{"id":"https://openalex.org/W3211030556","doi":"https://doi.org/10.1080/01902148.2021.1998734","title":"House dust mite-derived allergens effect on matrix metalloproteases in airway epithelial cells","display_name":"House dust mite-derived allergens effect on matrix metalloproteases in airway epithelial cells","publication_year":2021,"publication_date":"2021-10-21","ids":{"openalex":"https://openalex.org/W3211030556","doi":"https://doi.org/10.1080/01902148.2021.1998734","mag":"3211030556","pmid":"https://pubmed.ncbi.nlm.nih.gov/34739337"},"language":"en","primary_location":{"id":"doi:10.1080/01902148.2021.1998734","doi":"https://doi.org/10.1080/01902148.2021.1998734","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01902148.2021.1998734","pdf_url":null,"source":{"id":"https://openalex.org/S97217451","display_name":"Experimental Lung Research","issn_l":"0190-2148","issn":["0190-2148","1521-0499"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Lung Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068160174","display_name":"Dilara Karag\u00fczel","orcid":"https://orcid.org/0000-0001-5986-4311","observed_orcids":["https://orcid.org/0000-0001-5986-4311"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Dilara Karaguzel","raw_affiliation_strings":["Department of Biology, Molecular Biology Section, Faculty of Science, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Biology Section, Faculty of Science, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074691708","display_name":"Basak Ezgi Sarac","orcid":"https://orcid.org/0000-0003-1181-4598","observed_orcids":["https://orcid.org/0000-0003-1181-4598"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Basak Ezgi Sarac","raw_affiliation_strings":["Department of Biology, Molecular Biology Section, Faculty of Science, Hacettepe University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Biology Section, Faculty of Science, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069778739","display_name":"Hayriye Akel Bilgi\u00e7","orcid":"https://orcid.org/0000-0002-2950-2093","observed_orcids":["https://orcid.org/0000-0002-2950-2093"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hayriye Akel Bilgic","raw_affiliation_strings":["Department of Biology, Molecular Biology Section, Faculty of Science, Hacettepe University, Ankara, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-2950-2093","affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Biology Section, Faculty of Science, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042388578","display_name":"G\u00f6k\u00e7e Ya\u011fmur Summak","orcid":"https://orcid.org/0000-0001-6274-3385","observed_orcids":["https://orcid.org/0000-0001-6274-3385"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gokce Yagmur Summak","raw_affiliation_strings":["Department of Physics Engineering, Faculty of Engineering, Ankara University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics Engineering, Faculty of Engineering, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031770088","display_name":"Mehmet Altay \u00dcnal","orcid":"https://orcid.org/0000-0001-8607-5043","observed_orcids":["https://orcid.org/0000-0001-8607-5043"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Altay Unal","raw_affiliation_strings":["Department of Physics Engineering, Faculty of Engineering, Ankara University, Ankara, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-8607-5043","affiliations":[{"raw_affiliation_string":"Department of Physics Engineering, Faculty of Engineering, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046715953","display_name":"\u00d6mer Kalayc\u0131","orcid":"https://orcid.org/0000-0001-8715-5694","observed_orcids":["https://orcid.org/0000-0001-8715-5694"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Omer Kalayci","raw_affiliation_strings":["Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-8715-5694","affiliations":[{"raw_affiliation_string":"Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082551903","display_name":"\u00c7a\u011fatay Karaaslan","orcid":"https://orcid.org/0000-0003-4857-0857","observed_orcids":["https://orcid.org/0000-0003-4857-0857"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Cagatay Karaaslan","raw_affiliation_strings":["Department of Biology, Molecular Biology Section, Faculty of Science, Hacettepe University, Ankara, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-4857-0857","affiliations":[{"raw_affiliation_string":"Department of Biology, Molecular Biology Section, Faculty of Science, Hacettepe