{"id":"https://openalex.org/W3210072496","doi":"https://doi.org/10.4049/jimmunol.2100218","title":"FCRL1 Regulates B Cell Receptor\u2013Induced ERK Activation through GRB2","display_name":"FCRL1 Regulates B Cell Receptor\u2013Induced ERK Activation through GRB2","publication_year":2021,"publication_date":"2021-10-25","ids":{"openalex":"https://openalex.org/W3210072496","doi":"https://doi.org/10.4049/jimmunol.2100218","mag":"3210072496","pmid":"https://pubmed.ncbi.nlm.nih.gov/34697226","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8629370"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.2100218","doi":"https://doi.org/10.4049/jimmunol.2100218","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.2100218","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8629370","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041646951","display_name":"Jenna M DeLuca","orcid":"https://orcid.org/0000-0001-6390-8436","observed_orcids":["https://orcid.org/0000-0001-6390-8436"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna M DeLuca","raw_affiliation_strings":["Department of Microbiology, Miami University , Oxford, OH"],"raw_orcid":"https://orcid.org/0000-0001-6390-8436","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Miami University , Oxford, OH","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067742570","display_name":"Maegan K Murphy","orcid":"https://orcid.org/0000-0002-3913-8715","observed_orcids":["https://orcid.org/0000-0002-3913-8715"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maegan K Murphy","raw_affiliation_strings":["Department of Microbiology, Miami University , Oxford, OH"],"raw_orcid":"https://orcid.org/0000-0002-3913-8715","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Miami University , Oxford, OH","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100327995","display_name":"Xin Wang","orcid":"https://orcid.org/0000-0002-7174-3042","observed_orcids":["https://orcid.org/0000-0002-7174-3042"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":["Department of Microbiology, Miami University , Oxford, OH"],"raw_orcid":"https://orcid.org/0000-0002-7174-3042","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Miami University , Oxford, OH","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022226123","display_name":"Timothy James Wilson","orcid":"https://orcid.org/0000-0001-8403-9401","observed_orcids":["https://orcid.org/0000-0001-8403-9401"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy J Wilson","raw_affiliation_strings":["Department of Microbiology, Miami University , Oxford, OH"],"raw_orcid":"https://orcid.org/0000-0001-8403-9401","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Miami University , Oxford, OH","institution_ids":["https://openalex.org/I83328450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022226123"],"corresponding_institution_ids":["https://openalex.org/I83328450"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.4655,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.55750111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"207","issue":"11","first_page":"2688","last_page":"2698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/erk-activation","display_name":"ERK activation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/grb2","display_name":"Grb2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7540000081062317},{"id":"https://openalex.org/keywords/b-cell-tolerance","display_name":"B cell tolerance","score":0.7250000238418579},{"id":"https://openalex.org/keywords/b-cell-homeostasis","display_name":"B cell homeostasis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.628000020980835},{"id":"https://openalex.org/keywords/ship1","display_name":"SHIP1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sos1","display_name":"SOS1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C177917778","wikidata":"https://www.wikidata.org/wiki/Q14905188","display_name":"GRB2","level":4,"score":0.7613224983215332},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7306529879570007},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5609482526779175},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4834355115890503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48019397258758545},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3390781283378601},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.2819559574127197},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27125322818756104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25943976640701294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1084536612033844}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051380","descriptor_name":"GRB2 Adaptor Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.2100218","doi":"https://doi.org/10.4049/jimmunol.2100218","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.2100218","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:34697226","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34697226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8629370","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8629370","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8629370","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8629370","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1804992633","display_name":null,"funder_award_id":"R15-AI138184","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7413604855","display_name":null,"funder_award_id":"1726643","funder_id":"https://openalex.org/F4320337398","funder_display_name":"Division