{"id":"https://openalex.org/W321137847","doi":null,"title":"[Effects of scalp-acupuncture on astrocyte apoptosis in hippocampal CA 1 region in rats with vascular dementia].","display_name":"[Effects of scalp-acupuncture on astrocyte apoptosis in hippocampal CA 1 region in rats with vascular dementia].","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W321137847","mag":"321137847","pmid":"https://pubmed.ncbi.nlm.nih.gov/25845213"},"language":"zh","primary_location":{"id":"pmid:25845213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25845213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhen ci yan jiu = Acupuncture research","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wen-jing Tian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-jing Tian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lin-na Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin-na Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017001124","display_name":"Ruihui Wang","orcid":"https://orcid.org/0000-0003-2906-9848","observed_orcids":["https://orcid.org/0000-0003-2906-9848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui-hui Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050622057","display_name":"Junming An","orcid":"https://orcid.org/0000-0003-1051-4227","observed_orcids":["https://orcid.org/0000-0003-1051-4227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun-ming An","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Meng Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meng Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.00431623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"40","issue":"1","first_page":"6","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scalp-acupuncture","display_name":"scalp acupuncture","score":0.9829999804496765},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/astrocyte-apoptosis","display_name":"astrocyte apoptosis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.796999990940094},{"id":"https://openalex.org/keywords/learning-and-memory-impairment","display_name":"learning and memory impairment","score":0.9120000004768372},{"id":"https://openalex.org/keywords/four-vessel-occlusion-model","display_name":"four-vessel occlusion model","score":0.7549999952316284},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8330000042915344},{"id":"https://openalex.org/keywords/morris-water-maze","display_name":"Morris water maze","score":0.5210000276565552},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.6039999723434448},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2778515351","wikidata":"https://www.wikidata.org/wiki/Q9622","display_name":"Scalp","level":2,"score":0.853224515914917},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.7493009567260742},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.7239367365837097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7168731093406677},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6990981698036194},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6917442679405212},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.6321377754211426},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48108813166618347},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4575954079627991},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4538007378578186},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.4393094480037689},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3823351263999939},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37513917684555054},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29471009969711304},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27222293615341187},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2631910443305969},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13689115643501282},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07166394591331482},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012535","descriptor_name":"Scalp","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015670","descriptor_name":"Acupuncture Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:25845213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25845213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhen ci yan jiu = Acupuncture research","raw_type":"English Abstract"},{"id":"pmh:oai:doaj.org/article:decea6d98ca64aaabbf798f3496d976c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/decea6d98ca64aaabbf798f3496d976c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u9488\u523a\u7814\u7a76, Vol 40, Pp 6-12 (2015)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:ee40320824ea4182a9d59fea9ae26423","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ee40320824ea4182a9d59fea9ae26423","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u9488\u523a\u7814\u7a76, Vol 40, Pp 6-12 (2015)","raw_type":"article"},{"id":"mag:321137847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25845213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092954843","https://openalex.org/W2387939200","https://openalex.org/W2366605305","https://openalex.org/W2395511202","https://openalex.org/W1965293363","https://openalex.org/W2359552617","https://openalex.org/W2379011293","https://openalex.org/W2386091116","https://openalex.org/W7162928458","https://openalex.org/W2385508510"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"observe":[2],"the":[3,9,16,106,116,136,145,148,159,164,170,182,192,203,209,214,217,227,237,248,256,264,271,281,286,296,303,308,326,339,349,366],"effect":[4,364],"of":[5,11,13,36,108,113,140,147,172,195,216,233,239,242,273,307,313,320,329,341,346,353,368],"scalp-acupuncture":[6,51,84,204,228,262,282],"intervention":[7],"on":[8],"expression":[10,107,232,268,327,340],"Bcl-2":[12,112,234,266,331,345],"astrocytes":[14,114,347],"in":[15,18,30,54,115,158,175,181,202,206,220,226,247,280,302,316,348,355,365],"hippocampus":[17,117,354],"vascular":[19],"dementia":[20],"(VD)":[21],"rats,":[22],"so":[23],"as":[24],"to":[25,71,82,362],"reveal":[26],"its":[27,363],"underlying":[28],"mechanism":[29],"improving":[31],"VD.":[32,369],"METHODS:":[33],"A":[34],"total":[35],"40":[37],"male":[38],"SD":[39],"rats":[40,356],"were":[41,155,199,251,277,293],"randomly":[42],"divided":[43],"into":[44],"normal":[45,165,257,297],"control,":[46],"sham-operation,":[47],"VD":[48,58],"model,":[49],"and":[50,75,78,105,125,144,169,191,213,236,270,299,325],"groups":[52,301],"(n=10":[53],"each":[55],"group).":[56],"The":[57,94,186,231],"model":[59,160,183,210,249,287],"was":[60,69,98,118,178,223],"established":[61],"by":[62,100,120],"using":[63],"modified":[64],"Pulsinelli":[65],"4-vessel-occlusion":[66],"method.":[67],"Scalp-acupuncture":[68,335],"applied":[70],"bilateral":[72,76],"\"Daozang":[73],"Shangjiao\"":[74],"\"Jiyi\",":[77],"\"Siwei\"":[79],"acupoints":[80],"according":[81],"FANG's":[83],"therapy":[85],"for":[86,91],"30":[87],"min,":[88,318],"once":[89],"daily":[90],"10":[92],"days.":[93],"rat's":[95],"learning-memory":[96],"ability":[97],"detected":[99,119],"Morris":[101,130],"water":[102,131],"maze":[103,132],"tests,":[104],"apoptosis":[109,342],"related":[110,343],"proteins":[111,344],"immunofluorescence":[121],"double":[122,322],"labeling":[123],"technique":[124],"Western":[126],"blot,":[127],"respectively.":[128],"RESULTS:":[129],"tests":[133],"showed":[134],"that":[135],"average":[137,188],"escape":[138,189,304],"latency":[139,190],"place":[141],"navigation":[142],"test":[143],"duration":[146,194,306],"first":[149,196,309],"platform-site":[150,173,197,310],"crossover":[151,198],"(space":[152],"probing":[153],"test)":[154],"significantly":[156,224,278],"increased":[157,187,193,225],"group":[161,167,184,205,211,229,250,259,283,288],"compared":[162,254,284],"with":[163,208,255,285,357],"control":[166,258,298],"(P<0.01),":[168,212],"number":[171,215,238,272,312,319],"crossovers":[174,219,315],"2":[176,221,317],"min":[177,222],"markedly":[179,200],"decreased":[180,253,265],"(P<0.01).":[185,230,260,289],"shortened":[201],"comparison":[207],"platform":[218,314],"protein":[235,267,332],"GFAP/Bcl-2-labeled":[240],"cells":[241,276,324],"hippocampal":[243,330],"CA":[244,350],"1":[245,351],"region":[246,352],"remarkably":[252],"After":[261],"intervention,":[263],"level":[269,328],"double-labeled":[274],"GFAP/Bcl-2":[275,321],"up-regulated":[279],"No":[290],"significant":[291],"differences":[292],"found":[294],"between":[295],"sham-operation":[300],"latency,":[305],"crossover,":[311],"labeled":[323],"(P>0.05).":[333],"CONCLUSION:":[334],"can":[336],"effectively":[337],"regulate":[338],"VD,":[358],"which":[359],"may":[360],"contribute":[361],"improvement":[367]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
