{"id":"https://openalex.org/W3211201648","doi":"https://doi.org/10.26434/chemrxiv.12994250.v1","title":"Organoselenium mild electrophiles in the inhibition of Mpro and SARSCoV-2 replication","display_name":"Organoselenium mild electrophiles in the inhibition of Mpro and SARSCoV-2 replication","publication_year":2020,"publication_date":"2020-09-24","ids":{"openalex":"https://openalex.org/W3211201648","doi":"https://doi.org/10.26434/chemrxiv.12994250.v1","mag":"3211201648"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.12994250.v1","doi":"https://doi.org/10.26434/chemrxiv.12994250.v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.12994250.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.26434/chemrxiv.12994250.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073889564","display_name":"Luca Sancineto","orcid":"https://orcid.org/0000-0002-6199-7399","observed_orcids":["https://orcid.org/0000-0002-6199-7399"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Sancineto","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1 06100 Perugia (PG), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1 06100 Perugia (PG), Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047274015","display_name":"Francesca Mangiavacchi","orcid":"https://orcid.org/0000-0001-5344-2310","observed_orcids":["https://orcid.org/0000-0001-5344-2310"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Mangiavacchi","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1 06100 Perugia (PG), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1 06100 Perugia (PG), Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057489119","display_name":"Agnieszka D\u0105browska","orcid":"https://orcid.org/0000-0003-1499-4950","observed_orcids":["https://orcid.org/0000-0003-1499-4950"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Agnieszka D\u0105browska","raw_affiliation_strings":["Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland","Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007757838","display_name":"Agata Joanna Pacu\u0142a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Agata Pacu\u0142a","raw_affiliation_strings":["Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin Street, Torun, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin Street, Torun, Poland","institution_ids":["https://openalex.org/I3019271933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049437191","display_name":"Magdalena Obieziurska\u2010Fabisiak","orcid":"https://orcid.org/0000-0002-5274-0911","observed_orcids":["https://orcid.org/0000-0002-5274-0911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena Obieziurska-Fabisiak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075470568","display_name":"Cecilia Scimmi","orcid":"https://orcid.org/0009-0009-2194-8670","observed_orcids":["https://orcid.org/0009-0009-2194-8670","https://orcid.org/0000-0002-6967-1641"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]},{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["IT","PL"],"is_corresponding":false,"raw_author_name":"Cecilia Scimmi","raw_affiliation_strings":["Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin Street, Torun, Poland","Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1 06100 Perugia (PG), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin Street, Torun, Poland","institution_ids":["https://openalex.org/I3019271933"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1 06100 Perugia (PG), Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066638672","display_name":"Ying Duan Lei","orcid":"https://orcid.org/0000-0001-9909-7006","observed_orcids":["https://orcid.org/0000-0001-9909-7006"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Lei","raw_affiliation_strings":["Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055088908","display_name":"Juan Kong","orcid":"https://orcid.org/0000-0002-0208-6296","observed_orcids":["https://orcid.org/0000-0002-0208-6296"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Kong","raw_affiliation_strings":["Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061840421","display_name":"Yao Zhao","orcid":"https://orcid.org/0000-0002-2932-2164","observed_orcids":["https://orcid.org/0000-0002-2932-2164"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Zhao","raw_affiliation_strings":["Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-2932-2164","affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086333993","display_name":"Karina Machado","orcid":"https://orcid.org/0000-0002-8966-5708","observed_orcids":["https://orcid.org/0000-0002-8966-5708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karina dos Santos Machado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068664163","display_name":"Adriano Velasque Werhli","orcid":"https://orcid.org/0000-0001-7107-5024","observed_orcids":["https://orcid.org/0000-0001-7107-5024"]},"institutions":[{"id":"https://openalex.org/I126460647","display_name":"Universidade Federal do Rio Grande","ror":"https://ror.org/05hpfkn88","country_code":"BR","type":"education","lineage":["https://openalex.org/I126460647"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriano Velasque Werhli","raw_affiliation_strings":["Laborat\u00f3rio de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande -FURG, Avenia It\u00e1lia, km 8, 96201-900, Rio Grande, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande -FURG, Avenia It\u00e1lia, km 8, 96201-900, Rio Grande, RS, Brazil","institution_ids":["https://openalex.org/I126460647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000460535","display_name":"Gianluca Ciancaleoni","orcid":"https://orcid.org/0000-0001-5113-2351","observed_orcids":["https://orcid.org/0000-0001-5113-2351"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Ciancaleoni","raw_affiliation_strings":["Dipartimento