{"id":"https://openalex.org/W3211271908","doi":"https://doi.org/10.1002/1878-0261.13133","title":"A standalone approach to utilize telomere length measurement as a surveillance tool in oral leukoplakia","display_name":"A standalone approach to utilize telomere length measurement as a surveillance tool in oral leukoplakia","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W3211271908","doi":"https://doi.org/10.1002/1878-0261.13133","mag":"3211271908","pmid":"https://pubmed.ncbi.nlm.nih.gov/34725903","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9019888"},"language":"en","primary_location":{"id":"doi:10.1002/1878-0261.13133","doi":"https://doi.org/10.1002/1878-0261.13133","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1878-0261.13133","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.13133","source":{"id":"https://openalex.org/S80282989","display_name":"Molecular Oncology","issn_l":"1574-7891","issn":["1574-7891","1878-0261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.13133","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040654673","display_name":"Jagannath Pal","orcid":"https://orcid.org/0000-0002-7110-4048","observed_orcids":["https://orcid.org/0000-0002-7110-4048"]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Jagannath Pal","raw_affiliation_strings":["Multi-Disciplinary Research Unit (MRU), Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India"],"raw_orcid":"https://orcid.org/0000-0002-7110-4048","affiliations":[{"raw_affiliation_string":"Multi-Disciplinary Research Unit (MRU), Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021994557","display_name":"Yogita Rajput","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogita Rajput","raw_affiliation_strings":["Multi-Disciplinary Research Unit (MRU), Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multi-Disciplinary Research Unit (MRU), Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110712821","display_name":"Shruti Shrivastava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shruti Shrivastava","raw_affiliation_strings":["Deptt of Pathology, Govt. Medical College, Rajnandgaon, Chhattisgarh, India","Deptt of Pathology, Pt. J.N.M. Medical College, Raipur, Chhattisgarh","Department of Pathology, Govt. Medical College, Rajnandgaon, Chhattisgarh, India","Department of Pathology, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deptt of Pathology, Govt. Medical College, Rajnandgaon, Chhattisgarh, India","institution_ids":[]},{"raw_affiliation_string":"Deptt of Pathology, Pt. J.N.M. Medical College, Raipur, Chhattisgarh","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Pathology, Govt. Medical College, Rajnandgaon, Chhattisgarh, India","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079603976","display_name":"Renuka Gahine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Renuka Gahine","raw_affiliation_strings":["Deptt of Pathology, Pt. J.N.M. Medical College, Raipur, Chhattisgarh","Multi-Disciplinary Research Unit (MRU), Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","Department of Pathology, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deptt of Pathology, Pt. J.N.M. Medical College, Raipur, Chhattisgarh","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Multi-Disciplinary Research Unit (MRU), Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Pathology, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042191277","display_name":"Varsha Mungutwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Varsha Mungutwar","raw_affiliation_strings":["Deptt of ENT, Dr.B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","Department of ENT, Dr. B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deptt of ENT, Dr.B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of ENT, Dr. B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019083474","display_name":"Malti Sahu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Malti Sahu","raw_affiliation_strings":["Multi-Disciplinary Research Unit (MRU), Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multi-Disciplinary Research Unit (MRU), Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048536340","display_name":"Tripti Barardiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tripti barardiya","raw_affiliation_strings":["Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","Department of ENT, Dr. B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of ENT, Dr. B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005906489","display_name":"Ankur Kumar Chandrakar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ankur Chandrakar","raw_affiliation_strings":["Deptt of ENT, Dr.B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","Department of Oral Medicine and Radiology, Govt. Dental College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deptt of