{"id":"https://openalex.org/W3210186873","doi":"https://doi.org/10.18632/aging.203668","title":"Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance","display_name":"Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance","publication_year":2021,"publication_date":"2021-11-03","ids":{"openalex":"https://openalex.org/W3210186873","doi":"https://doi.org/10.18632/aging.203668","mag":"3210186873","pmid":"https://pubmed.ncbi.nlm.nih.gov/34731089","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8610113"},"language":"en","primary_location":{"id":"doi:10.18632/aging.203668","doi":"https://doi.org/10.18632/aging.203668","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.203668","pdf_url":"https://www.aging-us.com/article/203668/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.aging-us.com/article/203668/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041803019","display_name":"Karel M. Lopez-Vilaret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95013407","display_name":"Universidad Pablo de Olavide","ror":"https://ror.org/02z749649","country_code":"ES","type":"education","lineage":["https://openalex.org/I95013407"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Karel M. Lopez-Vilaret","raw_affiliation_strings":["Laboratory of Functional Neuroscience, Universidad Pablo de Olavide, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Functional Neuroscience, Universidad Pablo de Olavide, Seville, Spain","institution_ids":["https://openalex.org/I95013407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109006301","display_name":"Jos\u00e9 Luis Cantero","orcid":"https://orcid.org/0000-0002-2628-7076","observed_orcids":["https://orcid.org/0000-0002-2628-7076"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I95013407","display_name":"Universidad Pablo de Olavide","ror":"https://ror.org/02z749649","country_code":"ES","type":"education","lineage":["https://openalex.org/I95013407"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose L. Cantero","raw_affiliation_strings":["CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","Laboratory of Functional Neuroscience, Universidad Pablo de Olavide, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]},{"raw_affiliation_string":"Laboratory of Functional Neuroscience, Universidad Pablo de Olavide, Seville, Spain","institution_ids":["https://openalex.org/I95013407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033185819","display_name":"Marina Fernandez-Alvarez","orcid":"https://orcid.org/0000-0002-9258-3439","observed_orcids":["https://orcid.org/0000-0002-9258-3439"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I95013407","display_name":"Universidad Pablo de Olavide","ror":"https://ror.org/02z749649","country_code":"ES","type":"education","lineage":["https://openalex.org/I95013407"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marina Fernandez-Alvarez","raw_affiliation_strings":["CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","Laboratory of Functional Neuroscience, Universidad Pablo de Olavide, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]},{"raw_affiliation_string":"Laboratory of Functional Neuroscience, Universidad Pablo de Olavide, Seville, Spain","institution_ids":["https://openalex.org/I95013407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027745914","display_name":"Miguel Calero","orcid":"https://orcid.org/0000-0001-5366-3324","observed_orcids":["https://orcid.org/0000-0001-5366-3324"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Calero","raw_affiliation_strings":["CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","Chronic Disease Programme, Instituto de Salud Carlos III, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]},{"raw_affiliation_string":"Chronic Disease Programme, Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027241622","display_name":"Olga Calero","orcid":"https://orcid.org/0000-0001-9698-8735","observed_orcids":["https://orcid.org/0000-0001-9698-8735"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Olga Calero","raw_affiliation_strings":["CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","Chronic Disease Programme, Instituto de Salud Carlos III, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]},{"raw_affiliation_string":"Chronic Disease Programme, Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074593437","display_name":"M\u00f3nica Lind\u0131\u0301n","orcid":"https://orcid.org/0000-0001-5936-9644","observed_orcids":["https://orcid.org/0000-0001-5936-9644"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Lind\u00edn","raw_affiliation_strings":["Cognitive Neuroscience Laboratory, Universidade de Santiago de Compostela, Santiago de Compostela, Spain","CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","Chronic Disease Programme, Instituto de Salud Carlos III, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognitive Neuroscience Laboratory, Universidade de Santiago de Compostela, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I200284239"]},{"raw_affiliation_string":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]},{"raw_affiliation_string":"Chronic Disease Programme, Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061311954","display_name":"Montserrat Zurr\u00f3n","orcid":"https://orcid.org/0000-0001-9948-8840","observed_orcids":["https://orcid.org/0000-0001-9948-8840"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Montserrat Zurr\u00f3n","raw_affiliation_strings":["Cognitive Neuroscience Laboratory, Universidade de Santiago de Compostela, Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognitive Neuroscience Laboratory, Universidade de Santiago de Compostela, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004212551","display_name":"Fernando D\u0131\u0301az","orcid":"https://orcid.org/0000-0003-3373-4855","observed_orcids":["https://orcid.org/0000-0003-3373-4855"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fernando D\u00edaz","raw_affiliation_strings":["Cognitive Neuroscience Laboratory, Universidade de Santiago de Compostela, Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cognitive Neuroscience Laboratory, Universidade de Santiago de Compostela, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087707931","display_name":"Mercedes Atienza","orcid":"https://orcid.org/0000-0002-6760-1252","observed_orcids":["https://orcid.org/0000-0002-6760-1252"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I95013407","display_name":"Universidad Pablo de Olavide","ror":"https://ror.org/02z749649","country_code":"ES","type":"education","lineage":["https://openalex.org/I95013407"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Mercedes Atienza","raw_affiliation_strings":["CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","Laboratory of Functional Neuroscience, Universidad Pablo de Olavide, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]},{"raw_affiliation_string":"Laboratory of Functional Neuroscience, Universidad Pablo de Olavide, Seville, Spain","institution_ids":["https://openalex.org/I95013407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087707931"],"corresponding_institution_ids":["https://openalex.org/I4210086696","https://openalex.org/I95013407"],"apc_list":null,"apc_paid":null,"fwci":0.8584,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.72438375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":"21","first_page":"23936","last_page":"23952"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.6435999870300293,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.6435999870300293,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.34549999237060547,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8389999866485596},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9860000014305115},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.6669999957084656},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.5600000023841858},{"id":"https://openalex.org/keywords/cortical-thickness","display_name":"cortical thickness","score":0.9620000123977661},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.859000027179718},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8740000128746033},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.7760000228881836},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7200000286102295},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.9302939176559448},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.8625802993774414},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.817790150642395},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.789450466632843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7776885032653809},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7573072910308838},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6117790937423706},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.6031326651573181},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5936918258666992},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4880591630935669},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.46668657660484314},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.4662401080131531},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.45807501673698425},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.43718796968460083},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3401238024234772},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2879793643951416},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.1287962794303894},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0909113883972168},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07277554273605347}],"mesh":[{