{"id":"https://openalex.org/W3211070989","doi":"https://doi.org/10.2174/1389450122666211103165837","title":"Potential Implications of Angiotensin-converting Enzyme 2 Blockades on Neuroinflammation in SARS-CoV-2 Infection","display_name":"Potential Implications of Angiotensin-converting Enzyme 2 Blockades on Neuroinflammation in SARS-CoV-2 Infection","publication_year":2021,"publication_date":"2021-11-04","ids":{"openalex":"https://openalex.org/W3211070989","doi":"https://doi.org/10.2174/1389450122666211103165837","mag":"3211070989","pmid":"https://pubmed.ncbi.nlm.nih.gov/34732115"},"language":"en","primary_location":{"id":"doi:10.2174/1389450122666211103165837","doi":"https://doi.org/10.2174/1389450122666211103165837","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1389450122666211103165837","pdf_url":null,"source":{"id":"https://openalex.org/S140884253","display_name":"Current Drug Targets","issn_l":"1389-4501","issn":["1389-4501","1873-5592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Targets","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063309869","display_name":"Deepraj Paul","orcid":"https://orcid.org/0000-0001-9782-3350","observed_orcids":["https://orcid.org/0000-0001-9782-3350"]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deepraj Paul","raw_affiliation_strings":["TIFAC CORE in Herbal Drugs, Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher\nEducation & Research, Rocklands, Ooty, The Nilgiris 643001, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIFAC CORE in Herbal Drugs, Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher\nEducation & Research, Rocklands, Ooty, The Nilgiris 643001, Tamil Nadu, India","institution_ids":["https://openalex.org/I126824641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101511892","display_name":"Suresh K. Mohankumar","orcid":"https://orcid.org/0000-0001-8862-2979","observed_orcids":["https://orcid.org/0000-0001-8862-2979"]},"institutions":[{"id":"https://openalex.org/I39586589","display_name":"Swansea University","ror":"https://ror.org/053fq8t95","country_code":"GB","type":"education","lineage":["https://openalex.org/I39586589"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Suresh K. Mohankumar","raw_affiliation_strings":["Swansea University Medical School, Swansea University, Singleton Park, Wales SA2 8PP, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-8862-2979","affiliations":[{"raw_affiliation_string":"Swansea University Medical School, Swansea University, Singleton Park, Wales SA2 8PP, United Kingdom","institution_ids":["https://openalex.org/I39586589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073194262","display_name":"Rhian S. Thomas","orcid":"https://orcid.org/0000-0002-7286-2764","observed_orcids":["https://orcid.org/0000-0002-7286-2764"]},"institutions":[{"id":"https://openalex.org/I39586589","display_name":"Swansea University","ror":"https://ror.org/053fq8t95","country_code":"GB","type":"education","lineage":["https://openalex.org/I39586589"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rhian S. Thomas","raw_affiliation_strings":["Swansea University Medical\nSchool, Swansea University, Singleton Park, Wales SA2 8PP, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swansea University Medical\nSchool, Swansea University, Singleton Park, Wales SA2 8PP, United Kingdom","institution_ids":["https://openalex.org/I39586589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109524407","display_name":"Chai B. Kheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chai B. Kheng","raw_affiliation_strings":["Institute of Molecular Biology,\nAcademia Sinica, 128 Academia Road Section 2, Nangang District, Taipei City11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology,\nAcademia Sinica, 128 Academia Road Section 2, Nangang District, Taipei City11529, Taiwan","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114083346","display_name":"Duraiswamy Basavan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126824641","display_name":"JSS Academy of Higher Education and Research","ror":"https://ror.org/013x70191","country_code":"IN","type":"education","lineage":["https://openalex.org/I126824641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Duraiswamy Basavan","raw_affiliation_strings":["TIFAC CORE in Herbal Drugs, Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher\nEducation & Research, Rocklands, Ooty, The Nilgiris 643001, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIFAC CORE in Herbal Drugs, Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher\nEducation & Research, Rocklands, Ooty, The Nilgiris 643001, Tamil