{"id":"https://openalex.org/W3211022969","doi":"https://doi.org/10.1016/j.jval.2021.09.005","title":"Performance of the UK Prospective Diabetes Study Outcomes Model 2 in a Contemporary UK Type 2 Diabetes Trial Cohort","display_name":"Performance of the UK Prospective Diabetes Study Outcomes Model 2 in a Contemporary UK Type 2 Diabetes Trial Cohort","publication_year":2021,"publication_date":"2021-10-27","ids":{"openalex":"https://openalex.org/W3211022969","doi":"https://doi.org/10.1016/j.jval.2021.09.005","mag":"3211022969","pmid":"https://pubmed.ncbi.nlm.nih.gov/35227456","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8881217"},"language":"en","primary_location":{"id":"doi:10.1016/j.jval.2021.09.005","doi":"https://doi.org/10.1016/j.jval.2021.09.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jval.2021.09.005","pdf_url":null,"source":{"id":"https://openalex.org/S678965","display_name":"Value in Health","issn_l":"1098-3015","issn":["1098-3015","1524-4733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Value in Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jval.2021.09.005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076150605","display_name":"Mi Jun Keng","orcid":"https://orcid.org/0000-0001-5979-1706","observed_orcids":["https://orcid.org/0000-0001-5979-1706"]},"institutions":[{"id":"https://openalex.org/I32003884","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I32003884"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mi Jun Keng","raw_affiliation_strings":["Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK; British Heart Foundation Centre of Research Excellence, Oxford, England, UK. Electronic address: mijun.keng@ndph.ox.ac.uk","British Heart Foundation Centre of Research Excellence, Oxford, England, UK","Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK; British Heart Foundation Centre of Research Excellence, Oxford, England, UK. Electronic address: mijun.keng@ndph.ox.ac.uk","institution_ids":["https://openalex.org/I32003884","https://openalex.org/I40120149"]},{"raw_affiliation_string":"British Heart Foundation Centre of Research Excellence, Oxford, England, UK","institution_ids":["https://openalex.org/I32003884"]},{"raw_affiliation_string":"Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062863205","display_name":"Jos\u00e9 Leal","orcid":"https://orcid.org/0000-0001-7870-6730","observed_orcids":["https://orcid.org/0000-0001-7870-6730"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jose Leal","raw_affiliation_strings":["Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085447535","display_name":"Marion M. Mafham","orcid":"https://orcid.org/0000-0003-0562-3963","observed_orcids":["https://orcid.org/0000-0003-0562-3963"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4387153988","display_name":"MRC Population Health Research Unit","ror":"https://ror.org/01p4s0142","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4387153988","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marion Mafham","raw_affiliation_strings":["Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4387153988"]},{"raw_affiliation_string":"Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4387153988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079958135","display_name":"Louise J. Bowman","orcid":"https://orcid.org/0000-0003-1125-8616","observed_orcids":["https://orcid.org/0000-0003-1125-8616"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4387153988","display_name":"MRC Population Health Research Unit","ror":"https://ror.org/01p4s0142","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4387153988","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise Bowman","raw_affiliation_strings":["Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4387153988"]},{"raw_affiliation_string":"Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4387153988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025156367","display_name":"Jane Armitage","orcid":"https://orcid.org/0000-0001-8691-9226","observed_orcids":["https://orcid.org/0000-0001-8691-9226"]},"institutions":[{"id":"https://openalex.org/I32003884","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I32003884"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4387153988","display_name":"MRC Population Health Research Unit","ror":"https://ror.org/01p4s0142","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210087105","https://openalex.org/I4387153988","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jane Armitage","raw_affiliation_strings":["British Heart Foundation Centre of Research Excellence, Oxford, England, UK; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","British Heart Foundation Centre of Research Excellence, Oxford, England, UK","Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Heart Foundation Centre of Research Excellence, Oxford, England, UK; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I32003884","https://openalex.org/I40120149","https://openalex.org/I4387153988"]},{"raw_affiliation_string":"British Heart Foundation Centre of Research Excellence, Oxford, England, UK","institution_ids":["https://openalex.org/I32003884"]},{"raw_affiliation_string":"Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4387153988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075617051","display_name":"Borislava Mihaylova","orcid":"https://orcid.org/0000-0002-0951-1304","observed_orcids":["https://orcid.org/0000-0002-0951-1304"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Borislava