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.18632/aging.203668","doi":"https://doi.org/10.18632/aging.203668","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.203668","pdf_url":"https://www.aging-us.com/article/203668/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8610113","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8610113","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},{"id":"pmid:34731089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34731089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"},{"id":"pmh:oai:rio.upo.es:10433/22155","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10433/22155","pdf_url":"https://rio.upo.es/bitstreams/3b648512-90f2-477e-ade4-e238d7bde44f/download","source":{"id":"https://openalex.org/S7407063271","display_name":"RIO (Universidad Pablo de Olavide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:hispana.mcu.es:58716670","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10347/27494","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:minerva.usc.es:10347/27494","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10347/27494","pdf_url":null,"source":{"id":"https://openalex.org/S4306400376","display_name":"Repositorio institucional da Universidade de Santiago de Compostela (University of Santiago de Compostela)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200284239","host_organization_name":"Universidade de Santiago de Compostela","host_organization_lineage":["https://openalex.org/I200284239"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.18632/aging.203668","doi":"https://doi.org/10.18632/aging.203668","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.203668","pdf_url":"https://www.aging-us.com/article/203668/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1394673021","display_name":null,"funder_award_id":"PID2020-118825GB-I00","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G4351339354","display_name":null,"funder_award_id":"UPO-1380913","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G5425620976","display_name":null,"funder_award_id":"CB06/05/1111","funder_id":"https://openalex.org/F4320328990","funder_display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas"},{"id":"https://openalex.org/G5706480193","display_name":null,"funder_award_id":"PID2020-119978RB-I00","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G5996066374","display_name":null,"funder_award_id":"PSI2017-85311-P","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G6172646678","display_name":null,"funder_award_id":"PY20_00858","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G7992566157","display_name":null,"funder_award_id":"PID2020-119978RB-I00","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G8360945367","display_name":null,"funder_award_id":"0551_PSL_6_E","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G8401454605","display_name":null,"funder_award_id":"PID2020","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G951715847","display_name":null,"funder_award_id":"PSI2017-89389-C2-2-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320326754","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82"},{"id":"https://openalex.org/F4320328990","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas","ror":"https://ror.org/00zca7903"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3210186873.pdf","grobid_xml":"https://content.openalex.org/works/W3210186873.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W129305155","https://openalex.org/W216263296","https://openalex.org/W779248862","https://openalex.org/W803585008","https://openalex.org/W1565240736","https://openalex.org/W1598142912","https://openalex.org/W1964571245","https://openalex.org/W1970014943","https://openalex.org/W1971351343","https://openalex.org/W1980216865","https://openalex.org/W1989819318","https://openalex.org/W1994191662","https://openalex.org/W1997957523","https://openalex.org/W2003490608","https://openalex.org/W2017026767","https://openalex.org/W2017918734","https://openalex.org/W2020040555","https://openalex.org/W2033834589","https://openalex.org/W2037952562","https://openalex.org/W2048019775","https://openalex.org/W2051229225","https://openalex.org/W2057528564","https://openalex.org/W2071128053","https://openalex.org/W2082137964","https://openalex.org/W2082394860","https://openalex.org/W2084890314","https://openalex.org/W2091805259","https://openalex.org/W2091978401","https://openalex.org/W2107957047","https://openalex.org/W2112519660","https://openalex.org/W2113795339","https://openalex.org/W2128828378","https://openalex.org/W2143104968","https://openalex.org/W2147474139","https://openalex.org/W2169302269","https://openalex.org/W2170384884","https://openalex.org/W2187014633","https://openalex.org/W2291092290","https://openalex.org/W2294586018","https://openalex.org/W2300004503","https://openalex.org/W2302151110","https://openalex.org/W2338520572","https://openalex.org/W2361659253","https://openalex.org/W2520272137","https://openalex.org/W2546888985","https://openalex.org/W2592741634","https://openalex.org/W2609763491","https://openalex.org/W2617452458","https://openalex.org/W2626342128","https://openalex.org/W2742569683","https://openalex.org/W2761060803","https://openalex.org/W2761568588","https://openalex.org/W2767601386","https://openalex.org/W2781322432","https://openalex.org/W2802538430","https://openalex.org/W2802728198","https://openalex.org/W2852169689","https://openalex.org/W2883692834","https://openalex.org/W2887914699","https://openalex.org/W2888596526","https://openalex.org/W2899043265","https://openalex.org/W2899193883","https://openalex.org/W2900034165","https://openalex.org/W2902320865","https://openalex.org/W2909321814","https://openalex.org/W2912842488","https://openalex.org/W2916386271","https://openalex.org/W2921161310","https://openalex.org/W2943656785","https://openalex.org/W2947370882","https://openalex.org/W2950353358","https://openalex.org/W2952190769","https://openalex.org/W2961954273","https://openalex.org/W2964884313","https://openalex.org/W2965833339","https://openalex.org/W2987043898","https://openalex.org/W2995030404","https://openalex.org/W2996608732","https://openalex.org/W3005431294","https://openalex.org/W3011649292","https://openalex.org/W3022432727","https://openalex.org/W3026175263","https://openalex.org/W3032755709","https://openalex.org/W3037696511","https://openalex.org/W3045501231","https://openalex.org/W3080673631","https://openalex.org/W3189071594"],"related_works":["https://openalex.org/W7170855663","https://openalex.org/W2552792747","https://openalex.org/W2070114218","https://openalex.org/W2852169689","https://openalex.org/W2105333689","https://openalex.org/W2969856795","https://openalex.org/W3037696511","https://openalex.org/W4391264971","https://openalex.org/W4392002283","https://openalex.org/W4211198816"],"abstract_inverted_index":{"Evidence":[0],"suggests":[1],"that":[2,49,63,81,155,196,219],"aging-related":[3],"dysfunctions":[4],"of":[5,14,31,86,125,128,133,166,177,200,211,223,245],"adipose":[6],"tissue":[7],"and":[8,16,25,122,139,149,159,207,247],"metabolic":[9,17,47,79],"disturbances":[10],"increase":[11],"the":[12,28,84,115,123,131,140,163,174,198,201,220,242],"risk":[13],"diabetes":[15],"syndrome":[18],"(MtbS),":[19],"eventually":[20],"leading":[21],"to":[22,45,105,142],"cognitive":[23,147,181,205],"impairment":[24],"dementia.":[26],"However,":[27],"neuroprotective":[29,56,164,221],"role":[30],"adipocytokines":[32,52,135,224],"in":[33,58,95,183],"this":[34],"process":[35],"has":[36],"not":[37,227],"been":[38],"specifically":[39],"investigated.":[40],"The":[41,152],"present":[42],"study":[43],"aims":[44],"identify":[46],"alterations":[48,80],"may":[50,65],"prevent":[51],"from":[53],"exerting":[54],"their":[55],"action":[57,85,222],"normal":[59,98,232],"ageing.":[60],"We":[61,112],"hypothesize":[62],"neuroprotection":[64],"occur":[66],"under":[67,187],"insulin":[68,119],"resistance":[69,120],"(IR)":[70],"conditions":[71],"as":[72,74,89],"long":[73],"there":[75],"are":[76,235],"no":[77],"other":[78],"indirectly":[82],"impair":[83],"adipocytokines,":[87],"such":[88],"hyperglycemia.":[90],"This":[91],"hypothesis":[92],"was":[93,192],"tested":[94],"239":[96],"cognitively":[97,231],"older":[99,233],"adults":[100,234],"(149":[101],"females)":[102],"aged":[103],"52":[104],"87":[106],"years":[107],"(67.4":[108],"\u00b1":[109],"5.9":[110],"yr).":[111],"assessed":[113],"whether":[114,230],"homeostasis":[116],"model":[117],"assessment-estimated":[118],"(HOMA-IR)":[121],"presence":[124],"different":[126],"components":[127],"MtbS":[129],"moderated":[130,162],"association":[132,199],"plasma":[134],"(i.e.,":[136],"adiponectin,":[137],"leptin":[138,143],"adiponectin":[141],"[Ad/L]":[144],"ratio)":[145],"with":[146,204,208],"functioning":[148,182,206],"cortical":[150,209],"thickness.":[151],"results":[153],"showed":[154],"HOMA-IR,":[156],"circulating":[157,243],"triglyceride":[158,171],"glucose":[160,194],"levels":[161,172,195,244],"effect":[165,176],"adipocytokines.":[167],"In":[168],"particular,":[169],"elevated":[170,193],"reduced":[173],"beneficial":[175],"Ad/L":[178,202],"ratio":[179,203],"on":[180],"insulin-sensitive":[184,236],"individuals;":[185],"whereas":[186],"high":[188],"IR":[189],"conditions,":[190],"it":[191],"weakened":[197],"thickness":[210],"prefrontal":[212],"regions.":[213],"Taken":[214],"together,":[215],"these":[216],"findings":[217],"suggest":[218],"is":[225],"conditioned":[226],"only":[228],"by":[229,241],"or":[237],"not,":[238],"but":[239],"also":[240],"triglycerides":[246],"glucose,":[248],"respectively.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}
