{"id":"https://openalex.org/W3211290015","doi":null,"title":"Long-term effects of oxandrolone treatment in childhood on neurocognition, wellbeing and social-emotional functioning in young adults with Turner syndrome","display_name":"Long-term effects of oxandrolone treatment in childhood on neurocognition, wellbeing and social-emotional functioning in young adults with Turner syndrome","publication_year":2013,"publication_date":"2013-06-30","ids":{"openalex":"https://openalex.org/W3211290015","mag":"3211290015"},"language":"en","primary_location":{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_2990565","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/104376","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Reproduction, 28, 111 - 111","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017801853","display_name":"Kim Freriks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kim Freriks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028369455","display_name":"C.M. Verhaak","orcid":"https://orcid.org/0000-0003-3269-3043","observed_orcids":["https://orcid.org/0000-0003-3269-3043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.M. Verhaak","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3269-3043","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013809975","display_name":"Theo Sas","orcid":"https://orcid.org/0000-0002-8727-1385","observed_orcids":["https://orcid.org/0000-0002-8727-1385","https://orcid.org/0000-0002-8772-740X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theo Sas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8727-1385","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068604873","display_name":"Leonie A. Menke","orcid":"https://orcid.org/0000-0002-8312-7730","observed_orcids":["https://orcid.org/0000-0002-8312-7730"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonie A. Menke","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8312-7730","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112806327","display_name":"B.J. Otten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.J. Otten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112702424","display_name":"Sabine M.P.F. de Muinck Keizer\u2010Schrama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabine M.P.F. de Muinck Keizer\u2010Schrama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054571302","display_name":"Jan Maarten Wit","orcid":"https://orcid.org/0000-0002-1715-5020","observed_orcids":["https://orcid.org/0000-0002-1715-5020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan M. Wit","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1715-5020","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083660817","display_name":"Romana Teodora Netea-Maier","orcid":"https://orcid.org/0000-0002-9603-0460","observed_orcids":["https://orcid.org/0000-0002-9603-0460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romana T. Netea\u2010Maier","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9603-0460","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039138511","display_name":"A. R. M. M. Hermus","orcid":"https://orcid.org/0000-0003-1075-2655","observed_orcids":["https://orcid.org/0000-0003-1075-2655"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. R. M. M. Hermus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1075-2655","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003017256","display_name":"Roy P. C. Kessels","orcid":"https://orcid.org/0000-0001-9500-9793","observed_orcids":["https://orcid.org/0000-0001-9500-9793","https://orcid.org/0000-0002-7107-8900"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.P.C. Kessels","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7107-8900","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048446979","display_name":"Henri J L M Timmers","orcid":"https://orcid.org/0000-0002-1208-5748","observed_orcids":["https://orcid.org/0000-0002-1208-5748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henri Timmers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1208-5748","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.4628183,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":null,"first_page":"111","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.21719999611377716,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/turner-syndrome","display_name":"Turner syndrome","score":1.0},{"id":"https://openalex.org/keywords/oxandrolone","display_name":"oxandrolone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/androgen-therapy","display_name":"androgen therapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/neurocognitive-function","display_name":"neurocognitive function","score":0.8519999980926514},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9700000286102295},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.7419999837875366},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9990000128746033},{"id":"https://openalex.org/keywords/social-emotional-functioning","display_name":"social-emotional functioning","score":0.9869999885559082},{"id":"https://openalex.org/keywords/emotion-perception","display_name":"emotion perception","score":0.9340000152587891},{"id":"https://openalex.org/keywords/fearful-facial-expressions","display_name":"fearful faces","score":0.6290000081062317},{"id":"https://openalex.org/keywords/long-term-psychological-effects","display_name":"long-term psychological effects","score":0.7020000219345093},{"id":"https://openalex.org/keywords/growth-hormone-therapy","display_name":"growth hormone therapy","score":0.5929999947547913},{"id":"https://openalex.org/keywords/estrogen-therapy","display_name":"estrogen therapy","score":0.6499999761581421},{"id":"https://openalex.org/keywords/young-adult-women","display_name":"young