{"id":"https://openalex.org/W3210259248","doi":"https://doi.org/10.1016/j.phymed.2021.153815","title":"Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway","display_name":"Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway","publication_year":2021,"publication_date":"2021-10-25","ids":{"openalex":"https://openalex.org/W3210259248","doi":"https://doi.org/10.1016/j.phymed.2021.153815","mag":"3210259248","pmid":"https://pubmed.ncbi.nlm.nih.gov/34781232"},"language":"en","primary_location":{"id":"doi:10.1016/j.phymed.2021.153815","doi":"https://doi.org/10.1016/j.phymed.2021.153815","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phymed.2021.153815","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100354730","display_name":"Yang Zhang","orcid":"https://orcid.org/0009-0007-4970-2213","observed_orcids":["https://orcid.org/0009-0007-4970-2213"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhang","raw_affiliation_strings":["Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Liu","raw_affiliation_strings":["Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073037452","display_name":"Jiulong Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiu-Long Ma","raw_affiliation_strings":["Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418337","display_name":"Chen Chen","orcid":"https://orcid.org/0000-0003-3646-1813","observed_orcids":["https://orcid.org/0000-0003-3646-1813"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Chen","raw_affiliation_strings":["Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101630219","display_name":"Peng Huang","orcid":"https://orcid.org/0000-0001-8556-5606","observed_orcids":["https://orcid.org/0000-0001-8556-5606"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Huang","raw_affiliation_strings":["Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051095930","display_name":"Jia-Hua Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Hua Ji","raw_affiliation_strings":["Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103052963","display_name":"Di Wu","orcid":"https://orcid.org/0000-0002-5846-3003","observed_orcids":["https://orcid.org/0000-0002-5846-3003"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Wu","raw_affiliation_strings":["Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086021526","display_name":"Liqun Ren","orcid":"https://orcid.org/0000-0002-6939-3266","observed_orcids":["https://orcid.org/0000-0002-6939-3266","https://orcid.org/0000-0002-9390-2091","https://orcid.org/0000-0001-9268-0602","https://orcid.org/0000-0001-8958-330X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li-Qun Ren","raw_affiliation_strings":["Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China. Electronic address: renlq630210@163.com","Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China. Electronic address: renlq630210@163.com","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086021526"],"corresponding_institution_ids":["https://openalex.org/I194450716"],"apc_list":{"value":2930,"currency":"USD","value_usd":2930},"apc_paid":null,"fwci":6.1298,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.97692415,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"94","issue":null,"first_page":"153815","last_page":"153815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apocynum-venetum","display_name":"Apocynum venetum","score":0.9779999852180481},{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mitochondrial-membrane-permeability","display_name":"mitochondrial membrane permeability","score":0.8309999704360962},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8069999814033508},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.8500000238418579},{"id":"https://openalex.org/keywords/rutin","display_name":"rutin","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hyperoside","display_name":"hyperoside","score":0.6499999761581421},{"id":"https://openalex.org/keywords/isoquercitrin","display_name":"isoquercitrin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/myricetin","display_name":"myricetin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cyclophilin-d","display_name":"cyclophilin D","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7294092774391174},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.665166974067688},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5896515250205994},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5192503929138184},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5186902284622192},{"id":"https://openalex.org/C2778173338","wikidata":"https://www.wikidata.org/wiki/Q951449","display_name":"Myricetin","level":5,"score":0.4776141345500946},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.4348439872264862},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4259431064128876},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.42129185795783997},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.3680065870285034},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3419541120529175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24132278561592102},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20787569880485535},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.14388200640678406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14371207356452942},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.06577882170677185},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030010","descriptor_name":"Apocynum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phymed.2021.153815","doi":"https://doi.org/10.1016/j.phymed.2021.153815","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phymed.2021.153815","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},{"id":"pmid:34781232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34781232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine : international journal of phytotherapy and phytopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2144610734","display_name":null,"funder_award_id":"81773934","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W295172491","https://openalex.org/W1543790510","https://openalex.org/W1640776676","https://openalex.org/W1680724289","https://openalex.org/W1828224642","https://openalex.org/W1984479268","https://openalex.org/W1991896518","https://openalex.org/W2011893748","https://openalex.org/W2021635812","https://openalex.org/W2047721438","https://openalex.org/W2052455413","https://openalex.org/W2058096049","https://openalex.org/W2066763993","https://openalex.org/W2078337753","https://openalex.org/W2115139474","https://openalex.org/W2117089147","https://openalex.org/W2165681130","https://openalex.org/W2169427218","https://openalex.org/W2264796820","https://openalex.org/W2567441913","https://openalex.org/W2569152931","https://openalex.org/W2741822527","https://openalex.org/W2765420096","https://openalex.org/W2783369467","https://openalex.org/W2794115003","https://openalex.org/W2897406102","https://openalex.org/W2902587537","https://openalex.org/W2904753128","https://openalex.org/W2909203111","https://openalex.org/W2913089588","https://openalex.org/W2948195998","https://openalex.org/W2950066806","https://openalex.org/W2955417028","https://openalex.org/W2957781031","https://openalex.org/W2966751058","https://openalex.org/W2971325000","https://openalex.org/W2971415170","https://openalex.org/W2971625700","https://openalex.org/W2983288113","https://openalex.org/W2991584257","https://openalex.org/W2998716952","https://openalex.org/W3003640463","https://openalex.org/W3012063761","https://openalex.org/W3022302343","https://openalex.org/W3084320668","https://openalex.org/W4248511192","https://openalex.org/W4312861576"],"related_works":["https://openalex.org/W4388931617","https://openalex.org/W2465302470","https://openalex.org/W3132823909","https://openalex.org/W3040266138","https://openalex.org/W3022302343","https://openalex.org/W1579888370","https://openalex.org/W2753953641","https://openalex.org/W4214888274","https://openalex.org/W4200004948","https://openalex.org/W4411571352"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}