di Chimica e Chimica Industriale (DCCI) Universit\u00e0 di Pisa Via Giuseppe Moruzzi, 13 -56124 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Chimica e Chimica Industriale (DCCI) Universit\u00e0 di Pisa Via Giuseppe Moruzzi, 13 -56124 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091109300","display_name":"Vanessa Nascimento","orcid":"https://orcid.org/0000-0001-9413-7638","observed_orcids":["https://orcid.org/0000-0001-9413-7638"]},"institutions":[{"id":"https://openalex.org/I161127581","display_name":"Universidade Federal Fluminense","ror":"https://ror.org/02rjhbb08","country_code":"BR","type":"education","lineage":["https://openalex.org/I161127581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vanessa Nascimento","raw_affiliation_strings":["Departamento de Qu\u0131mica Organica, Universidade Federal Fluminense, Laboratorio de S\u0131ntese e Aplica\u00e7ao de Substancias Supramoleculares e Organocalcogenios (SupraSelen), Outeiro Sao Joao Batista s/n, 24020-141, Niteroi, RJ, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9413-7638","affiliations":[{"raw_affiliation_string":"Departamento de Qu\u0131mica Organica, Universidade Federal Fluminense, Laboratorio de S\u0131ntese e Aplica\u00e7ao de Substancias Supramoleculares e Organocalcogenios (SupraSelen), Outeiro Sao Joao Batista s/n, 24020-141, Niteroi, RJ, Brazil","institution_ids":["https://openalex.org/I161127581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101660501","display_name":"Anna Kula","orcid":"https://orcid.org/0000-0001-8404-2176","observed_orcids":["https://orcid.org/0000-0001-8404-2176"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Kula-Pacurar","raw_affiliation_strings":["Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland"],"raw_orcid":"https://orcid.org/0000-0001-8404-2176","affiliations":[{"raw_affiliation_string":"Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103096651","display_name":"Eder Joao Lenardao","orcid":"https://orcid.org/0000-0001-7920-3289","observed_orcids":["https://orcid.org/0000-0001-7920-3289"]},"institutions":[{"id":"https://openalex.org/I169248161","display_name":"Universidade Federal de Pelotas","ror":"https://ror.org/05msy9z54","country_code":"BR","type":"education","lineage":["https://openalex.org/I169248161"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eder Jo\u00e3o Lenard\u00e3o","raw_affiliation_strings":["Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clean Organic Synthesis, Federal University of Pelotas, Pelotas, RS, Brazil","institution_ids":["https://openalex.org/I169248161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013550923","display_name":"Haitao Yang","orcid":"https://orcid.org/0000-0002-1875-3268","observed_orcids":["https://orcid.org/0000-0002-1875-3268"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haitao Yang","raw_affiliation_strings":["Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050276174","display_name":"Jacek \u015acianowski","orcid":"https://orcid.org/0000-0002-3868-2022","observed_orcids":["https://orcid.org/0000-0002-3868-2022"]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jacek \u015acianowski","raw_affiliation_strings":["Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin Street, Torun, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin Street, Torun, Poland","institution_ids":["https://openalex.org/I3019271933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066890613","display_name":"Krzysztof Pyr\u0107","orcid":"https://orcid.org/0000-0002-3867-7688","observed_orcids":["https://orcid.org/0000-0002-3867-7688"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Krzysztof Pyrc","raw_affiliation_strings":["Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041279745","display_name":"Claudio Santi","orcid":"https://orcid.org/0000-0002-7698-8970","observed_orcids":["https://orcid.org/0000-0002-7698-8970"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Santi","raw_affiliation_strings":["University of Perugia"],"raw_orcid":"https://orcid.org/0000-0002-7698-8970","affiliations":[{"raw_affiliation_string":"University of Perugia","institution_ids":["https://openalex.org/I27483092"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/main-protease","display_name":"main protease","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mpro-inhibition","display_name":"Mpro inhibition","score":0.8320000171661377},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.7229999899864197},{"id":"https://openalex.org/keywords/diselenides","display_name":"diselenides","score":0.8500000238418579},{"id":"https://openalex.org/keywords/thiol-exchange","display_name":"thiol exchange","score":0.9549999833106995},{"id":"https://openalex.org/keywords/electrophilicity","display_name":"electrophilicity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/pains","display_name":"PAINS","score":0.5070000290870667},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6019999980926514},{"id":"https://openalex.org/keywords/cytopathic-effect","display_name":"cytopathic effect","score":0.9089999794960022},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2779138974","wikidata":"https://www.wikidata.org/wiki/Q5332073","display_name":"Ebselen","level":5,"score":0.9538426399230957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7490144371986389},{"id":"https://openalex.org/C50027330","wikidata":"https://www.wikidata.org/wiki/Q908086","display_name":"Electrophile","level":3,"score":0.7385944724082947},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.6308068037033081},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5970181226730347},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.48432862758636475},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.45120322704315186},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42990145087242126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3801504671573639},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34059956669807434},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.2088564932346344},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.26434/chemrxiv.12994250.v1","doi":"https://doi.org/10.26434/chemrxiv.12994250.v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.12994250.