{"id":"https://openalex.org/W3210130194","doi":null,"title":"Neuroprotective Effect Of Citicholine In Mercury Intoxication","display_name":"Neuroprotective Effect Of Citicholine In Mercury Intoxication","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W3210130194","mag":"3210130194"},"language":"en","primary_location":{"id":"pmh:oai:repository.unair.ac.id:97837","doi":null,"is_oa":true,"landing_page_url":"http://repository.unair.ac.id/97837/1/Neuroprotective%20Effect%20of%20Citicholine%20in%20Mercury%20Intoxication.pdf","pdf_url":"http://repository.unair.ac.id/97837/1/Neuroprotective%20Effect%20of%20Citicholine%20in%20Mercury%20Intoxication.pdf","source":{"id":"https://openalex.org/S4306400777","display_name":"Universitas Airlangga Repository (Universitas Airlangga)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205133468","host_organization_name":"Universitas Airlangga","host_organization_lineage":["https://openalex.org/I205133468"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repository.unair.ac.id/97837/1/Neuroprotective%20Effect%20of%20Citicholine%20in%20Mercury%20Intoxication.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073702460","display_name":"Paulus Sugianto","orcid":"https://orcid.org/0000-0002-6450-7586","observed_orcids":["https://orcid.org/0000-0002-6450-7586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paulus Sugianto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6450-7586","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103584846","display_name":"Aulanni\u2019am Aulanni\u2019am Aulanni\u2019am","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aulanni\u2019am","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009419543","display_name":"M. Aris Widodo","orcid":"https://orcid.org/0000-0002-5444-7989","observed_orcids":["https://orcid.org/0000-0002-5444-7989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Aris Widodo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5444-7989","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073504746","display_name":"Mohammad Hasan Machfoed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Hasan Machfoed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10819","display_name":"Mercury impact and mitigation studies","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/citicoline","display_name":"citicoline","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mercury-intoxication","display_name":"mercury intoxication","score":0.7889999747276306},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8949999809265137},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9879999756813049},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":1.0},{"id":"https://openalex.org/keywords/methylmercury","display_name":"methylmercury","score":0.6980000138282776},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.7630000114440918},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9417306184768677},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7742456793785095},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.6659426093101501},{"id":"https://openalex.org/C2777777548","wikidata":"https://www.wikidata.org/wiki/Q206040","display_name":"Mercury (programming language)","level":2,"score":0.634503960609436},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.49593648314476013},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4759005010128021},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4585944712162018},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.45770809054374695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4517102837562561},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.41991230845451355},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3847064673900604},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3324924111366272},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3317262530326843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3171252906322479},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1632530689239502},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.unair.ac.id:97837","doi":null,"is_oa":true,"landing_page_url":"http://repository.unair.ac.id/97837/1/Neuroprotective%20Effect%20of%20Citicholine%20in%20Mercury%20Intoxication.pdf","pdf_url":"http://repository.unair.ac.id/97837/1/Neuroprotective%20Effect%20of%20Citicholine%20in%20Mercury%20Intoxication.pdf","source":{"id":"https://openalex.org/S4306400777","display_name":"Universitas Airlangga Repository (Universitas Airlangga)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205133468","host_organization_name":"Universitas