ENT, Dr.B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Oral Medicine and Radiology, Govt. Dental College, Raipur, Chhattisgarh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022019138","display_name":"Pinaka Pani.R","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pinaka Pani R","raw_affiliation_strings":["Govt. Dental College, Raipur, Chhattisgarh, India","Department of Oral Medicine and Radiology, Govt. Dental College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Govt. Dental College, Raipur, Chhattisgarh, India","institution_ids":[]},{"raw_affiliation_string":"Department of Oral Medicine and Radiology, Govt. Dental College, Raipur, Chhattisgarh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042331351","display_name":"Shovana S. Mishra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shovana S. Mishra","raw_affiliation_strings":["Govt. Dental College, Raipur, Chhattisgarh, India","Department of ENT, Dr. B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Govt. Dental College, Raipur, Chhattisgarh, India","institution_ids":[]},{"raw_affiliation_string":"Department of ENT, Dr. B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019927451","display_name":"Hansa Banjara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hansa Banjara","raw_affiliation_strings":["Deptt of ENT, Dr.B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","Department of Radiotherapy/Regional Cancer Center, Dr. B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deptt of ENT, Dr.B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Radiotherapy/Regional Cancer Center, Dr. B.R.A.M. Hospital & Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006043293","display_name":"Vivek Choudhary","orcid":"https://orcid.org/0000-0002-3664-5025","observed_orcids":["https://orcid.org/0000-0002-3664-5025"]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vivek Choudhary","raw_affiliation_strings":["Regional Cancer Centre, Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, India","Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional Cancer Centre, Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, India","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084990312","display_name":"Pradeep Kumar Patra","orcid":"https://orcid.org/0000-0003-4426-0384","observed_orcids":["https://orcid.org/0000-0003-4426-0384"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Pradeep K. Patra","raw_affiliation_strings":["Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","Harvard (Dana Farber) Cancer Institute and VA Boston Healthcare System, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Harvard (Dana Farber) Cancer Institute and VA Boston Healthcare System, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801671727","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063099799","display_name":"Masood A. Shammas","orcid":"https://orcid.org/0000-0002-8932-6829","observed_orcids":["https://orcid.org/0000-0002-8932-6829"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masood A. Shammas","raw_affiliation_strings":["Harvard (Dana Farber) Cancer Institute, Boston, USA","VA Boston Healthcare System, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard (Dana Farber) Cancer Institute, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"VA Boston Healthcare System, Boston, USA","institution_ids":["https://openalex.org/I2801671727"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040654673"],"corresponding_institution_ids":["https://openalex.org/I2799791569"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":{"value":3600,"currency":"USD","value_usd":3600},"fwci":1.5494,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.81397141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"16","issue":"8","first_page":"1650","last_page":"1660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.32670000195503235,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-leukoplakia","display_name":"oral leukoplakia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/oral-premalignant-lesions","display_name":"oral potentially malignant disorders","score":0.7770000100135803},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/oral-epithelial-dysplasia","display_name":"oral dysplasia","score":0.6909999847412109},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7450000047683716},{"id":"https://openalex.org/keywords/surveillance-medicine","display_name":"surveillance (medicine)","score":0.3190000057220459},{"id":"https://openalex.org/keywords/oral-brush-biopsy","display_name":"oral brush biopsy","score":0.6100000143051147},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7117905616760254},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5871511101722717},{"id":"https://openalex.org/C2909065260","wikidata":"https://www.wikidata.org/wiki/Q838145","display_name":"Oral