{"id":"https://openalex.org/W3211368558","doi":"https://doi.org/10.1182/blood-2021-146347","title":"Pharmacologic Inhibition of SUMO-Activating Enzyme Potentiates Interferon Response and T Cell-Mediated Anti-Tumor Immunity in Chronic Lymphocytic Leukemia (CLL) and Lymphoma Models","display_name":"Pharmacologic Inhibition of SUMO-Activating Enzyme Potentiates Interferon Response and T Cell-Mediated Anti-Tumor Immunity in Chronic Lymphocytic Leukemia (CLL) and Lymphoma Models","publication_year":2021,"publication_date":"2021-11-05","ids":{"openalex":"https://openalex.org/W3211368558","doi":"https://doi.org/10.1182/blood-2021-146347","mag":"3211368558"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2021-146347","doi":"https://doi.org/10.1182/blood-2021-146347","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-146347","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021469964","display_name":"Vi Lam","orcid":"https://orcid.org/0000-0003-4578-3531","observed_orcids":["https://orcid.org/0000-0003-4578-3531"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vi Lam","raw_affiliation_strings":["City Of Hope, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City Of Hope, Duarte, CA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379580","display_name":"Xiaoguang Wang","orcid":"https://orcid.org/0000-0003-3865-7537","observed_orcids":["https://orcid.org/0000-0003-3865-7537"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoguang Wang","raw_affiliation_strings":["City of Hope, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, Duarte, CA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031308530","display_name":"Scott Best","orcid":"https://orcid.org/0000-0002-0461-7919","observed_orcids":["https://orcid.org/0000-0002-0461-7919"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott R Best","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004071926","display_name":"Nur Bruss","orcid":"https://orcid.org/0009-0009-9995-4982","observed_orcids":["https://orcid.org/0009-0009-9995-4982"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nur Bruss","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441995","display_name":"Tingting Liu","orcid":"https://orcid.org/0000-0001-6396-7225","observed_orcids":["https://orcid.org/0000-0001-6396-7225"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingting Liu","raw_affiliation_strings":["City of Hope, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, Duarte, CA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103039650","display_name":"Olga V. Danilova","orcid":"https://orcid.org/0000-0001-9557-9032","observed_orcids":["https://orcid.org/0000-0001-9557-9032"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Danilova","raw_affiliation_strings":["City of Hope, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, Duarte, CA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005565037","display_name":"Tanya Siddiqi","orcid":"https://orcid.org/0000-0001-5292-8298","observed_orcids":["https://orcid.org/0000-0001-5292-8298"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanya Siddiqi","raw_affiliation_strings":["Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038644402","display_name":"Nathan D. Pennock","orcid":"https://orcid.org/0000-0001-5374-7843","observed_orcids":["https://orcid.org/0000-0001-5374-7843"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Pennock","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067633124","display_name":"Alexey Valeryevich Danilov","orcid":"https://orcid.org/0000-0003-4461-0970","observed_orcids":["https://orcid.org/0000-0003-4461-0970"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexey V. Danilov","raw_affiliation_strings":["City of Hope Comprehensive Cancer Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope Comprehensive Cancer Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"Supplement 1","first_page":"3719","last_page":"3719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.902999997138977},{"id":"https://openalex.org/keywords/tak-981","display_name":"TAK-981","score":0.8550000190734863},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.546999990940094},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.8960000276565552},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.6439999938011169},{"id":"https://openalex.org/keywords/sumo1","display_name":"SUMO1","score":0.6290000081062317},{"id":"https://openalex.org/keywords/sumo2-3","display_name":"SUMO2/3","score":0.9369999766349792},{"id":"https://openalex.org/keywords/a20-lymphoma","display_name":"A20 