{"id":"https://openalex.org/W3210022409","doi":"https://doi.org/10.1016/j.bbrc.2021.10.034","title":"Antisense oligonucleotide repress telomerase activity via manipulating alternative splicing or translation","display_name":"Antisense oligonucleotide repress telomerase activity via manipulating alternative splicing or translation","publication_year":2021,"publication_date":"2021-10-21","ids":{"openalex":"https://openalex.org/W3210022409","doi":"https://doi.org/10.1016/j.bbrc.2021.10.034","mag":"3210022409","pmid":"https://pubmed.ncbi.nlm.nih.gov/34710826"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2021.10.034","doi":"https://doi.org/10.1016/j.bbrc.2021.10.034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2021.10.034","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Junrui Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junrui Zhou","raw_affiliation_strings":["Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018557232","display_name":"Tingfang Li","orcid":"https://orcid.org/0009-0008-6324-9993","observed_orcids":["https://orcid.org/0009-0008-6324-9993"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingfang Li","raw_affiliation_strings":["Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033286474","display_name":"Xin Geng","orcid":"https://orcid.org/0000-0003-0604-5392","observed_orcids":["https://orcid.org/0000-0003-0604-5392"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Geng","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033582579","display_name":"Lei Sui","orcid":"https://orcid.org/0000-0003-3586-9999","observed_orcids":["https://orcid.org/0000-0003-3586-9999"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Sui","raw_affiliation_strings":["Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, 300070, China. Electronic address: suilei@tmu.edu.cn","Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, 300070, China. Electronic address: suilei@tmu.edu.cn","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, 300070, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100431441","display_name":"Feng Wang","orcid":"https://orcid.org/0000-0001-7235-1676","observed_orcids":["https://orcid.org/0000-0001-7235-1676","https://orcid.org/0009-0007-5238-8704","https://orcid.org/0000-0002-3826-5579"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Wang","raw_affiliation_strings":["Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China; Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, 300070, China. Electronic address: wangf@tmu.edu.cn","Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China","Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, 300070, China"],"raw_orcid":"https://orcid.org/0000-0001-7235-1676","affiliations":[{"raw_affiliation_string":"Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China; Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, 300070, China. Electronic address: wangf@tmu.edu.cn","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, 300070, China","institution_ids":["https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033582579","https://openalex.org/A5100431441"],"corresponding_institution_ids":["https://openalex.org/I5740404"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":null,"fwci":0.6275,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.66004099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"582","issue":null,"first_page":"118","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9580000042915344},{"id":"https://openalex.org/keywords/telomerase-inhibition","display_name":"telomerase inhibition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.8870000243186951},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9660000205039978},{"id":"https://openalex.org/keywords/exon-skipping","display_name":"exon skipping","score":0.9570000171661377},{"id":"https://openalex.org/keywords/phosphorothioate-oligonucleotides","display_name":"phosphorothioate oligonucleotides","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.9002987146377563},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.7880676984786987},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.6648493409156799},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6508251428604126},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.5607448220252991},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5514293909072876},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5503336191177368},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5086660981178284},{"id":"https://openalex.org/C136571751","wikidata":"https://www.wikidata.org/wiki/Q424607","display_name":"Morpholino","level":4,"score":0.4753789007663727},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.47403860092163086},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.46025168895721436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45797985792160034},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.45422083139419556},{"id":"https://openalex.org/C143141573","wikidata":"https://www.wikidata.org/wiki/Q7450971","display_name":"Sense (electronics)","level":2,"score":0.4475107491016388},{"id":"https://openalex.org/C2778776201","wikidata":"https://www.wikidata.org/wiki/Q3474283","display_name":"Exon skipping","level":5,"score":0.4313916563987732},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.4182882308959961},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40769559144973755},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3412051200866699},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.31484493613243103},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2910011410713196},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21471214294433594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14143630862236023},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.13019120693206787},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054735","descriptor_name":"Phosphorothioate Oligonucleotides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D054735","descriptor_name":"Phosphorothioate Oligonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054735","descriptor_name":"Phosphorothioate Oligonucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060172","descriptor_name":"Morpholinos","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D060172","descriptor_name":"Morpholinos","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060172","descriptor_name":"Morpholinos","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2021.10.034","doi":"https://doi.org/10.1016/j.bbrc.2021.10.034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2021.10.034","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:34710826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34710826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6899999976158142}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1081967324","display_name":null,"funder_award_id":"91649102","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1917115871","display_name":null,"funder_award_id":"31471293","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G281346788","display_name":null,"funder_award_id":"19JCJQJC63500","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2901440725","display_name":null,"funder_award_id":"31771520","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G378748507","display_name":null,"funder_award_id":"81970958","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G426227850","display_name":null,"funder_award_id":"19JCZDJC35600","funder_id":"https://openalex.org/F4320338149","funder_display_name":"Tianjin Research Program of Application Foundation and Advanced Technology of China"},{"id":"https://openalex.org/G6270369181","display_name":null,"funder_award_id":"81771135","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G65776789","display_name":null,"funder_award_id":"32170762","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8973268875","display_name":null,"funder_award_id":"81772243","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338149","display_name":"Tianjin Research Program of Application Foundation and Advanced Technology of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W308364951","https://openalex.org/W642009597","https://openalex.org/W1915004688","https://openalex.org/W2009896186","https://openalex.org/W2025566170","https://openalex.org/W2060896826","https://openalex.org/W2093109424","https://openalex.org/W2112066726","https://openalex.org/W2114000430","https://openalex.org/W2124535586","https://openalex.org/W2124699861","https://openalex.org/W2242855051","https://openalex.org/W2290642869","https://openalex.org/W2316132657","https://openalex.org/W2321647501","https://openalex.org/W2328535333","https://openalex.org/W2562574576","https://openalex.org/W2577194681","https://openalex.org/W2743650830","https://openalex.org/W2791696217","https://openalex.org/W2909183032","https://openalex.org/W6742746474"],"related_works":["https://openalex.org/W2006877642","https://openalex.org/W2391664201","https://openalex.org/W2124685071","https://openalex.org/W2364777438","https://openalex.org/W7218829552","https://openalex.org/W2373442798","https://openalex.org/W2070094741","https://openalex.org/W35827988","https://openalex.org/W2363822530","https://openalex.org/W2130339110"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}