{"id":"https://openalex.org/W3211247645","doi":"https://doi.org/10.1186/s12885-021-08916-z","title":"Cardiopulmonary-related patient-reported outcomes in a randomized clinical trial of radiation therapy for breast cancer","display_name":"Cardiopulmonary-related patient-reported outcomes in a randomized clinical trial of radiation therapy for breast cancer","publication_year":2021,"publication_date":"2021-11-04","ids":{"openalex":"https://openalex.org/W3211247645","doi":"https://doi.org/10.1186/s12885-021-08916-z","mag":"3211247645","pmid":"https://pubmed.ncbi.nlm.nih.gov/34736429","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8569957"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-021-08916-z","doi":"https://doi.org/10.1186/s12885-021-08916-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-021-08916-z","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-021-08916-z","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-021-08916-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002010201","display_name":"Hilde Van Parijs","orcid":"https://orcid.org/0000-0002-0595-0668","observed_orcids":["https://orcid.org/0000-0002-0595-0668"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hilde Van Parijs","raw_affiliation_strings":["Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091568017","display_name":"Vincent Vinh\u2010Hung","orcid":"https://orcid.org/0000-0002-6403-6120","observed_orcids":["https://orcid.org/0000-0002-6403-6120"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]},{"id":"https://openalex.org/I4210135110","display_name":"Centre Hospitalier Universitaire de Martinique","ror":"https://ror.org/0376kfa34","country_code":"MQ","type":"healthcare","lineage":["https://openalex.org/I4210135110"]}],"countries":["BE","MQ"],"is_corresponding":true,"raw_author_name":"Vincent Vinh-Hung","raw_affiliation_strings":["Centre Hospitalier Universitaire (CHU) de Martinique, Fort-de-France, France. vh@onco.be","Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium. vh@onco.be","Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-6403-6120","affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire (CHU) de Martinique, Fort-de-France, France. vh@onco.be","institution_ids":["https://openalex.org/I4210135110"]},{"raw_affiliation_string":"Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium. vh@onco.be","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764"]},{"raw_affiliation_string":"Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089093250","display_name":"Christel Fontaine","orcid":"https://orcid.org/0000-0002-4524-5744","observed_orcids":["https://orcid.org/0000-0002-4524-5744"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Christel Fontaine","raw_affiliation_strings":["Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024554584","display_name":"Guy A Storme","orcid":"https://orcid.org/0000-0003-0806-7915","observed_orcids":["https://orcid.org/0000-0003-0806-7915"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Guy Storme","raw_affiliation_strings":["Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089486616","display_name":"Claire F. Verschraegen","orcid":"https://orcid.org/0000-0001-6544-3089","observed_orcids":["https://orcid.org/0000-0001-6544-3089"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Verschraegen","raw_affiliation_strings":["Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048116861","display_name":"Nguyen Minh Dung","orcid":"https://orcid.org/0000-0002-0662-1786","observed_orcids":["https://orcid.org/0000-0002-0662-1786"]},"institutions":[{"id":"https://openalex.org/I123565023","display_name":"Vietnam National University Ho Chi Minh City","ror":"https://ror.org/00waaqh38","country_code":"VN","type":"education","lineage":["https://openalex.org/I123565023"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Dung M. Nguyen","raw_affiliation_strings":["School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam","institution_ids":["https://openalex.org/I123565023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023251547","display_name":"Nele Adriaenssens","orcid":"https://orcid.org/0000-0002-3018-2533","observed_orcids":["https://orcid.org/0000-0002-3018-2533"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nele Adriaenssens","raw_affiliation_strings":["Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024166341","display_name":"Nam Phong Nguyen","orcid":"https://orcid.org/0000-0001-5106-6665","observed_orcids":["https://orcid.org/0000-0001-5106-6665"]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nam