{"id":"https://openalex.org/W3209938867","doi":null,"title":"COPD P-002 : Association of miRNA-Mrna in PM-induced Inflammation in Human Bronchial Epithelial Cells","display_name":"COPD P-002 : Association of miRNA-Mrna in PM-induced Inflammation in Human Bronchial Epithelial Cells","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3209938867","mag":"3209938867"},"language":"ko","primary_location":{"id":"mag:3209938867","doi":null,"is_oa":false,"landing_page_url":"https://papersearch.net/google_link/fulltext.asp?file_name=0y913177.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306496805","display_name":"\ub300\ud55c\uacb0\ud575\ubc0f\ud638\ud761\uae30\ud559\ud68c \ucd94\uacc4\ud559\uc220\ubc1c\ud45c\ucd08\ub85d\uc9d1","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ub300\ud55c\uacb0\ud575\ubc0f\ud638\ud761\uae30\ud559\ud68c \ucd94\uacc4\ud559\uc220\ubc1c\ud45c\ucd08\ub85d\uc9d1","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tae-Hyun Nam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tae-Hyun Nam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041272233","display_name":"Eun Suk Son","orcid":"https://orcid.org/0000-0002-8149-4553","observed_orcids":["https://orcid.org/0000-0002-8149-4553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eun Suk Son","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8149-4553","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013860466","display_name":"Sung Hwan Jeong","orcid":"https://orcid.org/0000-0001-5031-1251","observed_orcids":["https://orcid.org/0000-0001-5031-1251","https://orcid.org/0000-0002-2182-8523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sung Hwan Jeong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063736270","display_name":"Sun Young Kyung","orcid":"https://orcid.org/0000-0001-6822-1027","observed_orcids":["https://orcid.org/0000-0001-6822-1027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sun Young Kyung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6822-1027","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21504666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"128","issue":null,"first_page":"511","last_page":"511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.48240000009536743,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.48240000009536743,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.2833999991416931,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.19099999964237213,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/particulate-matter","display_name":"particulate matter","score":0.8809999823570251},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.6700000166893005},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.902999997138977},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/beas-2b-cells","display_name":"BEAS-2B cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mirna-mrna-correlation","display_name":"miRNA-mRNA correlation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/mir-155-5p","display_name":"miR-155-5p","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cxcl1","display_name":"CXCL1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cxcl3","display_name":"CXCL3","score":0.996999979019165},{"id":"https://openalex.org/keywords/csf2","display_name":"CSF2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7627711296081543},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7548985481262207},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.5878077149391174},{"id":"https://openalex.org/C96525457","wikidata":"https://www.wikidata.org/wiki/Q5014879","display_name":"CXCL1","level":4,"score":0.5324215888977051},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5005702972412109},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48762741684913635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4765932261943817},{"id":"https://openalex.org/C2779018089","wikidata":"https://www.wikidata.org/wiki/Q17014303","display_name":"Fold change","level":4,"score":0.45378443598747253},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4167943298816681},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.3991289734840393},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35531842708587646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3372015953063965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14139115810394287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1289333999156952}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3209938867","doi":null,"is_oa":false,"landing_page_url":"https://papersearch.net/google_link/fulltext.asp?file_name=0y913177.