{"id":"https://openalex.org/W3210038041","doi":"https://doi.org/10.1016/j.jff.2021.104824","title":"Lactobacillus plantarum K8-based paraprobiotics suppress lipid accumulation during adipogenesis by the regulation of JAK/STAT and AMPK signaling pathways","display_name":"Lactobacillus plantarum K8-based paraprobiotics suppress lipid accumulation during adipogenesis by the regulation of JAK/STAT and AMPK signaling pathways","publication_year":2021,"publication_date":"2021-10-29","ids":{"openalex":"https://openalex.org/W3210038041","doi":"https://doi.org/10.1016/j.jff.2021.104824","mag":"3210038041"},"language":"en","primary_location":{"id":"doi:10.1016/j.jff.2021.104824","doi":"https://doi.org/10.1016/j.jff.2021.104824","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jff.2021.104824","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1756464621004734/pdf","source":{"id":"https://openalex.org/S8548135","display_name":"Journal of Functional Foods","issn_l":"1756-4646","issn":["1756-4646","2214-9414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Functional Foods","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1756464621004734/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039092253","display_name":"Hoon Kim","orcid":"https://orcid.org/0000-0001-9153-382X","observed_orcids":["https://orcid.org/0000-0001-9153-382X"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hoon Kim","raw_affiliation_strings":["College of Biotechnology and Natural Resources, Chung-Ang University, Anseong 17546, Republic of Korea","Skin-biotechnology Center, Kyung Hee University, Gwanggyo-ro 147, Yeongtong-gu, Suwon 16229, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biotechnology and Natural Resources, Chung-Ang University, Anseong 17546, Republic of Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"Skin-biotechnology Center, Kyung Hee University, Gwanggyo-ro 147, Yeongtong-gu, Suwon 16229, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011070329","display_name":"Jeong-Ju Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong-Ju Lim","raw_affiliation_strings":["Department of Public Health Science, Korea University, Seoul 02841, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Science, Korea University, Seoul 02841, Republic of Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083231283","display_name":"Hyun Young Shin","orcid":"https://orcid.org/0000-0001-9196-0434","observed_orcids":["https://orcid.org/0000-0001-9196-0434"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Young Shin","raw_affiliation_strings":["Department of Integrated Biomedical and Life Science, Korea University, Seoul 02841, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Biomedical and Life Science, Korea University, Seoul 02841, Republic of Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079848254","display_name":"Hyung Joo Suh","orcid":"https://orcid.org/0000-0001-8869-3929","observed_orcids":["https://orcid.org/0000-0001-8869-3929"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung Joo Suh","raw_affiliation_strings":["Department of Integrated Biomedical and Life Science, Korea University, Seoul 02841, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Biomedical and Life Science, Korea University, Seoul 02841, Republic of Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103815448","display_name":"Hyeon\u2010Son Choi","orcid":"https://orcid.org/0000-0002-0165-7886","observed_orcids":["https://orcid.org/0000-0002-0165-7886"]},"institutions":[{"id":"https://openalex.org/I157264075","display_name":"Sangmyung University","ror":"https://ror.org/01x4whx42","country_code":"KR","type":"education","lineage":["https://openalex.org/I157264075"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyeon-Son Choi","raw_affiliation_strings":["Department of Food Nutrition, Sangmyung University, Seoul 03016, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Nutrition, Sangmyung University, Seoul 03016, Republic of Korea","institution_ids":["https://openalex.org/I157264075"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103815448"],"corresponding_institution_ids":["https://openalex.org/I157264075"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":3.0958,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.91326034,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"87","issue":null,"first_page":"104824","last_page":"104824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paraprobiotics","display_name":"paraprobiotics","score":0.984000027179718},{"id":"https://openalex.org/keywords/lactiplantibacillus-plantarum","display_name":"Lactobacillus plantarum","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/3t3-l1-preadipocytes","display_name":"3T3-L1 preadipocytes","score":0.9639999866485596},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ampk-signaling","display_name":"AMPK signaling","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/c-ebpalpha","display_name":"C/EBP\u03b1","score":0.8930000066757202},{"id":"https://openalex.org/keywords/c-ebpdelta","display_name":"C/EBP\u03b4","score":0.7590000033378601},{"id":"https://openalex.org/keywords/c-ebpbeta","display_name":"C/EBP\u03b2","score":0.8289999961853027},{"id":"https://openalex.org/keywords/klf4","display_name":"KLF4","score":0.9110000133514404},{"id":"https://openalex.org/keywords/klf5","display_name":"KLF5","score":0.9850000143051147},{"id":"https://openalex.org/keywords/krox20","display_name":"Krox20","score":0.9539999961853027},{"id":"https://openalex.org/keywords/dlk1","display_name":"DLK1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/functional-food-ingredients","display_name":"functional food ingredients","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.9368206858634949},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8370842933654785},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.6057425737380981},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5236330032348633},{"id":"https://openalex.org/C142536801","wikidata":"https://www.wikidata.org/wiki/Q4636414","display_name":"3T3-L1","level":4,"score":0.4798300266265869},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45422178506851196},{"id":"https://openalex.org/C2778265714","wikidata":"https://www.wikidata.org/wiki/Q18033993","display_name":"KLF4","level":5,"score":0.4446665048599243},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43910956382751465},{"id":"https://openalex.org/C2778985185","wikidata":"https://www.wikidata.org/wiki/Q1756682","display_name":"Lactobacillus