P. Nguyen","raw_affiliation_strings":["Howard University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University, Washington, DC, USA","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068077473","display_name":"Olena Gorobets","orcid":"https://orcid.org/0000-0003-2589-092X","observed_orcids":["https://orcid.org/0000-0003-2589-092X"]},"institutions":[{"id":"https://openalex.org/I4210128404","display_name":"Ukrainian Military Medical Academy","ror":"https://ror.org/02rv28335","country_code":"UA","type":"education","lineage":["https://openalex.org/I4210128404"]},{"id":"https://openalex.org/I4210135110","display_name":"Centre Hospitalier Universitaire de Martinique","ror":"https://ror.org/0376kfa34","country_code":"MQ","type":"healthcare","lineage":["https://openalex.org/I4210135110"]}],"countries":["MQ","UA"],"is_corresponding":false,"raw_author_name":"Olena Gorobets","raw_affiliation_strings":["Centre Hospitalier Universitaire (CHU) de Martinique, Fort-de-France, France","Ukrainian Military Medical Academy, Kiev, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Universitaire (CHU) de Martinique, Fort-de-France, France","institution_ids":["https://openalex.org/I4210135110"]},{"raw_affiliation_string":"Ukrainian Military Medical Academy, Kiev, Ukraine","institution_ids":["https://openalex.org/I4210128404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040579751","display_name":"Mark De Ridder","orcid":"https://orcid.org/0000-0003-4433-8807","observed_orcids":["https://orcid.org/0000-0003-4433-8807"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210126764","display_name":"Universitair Ziekenhuis Brussel","ror":"https://ror.org/038f7y939","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210126764"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mark De Ridder","raw_affiliation_strings":["Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5091568017"],"corresponding_institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210126764","https://openalex.org/I4210135110"],"apc_list":{"value":2570,"currency":"USD","value_usd":2570},"apc_paid":{"value":2570,"currency":"USD","value_usd":2570},"fwci":0.9454,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.67286899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"21","issue":"1","first_page":"1177","last_page":"1177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7314000129699707,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.7314000129699707,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.1793999969959259,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tomotherapy","display_name":"helical tomotherapy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/conventional-radiotherapy","display_name":"conventional radiotherapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pulmonary-toxicity","display_name":"pulmonary toxicity","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.925000011920929},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.925000011920929},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.984000027179718},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.6269999742507935},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.7300000190734863},{"id":"https://openalex.org/keywords/eortc-qlq-c30","display_name":"EORTC QLQ-C30","score":0.8289999961853027},{"id":"https://openalex.org/keywords/long-term-quality-of-life","display_name":"long-term quality of life","score":0.6970000267028809},{"id":"https://openalex.org/keywords/simultaneous-integrated-boost","display_name":"simultaneous integrated boost","score":0.5479999780654907},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9219931364059448},{"id":"https://openalex.org/C2779572924","wikidata":"https://www.wikidata.org/wiki/Q542022","display_name":"Lumpectomy","level":5,"score":0.7507193088531494},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7012537717819214},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.633489727973938},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.5725675821304321},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5115681290626526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4447237253189087},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.42680051922798157},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3697756826877594},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.3609473705291748},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3460283875465393},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28092896938323975}],"mesh":[{"descriptor_ui":"D000069584","descriptor_name":"Unilateral Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000069584","descriptor_name":"Unilateral