{"id":"https://openalex.org/W3211266992","doi":"https://doi.org/10.1007/s00115-008-2496-0","title":"Alzheimer-Demenz","display_name":"Alzheimer-Demenz","publication_year":2008,"publication_date":"2008-09-26","ids":{"openalex":"https://openalex.org/W3211266992","doi":"https://doi.org/10.1007/s00115-008-2496-0","mag":"3211266992","pmid":"https://pubmed.ncbi.nlm.nih.gov/18820894"},"language":"de","primary_location":{"id":"doi:10.1007/s00115-008-2496-0","doi":"https://doi.org/10.1007/s00115-008-2496-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00115-008-2496-0","pdf_url":null,"source":{"id":"https://openalex.org/S62507270","display_name":"Der Nervenarzt","issn_l":"0028-2804","issn":["0028-2804","1433-0407"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Der Nervenarzt","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/53062","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019205615","display_name":"Thomas A. Bayer","orcid":"https://orcid.org/0000-0001-8453-228X","observed_orcids":["https://orcid.org/0000-0001-8453-228X"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"T. A. Bayer","raw_affiliation_strings":["Klinik f\u00fcr Psychiatrie, Universit\u00e4tsmedizin G\u00f6ttingen, Von-Siebold-Strasse 5, 37075, G\u00f6ttingen. tbayer@gwdg.de","Klinik f\u00fcr Psychiatrie, Universit\u00e4tsmedizin G\u00f6ttingen, Von-Siebold-Stra\u00dfe 5, 37075, G\u00f6ttingen, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Psychiatrie, Universit\u00e4tsmedizin G\u00f6ttingen, Von-Siebold-Strasse 5, 37075, G\u00f6ttingen. tbayer@gwdg.de","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Klinik f\u00fcr Psychiatrie, Universit\u00e4tsmedizin G\u00f6ttingen, Von-Siebold-Stra\u00dfe 5, 37075, G\u00f6ttingen, Deutschland","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062788542","display_name":"Oliver Wirths","orcid":"https://orcid.org/0000-0002-4115-0334","observed_orcids":["https://orcid.org/0000-0002-4115-0334"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O. Wirths","raw_affiliation_strings":["Klinik f\u00fcr Psychiatrie, Universit\u00e4tsmedizin G\u00f6ttingen, Von-Siebold-Stra\u00dfe 5, 37075, G\u00f6ttingen, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Psychiatrie, Universit\u00e4tsmedizin G\u00f6ttingen, Von-Siebold-Stra\u00dfe 5, 37075, G\u00f6ttingen, Deutschland","institution_ids":["https://openalex.org/I4210116730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019205615"],"corresponding_institution_ids":["https://openalex.org/I4210116730"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":0.2496,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.48431318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"79","issue":"S3","first_page":"117","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/amyloid-hypothesis","display_name":"amyloid hypothesis","score":0.972000002861023},{"id":"https://openalex.org/keywords/animal-models-of-alzheimer-s-disease","display_name":"animal models of Alzheimer's disease","score":0.6790000200271606},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.875},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.753000020980835},{"id":"https://openalex.org/keywords/axon-degeneration","display_name":"axonal degeneration","score":0.9700000286102295},{"id":"https://openalex.org/keywords/behavioural-deficits","display_name":"behavioural deficits","score":0.9409999847412109},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.45899999141693115},{"id":"https://openalex.org/keywords/alzheimer-s-disease-drugs","display_name":"Alzheimer's disease drugs","score":0.49799999594688416},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6640840768814087},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5914128422737122}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012183","descriptor_name":"Retrograde Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00115-008-2496-0","doi":"https://doi.org/10.1007/s00115-008-2496-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00115-008-2496-0","pdf_url":null,"source":{"id":"https://openalex.org/S62507270","display_name":"Der Nervenarzt","issn_l":"0028-2804","issn":["0028-2804","1433-0407"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Der Nervenarzt","raw_type":"journal-article"},{"id":"pmid:18820894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18820894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Der Nervenarzt","raw_type":"English Abstract"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/53062","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/53062","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3208323549","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007/s00115-008-2496-0.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S62507270","display_name":"Der Nervenarzt","issn_l":"0028-2804","issn":["0028-2804","1433-0407"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Der Nervenarzt","raw_type":null},{"id":"mag:99620156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18820894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:publications.goettingen-research-online.de:2/53062","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/53062","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W155930382","https://openalex.org/W1548797188","https://openalex.org/W1820021925","https://openalex.org/W1975448620","https://openalex.org/W1987970630","https://openalex.org/W2002399569","https://openalex.org/W2010773967","https://openalex.org/W2016436495","https://openalex.org/W2017079501","https://openalex.org/W2029073267","https://openalex.org/W2041689445","https://openalex.org/W2047613132","https://openalex.org/W2058723245","https://openalex.org/W2071310220","https://openalex.org/W2079472896","https://openalex.org/W2082027220","https://openalex.org/W2084972185","https://openalex.org/W2090233590","https://openalex.org/W2100298346","https://openalex.org/W2132510306","https://openalex.org/W2133019124","https://openalex.org/W2169152986","https://openalex.org/W2185500845","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7011381027","https://openalex.org/W2604587297","https://openalex.org/W4413848379","https://openalex.org/W2147326443","https://openalex.org/W2312123478","https://openalex.org/W1966050431","https://openalex.org/W4234395332","https://openalex.org/W2321487144","https://openalex.org/W2012220782","https://openalex.org/W2917810483"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-11-08T00:00:00"}