{"id":"https://openalex.org/W3210039936","doi":"https://doi.org/10.1016/j.diff.2021.11.001","title":"Role of the extracellular matrix and YAP/TAZ in cell reprogramming","display_name":"Role of the extracellular matrix and YAP/TAZ in cell reprogramming","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W3210039936","doi":"https://doi.org/10.1016/j.diff.2021.11.001","mag":"3210039936","pmid":"https://pubmed.ncbi.nlm.nih.gov/34768156"},"language":"en","primary_location":{"id":"doi:10.1016/j.diff.2021.11.001","doi":"https://doi.org/10.1016/j.diff.2021.11.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.diff.2021.11.001","pdf_url":null,"source":{"id":"https://openalex.org/S53475899","display_name":"Differentiation","issn_l":"0301-4681","issn":["0301-4681","1432-0436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Differentiation","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100609535","display_name":"Lan Liu","orcid":"https://orcid.org/0000-0002-3566-9666","observed_orcids":["https://orcid.org/0000-0002-3566-9666"]},"institutions":[{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lan Liu","raw_affiliation_strings":["Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China","institution_ids":["https://openalex.org/I4210086248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023203464","display_name":"Mengchang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengchang Liu","raw_affiliation_strings":["Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China","institution_ids":["https://openalex.org/I4210086248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045842116","display_name":"Defu Xie","orcid":"https://orcid.org/0000-0002-4040-3088","observed_orcids":["https://orcid.org/0000-0002-4040-3088"]},"institutions":[{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Defu Xie","raw_affiliation_strings":["Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China","institution_ids":["https://openalex.org/I4210086248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019583511","display_name":"Xingke Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingke Liu","raw_affiliation_strings":["Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China","institution_ids":["https://openalex.org/I4210086248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101799232","display_name":"Hong Yan","orcid":"https://orcid.org/0000-0002-7535-5848","observed_orcids":["https://orcid.org/0000-0002-7535-5848"]},"institutions":[{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong Yan","raw_affiliation_strings":["Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China. Electronic address: zxsswk@163.com","Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China"],"raw_orcid":"https://orcid.org/0000-0002-7535-5848","affiliations":[{"raw_affiliation_string":"Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China. Electronic address: zxsswk@163.com","institution_ids":["https://openalex.org/I4210086248"]},{"raw_affiliation_string":"Department of Plastic and Burns Surgery, The Affiliated Hospital of Southwest Medical University, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, Luzhou, Sichuan Province, 646000, China","institution_ids":["https://openalex.org/I4210086248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101799232"],"corresponding_institution_ids":["https://openalex.org/I4210086248"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.4959,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.43794526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"122","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.21170000731945038,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.968999981880188},{"id":"https://openalex.org/keywords/yap-taz","display_name":"YAP/TAZ","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.8799999952316284},{"id":"https://openalex.org/keywords/somatic-cell-reprogramming","display_name":"somatic cell reprogramming","score":0.7250000238418579},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mechanical-cues","display_name":"mechanical cues","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cellular-microenvironment","display_name":"cell microenvironment","score":0.9279999732971191},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.9629999995231628},{"id":"https://openalex.org/keywords/linc-complex","display_name":"LINC complex","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.943507194519043},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7616084814071655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7143640518188477},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7064477801322937},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.6748026609420776},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.6105614304542542},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5434820652008057},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.5209671258926392},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5019316673278809},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3573276996612549},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12176239490509033},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.diff.2021.11.001","doi":"https://doi.org/10.1016/j.diff.2021.11.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.diff.2021.11.001","pdf_url":null,"source":{"id":"https://openalex.org/S53475899","display_name":"Differentiation","issn_l":"0301-4681","issn":["0301-4681","1432-0436"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Differentiation","raw_type":"journal-article"},{"id":"pmid:34768156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34768156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Differentiation; research in biological diversity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328652","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1680405798","https://openalex.org/W1732989311","https://openalex.org/W1821245682","https://openalex.org/W1946158702","https://openalex.org/W1969165478","https://openalex.org/W1970970501","https://openalex.org/W1976543587","https://openalex.org/W1986960759","https://openalex.org/W1988194926","https://openalex.org/W1999800789","https://openalex.org/W2000121424","https://openalex.org/W2002596571","https://openalex.org/W2021057876","https://openalex.org/W2023392069","https://openalex.org/W2027034506","https://openalex.org/W2028593002","https://openalex.org/W2033778676","https://openalex.org/W2035697399","https://openalex.org/W2052700237","https://openalex.org/W2053809735","https://openalex.org/W2054971583","https://openalex.org/W2058379920","https://openalex.org/W2064625637","https://openalex.org/W2069341514","https://openalex.org/W2070972498","https://openalex.org/W2075922899","https://openalex.org/W2078811578","https://openalex.org/W2079671128","https://openalex.org/W2079907174","https://openalex.org/W2085767196","https://openalex.org/W2087883990","https://openalex.org/W2091862729","https://openalex.org/W2093021491","https://openalex.org/W2096169987","https://openalex.org/W2103239302","https://openalex.org/W2135073071","https://openalex.org/W2138239543","https://openalex.org/W2143076230","https://openalex.org/W2180144971","https://openalex.org/W2230606086","https://openalex.org/W2273958019","https://openalex.org/W2309249759","https://openalex.org/W2317518760","https://openalex.org/W2474348257","https://openalex.org/W2518767576","https://openalex.org/W2544726413","https://openalex.org/W2555679923","https://openalex.org/W2576822117","https://openalex.org/W2593997528","https://openalex.org/W2618931365","https://openalex.org/W2619520930","https://openalex.org/W2758838459","https://openalex.org/W2765939774","https://openalex.org/W2773293509","https://openalex.org/W2788809291","https://openalex.org/W2792303113","https://openalex.org/W2792844146","https://openalex.org/W2797423834","https://openalex.org/W2800832389","https://openalex.org/W2808086361","https://openalex.org/W2884435515","https://openalex.org/W2886651421","https://openalex.org/W2898723593","https://openalex.org/W2899878476","https://openalex.org/W2904492726","https://openalex.org/W2905097208","https://openalex.org/W2909951354","https://openalex.org/W2917854454","https://openalex.org/W2926781175","https://openalex.org/W2936964369","https://openalex.org/W2950733781","https://openalex.org/W2970524282","https://openalex.org/W2972287266","https://openalex.org/W2981267455","https://openalex.org/W2998035952","https://openalex.org/W3003051803","https://openalex.org/W3003512430","https://openalex.org/W3005933224","https://openalex.org/W3047759581","https://openalex.org/W3108564922"],"related_works":["https://openalex.org/W3162888110","https://openalex.org/W2884435515","https://openalex.org/W4310024828","https://openalex.org/W4221132688","https://openalex.org/W2616658238","https://openalex.org/W2980104037","https://openalex.org/W2146337514","https://openalex.org/W2758838459","https://openalex.org/W7220830975","https://openalex.org/W7127390094"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}