adult women","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2779733885","wikidata":"https://www.wikidata.org/wiki/Q420859","display_name":"Oxandrolone","level":4,"score":0.9514287710189819},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.7478201389312744},{"id":"https://openalex.org/C2779683239","wikidata":"https://www.wikidata.org/wiki/Q202849","display_name":"Turner syndrome","level":2,"score":0.6228160262107849},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6108035445213318},{"id":"https://openalex.org/C2992104508","wikidata":"https://www.wikidata.org/wiki/Q1413287","display_name":"Social functioning","level":3,"score":0.5947452783584595},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5488326549530029},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.4865376055240631},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.4345473051071167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32318586111068726},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3205275535583496},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2857576012611389},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.21923401951789856},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.15299847722053528},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0838259756565094},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.07318755984306335},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06260830163955688},{"id":"https://openalex.org/C139265228","wikidata":"https://www.wikidata.org/wiki/Q5283089","display_name":"Distress","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_2990565","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/104376","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Reproduction, 28, 111 - 111","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/104376","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/104376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"28","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/140428","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/140428","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2990565","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/104376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Reproduction","raw_type":"Article / Letter to editor"},{"id":"mag:3211290015","doi":null,"is_oa":false,"landing_page_url":"https://www.narcis.nl/publication/RecordID/oai%3Ascholarlypublications.universiteitleiden.nl%3Aitem_2990565","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Human Reproduction","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043667336","https://openalex.org/W2913021657","https://openalex.org/W1994849757","https://openalex.org/W2144857070","https://openalex.org/W2161179909","https://openalex.org/W2982325035","https://openalex.org/W2046451814","https://openalex.org/W2102501531","https://openalex.org/W1966056255","https://openalex.org/W2152789511"],"abstract_inverted_index":{"Turner":[0],"syndrome":[1],"(TS)":[2],"is":[3,188],"the":[4,64,86,93,101,150,154,177,189,228],"result":[5],"of":[6,9,30,55,58,88,95,125,153,205,217,230,234],"(partial)":[7],"absence":[8],"one":[10],"X-chromosome.":[11],"Besides":[12],"short":[13],"stature,":[14],"gonadal":[15],"dysgenesis":[16],"and":[17,60,90,146,207,214],"other":[18],"physical":[19],"aspects,":[20],"TS":[21,52],"women":[22,98,127],"have":[23],"typical":[24],"psychological":[25,28,41,235],"features.":[26],"Since":[27],"effects":[29,120,201],"androgen":[31,194],"exposure":[32],"in":[33,49,53,100,176,196,232],"childhood":[34,48],"probably":[35],"are":[36,212],"long-lasting,":[37],"we":[38,223],"explored":[39],"long-term":[40,200],"functioning":[42],"after":[43],"oxandrolone":[44],"(Ox)":[45],"therapy":[46],"during":[47],"adults":[50],"with":[51,70,75,129],"terms":[54],"neurocognition,":[56],"quality":[57,124,204],"life":[59,126,206],"social-emotional":[61,167,208],"functioning.":[62,209],"During":[63],"initial":[65],"study,":[66],"girls":[67],"were":[68],"treated":[69,128],"growth":[71],"hormone":[72],"(GH)":[73],"combined":[74],"placebo":[76],"(PI),":[77],"Ox":[78,82,130,231],"0.03":[79],"mg/kg/day,":[80],"or":[81],"0.06":[83],"mg/kg/day":[84],"from":[85,92],"age":[87,94,107],"eight,":[89],"estrogen":[91],"twelve.":[96],"Sixty-eight":[97],"participated":[99],"current":[102],"double-blinded":[103],"follow-up":[104],"study":[105,187],"(mean":[106],"24.0":[108],"years,":[109],"mean":[110],"time":[111],"since":[112],"stopping":[113],"GH/Ox":[114],"8.7":[115],"years).":[116],"We":[117],"found":[118],"no":[119],"on":[121,149,182,202],"neurocognition.":[122],"Concerning":[123],"had":[131],"higher":[132,147],"anxiety":[133],"levels":[134],"(STAI":[135],"37.4":[136],"+/-":[137,141,157,161],"8.4":[138],"vs":[139,159],"31.8":[140],"5.0,":[142],"p":[143,163],"=":[144,164],"0.002)":[145],"scores":[148],"depression":[151],"subscale":[152],"SCL-90-R":[155],"(25.7":[156],"10.7":[158],"20.5":[160],"4.7,":[162],"0.01).":[165],"Regarding":[166],"functioning,":[168],"emotion":[169],"perception":[170],"for":[171],"fearful":[172],"faces":[173],"was":[174],"lower":[175],"Ox-treated":[178],"patients,":[179],"without":[180],"effect":[181],"interpersonal":[183],"behavior.":[184],"Our":[185],"exploratory":[186],"first":[190],"to":[191],"suggest":[192],"that":[193],"treatment":[195],"adolescence":[197],"possibly":[198],"has":[199],"adult":[203],"However,":[210],"differences":[211],"small":[213],"clinical":[215],"implications":[216],"our":[218],"results":[219],"seem":[220],"limited.":[221],"Therefore":[222],"would":[224],"not":[225],"recommend":[226],"against":[227],"use":[229],"light":[233],"consequences.":[236]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-11-08T00:00:00"}
