{"id":"https://openalex.org/W3210084002","doi":"https://doi.org/10.3390/antiox10111682","title":"17\u03b2-Estradiol Abrogates Oxidative Stress and Neuroinflammation after Cortical Stab Wound Injury","display_name":"17\u03b2-Estradiol Abrogates Oxidative Stress and Neuroinflammation after Cortical Stab Wound Injury","publication_year":2021,"publication_date":"2021-10-25","ids":{"openalex":"https://openalex.org/W3210084002","doi":"https://doi.org/10.3390/antiox10111682","mag":"3210084002","pmid":"https://pubmed.ncbi.nlm.nih.gov/34829553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8615181"},"language":"en","primary_location":{"id":"doi:10.3390/antiox10111682","doi":"https://doi.org/10.3390/antiox10111682","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox10111682","pdf_url":null,"source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/antiox10111682","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101593800","display_name":"Kamran Muddasar Saeed","orcid":"https://orcid.org/0000-0002-7746-321X","observed_orcids":["https://orcid.org/0000-0002-7746-321X"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kamran Saeed","raw_affiliation_strings":["Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079510489","display_name":"Myeung Hoon Jo","orcid":"https://orcid.org/0000-0002-1015-6768","observed_orcids":["https://orcid.org/0000-0002-1015-6768"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myeung Hoon Jo","raw_affiliation_strings":["Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100715668","display_name":"Jun Sung Park","orcid":"https://orcid.org/0000-0002-3880-6478","observed_orcids":["https://orcid.org/0000-0002-3880-6478"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun Sung Park","raw_affiliation_strings":["Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060951883","display_name":"Sayed Ibrar Alam","orcid":"https://orcid.org/0000-0002-7286-564X","observed_orcids":["https://orcid.org/0000-0002-7286-564X"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sayed Ibrar Alam","raw_affiliation_strings":["Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017710917","display_name":"Ibrahim Khan","orcid":"https://orcid.org/0000-0002-4138-0359","observed_orcids":["https://orcid.org/0000-0002-4138-0359"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ibrahim Khan","raw_affiliation_strings":["Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea"],"raw_orcid":"https://orcid.org/0000-0002-4138-0359","affiliations":[{"raw_affiliation_string":"Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058598644","display_name":"Riaz Ahmad","orcid":"https://orcid.org/0000-0001-7411-9483","observed_orcids":["https://orcid.org/0000-0001-7411-9483"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Riaz Ahmad","raw_affiliation_strings":["Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea"],"raw_orcid":"https://orcid.org/0000-0001-7411-9483","affiliations":[{"raw_affiliation_string":"Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086518723","display_name":"Amjad Khan","orcid":"https://orcid.org/0000-0001-6248-167X","observed_orcids":["https://orcid.org/0000-0001-6248-167X"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Amjad Khan","raw_affiliation_strings":["Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea"],"raw_orcid":"https://orcid.org/0000-0001-6248-167X","affiliations":[{"raw_affiliation_string":"Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089394557","display_name":"Rahat Ullah","orcid":"https://orcid.org/0000-0002-2628-0819","observed_orcids":["https://orcid.org/0000-0002-2628-0819"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Rahat Ullah","raw_affiliation_strings":["Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102020892","display_name":"Myeong Ok Kim","orcid":"https://orcid.org/0000-0003-4317-1072","observed_orcids":["https://orcid.org/0000-0003-4317-1072","https://orcid.org/0000-0003-2492-5369"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Myeong Ok Kim","raw_affiliation_strings":["Alz-Dementia Korea Co., Jinju 52828, Korea","Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alz-Dementia Korea Co., Jinju 52828, Korea","institution_ids":[]},{"raw_affiliation_string":"Division of Life Sciences and Applied Life Science (BK 21 FOUR), College of Natural Science, Gyeongsang National University, Jinju 52828, Korea","institution_ids":["https://openalex.org/I189442560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102020892"],"corresponding_institution_ids":["https://openalex.org/I189442560"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":2.6552,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.91851313,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"11","first_page":"1682","last_page":"1682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9129999876022339},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.6819999814033508},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9739999771118164},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9240000247955322},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.703000009059906},{"id":"https://openalex.org/keywords/gliosis","display_name":"gliosis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8679999709129333},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.8399999737739563},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9670000076293945},