leukoplakia","level":4,"score":0.5867931842803955},{"id":"https://openalex.org/C2777550702","wikidata":"https://www.wikidata.org/wiki/Q838145","display_name":"Leukoplakia","level":3,"score":0.5838233232498169},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5769779682159424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5577326416969299},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5057528018951416},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.49775293469429016},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.443094402551651},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4414333701133728},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43016162514686584},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.42056381702423096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38134196400642395},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3532436490058899},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28067123889923096},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.19419360160827637},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08350381255149841},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007972","descriptor_name":"Leukoplakia, Oral","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007972","descriptor_name":"Leukoplakia, Oral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007972","descriptor_name":"Leukoplakia, Oral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/1878-0261.13133","doi":"https://doi.org/10.1002/1878-0261.13133","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1878-0261.13133","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.13133","source":{"id":"https://openalex.org/S80282989","display_name":"Molecular Oncology","issn_l":"1574-7891","issn":["1574-7891","1878-0261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oncology","raw_type":"journal-article"},{"id":"doi:10.1101/2020.09.25.20193946","doi":"https://doi.org/10.1101/2020.09.25.20193946","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.09.25.20193946","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2020/12/07/2020.09.25.20193946.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9019888","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9019888","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Oncol","raw_type":"Text"},{"id":"pmid:34725903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34725903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bc0ea549fbc748d09a53aaed42127ef8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bc0ea549fbc748d09a53aaed42127ef8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Oncology, Vol 16, Iss 8, Pp 1650-1660 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/1878-0261.13133","doi":"https://doi.org/10.1002/1878-0261.13133","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1878-0261.13133","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.13133","source":{"id":"https://openalex.org/S80282989","display_name":"Molecular Oncology","issn_l":"1574-7891","issn":["1574-7891","1878-0261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3643881707","display_name":null,"funder_award_id":"I01BX001584-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3668218448","display_name":null,"funder_award_id":"I01 BX001584","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4933731489","display_name":"SPORE in Multiple Myeloma","funder_award_id":"P50CA100707","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7539252105","display_name":null,"funder_award_id":"I01BX001584-01","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8111695270","display_name":null,"funder_award_id":"I01-BX001584","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000066536","display_name":null,"funder_award_id":"CA100707","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320324333","display_name":"Ministry of Health and Family Welfare","ror":"https://ror.org/04pqetg36"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3211271908.pdf","grobid_xml":"https://content.openalex.org/works/W3211271908.