Airlangga","host_organization_lineage":["https://openalex.org/I205133468"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:3210130194","doi":null,"is_oa":false,"landing_page_url":"https://repository.unair.ac.id/97837/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.unair.ac.id:97837","doi":null,"is_oa":true,"landing_page_url":"http://repository.unair.ac.id/97837/1/Neuroprotective%20Effect%20of%20Citicholine%20in%20Mercury%20Intoxication.pdf","pdf_url":"http://repository.unair.ac.id/97837/1/Neuroprotective%20Effect%20of%20Citicholine%20in%20Mercury%20Intoxication.pdf","source":{"id":"https://openalex.org/S4306400777","display_name":"Universitas Airlangga Repository (Universitas Airlangga)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205133468","host_organization_name":"Universitas Airlangga","host_organization_lineage":["https://openalex.org/I205133468"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3210130194.pdf","grobid_xml":"https://content.openalex.org/works/W3210130194.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W39352273","https://openalex.org/W1966109513","https://openalex.org/W2013188833","https://openalex.org/W2014531078","https://openalex.org/W2017726148","https://openalex.org/W2034973427","https://openalex.org/W2047151046","https://openalex.org/W2050025660","https://openalex.org/W2052190170","https://openalex.org/W2057856508","https://openalex.org/W2061040672","https://openalex.org/W2064504141","https://openalex.org/W2070692423","https://openalex.org/W2073116185","https://openalex.org/W2078814822","https://openalex.org/W2081808464","https://openalex.org/W2089946282","https://openalex.org/W2103498561","https://openalex.org/W2103616303","https://openalex.org/W2111981107","https://openalex.org/W2112209346","https://openalex.org/W2118675466","https://openalex.org/W2127031191","https://openalex.org/W2140098312","https://openalex.org/W2140665078","https://openalex.org/W2141487162","https://openalex.org/W2144907902","https://openalex.org/W2150710841","https://openalex.org/W2152692075","https://openalex.org/W2155851326","https://openalex.org/W2156299289","https://openalex.org/W2185212159","https://openalex.org/W2916566788"],"related_works":["https://openalex.org/W2745698045","https://openalex.org/W2012269182","https://openalex.org/W2901779956","https://openalex.org/W4405021620","https://openalex.org/W2079375161","https://openalex.org/W2769217155","https://openalex.org/W4226016479","https://openalex.org/W2003443737","https://openalex.org/W2085028566","https://openalex.org/W2110446196"],"abstract_inverted_index":{"Objective:":[0],"Mercury":[1],"induces":[2],"cell":[3,7],"death":[4],"in":[5,34,49,54,145,186],"various":[6],"lines":[8],"by":[9,178],"apoptosis":[10,20,53],"or":[11],"necrosis.":[12],"It":[13],"is":[14,111],"associated":[15],"with":[16,56],"alteration":[17],"of":[18,47,62,78,109,143,182],"some":[19],"regulators":[21],"such":[22],"as":[23,32,94],"p53":[24,130,144,183],"and":[25,37,52,58,97,105,121,131,155,184],"caspase-3.":[26],"Citicholin":[27,119],"has":[28],"been":[29],"widely":[30],"used":[31,65],"neuroprotectant":[33],"cerebrovascular":[35],"disease":[36],"other":[38],"neurologic":[39],"disorder.":[40],"Previous":[41],"studies":[42],"have":[43,64],"shown":[44],"beneficial":[45],"effect":[46,77,173],"citicholin":[48,79],"reducing":[50,179],"inflammation":[51],"patient":[55],"stroke":[57],"pain,":[59],"but":[60],"none":[61],"those":[63],"mercury":[66,80,191],"intoxicated":[67,192],"rat":[68],"animal":[69,95],"model.":[70],"We":[71,84],"try":[72],"to":[73,116],"investigate":[74],"the":[75,99,127,180],"neuroprotective":[76,172],"intoxication.":[81],"Methods":[82],":":[83,139,168],"conducted":[85],"an":[86],"controlled":[87],"study":[88],"using":[89],"male":[90],"rats":[91],"(Rattus":[92],"Novergicus)":[93],"model":[96],"devided":[98],"subjects":[100],"into":[101],"5":[102],"groups":[103],"(P0,P1,P2,P3,P4)":[104],"0.4":[106],"mg/kg":[107],"BW":[108],"MeHgCl3":[110],"administered":[112],"for":[113,156],"21":[114],"days":[115],"all":[117],"groups.":[118],"(0,5,10,20":[120],"40":[122],"mg/kgBW/day":[123],"was":[124],"added":[125],"during":[126],"exposure.":[128],"Protein":[129],"Caspase-3":[132],"expression":[133,181],"on":[134,190],"neurons":[135],"were":[136,148,159],"counted.":[137],"Result":[138],"The":[140],"mean":[141],"scores\u00b1SD":[142],"group":[146],"P0;P1;P2;P3;P4":[147],"8,406\u00b10,70;":[149],"6,828\u00b11,40;":[150],"4,680\u00b11,2;":[151],"1,752\u00b10,4;":[152],"0,807\u00b10,1":[153],"respectively":[154],"Caspase":[157],"3":[158],"8,854\u00b11,91;":[160],"6.670\u00b10,61;":[161],"4,21\u00b11,02;":[162],"2,632\u00b11,00;":[163],"0,818\u00b1":[164],"0,22":[165],"respectively.":[166],"Conclusion":[167],"citicoline":[169],"treatment":[170],"exerts":[171],"against":[174],"neuronal":[175],"apoptotic":[176],"changes":[177],"caspase-3":[185],"dose":[187],"dependent":[188],"manner":[189],"rat.":[193]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-11-08T00:00:00"}