plantarum","level":4,"score":0.4214509129524231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27619650959968567},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2513798475265503},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2318136990070343},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.18657439947128296},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.18581587076187134},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.16581621766090393},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.10161846876144409},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jff.2021.104824","doi":"https://doi.org/10.1016/j.jff.2021.104824","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jff.2021.104824","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1756464621004734/pdf","source":{"id":"https://openalex.org/S8548135","display_name":"Journal of Functional Foods","issn_l":"1756-4646","issn":["1756-4646","2214-9414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Functional Foods","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jff.2021.104824","doi":"https://doi.org/10.1016/j.jff.2021.104824","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jff.2021.104824","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1756464621004734/pdf","source":{"id":"https://openalex.org/S8548135","display_name":"Journal of Functional Foods","issn_l":"1756-4646","issn":["1756-4646","2214-9414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Functional Foods","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3820291729","display_name":null,"funder_award_id":"2019R1I1A1A01061083","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321332","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3210038041.pdf","grobid_xml":"https://content.openalex.org/works/W3210038041.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1972686367","https://openalex.org/W1975202380","https://openalex.org/W1991932355","https://openalex.org/W2011574523","https://openalex.org/W2013312246","https://openalex.org/W2024292392","https://openalex.org/W2029565396","https://openalex.org/W2034776654","https://openalex.org/W2043348456","https://openalex.org/W2067913177","https://openalex.org/W2070760129","https://openalex.org/W2073900522","https://openalex.org/W2088440113","https://openalex.org/W2117833492","https://openalex.org/W2118733706","https://openalex.org/W2140882300","https://openalex.org/W2150004800","https://openalex.org/W2159659449","https://openalex.org/W2169101579","https://openalex.org/W2292942377","https://openalex.org/W2344469462","https://openalex.org/W2529973462","https://openalex.org/W2567264284","https://openalex.org/W2606953164","https://openalex.org/W2753482932","https://openalex.org/W2763871199","https://openalex.org/W2765956576","https://openalex.org/W2768709537","https://openalex.org/W2793397992","https://openalex.org/W2797148322","https://openalex.org/W2883562787","https://openalex.org/W2884154656","https://openalex.org/W2889312503","https://openalex.org/W2897981765","https://openalex.org/W2915899113","https://openalex.org/W2946568639","https://openalex.org/W2956175090","https://openalex.org/W3002368479","https://openalex.org/W3007815550","https://openalex.org/W3010675142","https://openalex.org/W3032990259","https://openalex.org/W3034669239","https://openalex.org/W3088228399","https://openalex.org/W3093521289","https://openalex.org/W3094044588","https://openalex.org/W6773104965"],"related_works":["https://openalex.org/W3092292062","https://openalex.org/W4213454555","https://openalex.org/W2048072059","https://openalex.org/W3158292163","https://openalex.org/W4315853432","https://openalex.org/W4281488190","https://openalex.org/W4392170142","https://openalex.org/W2138238123","https://openalex.org/W3157759545","https://openalex.org/W3160028939"],"abstract_inverted_index":{"Paraprobiotics":[0],"are":[1],"non-viable":[2],"cells":[3,52],"or":[4,130,147],"cell":[5],"fractions":[6],"that":[7,98],"have":[8],"beneficial":[9],"effects":[10,33,101],"on":[11,34,104],"the":[12,19,38,50,66,118],"host;":[13],"they":[14],"may":[15],"help":[16],"in":[17,41],"overcoming":[18],"limitations":[20],"of":[21,53,65,74,83,92,102,120],"probiotics":[22],"and":[23,37,70,88,90,111,133],"expanding":[24],"their":[25,32],"benefits.":[26],"Here,":[27],"we":[28],"aimed":[29],"to":[30,127,144],"investigate":[31],"lipid":[35,59,75,148],"accumulation":[36,60,76],"underlying":[39],"mechanisms":[40],"3T3-L1":[42],"preadipocytes.":[43],"A":[44],"novel":[45],"paraprobiotic,":[46],"LAB-P,":[47],"prepared":[48],"from":[49],"live":[51],"Lactobacillus":[54],"plantarum":[55],"K8,":[56],"effectively":[57],"inhibited":[58],"during":[61],"adipogenesis":[62,105],"via":[63],"downregulation":[64,82],"key":[67],"activators":[68],"PPAR\u03b3":[69],"C/EBP\u03b1.":[71],"LAB-P-mediated":[72],"reduction":[73],"regulated":[77],"early":[78],"adipogenic":[79],"factors,":[80],"including":[81],"C/EBP\u03b2,":[84],"KLF4,":[85],"KLF5,":[86],"KROX20,":[87],"C/EBP\u03b4,":[89],"upregulation":[91],"DLK1.":[93],"Western":[94],"blotting":[95],"analysis":[96],"revealed":[97],"these":[99],"inhibitory":[100],"LAB-P":[103,139],"were":[106],"associated":[107],"with":[108],"regulating":[109],"JAK-STAT":[110],"AMPK\u03b1":[112],"signaling":[113],"pathways.":[114],"This":[115],"study":[116],"highlights":[117],"potential":[119],"paraprobiotics":[121],"as":[122,140],"a":[123,141],"functional":[124,142],"food":[125],"material":[126],"control":[128],"obesity":[129,146],"obesity-related":[131],"diseases,":[132],"provides":[134],"valuable":[135],"groundwork":[136],"for":[137],"utilizing":[138],"ingredient":[143],"alleviate":[145],"accumulation.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-11-08T00:00:00"}