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7310000061988831},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8874683380126953},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7856292128562927},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7318507432937622},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.714905858039856},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.665928840637207},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5136489272117615},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.510480523109436},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.45189714431762695},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4512438476085663},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4310155510902405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4277372658252716},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.30852341651916504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30771201848983765},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2700369358062744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21953502297401428},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16782620549201965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10920315980911255},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/antiox10111682","doi":"https://doi.org/10.3390/antiox10111682","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox10111682","pdf_url":null,"source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8615181","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8615181/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8615181/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel)","raw_type":"Text"},{"id":"pmid:34829553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34829553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8a4d88c1ef274e13b47aefee47a464d7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8a4d88c1ef274e13b47aefee47a464d7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants, Vol 10, Iss 11, p 1682 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antiox10111682","doi":"https://doi.org/10.3390/antiox10111682","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antiox10111682","pdf_url":null,"source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5265839784","display_name":null,"funder_award_id":"2020M3E5D9080660","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G7332383363","display_name":null,"funder_award_id":"2020M3E5D9080660","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321318","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3210084002.pdf","grobid_xml":"https://content.openalex.org/works/W3210084002.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W23520400","https://openalex.org/W91154270","https://openalex.org/W756826172","https://openalex.org/W1505690426","https://openalex.org/W1768846296","https://openalex.org/W1852128587","https://openalex.org/W1968269211","https://openalex.org/W1970205234","https://openalex.org/W1972296893","https://openalex.org/W1973986558","https://openalex.org/W1977334935","https://openalex.org/W1988848089","https://openalex.org/W1989397653","https://openalex.org/W1997378604","https://openalex.org/W2003674452","https://openalex.org/W2006409502","https://openalex.org/W2008715871","https://openalex.org/W2009178440","https://openalex.org/W2010740759","https://openalex.org/W2015551349","https://openalex.org/W2023017563","https://openalex.org/W2025806801","https://openalex.org/W2027424508","https://openalex.org/W2029026381","https://openalex.org/W2030393531","https://openalex.org/W2030796131","https://openalex.org/W2033557808","https://openalex.org/W2041363468","https://openalex.org/W2042733452","https://openalex.org/W2045096990","https://openalex.org/W2045668700","https://openalex.org/W2048137511","https://openalex.org/W2048700223","https://openalex.org/W2048835444","https://openalex.org/W2063165012","https://openalex.org/W2064725661","https://openalex.org/W2073427034","https://openalex.org/W2075924924","https://openalex.org/W2084188625","https://openalex.org/W2092730252","https://openalex.org/W2101898118","https://openalex.org/W2104399515","https://openalex.org/W2105670925","https://openalex.org/W2109837753","https://openalex.org/W2113880766","https://openalex.org/W2122774685","https://openalex.org/W2130198578","https://openalex.org/W2134729461","https://openalex.org/W2139565721","https://openalex.org/W2144284013","https://openalex.org/W2147180300","https://openalex.org/W2149785020","https://openalex.org/W2150678551","https://openalex.org/W2151283331","https://openalex.org/W2159950713","https://openalex.org/W2160510102","https://openalex.org/W2162289848","https://openalex.org/W2170959966","https://openalex.org/W2172193893","https://openalex.org/W2332304720","https://openalex.org/W2346184067","https://openalex.org/W2403424502","https://openalex.org/W2409961294","https://openalex.org/W2461388993","https://openalex.org/W2531213638","https://openalex.org/W2533003797","https://openalex.org/W2583316661","https://openalex.org/W2590302834","https://openalex.org/W2592071978","https://openalex.org/W2592378998","https://openalex.org/W2592745481","https://openalex.org/W2605631009","https://openalex.org/W2728577001","https://openalex.org/W2731266111","https://openalex.org/W2750331912","https://openalex.org/W2756440148","https://openalex.org/W2761635843","