetts, USA. Electronic address: richcate@comcast.net","Department of Chemistry, Boston University, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, Massachusetts, USA. Electronic address: richcate@comcast.net","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039335985","display_name":"Nathalie di Clemente","orcid":"https://orcid.org/0000-0001-9087-3486","observed_orcids":["https://orcid.org/0000-0001-9087-3486"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210134622","display_name":"Centre de Recherche Saint-Antoine","ror":"https://ror.org/03wxndv36","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210129850","https://openalex.org/I4210134622"]},{"id":"https://openalex.org/I4210154657","display_name":"Fondation pour l\u2019innovation en Cadiom\u00e9tabolisme et Nutrition","ror":"https://ror.org/050c3pq49","country_code":"FR","type":"other","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210154657"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie di Clemente","raw_affiliation_strings":["INSERM, Centre de Recherche Saint Antoine (CRSA), IHU ICAN, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Centre de Recherche Saint Antoine (CRSA), IHU ICAN, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210134622","https://openalex.org/I4210154657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013530671","display_name":"Chryst\u00e8le Racine","orcid":"https://orcid.org/0000-0003-0250-5355","observed_orcids":["https://orcid.org/0000-0003-0250-5355"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210134622","display_name":"Centre de Recherche Saint-Antoine","ror":"https://ror.org/03wxndv36","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210129850","https://openalex.org/I4210134622"]},{"id":"https://openalex.org/I4210154657","display_name":"Fondation pour l\u2019innovation en Cadiom\u00e9tabolisme et Nutrition","ror":"https://ror.org/050c3pq49","country_code":"FR","type":"other","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210154657"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chryst\u00e8le Racine","raw_affiliation_strings":["INSERM, Centre de Recherche Saint Antoine (CRSA), IHU ICAN, Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Centre de Recherche Saint Antoine (CRSA), IHU ICAN, Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210134622","https://openalex.org/I4210154657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111518206","display_name":"Nigel P. Groome","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124261462","display_name":"Oxford Brookes University","ror":"https://ror.org/04v2twj65","country_code":"GB","type":"education","lineage":["https://openalex.org/I124261462"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nigel P. Groome","raw_affiliation_strings":["School of Biological and Molecular Sciences, Oxford Brookes University, Headington, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological and Molecular Sciences, Oxford Brookes University, Headington, Oxford, UK","institution_ids":["https://openalex.org/I124261462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037742138","display_name":"R. Blake Pepinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297540436","display_name":"Biogen (United States)","ror":"https://ror.org/02jqkb192","country_code":"US","type":"company","lineage":["https://openalex.org/I1297540436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Blake Pepinsky","raw_affiliation_strings":["Department of Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I1297540436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081618576","display_name":"Adrian Whitty","orcid":"https://orcid.org/0000-0002-0331-4369","observed_orcids":["https://orcid.org/0000-0002-0331-4369"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian Whitty","raw_affiliation_strings":["Department of Chemistry, Boston University, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Boston University, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5044747824"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.863,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.70355869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"298","issue":"1","first_page":"101429","last_page":"101429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-mullerian-hormone","display_name":"anti-M\u00fcllerian hormone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-dimerization","display_name":"receptor dimerization","score":0.8220000267028809},{"id":"https://openalex.org/keywords/bone-morphogenetic-protein-7","display_name":"bone morphogenetic protein-7","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7266762256622314},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.627535343170166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6183308362960815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5794636011123657},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5384833812713623},{"id":"https://openalex.org/C2776620830","wikidata":"https://www.wikidata.org/wiki/Q4919211","display_name":"Bivalent (engine)","level":3,"score":0.5184623599052429},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.4257145822048187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32188889384269714},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.211788147687912},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.07526618242263794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06812244653701782},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036361","descriptor_name":"Peptide Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054304","descriptor_name":"Anti-Mullerian Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jbc.2021.101429","doi":"https://doi.org/10.1016/j.jbc.2021.101429","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2021.101429","pdf_url":"http://www.jbc.org/article/S0021925821012382/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8801479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8801479","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:34801555","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34801555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03990732v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-03990732","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, 