Mihaylova","raw_affiliation_strings":["Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK; Wolfson Institute of Population Health, Queen Mary University of London, London, England, UK","Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","Wolfson Institute of Population Health, Queen Mary University of London, London, England, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK; Wolfson Institute of Population Health, Queen Mary University of London, London, England, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Wolfson Institute of Population Health, Queen Mary University of London, London, England, UK","institution_ids":["https://openalex.org/I166337079"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076150605"],"corresponding_institution_ids":["https://openalex.org/I32003884","https://openalex.org/I40120149"],"apc_list":{"value":2850,"currency":"USD","value_usd":2850},"apc_paid":{"value":2850,"currency":"USD","value_usd":2850},"fwci":1.6387,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.84011416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"25","issue":"3","first_page":"435","last_page":"442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.41280001401901245,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.41280001401901245,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.3637999892234802,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction","display_name":"cardiovascular risk prediction","score":0.8309999704360962},{"id":"https://openalex.org/keywords/model-calibration","display_name":"model calibration","score":0.6679999828338623},{"id":"https://openalex.org/keywords/model-discrimination","display_name":"model discrimination","score":0.8040000200271606},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9100000262260437},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.9259999990463257},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ascend-trial","display_name":"ASCEND trial","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7573913335800171},{"id":"https://openalex.org/C2780920962","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"United Kingdom Prospective Diabetes Study","level":4,"score":0.7356767058372498},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6683304309844971},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.533137321472168},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.47605273127555847},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4676026403903961},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.45728060603141785},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4305742681026459},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.4156333804130554},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.342104971408844},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3335924744606018},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jval.2021.09.005","doi":"https://doi.org/10.1016/j.jval.2021.09.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jval.2021.09.005","pdf_url":null,"source":{"id":"https://openalex.org/S678965","display_name":"Value in Health","issn_l":"1098-3015","issn":["1098-3015","1524-4733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Value in Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8881217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8881217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Value Health","raw_type":"Text"},{"id":"pmid:35227456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35227456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research","raw_type":"Journal Article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:1a27d0da-8bda-4b4a-bb27-a193b574c07a","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:1a27d0da-8bda-4b4a-bb27-a193b574c07a","pdf_url":"https://ora.ox.ac.uk/objects/uuid:1a27d0da-8bda-4b4a-bb27-a193b574c07a","source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements","raw_type":"Journal article"},{"id":"mag:3198878190","doi":null,"is_oa":false,"landing_page_url":"https://www.ctsu.ox.ac.uk/publications/1193922","pdf_url":null,"source":{"id":"https://openalex.org/S678965","display_name":"Value in Health","issn_l":"1098-3015","issn":["1098-3015","1524-4733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Value in Health","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.jval.2021.09.005","doi":"https://doi.org/10.1016/j.jval.2021.09.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jval.2021.09.005","pdf_url":null,"source":{"id":"https://openalex.org/S678965","display_name":"Value in Health","issn_l":"1098-3015","issn":["1098-3015","1524-4733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Value in Health","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2509892817","display_name":"RENEWAL: ASCEND: a study of cardiovascular events in diabetes. A randomised study of aspirin and of omega-3 fatty acid supplementation for the primary prevention of cardiovascular events in diabetes","funder_award_id":"SP/08/010/25939","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G2628120876","display_name":null,"funder_award_id":"CH/1996001/9454","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G3926658862","display_name":"Research Excellence (renewal)","funder_award_id":"RE/13/1/30181","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G4221756634","display_name":null,"funder_award_id":"16896","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4587272","display_name":"ASCEND: A Study of Cardiovascular Events in Diabetes","funder_award_id":"SP/14/3/31114","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3211022969.pdf","grobid_xml":"https://content.openalex.org/works/W3211022969.