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306496805","display_name":"\ub300\ud55c\uacb0\ud575\ubc0f\ud638\ud761\uae30\ud559\ud68c \ucd94\uacc4\ud559\uc220\ubc1c\ud45c\ucd08\ub85d\uc9d1","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ub300\ud55c\uacb0\ud575\ubc0f\ud638\ud761\uae30\ud559\ud68c \ucd94\uacc4\ud559\uc220\ubc1c\ud45c\ucd08\ub85d\uc9d1","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4283796964","https://openalex.org/W3184251573","https://openalex.org/W3007863342","https://openalex.org/W2963653581","https://openalex.org/W2569672165","https://openalex.org/W2992111967","https://openalex.org/W2992958489","https://openalex.org/W4220902466","https://openalex.org/W2761953708","https://openalex.org/W7098053233"],"abstract_inverted_index":{"Background\nParticulate":[0],"matters":[1],"(PM)":[2],"are":[3,36],"known":[4],"to":[5,43,50,59,66,78,247],"be":[6],"associated":[7],"with":[8],"respiratory":[9],"diseases":[10],"such":[11],"as":[12],"pneumonia":[13],"and":[14,58,75,84,115,125,138,152,162,172,182,194,223,233],"chronic":[15,140],"obstructive":[16],"pulmonary":[17,27],"disease":[18],"(COPD).":[19],"We":[20],"hypothesized":[21],"PM":[22,201],"exacerbates":[23],"inflammatory":[24,51,141,197],"response":[25,52],"in":[26,53,87,118,135,215],"diseases.":[28],"However,":[29],"the":[30,45,80,95,105,110,113,136,144,189,209],"molecular":[31],"mechanisms":[32],"of":[33,82,185,191,196,205,211,242,250],"PM-mediated":[34],"inflammation":[35,120,137,249],"still":[37],"unclear.":[38],"Therefore,":[39],"this":[40],"study":[41,77],"aimed":[42],"identify":[44],"dysregulated":[46,131,148],"genes":[47,175,198,214],"that":[48,240],"related":[49],"PM-exposed":[54,88,216,251],"bronchial":[55,252],"epithelial":[56,253],"cells,":[57,238],"explore":[60],"potential":[61],"microRNA":[62],"(miRNA)":[63],"mRNA":[64,83],"correlations":[65,97],"inhibit":[67],"PM-induced":[68,119,235],"inflammation.\nMethods\nWe":[69],"performed":[70],"a":[71],"next-generation":[72],"sequencing":[73],"(NGS)":[74],"bioinformatics":[76],"evaluate":[79],"changes":[81],"miRNA":[85],"profiles":[86],"BEAS":[89],"2B":[90,237],"cells.":[91,254],"Also,":[92],"we":[93,164],"analyzed":[94],"miRNA-mRNA":[96,244],"by":[98,123,200],"ingenuity":[99],"pathway":[100],"analysis":[101],"(IPA).":[102],"To":[103],"validate":[104],"Results":[106],"from":[107],"NGS":[108],"analysis,":[109],"expression":[111,195,210],"levels":[112],"miRNAs":[114,149,168,187,207],"mRNAs":[116,155],"involved":[117,134],"were":[121,150,156],"assessed":[122],"qRT-PCR":[124],"western":[126],"blot":[127],"analysis.\nResults\nWe":[128],"identified":[129,165],"1,088":[130],"genes,":[132],"mostly":[133],"airway":[139],"disorder.":[142],"Using":[143],"miRmap":[145],"database,":[146],"12":[147],"identified,":[151],"166":[153],"target":[154,174,213,225],"predicted.":[157],"After":[158],"validation":[159],"using":[160],"TargetScan":[161],"qRT-PCR,":[163],"three":[166],"downregulated":[167],"(hsa-miR-155-5p,":[169],"hsa-miR-210-5p,":[170,220],"hsa-miR-6515-5p)":[171],"their":[173,186,206,224],"(CXCL1,":[176],"CXCL3,":[177,228],"CSF2,":[178,229],"CSF3,":[179,230],"ICAM1,":[180,231],"CYP1A1":[181,232],"HMOX1).":[183],"Overexpression":[184],"suppressed":[188],"production":[190],"pro-inflammatory":[192],"cytokines":[193],"induced":[199],"exposure.":[202],"Furthermore,":[203],"overexpression":[204],"decreased":[208],"predicted":[212],"epithelial.\nConclusion\nWe":[217],"discovered":[218],"hsa-miR-155-5p,":[219],"hsa-miR-6515-5p":[221],"miRNAs,":[222],"mRNAs,":[226],"CXCL1,":[227],"HMOX1in":[234],"Beas":[236],"suggesting":[239],"association":[241],"these":[243],"might":[245],"contribute":[246],"increased":[248]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-11-08T00:00:00"}