2022, 298 (1), pp.101429. &#x27E8;10.1016/j.jbc.2021.101429&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.jbc.2021.101429","doi":"https://doi.org/10.1016/j.jbc.2021.101429","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2021.101429","pdf_url":"http://www.jbc.org/article/S0021925821012382/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3211813232.pdf","grobid_xml":"https://content.openalex.org/works/W3211813232.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W563858482","https://openalex.org/W1481497040","https://openalex.org/W1520151781","https://openalex.org/W1542496341","https://openalex.org/W1967276782","https://openalex.org/W1969359875","https://openalex.org/W1969604044","https://openalex.org/W1976927564","https://openalex.org/W1981338881","https://openalex.org/W1983853935","https://openalex.org/W1984687467","https://openalex.org/W1985404997","https://openalex.org/W1998093640","https://openalex.org/W1998386780","https://openalex.org/W2002799589","https://openalex.org/W2019552711","https://openalex.org/W2042239308","https://openalex.org/W2051816002","https://openalex.org/W2077243848","https://openalex.org/W2077439481","https://openalex.org/W2084299260","https://openalex.org/W2087703318","https://openalex.org/W2091243882","https://openalex.org/W2107141278","https://openalex.org/W2110539138","https://openalex.org/W2111952057","https://openalex.org/W2116112998","https://openalex.org/W2122275081","https://openalex.org/W2143267806","https://openalex.org/W2144005229","https://openalex.org/W2149993139","https://openalex.org/W2160864692","https://openalex.org/W2164446986","https://openalex.org/W2216737812","https://openalex.org/W2262780773","https://openalex.org/W2317227250","https://openalex.org/W2325888887","https://openalex.org/W2469581423","https://openalex.org/W2518755163","https://openalex.org/W2520774406","https://openalex.org/W2697458340","https://openalex.org/W2736243613","https://openalex.org/W2793602970","https://openalex.org/W3014200867","https://openalex.org/W3036691348","https://openalex.org/W3174631381"],"related_works":["https://openalex.org/W4406321348","https://openalex.org/W4393443904","https://openalex.org/W2087703318","https://openalex.org/W4403152395","https://openalex.org/W4283266826","https://openalex.org/W2216737812","https://openalex.org/W3174631381","https://openalex.org/W1967276782","https://openalex.org/W1985404997","https://openalex.org/W2091243882"],"abstract_inverted_index":{"Noncovalent":[0],"complexes":[1,22],"of":[2,77,124,162,189],"transforming":[3],"growth":[4,114],"factor-\u03b2":[5],"family":[6],"growth/differentiation":[7],"factors":[8],"with":[9,86,97,238],"their":[10,25],"prodomains":[11],"are":[12],"classified":[13],"as":[14],"latent":[15],"or":[16],"active,":[17,37],"depending":[18],"on":[19,54,80,200],"whether":[20],"the":[21,29,33,39,55,59,75,89,106,113,125,147,152,169,178,182,190,196,214,227,236],"can":[23],"bind":[24,168],"respective":[26],"receptors.":[27],"For":[28],"anti-M\u00fcllerian":[30],"hormone":[31],"(AMH),":[32],"hormone\u2013prodomain":[34],"complex":[35,127,154,237],"is":[36,41,66,155,198,207,233],"and":[38,83,139],"prodomain":[40,78,107,143,205,232,255],"displaced":[42,234],"upon":[43],"binding":[44,94,149,219],"to":[45,73,88,128,158,167,173,220],"its":[46,239],"type":[47],"II":[48],"receptor,":[49],"AMH":[50,81,126,153,183],"receptor":[51,99,148],"type-2":[52],"(AMHR2),":[53],"cell":[56],"surface.":[57],"However,":[58,160],"mechanism":[60,252],"by":[61,209,217,241],"which":[62],"this":[63,136,247,258],"displacement":[64,79,206,256],"occurs":[65,193],"unclear.":[67],"Here,":[68],"we":[69,224],"used":[70],"ELISA":[71],"assays":[72],"measure":[74],"dependence":[76],"concentration":[82],"analyzed":[84],"results":[85],"respect":[87],"behavior":[90],"expected":[91],"for":[92,112,181,253],"reversible":[93],"in":[95,104,151,177,186,213,257],"combination":[96],"ligand-induced":[98],"dimerization.":[100],"We":[101],"found":[102],"that,":[103],"solution,":[105],"has":[108],"a":[109,129,163,174,201,210,242,250],"high":[110],"affinity":[111],"factor":[115],"(GF)":[116],"(":[117],"K":[118,137,179],"d":[119,138,180],"=":[120],"0.4":[121],"pM).":[122],"Binding":[123],"single":[130],"AMHR2":[131,165,197],"molecule":[132,166],"does":[133,140],"not":[134,141],"affect":[135],"induce":[142],"displacement,":[144],"indicating":[145,203],"that":[146,204,226,246],"site":[150],"fully":[156],"accessible":[157],"AMHR2.":[159,221],"recruitment":[161],"second":[164],"ligand":[170,259],"bivalently":[171],"leads":[172],"1000-fold":[175],"increase":[176],"complex,":[184],"resulting":[185],"rapid":[187],"release":[188],"prodomain.":[191],"Displacement":[192],"only":[194],"if":[195],"presented":[199],"surface,":[202],"caused":[208],"conformational":[211],"change":[212],"GF":[215,240],"induced":[216],"bivalent":[218],"In":[222],"addition,":[223],"demonstrate":[225],"bone":[228],"morphogenetic":[229],"protein":[230],"7":[231],"from":[235],"similar":[243],"process,":[244],"suggesting":[245],"may":[248],"represent":[249],"general":[251],"receptor-mediated":[254],"family.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-22T00:00:00"}
