{"id":"https://openalex.org/W3209931923","doi":null,"title":"Quantitative Biochemical Differences between Tumor and Host as a Basis for Cancer Chemotherapy","display_name":"Quantitative Biochemical Differences between Tumor and Host as a Basis for Cancer Chemotherapy","publication_year":1956,"publication_date":"1956-08-01","ids":{"openalex":"https://openalex.org/W3209931923","mag":"3209931923"},"language":"en","primary_location":{"id":"mag:3209931923","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/canres/13/10/703.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Daniel M. Shapiro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel M. Shapiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046135486","display_name":"L.S. Dietrich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L.S. Dietrich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113772382","display_name":"Maurice E. Shils","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maurice E. Shils","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Anna Rita Atti","orcid":"https://orcid.org/0000-0002-6188-2647","observed_orcids":["https://orcid.org/0000-0002-6188-2647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Rita Atti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6188-2647","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065763109","display_name":"Eleanor Borries","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleanor Borries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059544712","display_name":"Ruth A. Fugmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruth A. Fugmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"V M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V M\u00fcller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047063969","display_name":"P Hayworth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Hayworth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028604698","display_name":"E. Zanar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Zanar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9477,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.89550425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"7","first_page":"575","last_page":"580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.47780001163482666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.47780001163482666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.3732999861240387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/riboflavin-analogs","display_name":"riboflavin analogs","score":0.8840000033378601},{"id":"https://openalex.org/keywords/8-azaguanine","display_name":"8-azaguanine","score":0.8769999742507935},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.796999990940094},{"id":"https://openalex.org/keywords/deoxypyridoxine","display_name":"deoxypyridoxine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/adenocarcinoma-755","display_name":"adenocarcinoma 755","score":0.9729999899864197},{"id":"https://openalex.org/keywords/riboflavin","display_name":"riboflavin","score":0.796999990940094},{"id":"https://openalex.org/keywords/flavin-adenine-dinucleotide","display_name":"flavin adenine dinucleotide","score":0.9539999961853027},{"id":"https://openalex.org/keywords/flavin-mononucleotide","display_name":"flavin mononucleotide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.949999988079071},{"id":"https://openalex.org/keywords/flavoenzyme","display_name":"flavoenzyme","score":0.597000002861023},{"id":"https://openalex.org/keywords/c57bl-mice","display_name":"C57BL mice","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2776155809","wikidata":"https://www.wikidata.org/wiki/Q130365","display_name":"Riboflavin","level":2,"score":0.95363450050354},{"id":"https://openalex.org/C2777427158","wikidata":"https://www.wikidata.org/wiki/Q376061","display_name":"Flavin mononucleotide","level":4,"score":0.6770239472389221},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6619145274162292},{"id":"https://openalex.org/C33093398","wikidata":"https://www.wikidata.org/wiki/Q174337","display_name":"Flavin group","level":3,"score":0.6269195079803467},{"id":"https://openalex.org/C2775859393","wikidata":"https://www.wikidata.org/wiki/Q28746","display_name":"Flavin adenine dinucleotide","level":4,"score":0.5185418725013733},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.4244585931301117},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41741180419921875},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4101800322532654},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.39333653450012207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.256891131401062},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.20041197538375854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11604610085487366}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3209931923","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/canres/13/10/703.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W51277067","https://openalex.org/W109976126","https://openalex.org/W127493116","https://openalex.org/W332493613","https://openalex.org/W1506598546","https://openalex.org/W1525669245","https://openalex.org/W1541702708","https://openalex.org/W1543453753","https://openalex.org/W1553690937","https://openalex.org/W1608702119","https://openalex.org/W1965187563","https://openalex.org/W1989935185","https://openalex.org/W1997583552","https://openalex.org/W2106985791","https://openalex.org/W2150648904","https://openalex.org/W2315543398","https://openalex.org/W2316927398","https://openalex.org/W2318140687","https://openalex.org/W2328397337","https://openalex.org/W2401606005","https://openalex.org/W2407193032","https://openalex.org/W2424054541"],"related_works":["https://openalex.org/W2337232925","https://openalex.org/W2123498974","https://openalex.org/W1561474266","https://openalex.org/W2170365595","https://openalex.org/W2321360997","https://openalex.org/W3048150417","https://openalex.org/W3217375666","https://openalex.org/W1021603052","https://openalex.org/W2471500731","https://openalex.org/W1496813529"],"abstract_inverted_index":{"6,7-Dimethyl-9-hydroxyethyl-isoalloxazine":[0],"(U-2113),":[1],"an":[2],"analog":[3],"of":[4,25,41,67,73,76,93,103,156,179,184,191,197,202],"riboflavin,":[5,137],"was":[6,99,161,186],"observed":[7],"to":[8,46,163,181,189,199],"have":[9],"very":[10,187],"weak":[11],"carcinostatic":[12,54,84],"action":[13],"when":[14],"used":[15],"alone":[16,62],"against":[17],"the":[18,26,39,64,71,91,129,134,151,157,195],"adenocarcinoma":[19,152],"755":[20,135],"grown":[21],"in":[22,34,83,87,113,133,150,167],"either":[23,42,118],"sex":[24],"C57BL":[27],"mouse.\n\nChemotherapeutic":[28],"trials":[29],"employing":[30],"8-azaguanine":[31,61],"and":[32,97,105,145,153],"testosterone":[33],"double":[35],"combination,":[36,50],"or":[37,44,120],"with":[38,101],"addition":[40],"deoxypyridoxine":[43,98,106],"U-2113":[45,104],"give":[47],"a":[48,80,207],"triple":[49],"produced":[51,59,79],"no":[52],"greater":[53],"effect":[55],"than":[56,169],"could":[57],"be":[58,111,164],"by":[60,108],"under":[63],"particular":[65],"conditions":[66],"these":[68,77],"experiments.":[69],"However,":[70],"combination":[72],"all":[74],"four":[75],"compounds":[78],"significant":[81],"increase":[82,86],"action.\n\nThe":[85],"carcinostasis":[88],"resulting":[89],"from":[90],"combining":[92],"8-azaguanine,":[94],"testosterone,":[95],"U-2113,":[96,125],"achieved":[100],"doses":[102],"which":[107,210],"themselves":[109],"would":[110],"ineffective":[112],"producing":[114],"toxic":[115],"effects":[116],"on":[117],"tumor":[119,168,185],"host":[121,154],"tissue.\n\nThe":[122],"riboflavin":[123,147,183,201],"analog,":[124],"does":[126],"not":[127],"antagonize":[128],"flavo-enzyme,":[130],"xanthine":[131],"oxidase,":[132],"tumor.\n\nTotal":[136],"flavin":[138,142],"adenine":[139],"dinucleotide":[140],"(FAD),":[141],"mononucleotide":[143],"(FMN),":[144],"free":[146],"were":[148],"measured":[149],"tissues":[155,205],"mice":[158],"(C57).":[159],"Riboflavin":[160],"found":[162],"significantly":[165],"lower":[166],"any":[170],"normal":[171,204],"tissue":[172],"analyzed":[173],"except":[174],"skeletal":[175],"muscle.":[176],"The":[177],"ratio":[178,196],"FAD":[180],"total":[182,200],"similar":[188],"that":[190],"other":[192],"tissues,":[193],"while":[194],"FMN":[198],"various":[203],"covered":[206],"wide":[208],"range":[209],"included":[211],"tumor.":[212]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-11-08T00:00:00"}