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1630865570","https://openalex.org/W1736835535","https://openalex.org/W1936421873","https://openalex.org/W1971503458","https://openalex.org/W1978131526","https://openalex.org/W1994873752","https://openalex.org/W2003333623","https://openalex.org/W2004956279","https://openalex.org/W2005908883","https://openalex.org/W2022172287","https://openalex.org/W2026761826","https://openalex.org/W2028490774","https://openalex.org/W2030976397","https://openalex.org/W2033855112","https://openalex.org/W2033969676","https://openalex.org/W2038346400","https://openalex.org/W2043021712","https://openalex.org/W2050820138","https://openalex.org/W2053704023","https://openalex.org/W2058206917","https://openalex.org/W2059107557","https://openalex.org/W2060955969","https://openalex.org/W2062395030","https://openalex.org/W2075700061","https://openalex.org/W2091369486","https://openalex.org/W2095021043","https://openalex.org/W2097618972","https://openalex.org/W2099321184","https://openalex.org/W2106662896","https://openalex.org/W2111725588","https://openalex.org/W2120640970","https://openalex.org/W2122672345","https://openalex.org/W2128091997","https://openalex.org/W2130556253","https://openalex.org/W2130688853","https://openalex.org/W2131200409","https://openalex.org/W2134202395","https://openalex.org/W2150256054","https://openalex.org/W2150490516","https://openalex.org/W2152778958","https://openalex.org/W2156477973","https://openalex.org/W2160022977","https://openalex.org/W2160621707","https://openalex.org/W2167285829","https://openalex.org/W2344138156","https://openalex.org/W2347193990","https://openalex.org/W2375081401","https://openalex.org/W2505101453","https://openalex.org/W2507752161","https://openalex.org/W2520374450","https://openalex.org/W2556817732","https://openalex.org/W2583015248","https://openalex.org/W2601291486","https://openalex.org/W2615488483","https://openalex.org/W2752848216","https://openalex.org/W2752933713","https://openalex.org/W2752951686","https://openalex.org/W2768672921","https://openalex.org/W2776152832","https://openalex.org/W2909123291","https://openalex.org/W2913259928","https://openalex.org/W2939710943","https://openalex.org/W2951114699","https://openalex.org/W2967843354","https://openalex.org/W2985063978","https://openalex.org/W2994883550","https://openalex.org/W3131959303","https://openalex.org/W4254061016","https://openalex.org/W4254832465"],"related_works":["https://openalex.org/W7202381564","https://openalex.org/W1756179744","https://openalex.org/W2156477973","https://openalex.org/W3040679754","https://openalex.org/W4399804190","https://openalex.org/W2328648162","https://openalex.org/W2369351924","https://openalex.org/W7202049178","https://openalex.org/W2283812975","https://openalex.org/W2357453320"],"abstract_inverted_index":{"Oral":[0,90],"squamous":[1],"cell":[2],"carcinoma":[3],"(OSCC)":[4],"is":[5],"often":[6],"preceded":[7],"by":[8,114],"a":[9,13,43,56,62,160,169,173,186,200,217],"white":[10],"patch":[11,147,179],"on":[12],"surface":[14],"of":[15,55,71,118,196,207],"the":[16,127,136,146,178,205,233],"mouth,":[17],"called":[18],"oral":[19,153,162],"leukoplakia":[20],"(OL).":[21],"As":[22],"accelerated":[23],"telomere":[24,37],"length":[25,38],"(TL)":[26],"shortening":[27],"in":[28,46,145,150,239],"dividing":[29],"epithelial":[30],"cells":[31,79],"may":[32],"lead":[33],"to":[34,50,126,156,220],"oncogenic":[35],"transformation,":[36],"measurement":[39],"could":[40],"serve":[41],"as":[42,81],"predictive":[44],"biomarker":[45],"OL.":[47],"However,":[48],"due":[49],"high":[51],"variability":[52],"and":[53,85,93,104,215,235],"lack":[54],"universal":[57],"reference,":[58],"there":[59],"has":[60],"been":[61],"limited":[63],"translational":[64,88],"application.":[65],"Here,":[66],"we":[67],"describe":[68],"an":[69,82],"approach":[70,234],"evaluating":[72],"TL":[73,111,117,138,175,183,197],"using":[74,199],"paired":[75,94,128,187,201],"peripheral":[76],"blood":[77,96],"mononuclear":[78],"(PBMC)":[80],"internal":[83],"reference":[84,209],"demonstrate":[86],"its":[87,236],"relevance.":[89],"brush":[91],"biopsy":[92],"venous":[95],"were":[97],"collected":[98],"from":[99],"50":[100],"male":[101,106],"OL":[102,120,134,223],"patients":[103],"44":[105],"healthy":[107,122,157],"controls":[108,158],"(HC).":[109],"Relative":[110],"was":[112,124,140,165],"measured":[113],"quantitative":[115],"PCR.":[116],"each":[119],"or":[121],"sample":[123,130,203],"normalized":[125],"PBMC":[129,202],"(TL":[131],"ratio).":[132],"In":[133],"patients,":[135],"mean":[137],"ratio":[139,176,184],"significantly":[141,181],"smaller":[142,182],"not":[143],"only":[144],"but":[148,180],"also":[149],"distal":[151,189],"normal":[152,174,188],"tissue,":[154],"relative":[155],"without":[159],"high-risk":[161,222],"habit.":[163],"Dysplasia":[164],"frequently":[166],"associated":[167],"with":[168],"subgroup":[170],"that":[171,194],"showed":[172],"at":[177,185],"site.":[190],"Our":[191],"data":[192,212],"suggest":[193],"evaluation":[195],"attrition":[198],"eliminates":[204],"requirement":[206],"external":[208],"DNA,":[210],"makes":[211],"universally":[213],"comparable":[214],"provides":[216],"useful":[218],"marker":[219],"define":[221],"groups":[224],"for":[225],"follow-up":[226],"programs.":[227],"Larger":[228],"studies":[229],"will":[230],"further":[231],"validate":[232],"broader":[237],"application":[238],"other":[240],"premalignant":[241],"conditions.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2021-11-08T00:00:00"}