lymphoma","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5805241465568542},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.5496847629547119},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5452218651771545},{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.5307673811912537},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.501788854598999},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.48754045367240906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46694815158843994},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3926488161087036},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3882426619529724},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3602980375289917},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.14993801712989807},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12432757019996643},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10879701375961304},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2021-146347","doi":"https://doi.org/10.1182/blood-2021-146347","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2021-146347","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7099999785423279}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2053523004","https://openalex.org/W3032751721","https://openalex.org/W2048124721","https://openalex.org/W2088695563","https://openalex.org/W2001367558","https://openalex.org/W2091611701","https://openalex.org/W2164237668","https://openalex.org/W579273576","https://openalex.org/W2418031697","https://openalex.org/W88401132"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"CLL":[2,23,147,275,633],"is":[3,98,102],"characterized":[4],"by":[5,216,263,307,315,404,444],"deficient":[6],"immunity":[7],"which":[8],"clinically":[9],"manifests":[10],"as":[11,32,34,258,305,502,515,517],"increased":[12,283,540],"predisposition":[13],"towards":[14,450],"malignancies":[15],"and":[16,39,59,75,182,235,256,294,311,318,340,353,377,409,438,452,481,489,538,561,575,617,634],"infectious":[17],"complications.":[18],"T-cells":[19],"from":[20,144,188,272,454,522,598],"patients":[21,145,273,599],"with":[22,28,117,146,250,274,289,321,497,505,526,552,586,600],"exhibit":[24],"a":[25,49,103,114,448,462,531,570,624],"skewed":[26],"repertoire":[27],"predominance":[29],"of":[30,51,66,88,96,107,137,185,242,327,343,350,360,393,401,412,440,536,542,572,584,614,619,630,650,663,682,702,721,734,745],"Tregs":[31],"well":[33,516],"impaired":[35],"immune":[36,81,608],"synapse":[37],"formation":[38],"cytotoxic":[40,485],"function.":[41],"Small":[42],"ubiquitin-like":[43],"modifier":[44],"(SUMO)":[45],"family":[46],"proteins":[47],"regulate":[48],"variety":[50],"cellular":[52],"processes,":[53],"including":[54],"nuclear":[55],"trafficking,":[56],"gene":[57,171],"transcription":[58],"cell":[60,82,92,386,492,610],"cycle":[61],"progression,":[62],"via":[63,612],"post-translational":[64],"modification":[65],"target":[67],"proteins.":[68],"Sumoylation":[69],"regulates":[70],"NF\u03baB":[71],"signaling,":[72],"IFN":[73,365,465,615],"response":[74,366,466,616],"NFAT":[76,312],"activation,":[77],"processes":[78],"indispensable":[79],"in":[80,90,94,139,165,195,324,333,357,371,390,426,436,467,484,494,507,528,534,558,565,573,576,594,632],"activation.":[83],"Despite":[84],"this,":[85],"the":[86,108,127,134,328,358,391,547],"role":[87],"sumoylation":[89,280,585],"T":[91,142,158,192,270,336,385,415,472,487,491,520,595,609],"biology":[93],"context":[95],"cancer":[97],"not":[99,300,398,418,589],"known.":[100],"TAK-981":[101,138,217,260,290,322,527,553,587,631],"small":[104],"molecule":[105],"inhibitor":[106],"SUMO-activating":[109],"enzyme":[110,129],"(SAE)":[111],"that":[112,281,581],"forms":[113],"covalent":[115],"adduct":[116],"an":[118,364,434,539,647,660,674,679,699,718,731,742],"activated":[119],"SUMO":[120],"protein,":[121],"thereby":[122],"preventing":[123],"its":[124],"transfer":[125],"to":[126,230,604],"SUMO-conjugating":[128],"(Ubc9).":[130],"Here,":[131],"we":[132,579],"investigated":[133],"immunomodulatory":[135],"effects":[136],"CLL.":[140],"Methods:":[141],"cells":[143,159,200,255,271,337,373,416,488,499,521,596],"were":[148,160,201,238,248],"purified":[149],"using":[150],"Dynabeads.":[151],"For":[152,170,194,240],"polarization":[153],"assays,":[154],"FACS-sorted":[155,189],"na\u00efve":[156,190,471],"CD4+":[157,191,519,559],"cultured":[161],"for":[162,226,627],"7":[163],"days":[164,228],"control":[166,222,428],"or":[167,220,429,652,665,684,704,723,736,747],"differentiation":[168],"media.":[169],"expression":[172,349,442,535,557],"profiling":[173],"(GEP;":[174],"Clariom":[175],"S),":[176],"RNA":[177],"was":[178,261,355,368,388],"harvested":[179],"after":[180,374],"3":[181],"24":[183,375],"hours":[184,342,376],"TCR":[186,285,303,344,592],"engagement":[187,286],"cells.":[193,473],"vivo":[196,529,577],"immunization":[197],"experiments,":[198,578],"CD4+KJ1-26+":[199],"inoculated":[202],"IV":[203,211,223],"into":[204],"BALB/cJ":[205],"mice.":[206],"Mice":[207],"received":[208],"100":[209],"\u00b5g":[210],"ovalbumin":[212],"\u00b1":[213],"R848":[214],"followed":[215],"7.5":