University, Ankara, Turkey","institution_ids":["https://openalex.org/I66514158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082551903"],"corresponding_institution_ids":["https://openalex.org/I66514158"],"apc_list":null,"apc_paid":null,"fwci":1.6156,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79468495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"47","issue":"9","first_page":"436","last_page":"450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.5800999999046326,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.5800999999046326,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.4066999852657318,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/house-dust-mite-allergens","display_name":"house dust mite allergens","score":0.9990000128746033},{"id":"https://openalex.org/keywords/der-p-1","display_name":"Der p 1","score":0.8130000233650208},{"id":"https://openalex.org/keywords/der-p-2","display_name":"Der p 2","score":1.0},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/epithelial-permeability","display_name":"epithelial permeability","score":0.8830000162124634},{"id":"https://openalex.org/keywords/thermal-denaturation","display_name":"thermal denaturation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/allergen-structure","display_name":"allergen structure","score":0.6579999923706055},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8349999785423279},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9739999771118164},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9850000143051147},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7059483528137207},{"id":"https://openalex.org/C177430391","wikidata":"https://www.wikidata.org/wiki/Q1173648","display_name":"Zymography","level":3,"score":0.6872115731239319},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5663307905197144},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5361307859420776},{"id":"https://openalex.org/C2777283782","wikidata":"https://www.wikidata.org/wiki/Q419343","display_name":"Cysteine protease","level":4,"score":0.530763566493988},{"id":"https://openalex.org/C2778166374","wikidata":"https://www.wikidata.org/wiki/Q29938","display_name":"House dust mite","level":4,"score":0.5139316916465759},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.510380208492279},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49690917134284973},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.48258936405181885},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.45866551995277405},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.41607195138931274},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3815872371196747},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.33549776673316956},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3103589415550232},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30091187357902527},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28572237491607666},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2678161859512329},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21221324801445007},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.19377297163009644},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004391","descriptor_name":"Dust","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039741","descriptor_name":"Antigens, Dermatophagoides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039981","descriptor_name":"Pyroglyphidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/01902148.2021.1998734","doi":"https://doi.org/10.1080/01902148.2021.1998734","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01902148.2021.1998734","pdf_url":null,"source":{"id":"https://openalex.org/S97217451","display_name":"Experimental Lung Research","issn_l":"0190-2148","issn":["0190-2148","1521-0499"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Lung Research","raw_type":"journal-article"},{"id":"pmid:34739337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34739337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental lung research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"},{"id":"https://openalex.org/F4320323272","display_name":"Hacettepe \u00dcniversitesi","ror":"https://ror.org/04kwvgz42"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1487177241","https://openalex.org/W1489193873","https://openalex.org/W1862975947","https://openalex.org/W1966218896","https://openalex.org/W1985879208","https://openalex.org/W1996955331","https://openalex.org/W2007990665","https://openalex.org/W2011569383","https://openalex.org/W2012346988","https://openalex.org/W2012778341","https://openalex.org/W2017988098","https://openalex.org/W2021571733","https://openalex.org/W2035220900","https://openalex.org/W2051381895","https://openalex.org/W2055685990","https://openalex.org/W2059326285","https://openalex.org/W2062919894","https://openalex.org/W2063063715","https://openalex.org/W2072144864","https://openalex.org/W2074389578","https://openalex.org/W2085600133","https://openalex.org/W2085624556","https://openalex.org/W2095499340","https://openalex.org/W2096843723","https://openalex.org/W2098248531","https://openalex.org/W2102869731","https://openalex.org/W2115059491","https://openalex.org/W2121856873","https://openalex.org/W2125376271","https://openalex.org/W2139839269","https://openalex.org/W2144944593","https://openalex.org/W2161938158","https://openalex.org/W2164402028","https://openalex.org/W2215171161","https://openalex.org/W2529215255","https://openalex.org/W2570844862","https://openalex.org/W2680106545","https://openalex.org/W2730402578","https://openalex.org/W2737373628","https://openalex.org/W2759454477","https://openalex.org/W2769449671","https://openalex.org/W2808597111","https://openalex.org/W2922576528","https://openalex.org/W2971739096","https://openalex.org/W2991015982","https://openalex.org/W3013017400","https://openalex.org/W3014757079","https://openalex.org/W3016897056","https://openalex.org/W3035762603","https://openalex.org/W3038048939","https://openalex.org/W3194832321"],"related_works":["https://openalex.org/W1489193873","https://openalex.org/W1966218896","https://openalex.org/W2047094561","https://openalex.org/W2729891005","https://openalex.org/W2065965303","https://openalex.org/W2393612618","https://openalex.org/W2164402028","https://openalex.org/W2082193399","https://openalex.org/W7100020432","https://openalex.org/W2618942607"],"abstract_inverted_index":{"Aim":[0],"of":[1,13,37,101,163,175,191,239,250],"the":[2,10,19,35,119,173,189,244],"Study:":[3],"Many":[4],"allergens":[5,42],"have":[6],"protease":[7,24,45,80,252],"activities.":[8,253],"Although":[9],"immunomodulatory":[11],"effects":[12,20,36],"these":[14],"antigens":[15],"are":[16,26,237],"well":[17],"known,":[18],"attributed":[21,180],"to":[22,33,181,184],"their":[23,251],"activities":[25,46],"not":[27,137],"thoroughly":[28],"investigated.":[29],"We":[30],"set":[31],"out":[32],"determine":[34],"house":[38,234],"dust":[39,235],"mite":[40],"(HDM)":[41],"with":[43,63,76,92,224],"varying":[44],"on":[47,104],"bronchial":[48],"epithelial":[49,88,245],"cell":[50,246],"functions.":[51],"Materials":[52],"and":[53,61,72,77,87,94,124,150,194,198,206,227],"methods:":[54],"BEAS-2B":[55],"cells":[56],"were":[57,90,116,201],"maintained":[58],"in":[59,110,176,233,243],"ALI-culture":[60],"stimulated":[62],"Der":[64,68,73,134,139,142,145,154,164,204,207,212,218,225,229],"p1":[65,140,155,165,205,219],"(cysteine":[66],"protease),":[67,71],"p6":[69,135,213,226],"(serine":[70],"p2":[74,143,146,208],"(non-protease)":[75],"without":[78],"specific":[79],"inhibitors":[81],"or":[82,141],"heat":[83,102],"denaturation.":[84],"Cell":[85],"viability":[86],"permeability":[89,130],"measured":[91],"MTT":[93],"paracellular":[95],"flux":[96],"assay,":[97],"respectively.":[98],"The":[99,160],"effect":[100],"denaturation":[103],"allergen":[105],"structure":[106],"was":[107,179],"examined":[108],"using":[109],"silico":[111,177],"models.":[112],"Matrix":[113],"metalloproteinases":[114],"(MMPs)":[115],"investigated":[117],"at":[118],"transcription":[120],"(qPCR),":[121],"protein":[122],"(ELISA),":[123],"functional":[125],"(zymography)":[126],"levels.":[127],"Results:":[128],"Epithelial":[129],"increased":[131,147,156,167,202,221],"only":[132,157],"after":[133,138,203,211,217],"but":[136,209,220],"stimulation.":[144,214],"both":[148],"MMP-2":[149],"MMP-9":[151,158,168],"expression,":[152,170],"while":[153],"expression.":[159],"heat-denatured":[161,228],"form":[162],"unexpectedly":[166],"gene":[169],"which,":[171],"through":[172],"use":[174],"models,":[178],"its":[182],"ability":[183],"change":[185],"receptor":[186],"connections":[187],"by":[188,248],"formation":[190],"new":[192],"electrostatic":[193],"hydrogen":[195],"bonds.":[196],"IL-8":[197],"GM-CSF":[199],"production":[200],"decreased":[210,216],"IL-6":[215],"following":[222],"stimulation":[223],"p2.":[230],"Conclusion:":[231],"Allergens":[232],"mites":[236],"capable":[238],"inducing":[240],"various":[241],"changes":[242],"functions":[247],"virtue":[249]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-11-08T00:00:00"}