Nadu, India","institution_ids":["https://openalex.org/I126824641"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101511892"],"corresponding_institution_ids":["https://openalex.org/I39586589"],"apc_list":null,"apc_paid":null,"fwci":0.0497,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.11949375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"4","first_page":"364","last_page":"372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.7279999852180481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.7279999852180481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.12380000203847885,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.05829999968409538,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme-2","display_name":"angiotensin-converting enzyme 2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9990000128746033},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.984000027179718},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neuroprotective-peptides","display_name":"neuroprotective peptides","score":0.6830000281333923},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.7509999871253967},{"id":"https://openalex.org/keywords/apelin-13","display_name":"apelin-13","score":0.6439999938011169},{"id":"https://openalex.org/keywords/covid-19-severity","display_name":"COVID-19 severity","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8409960865974426},{"id":"https://openalex.org/C2775946041","wikidata":"https://www.wikidata.org/wiki/Q14875321","display_name":"Angiotensin-converting enzyme 2","level":5,"score":0.7087211608886719},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6767871975898743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6207711696624756},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5553339719772339},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5456108450889587},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5234179496765137},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.48477715253829956},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.4318813383579254},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3903507888317108},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33100253343582153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32659709453582764},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31932514905929565},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3156224489212036},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.27711939811706543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15235522389411926},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1373574137687683},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.07665863633155823},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2174/1389450122666211103165837","doi":"https://doi.org/10.2174/1389450122666211103165837","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1389450122666211103165837","pdf_url":null,"source":{"id":"https://openalex.org/S140884253","display_name":"Current Drug Targets","issn_l":"1389-4501","issn":["1389-4501","1873-5592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Targets","raw_type":"journal-article"},{"id":"pmid:34732115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34732115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug targets","raw_type":"Journal Article"},{"id":"pmh:oai:cronfa.swan.ac.uk:cronfa58742","doi":null,"is_oa":false,"landing_page_url":"https://cronfa.swan.ac.uk/Record/cronfa58742","pdf_url":null,"source":{"id":"https://openalex.org/S4306401612","display_name":"Cronfa (Swansea University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39586589","host_organization_name":"Swansea University","host_organization_lineage":["https://openalex.org/I39586589"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W187333225","https://openalex.org/W1480124154","https://openalex.org/W1519321668","https://openalex.org/W1911237238","https://openalex.org/W1966865110","https://openalex.org/W1968659654","https://openalex.org/W2006199986","https://openalex.org/W2012358869","https://openalex.org/W2031777104","https://openalex.org/W2032062610","https://openalex.org/W2032965353","https://openalex.org/W2034004569","https://openalex.org/W2040695574","https://openalex.org/W2049521850","https://openalex.org/W2088112872","https://openalex.org/W2092494622","https://openalex.org/W2100021456","https://openalex.org/W2111661564","https://openalex.org/W2118594384","https://openalex.org/W2139876205","https://openalex.org/W2149356826","https://openalex.org/W2150905655","https://openalex.org/W2162721194","https://openalex.org/W2167384912","https://openalex.org/W2168782395