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W85469694","https://openalex.org/W1524829680","https://openalex.org/W1967327975","https://openalex.org/W1976775719","https://openalex.org/W2001258453","https://openalex.org/W2017313359","https://openalex.org/W2037809152","https://openalex.org/W2038500678","https://openalex.org/W2039713231","https://openalex.org/W2041508558","https://openalex.org/W2054405610","https://openalex.org/W2061718307","https://openalex.org/W2078271269","https://openalex.org/W2089463633","https://openalex.org/W2091237544","https://openalex.org/W2100764138","https://openalex.org/W2112688502","https://openalex.org/W2119910794","https://openalex.org/W2120579447","https://openalex.org/W2126252058","https://openalex.org/W2130408910","https://openalex.org/W2131104198","https://openalex.org/W2134023402","https://openalex.org/W2145216999","https://openalex.org/W2149516335","https://openalex.org/W2151056789","https://openalex.org/W2157117527","https://openalex.org/W2171294019","https://openalex.org/W2302447233","https://openalex.org/W2337454357","https://openalex.org/W2345478245","https://openalex.org/W2516998275","https://openalex.org/W2520696266","https://openalex.org/W2554127971","https://openalex.org/W2743505738","https://openalex.org/W2762777606","https://openalex.org/W2770196824","https://openalex.org/W2777318825","https://openalex.org/W2778919216","https://openalex.org/W2779357131","https://openalex.org/W2899755710","https://openalex.org/W2900151286","https://openalex.org/W2908662562","https://openalex.org/W2944448728","https://openalex.org/W2966012900","https://openalex.org/W2976081967","https://openalex.org/W3047004355","https://openalex.org/W3110290578","https://openalex.org/W3114602469","https://openalex.org/W3122152400","https://openalex.org/W3186441515","https://openalex.org/W4229629337"],"related_works":["https://openalex.org/W3198878190","https://openalex.org/W2966012900","https://openalex.org/W3114602469","https://openalex.org/W2091237544","https://openalex.org/W2118236795","https://openalex.org/W3213176896","https://openalex.org/W2017313359","https://openalex.org/W2131104198","https://openalex.org/W4416138362","https://openalex.org/W4311496638"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,82,145,166,222],"UK":[2,42,76],"Prospective":[3],"Diabetes":[4,67],"Study":[5,62],"(UKPDS)":[6],"Outcomes":[7],"Model":[8],"(UKPDS-OM)":[9],"developed":[10],"using":[11,58],"30-year":[12],"(1977-2007)":[13],"data":[14,59],"from":[15,60,217],"the":[16,49,55,75,88,106,138,178,194],"UKPDS":[17],"is":[18,45],"widely":[19],"used":[20,85,160],"for":[21,30,40,142,196,212,248],"health":[22],"outcomes'":[23],"projections":[24],"and":[25,79,102,126,134,174,186,198,205,231],"economic":[26],"evaluations":[27],"of":[28,51,54,63,90,124,137,156,193,227,250,253],"therapies":[29],"patients":[31],"with":[32,72,110,235],"type":[33],"2":[34,53],"diabetes":[35,73],"(T2D).":[36],"Nevertheless,":[37],"its":[38],"reliability":[39],"contemporary":[41,256],"T2D":[43,111,236,257],"populations":[44],"unclear.":[46],"We":[47],"assessed":[48,141],"performance":[50],"version":[52],"model":[56,139,163,195,244],"(UKPDS-OM2)":[57],"A":[61],"Cardiovascular":[64],"Events":[65],"in":[66,74,112,148,233,237,255],"(ASCEND),":[68],"which":[69],"followed":[70],"participants":[71,109],"between":[77],"2005":[78],"2017.":[80],"METHODS:":[81],"UKPDS-OM2":[83,167,223],"was":[84,159,208],"to":[86,161,219],"predict":[87],"occurrence":[89],"myocardial":[91],"infarction":[92],"(MI),":[93],"other":[94,103,175,199,213],"ischemic":[95,200],"heart":[96,201],"disease,":[97],"stroke,":[98,171],"cardiovascular":[99],"(CV)":[100],"death,":[101,173],"death":[104,176,232],"among":[105],"14":[107],"569":[108],"ASCEND,":[113],"all":[114],"without":[115],"previous":[116],"CV":[117,172,229],"disease":[118,202],"at":[119,151,189],"study":[120],"entry.":[121],"Calibration":[122],"(comparison":[123],"predicted":[125],"observed":[127],"year-on-year":[128],"cumulative":[129],"incidence":[130],"over":[131,177],"10":[132],"years)":[133],"discrimination":[135],"(c-statistics)":[136],"were":[140],"each":[143],"endpoint.":[144],"percentage":[146],"error":[147],"event":[149],"rates":[150],"year":[152,190],"7":[153],"(mean":[154],"duration":[155],"follow":[157],"up)":[158],"quantify":[162],"bias.":[164],"RESULTS:":[165],"substantially":[168,224],"overpredicted":[169,225],"MI,":[170],"10-year":[179],"follow-up":[180],"period":[181],"(by":[182],"149%,":[183],"42%,":[184],"269%,":[185],"52%,":[187],"respectively,":[188],"7).":[191],"Discrimination":[192],"MI":[197],"(c-statistics":[203,215],"0.58":[204],"0.60,":[206],"respectively)":[207],"poorer":[209],"than":[210],"that":[211],"outcomes":[214,230],"ranging":[216],"0.66":[218],"0.72).":[220],"CONCLUSIONS:":[221],"risks":[226],"key":[228],"people":[234],"ASCEND.":[238],"Appropriate":[239],"adjustments":[240],"or":[241],"a":[242],"new":[243],"may":[245],"be":[246],"required":[247],"assessments":[249],"long-term":[251],"effects":[252],"treatments":[254],"cohorts.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-11-08T00:00:00"}