[218],"mg/kg":[219],"vehicle":[221],"twice":[224],"weekly":[225],"10":[227],"prior":[229],"spleen":[231],"collection.":[232],"Both":[233],"recipient":[234,523],"transplanted":[236,511],"splenocytes":[237],"analyzed.":[239],"analysis":[241],"tumor-infiltrating":[243],"lymphocytes":[244],"(TILs),":[245],"BALB/c":[246],"mice":[247,524],"injected":[249],"1x10":[251],"6":[252],"A20":[253,548],"lymphoma":[254,498],"treated":[257,525],"above.":[259],"provided":[262],"Millennium":[264],"Pharmaceuticals,":[265],"Inc.":[266],"(Cambridge,":[267],"MA).":[268],"Results:":[269],"demonstrated":[276],"high":[277,380,394],"baseline":[278],"protein":[279,296],"slightly":[282],"following":[284,338],"(\u03b1CD3/CD28).":[287],"Treatment":[288,320],"significantly":[291],"downregulated":[292,555],"SUMO1":[293],"SUMO2/3-modified":[295],"levels":[297,381],"yet":[298],"did":[299,417],"disrupt":[301],"early":[302,329],"signaling":[304,593],"evidenced":[306],"sustained":[308],"ZAP70,":[309],"p65/NF\u03baB":[310],"activation":[313,330],"detected":[314],"immunoblotting,":[316],"immunocytochemistry":[317],"GEP.":[319],"resulted":[323],"dose-dependent":[325],"upregulation":[326],"marker":[331],"CD69":[332],"CD4":[334,469],"+":[335,470],"72":[339],"96":[341],"stimulation":[345],"vs.":[346],"control.":[347],"Meanwhile,":[348],"CD25,":[351],"HLA-DR":[352],"CD40L":[354],"delayed":[356],"presence":[359,392],"TAK-981.":[361],"Interestingly,":[362],"CD38,":[363],"target,":[367],"induced":[369,562],"two-fold":[370],"TAK-981-treated":[372,468],"persisted":[378],"at":[379,382],"subsequent":[383],"timepoints.":[384],"proliferation":[387],"reduced":[389,405],"(1":[395],"\u03bcM)":[396],"but":[397,602],"low/intermediate":[399],"concentrations":[400],"TAK-981,":[402],"accompanied":[403],"S":[406],"phase":[407],"entry":[408],"decreased":[410,445],"synthesis":[411],"IL-2.":[413],"However,":[414],"undergo":[419],"apoptosis":[420],"under":[421],"those":[422],"conditions.":[423],"Targeting":[424],"SAE":[425,476],"either":[427],"Th1/Treg":[430],"polarizing":[431],"conditions":[432],"facilitated":[433],"increase":[435],"IFN\u03b3":[437,480,543,563],"loss":[439],"FoxP3":[441,537,556],"(accompanied":[443],"IL-2/STAT5),":[446],"suggesting":[447],"shift":[449],"Th1":[451],"away":[453],"Treg":[455],"phenotype,":[456],"respectively.":[457],"GEP":[458],"(Reactome,":[459],"GSEA)":[460],"confirmed":[461],"dramatically":[463],"upregulated":[464],"Furthermore,":[474],"targeting":[475,583],"enhanced":[477],"degranulation":[478],"(CD107a),":[479],"perforin":[482],"secretion":[483,564],"CD8+":[486,566],"potentiated":[490],"cytotoxicity":[493],"allogeneic":[495],"assays":[496],"(OCI-LY3,":[500],"U2932)":[501],"targets.":[503],"Consistent":[504],"our":[506],"vitro":[508,574],"data,":[509],"OVA-stimulated":[510],"transgenic":[512],"KJ1-26+":[513],"splenocytes,":[514],"total":[518],"exhibited":[530],"significant":[532],"reduction":[533],"production":[541],"(Figure":[544],"1).":[545],"In":[546],"syngeneic":[549],"model,":[550],"treatment":[551],"similarly":[554],"TILs":[560],"TILs.":[567],"Conclusion.":[568],"Using":[569],"combination":[571],"demonstrate":[580],"pharmacologic":[582],"does":[588],"impair":[590],"proximal":[591],"obtained":[597],"CLL,":[601],"leads":[603],"rebalancing":[605],"toward":[606],"healthy":[607],"subsets":[611],"induction":[613],"downmodulation":[618],"Tregs.":[620],"These":[621],"data":[622],"provide":[623],"strong":[625],"rationale":[626],"continued":[628],"investigation":[629],"lymphoid":[635],"malignancies.":[636],"Figure":[637,639],"1":[638],"1.":[640],"Disclosures":[641],"Siddiqi:":[642],"Juno":[643],"Therapeutics:":[644,692,774],"Membership":[645,658,677,697,716,729,740],"on":[646,659,678,698,717,730,741],"entity's":[648,661,680,700,719,732,743],"Board":[649,662,681,701,720,733,744],"Directors":[651,664,683,703,722,735,746],"advisory":[653,666,685,705,724,737,748],"committees,":[654,667,686,706,725,749],"Research":[655,668,687,693,707,710,750,756,762,767,771,776,792,796,802],"Funding;":[656,694,708,711,757,763,768,772,777,793,797],"BeiGene:":[657],"Funding,":[669,688,751],"Speakers":[670,689,713,726,752],"Bureau;":[671,690,714,727],"Pharmacyclics":[672],"LLC,":[673],"AbbVie":[675],"Company:":[676],"TG":[691,773],"Kite":[695],"Pharma:":[696],"Oncternal:":[709],"Janssen:":[712],"AstraZeneca:":[715],"Celgene:":[728],"committees;":[738],"BMS:":[739],"Bureau.":[753],"Danilov:":[754],"SecuraBio:":[755],"Bayer":[758],"Oncology:":[759,770],"Consultancy,":[760,765,775,782,785,788,800],"Honoraria,":[761,766,795,801],"Genentech:":[764],"Takeda":[769],"Rigel":[778],"Pharm:":[779],"Honoraria;":[780,783,786,789],"Abbvie:":[781],"Beigene:":[784],"Pharmacyclics:":[787],"Gilead":[790],"Sciences:":[791],"Bristol-Meyers-Squibb:":[794],"Astra":[798],"Zeneca:":[799],"Funding.":[803]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