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/12994250","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/preprint/Organoselenium_mild_electrophiles_in_the_inhibition_of_Mpro_and_SARSCoV-2_replication/12994250","pdf_url":null,"source":{"id":"https://openalex.org/S7407051385","display_name":"Royal College of Surgeons in Ireland","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142762351","host_organization_name":"Royal College of Surgeons in Ireland","host_organization_lineage":["https://openalex.org/I142762351"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.12994250.v1","doi":"https://doi.org/10.26434/chemrxiv.12994250.v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.12994250.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326523","display_name":"Universit\u00e0 degli Studi di Perugia","ror":"https://ror.org/00x27da85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1980275264","https://openalex.org/W2069762003","https://openalex.org/W2072013113","https://openalex.org/W2074473216","https://openalex.org/W2081303563","https://openalex.org/W2126707939","https://openalex.org/W2134967712","https://openalex.org/W2138324310","https://openalex.org/W2169152034","https://openalex.org/W2169678694","https://openalex.org/W2178118169","https://openalex.org/W2261821674","https://openalex.org/W2461611299","https://openalex.org/W2599721096","https://openalex.org/W2739439285","https://openalex.org/W2766241187","https://openalex.org/W2783575921","https://openalex.org/W2810049713","https://openalex.org/W2951800009","https://openalex.org/W2982521641","https://openalex.org/W2991015252","https://openalex.org/W3006812547","https://openalex.org/W3015608194","https://openalex.org/W3018039793","https://openalex.org/W3022197074","https://openalex.org/W3024153111","https://openalex.org/W3024246131","https://openalex.org/W3027085332","https://openalex.org/W3037487072","https://openalex.org/W3048243203","https://openalex.org/W4205392594"],"related_works":["https://openalex.org/W3165497123","https://openalex.org/W3212167288","https://openalex.org/W3210273423","https://openalex.org/W3211557502","https://openalex.org/W4313573932","https://openalex.org/W7118090810","https://openalex.org/W4386569695","https://openalex.org/W4379537808","https://openalex.org/W3180026098","https://openalex.org/W4388595458"],"abstract_inverted_index":{"New":[0],"Ebselen-like":[1,77],"derivatives":[2,78,210],"resulted":[3],"to":[4,39,45,59,73,163,197,201,234],"be":[5,46,107,245],"very":[6,67],"strong":[7],"in":[8,33,90,110,118,128,136,142,155,171],"vitro":[9,129],"inhibitors":[10],"of":[11,25,139,151,167,174,183,208,214,219,256],"SARS-CoV-2":[12],"main":[13],"protease.":[14],"We":[15,123],"demonstrated":[16,125],"that":[17,29,55,70,105,126,148,241],"this":[18,189],"activity":[19,131,204,255],"mainly":[20],"depends":[21],"on":[22],"the":[23,26,34,40,84,91,94,112,119,127,137,143,149,152,156,165,168,172,184,203,206,212,215,223,236,251],"electrophilicity":[24],"selenium":[27,100],"atom":[28],"is":[30,132,159,194],"considerably":[31],"higher":[32],"N-substituted":[35],"1,2-":[36],"benzoselenazol-3(2H)-ones":[37],"respect":[38],"corresponding":[41],"diselenides":[42],"allowing":[43],"it":[44],"rapidly":[47],"attached":[48],"by":[49],"free":[50,87,96],"thiols":[51,88],"affording":[52],"sulfur-selenium":[53],"intermediates":[54,101],"are":[56,102],"further":[57],"subjected":[58],"thiol":[60,175],"exchange":[61],"processes.":[62],"This":[63,146],"data":[64],"paints":[65],"a":[66,160,231],"complex":[68],"scenario":[69],"requires":[71],"us":[72],"consider":[74,249],"Ebselen":[75,157,209,257],"and":[76,205,258],"as":[79,115,117,177,179],"potential":[80],"electrophilic":[81],"substrates":[82],"for":[83,180],"several":[85],"other":[86,242],"present":[89],"cell":[92],"beside":[93],"target":[95],"cysteine.":[97,187],"The":[98],"sulfur":[99],"milder":[103],"electrophiles":[104],"could":[106,244],"theoretically":[108],"implicated":[109],"both":[111],"detoxification":[113],"process":[114],"well":[116,178],"final":[120],"enzymatic":[121,186],"inhibition.":[122],"here":[124,250],"inhibition":[130],"not":[133],"fully":[134],"reproduced":[135],"prevention":[138],"viral":[140],"replication":[141],"cell-based":[144],"assay.":[145],"indicates":[147],"structure":[150],"substituents":[153],"introduced":[154],"scaffold":[158],"crucial":[161],"factor":[162],"control":[164],"reactivity":[166],"selenated":[169],"molecule":[170],"network":[173],"exchanges,":[176],"molecular":[181],"recognition":[182],"targeted":[185],"For":[188],"reason,":[190],"an":[191],"in-depth":[192],"investigation":[193],"strongly":[195],"desirable":[196],"better":[198],"understand":[199],"how":[200],"increase":[202],"selectivity":[207],"overcoming":[211],"issues":[213],"apparent":[216],"PAINS-like":[217],"role":[218],"Ebselen.":[220],"Furthermore,":[221],"besides":[222],"antiviral":[224],"activity,":[225],"thee":[226],"selected":[227],"compounds":[228],"also":[229],"showed":[230],"different":[232],"ability":[233],"reduce":[235],"virus-induced":[237],"cytopathic":[238],"effect,":[239],"indicating":[240],"mechanisms":[243],"implicated.":[246],"One":[247],"may":[248],"well-known":[252],"cytoprotective":[253],"antioxidant":[254],"its":[259],"derivatives.":[260]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2021-11-08T00:00:00"}