https://openalex.org/W2780399282","https://openalex.org/W2783763012","https://openalex.org/W2789535115","https://openalex.org/W2795957895","https://openalex.org/W2802258287","https://openalex.org/W2805274467","https://openalex.org/W2895203810","https://openalex.org/W2903474765","https://openalex.org/W2911448712","https://openalex.org/W2922123514","https://openalex.org/W2939660604","https://openalex.org/W2948852917","https://openalex.org/W2961162867","https://openalex.org/W2962601722","https://openalex.org/W2963708423","https://openalex.org/W2968592185","https://openalex.org/W2969661570","https://openalex.org/W2994514210","https://openalex.org/W3002509135","https://openalex.org/W3005303475","https://openalex.org/W3014932431","https://openalex.org/W3048426432","https://openalex.org/W3088685572","https://openalex.org/W3093494259","https://openalex.org/W3105299890","https://openalex.org/W3108725480","https://openalex.org/W3118995768","https://openalex.org/W3128543488","https://openalex.org/W3154419549","https://openalex.org/W3156451771","https://openalex.org/W3171045923","https://openalex.org/W3171777836","https://openalex.org/W4214829914"],"related_works":["https://openalex.org/W3093494259","https://openalex.org/W2728577001","https://openalex.org/W1994542887","https://openalex.org/W3025729649","https://openalex.org/W25779412","https://openalex.org/W4401050104","https://openalex.org/W2155924485","https://openalex.org/W2002257605","https://openalex.org/W2134186952","https://openalex.org/W2791467769"],"abstract_inverted_index":{"Disruptions":[0],"in":[1,12,56,60,247,259],"brain":[2,14,25,48,74,95,113,144,233,284,308],"energy":[3,174],"metabolism,":[4],"oxidative":[5,92,177],"damage,":[6],"and":[7,79,91,133,142,157,176,186,196,200,210,214,230,245,272,274,287,291],"neuroinflammation":[8],"are":[9],"commonly":[10],"seen":[11],"traumatic":[13],"injury":[15,49,108],"(TBI).":[16],"Microglial":[17],"activation":[18],"is":[19,302],"the":[20,52,61,66,72,115,140,147,181,189,225,248,260,265,292,307,323],"hallmark":[21],"of":[22,54,149,183,191,228,267,294],"neuroinflammation.":[23],"After":[24],"injury,":[26,114],"microglia":[27,43],"also":[28,239],"act":[29],"as":[30,222],"a":[31,104],"double-edged":[32],"sword":[33],"with":[34,119,237],"distinctive":[35],"phenotypic":[36],"changes.":[37],"Therefore,":[38],"therapeutic":[39],"applications":[40],"to":[41,102,138,202,321],"potentiate":[42],"towards":[44],"pro-inflammatory":[45],"response":[46,85,221],"following":[47,313],"have":[50],"become":[51],"focus":[53],"attention":[55],"recent":[57],"years.":[58],"Here,":[59],"current":[62],"study,":[63],"we":[64,161],"investigated":[65],"hypothesis":[67],"that":[68,168,300],"17\u03b2-estradiol":[69,120,169,206,238,252,301],"could":[70],"rescue":[71],"mouse":[73],"against":[75,306],"apoptotic":[76,256],"cell":[77,257],"death":[78,258],"neurodegeneration":[80],"by":[81,87,179,187,224,263],"suppressing":[82],"deleterious":[83],"proinflammatory":[84,211],"probably":[86],"abrogating":[88],"metabolic":[89],"stress":[90,178],"damage":[93],"after":[94,112,232],"injury.":[96,234],"Male":[97],"C57BL/6N":[98],"mice":[99,116,281],"were":[100,117],"used":[101,162],"establish":[103],"cortical":[105,141],"stab":[106],"wound":[107],"(SWI)":[109],"model.":[110],"Immediately":[111],"treated":[118],"(10":[121],"mg/kg,":[122],"once":[123],"every":[124],"day":[125],"via":[126],"i.p.":[127],"injection)":[128],"for":[129],"one":[130],"week.":[131],"Immunoblotting":[132],"immunohistochemical":[134],"analysis":[135],"was":[136],"performed":[137],"examine":[139],"hippocampal":[143],"regions.":[145],"For":[146],"evaluation":[148],"reactive":[150],"oxygen":[151],"species":[152],"(ROS),":[153],"reduced":[154,240,283],"glutathione":[155,159],"(GSH),":[156],"oxidized":[158],"(GSSG),":[160],"specific":[163],"kits.":[164],"Our":[165],"findings":[166,298],"revealed":[167],"treatment":[170,207,236],"significantly":[171,217],"alleviated":[172],"SWI-induced":[173],"dyshomeostasis":[175],"increasing":[180],"activity":[182],"phospho-AMPK":[184],"(Thr172)":[185],"regulating":[188,264],"expression":[190,227,266,293],"an":[192,219,303],"antioxidant":[193],"gene":[194],"(Nrf2)":[195],"cytoprotective":[197],"enzymes":[198],"(HO-1":[199],"GSH)":[201],"mitigate":[203],"ROS.":[204],"Importantly,":[205],"downregulated":[208],"gliosis":[209],"markers":[212],"(iNOS":[213],"CD64)":[215],"while":[216],"augmenting":[218],"anti-inflammatory":[220],"evidenced":[223],"robust":[226],"TGF-\u03b2":[229],"IGF-1":[231],"The":[235],"inflammatory":[241],"mediators":[242],"(Tnf-\u03b1,":[243],"IL-1\u03b2,":[244],"COX-2)":[246],"injured":[249],"mouse.":[250],"Moreover,":[251],"administration":[253],"rescued":[254],"p53-associated":[255],"SWI":[261,278],"model":[262],"Bcl-2":[268],"family":[269],"proteins":[270],"(Bax":[271],"Bcl-2)":[273],"caspase-3":[275],"activation.":[276],"Finally,":[277],"+":[279],"17\u03b2-estradiol-treated":[280],"illustrated":[282],"lesion":[285],"volume":[286],"enhanced":[288],"neurotrophic":[289],"effect":[290],"synaptic":[295],"proteins.":[296],"These":[297],"suggest":[299],"effective":[304],"therapy":[305],"secondary":[309],"injury-induced":[310],"pathological":[311],"cascade":[312],"trauma,":[314],"although":[315],"further":[316],"studies":[317],"may":[318],"be":[319],"conducted":[320],"explore":[322],"exact":[324],"mechanisms.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-11-08T00:00:00"}