of Biological Infrastructure"},{"id":"https://openalex.org/G7767117307","display_name":"Regulation of Type-I Interferon by SLAMF9","funder_award_id":"1r15ai138184-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337398","display_name":"Division of Biological Infrastructure","ror":"https://ror.org/04qn9mx93"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W26662283","https://openalex.org/W27857866","https://openalex.org/W130515558","https://openalex.org/W164293537","https://openalex.org/W183074326","https://openalex.org/W1543903698","https://openalex.org/W1551324456","https://openalex.org/W1595867504","https://openalex.org/W1647059547","https://openalex.org/W1771636604","https://openalex.org/W1805423323","https://openalex.org/W1835218586","https://openalex.org/W1915085848","https://openalex.org/W1915104373","https://openalex.org/W1942264103","https://openalex.org/W1965053438","https://openalex.org/W1965802234","https://openalex.org/W1981301575","https://openalex.org/W1981352846","https://openalex.org/W1993329056","https://openalex.org/W1996447998","https://openalex.org/W2000360919","https://openalex.org/W2004756723","https://openalex.org/W2008969896","https://openalex.org/W2012751406","https://openalex.org/W2014436895","https://openalex.org/W2015179859","https://openalex.org/W2026520078","https://openalex.org/W2032346440","https://openalex.org/W2033316505","https://openalex.org/W2033316789","https://openalex.org/W2037011949","https://openalex.org/W2038204022","https://openalex.org/W2042209841","https://openalex.org/W2044005459","https://openalex.org/W2046548076","https://openalex.org/W2047342342","https://openalex.org/W2055978688","https://openalex.org/W2056462157","https://openalex.org/W2058506362","https://openalex.org/W2069187561","https://openalex.org/W2079270029","https://openalex.org/W2084669174","https://openalex.org/W2098680102","https://openalex.org/W2103690233","https://openalex.org/W2109400604","https://openalex.org/W2111807002","https://openalex.org/W2113809180","https://openalex.org/W2114551673","https://openalex.org/W2115006443","https://openalex.org/W2117189326","https://openalex.org/W2118128813","https://openalex.org/W2120245870","https://openalex.org/W2126021631","https://openalex.org/W2134057839","https://openalex.org/W2134452781","https://openalex.org/W2136985023","https://openalex.org/W2138483765","https://openalex.org/W2144121653","https://openalex.org/W2160520579","https://openalex.org/W2160922815","https://openalex.org/W2196345157","https://openalex.org/W2605871488","https://openalex.org/W2768766207","https://openalex.org/W2787240390","https://openalex.org/W2793200689","https://openalex.org/W2887814673","https://openalex.org/W2958834948","https://openalex.org/W2964920290","https://openalex.org/W2989724420","https://openalex.org/W3005104413","https://openalex.org/W3033361188","https://openalex.org/W4243534230","https://openalex.org/W6753774020"],"related_works":["https://openalex.org/W4319432040","https://openalex.org/W2021976643","https://openalex.org/W7171497503","https://openalex.org/W2033316789","https://openalex.org/W2989724420","https://openalex.org/W2271361554","https://openalex.org/W1545750014","https://openalex.org/W4387099407","https://openalex.org/W2136985023","https://openalex.org/W4416447130"],"abstract_inverted_index":{"Abstract":[0],"Regulation":[1],"of":[2,18,27,35,47,61,74,86,114,134,143,158],"BCR":[3],"signaling":[4,49,63],"has":[5],"important":[6],"consequences":[7],"for":[8,97,152],"generating":[9],"effective":[10],"Ab":[11,41],"responses":[12],"to":[13,53,145,154],"pathogens":[14],"and":[15,40,50,71,105,164],"preventing":[16],"production":[17],"autoreactive":[19],"B":[20,54,115,160],"cells":[21,116,135],"during":[22],"development.":[23],"Currently":[24],"defined":[25],"functions":[26],"Fc":[28],"receptor-like":[29],"(FCRL)":[30],"1":[31],"include":[32],"positive":[33],"regulation":[34],"BCR-induced":[36],"calcium":[37],"flux,":[38],"proliferation,":[39],"production;":[42],"however,":[43],"the":[44,132],"mechanistic":[45],"basis":[46],"FCRL1":[48,62,87,98,125,144,153],"its":[51],"contributions":[52],"cell":[55,161],"development":[56],"remain":[57],"undefined.":[58],"Molecular":[59],"characterization":[60],"shows":[64,120],"phosphotyrosine-dependent":[65],"associations":[66],"with":[67,83,128],"GRB2,":[68],"GRAP,":[69],"SHIP-1,":[70],"SOS1,":[72],"all":[73],"which":[75],"can":[76],"profoundly":[77],"influence":[78],"MAPK":[79],"signaling.":[80],"In":[81],"contrast":[82],"previous":[84],"characterizations":[85],"as":[88],"a":[89,95,109,129,150,156],"strictly":[90],"activating":[91],"receptor,":[92],"we":[93],"discover":[94],"role":[96],"in":[99,108,117,131,139],"suppressing":[100],"ERK":[101,122,147],"activation":[102,148],"under":[103],"homeostatic":[104],"BCR-stimulated":[106],"conditions":[107],"GRB2-dependent":[110],"manner.":[111],"Our":[112],"analysis":[113],"Fcrl1\u2212/\u2212":[118],"mice":[119],"that":[121],"suppression":[123],"by":[124],"is":[126],"associated":[127],"restriction":[130],"number":[133],"surviving":[136],"splenic":[137],"maturation":[138],"vivo.":[140],"The":[141],"capacity":[142],"modulate":[146],"presents":[149],"potential":[151],"be":[155],"regulator":[157],"peripheral":[159],"tolerance,":[162],"homeostasis,":[163],"activation.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}