Breast Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000069584","descriptor_name":"Unilateral Breast Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000071066","descriptor_name":"Patient Reported Outcome Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000072836","descriptor_name":"Surgical Wound","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D004417","descriptor_name":"Dyspnea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008408","descriptor_name":"Mastectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011182","descriptor_name":"Postoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015182","descriptor_name":"Lymphatic Irradiation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015412","descriptor_name":"Mastectomy, Segmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050397","descriptor_name":"Radiotherapy, Intensity-Modulated","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D050397","descriptor_name":"Radiotherapy, Intensity-Modulated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12885-021-08916-z","doi":"https://doi.org/10.1186/s12885-021-08916-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-021-08916-z","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-021-08916-z","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7462989","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8569957","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34736429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34736429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:pubmedcentral.nih.gov:8569957","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8569957/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:84a1938cdab54b1daefba478f0804a58","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/84a1938cdab54b1daefba478f0804a58","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)","raw_type":"article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:153692","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/cardiopulmonaryrelated-patientreported-outcomes-in-a-randomized-clinical-trial-of-radiation-therapy-for-breast-cancer(268bbb4a-3422-426e-8625-d2bcb73c6e98).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12885-021-08916-z","doi":"https://doi.org/10.1186/s12885-021-08916-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-021-08916-z","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-021-08916-z","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1400245357","display_name":null,"funder_award_id":"SCIE2006-30","funder_id":"https://openalex.org/F4320323069","funder_display_name":"Stichting Tegen Kanker"}],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320323069","display_name":"Stichting Tegen Kanker","ror":"https://ror.org/01h3dr788"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3211247645.pdf","grobid_xml":"https://content.openalex.org/works/W3211247645.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W126071311","https://openalex.org/W160934420","https://openalex.org/W402198080","https://openalex.org/W1536690700","https://openalex.org/W1570622790","https://openalex.org/W1737973877","https://openalex.org/W1745036040","https://openalex.org/W1757407923","https://openalex.org/W1947168884","https://openalex.org/W1951724000","https://openalex.org/W1987214188","https://openalex.org/W1992502241","https://openalex.org/W2005219467","https://openalex.org/W2007316542","https://openalex.org/W2026889379","https://openalex.org/W2033433258","https://openalex.org/W2038366968","https://openalex.org/W2043945205","https://openalex.org/W2054787481","https://openalex.org/W2064974469","https://openalex.org/W2076761842","https://openalex.org/W2082556289","https://openalex.org/W2083928251","https://openalex.org/W2102708069","https://openalex.org/W2105361492","https://openalex.org/W2110206005","https://openalex.org/W2112825053","https://openalex.org/W2121167824","https://openalex.org/W2124879124","https://openalex.org/W2138048392","https://openalex.org/W2147194879","https://openalex.org/W2167571044","https://openalex.org/W2264404529","https://openalex.org/W2475879107","https://openalex.org/W2548000951","https://openalex.org/W2549871891","https://openalex.org/W2790248051","https://openalex.org/W2898962716","https://openalex.org/W2913181387","https://openalex.org/W2944801570","https://openalex.org/W3087143328","https://openalex.org/W3120247980","https://openalex.org/W3159164887","https://openalex.org/W3203931713"],"related_works":["https://openalex.org/W3013245192","https://openalex.org/W6921212123","https://openalex.org/W4322771059","https://openalex.org/W3094025853","https://openalex.org/W4412785815","https://openalex.org/W2105361492","https://openalex.org/W2109330988","https://openalex.org/W2946255105","https://openalex.org/W2110206005","https://openalex.org/W4293224529"],"abstract_inverted_index":{"BACKGROUND:":[0],"Long-term":[1],"prospective":[2],"patient-reported":[3],"outcomes":[4],"(PRO)":[5],"after":[6,69],"breast":[7],"cancer":[8],"adjuvant":[9],"radiotherapy":[10,16],"is":[11],"scarce.":[12],"TomoBreast":[13],"compared":[14],"conventional":[15],"(CR)":[17],"with":[18,61,90,279,289,320,324],"tomotherapy":[19],"(TT),":[20],"on":[21,174,244,266],"the":[22,96,137,194,203,209,229,236,305],"hypothesis":[23],"that":[24],"TT":[25,71,230,272,310],"might":[26],"reduce":[27],"lung-heart":[28],"toxicity.":[29],"METHODS:":[30],"Among":[31],"123":[32],"women":[33],"consenting":[34],"to":[35,40,43,53,77,145,307,322],"participate,":[36],"64":[37],"were":[38,93,109,134,201,238],"randomized":[39],"CR,":[41],"59":[42],"TT.":[44],"CR":[45,232,274,321],"delivered":[46,72],"50":[47],"Gy":[48,86],"in":[49,88,157,228],"25":[50],"fractions/5":[51],"weeks":[52,76],"breast/chest":[54,78],"wall":[55,79],"and":[56,80,101,222],"regional":[57,81],"nodes":[58,82],"if":[59,83],"node-positive,":[60,84],"a":[62,112,117,179,290],"sequential":[63],"boost":[64],"(16":[65],"Gy/8":[66],"fractions/1.6":[67],"weeks)":[68],"lumpectomy.":[70,91],"42":[73],"Gy/15":[74],"fractions/3":[75],"51":[85],"simultaneous-integrated-boost":[87],"patients":[89,172],"PRO":[92,107,131,183,198,308],"assessed":[94],"using":[95,136],"European":[97],"Organization":[98],"for":[99,254],"Research":[100],"Treatment":[102],"of":[103,125,130,159,181,261,281,294,304,315],"Cancer":[104],"questionnaire":[105],"QLQ-C30.":[106],"scores":[108,251,285],"converted":[110],"into":[111],"symptom-free":[113,119,206],"scale,":[114],"100":[115],"indicating":[116,122],"fully":[118],"score,":[120,207],"0":[121],"total":[123,180],"loss":[124],"freedom":[126,295],"from":[127,296,318],"symptom.":[128],"Changes":[129],"over":[132],"time":[133,144,306],"analyzed":[135],"linear":[138],"mixed-effect":[139,242],"model.":[140],"Survival":[141],"analysis":[142,303],"computed":[143],">":[146],"10%":[147],"PRO-deterioration.":[148],"A":[149],"post-hoc":[150],"cardiorespiratory":[151,316],"outcome":[152],"was":[153,187,213,218,224,275,287],"defined":[154],"as":[155],"deterioration":[156,317],"any":[158],"dyspnea,":[160,297],"fatigue,":[161,255],"physical":[162],"functioning,":[163],"or":[164,283],"pain.":[165],"RESULTS:":[166],"At":[167],"10.4":[168],"years":[169,247],"median":[170],"follow-up,":[171],"returned":[173],"average":[175],"9":[176],"questionnaires/patient,":[177],"providing":[178],"1139":[182],"records.":[184],"Item":[185],"completeness":[186],"96.6%.":[188],"Missingness":[189],"did":[190],"not":[191,239,276],"differ":[192],"between":[193],"randomization":[195,262],"arms.":[196],"The":[197],"at":[199],"baseline":[200],"below":[202],"nominal":[204],"100%":[205],"notably":[208],"mean":[210],"fatigue-free":[211,282],"score":[212],"64.8%":[214],"vs.":[215,220,226,231],"69.6%,":[216],"pain-free":[217,284],"75.4%":[219],"75.3%,":[221],"dyspnea-free":[223],"84.8%":[225],"88.5%,":[227],"arm,":[233],"respectively,":[234],"although":[235],"differences":[237],"significant.":[240],"By":[241,264,301],"modeling":[243,265],"early":[245],"\u22642":[246],"assessment,":[248],"all":[249],"three":[250],"deteriorated,":[252],"significantly":[253,277,334],"P":[256,298,326],"\u2264":[257],"0.01,":[258],"without":[259],"effect":[260],"arm.":[263],"late":[267],"assessment":[268],"beyond":[269],"2":[270],"years,":[271],"versus":[273],"associated":[278,288],"changes":[280],"but":[286],"significant":[291],"8.9%":[292],"improvement":[293],"=":[299,327],"0.035.":[300],"survival":[302,313],"deterioration,":[309],"improved":[311],"10-year":[312],"free":[314],"66.9%":[319],"84.5%":[323],"TT,":[325],"0.029.":[328],"CONCLUSION:":[329],"Modern":[330],"radiation":[331],"therapy":[332],"can":[333],"improve":[335],"long-term":[336],"PRO.":[337],"TRIAL":[338],"REGISTRATION:":[339],"Trial":[340],"registration":[341],"number":[342],"ClinicalTrials.gov":[343],"NCT00459628":[344],",":[345],"April":[346],"12,":[347],"2007":[348],"prospectively.":[349]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-11-08T00:00:00"}