","https://openalex.org/W2313889229","https://openalex.org/W2329336071","https://openalex.org/W2345586879","https://openalex.org/W2401854918","https://openalex.org/W2522692264","https://openalex.org/W2536701740","https://openalex.org/W2559307267","https://openalex.org/W2572076579","https://openalex.org/W2792200090","https://openalex.org/W2911084911","https://openalex.org/W2919182632","https://openalex.org/W2939381803","https://openalex.org/W2942166600","https://openalex.org/W2954314772","https://openalex.org/W2971465822","https://openalex.org/W2994276827","https://openalex.org/W3004342498","https://openalex.org/W3009120067","https://openalex.org/W3010126769","https://openalex.org/W3013270768","https://openalex.org/W3013529907","https://openalex.org/W3014023397","https://openalex.org/W3014571869","https://openalex.org/W3015379548","https://openalex.org/W3017331996","https://openalex.org/W3018322638","https://openalex.org/W3019849260","https://openalex.org/W3021640348","https://openalex.org/W3024021053","https://openalex.org/W3025048372","https://openalex.org/W3027462748","https://openalex.org/W3028333352","https://openalex.org/W3033051725","https://openalex.org/W3035828702","https://openalex.org/W3042338201","https://openalex.org/W3047375053","https://openalex.org/W3054686440","https://openalex.org/W3082724465","https://openalex.org/W3091122434","https://openalex.org/W3122083218","https://openalex.org/W3122343326"],"related_works":["https://openalex.org/W3215052852","https://openalex.org/W3044495130","https://openalex.org/W3101784203","https://openalex.org/W3041146203","https://openalex.org/W4392457988","https://openalex.org/W3026386488","https://openalex.org/W3133772724","https://openalex.org/W3036500066","https://openalex.org/W3125556141","https://openalex.org/W3041270343"],"abstract_inverted_index":{"BACKGROUND:":[0],"Angiotensin-converting":[1],"enzyme":[2,77],"2":[3,18,208],"(ACE2)":[4],"has":[5,224],"been":[6,53,225],"reported":[7],"as":[8],"a":[9,44,132,159],"portal":[10],"for":[11],"the":[12,58,139,147,163,182,201,214],"severe":[13,136],"acute":[14],"respiratory":[15],"syndrome":[16],"coronavirus":[17,26],"(SARS-CoV-2)":[19],"infection.":[20],"Consequently,":[21],"scientific":[22],"strategies":[23],"to":[24,33,47,57],"combat":[25],"disease":[27,137],"of":[28,62,126,135,150,162,165,204,217],"2019":[29],"(COVID-19)":[30],"were":[31],"targeted":[32],"arrest":[34],"SARS-CoV-2":[35,140],"invasion":[36,209],"by":[37],"blocking":[38,41],"ACE2.":[39],"While":[40],"ACE2":[42,63,81,83,127,166,205,218,228],"appears":[43],"beneficial":[45,148],"approach":[46],"treat":[48],"COVID-19,":[49],"clinical":[50,144],"concerns":[51],"have":[52,123],"raised":[54],"primarily":[55],"due":[56],"various":[59],"intrinsic":[60],"roles":[61,203],"in":[64,152,168,206],"neurological":[65],"functions.":[66],"Selective":[67],"reports":[68,145],"indicate":[69,146],"that":[70,114,227],"angiotensin":[71,85],"receptor":[72],"blockers":[73],"(ARBs)":[74],"and":[75,87,97,106,120,128,174,187,210,213],"angiotensin-converting":[76],"inhibitors":[78],"(ACEIs)":[79],"upregulate":[80,108],"levels.":[82],"metabolizes":[84],"II":[86],"several":[88],"peptides,":[89],"including":[90],"apelin-13,":[91],"neurotensin,":[92],"kinetensin,":[93],"dynorphin,":[94],"(des-Arg9)":[95],"bradykinin,":[96],"(Lys-des-Arg9)-bradykinin,":[98],"which":[99],"may":[100,111,122],"elicit":[101],"neuroprotective":[102],"effects.":[103],"Since":[104],"ARBs":[105,119],"ACEIs":[107,121],"ACE2,":[109],"it":[110],"be":[112,130],"hypothesized":[113],"patients":[115,170],"with":[116,172],"hypertension":[117],"receiving":[118],"higher":[124],"expression":[125],"thus":[129],"at":[131],"greater":[133],"risk":[134],"from":[138],"infections.":[141],"However,":[142,181],"recent":[143],"role":[149],"ARBs/ACEIs":[151],"reducing":[153],"COVID-19":[154],"severity.":[155],"Together,":[156],"this":[157],"warrants":[158],"further":[160,192],"study":[161],"effects":[164],"blockades":[167],"hypertensive":[169],"medicated":[171],"ARBs/ACEIs,":[173],"their":[175,185],"consequential":[176],"impact":[177,216],"on":[178,220],"neuronal":[179],"health.":[180],"associations":[183],"between":[184],"blockade":[186,219,229],"any":[188],"neuroinflammation":[189],"also":[190],"warrant":[191],"research.":[193],"OBJECTIVE:":[194],"This":[195],"review":[196],"collates":[197],"mechanistic":[198],"insights":[199],"into":[200],"dichotomous":[202],"SARSCoV-":[207],"neurometabolic":[211],"functions":[212],"possible":[215],"neuroinflammation.":[221,231],"CONCLUSION:":[222],"It":[223],"concluded":[226],"imposes":[230]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-11-08T00:00:00"}