{"id":"https://openalex.org/W3209813652","doi":"https://doi.org/10.1099/acmi.0.000271","title":"Genetic characterization of co-trimoxazole non-susceptible Streptococcus pneumoniae isolates from Indonesia","display_name":"Genetic characterization of co-trimoxazole non-susceptible Streptococcus pneumoniae isolates from Indonesia","publication_year":2021,"publication_date":"2021-10-25","ids":{"openalex":"https://openalex.org/W3209813652","doi":"https://doi.org/10.1099/acmi.0.000271","mag":"3209813652","pmid":"https://pubmed.ncbi.nlm.nih.gov/34816091","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8604174"},"language":"en","primary_location":{"id":"doi:10.1099/acmi.0.000271","doi":"https://doi.org/10.1099/acmi.0.000271","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.000271","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1099/acmi.0.000271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083999961","display_name":"Dodi Safari","orcid":"https://orcid.org/0000-0002-7639-7441","observed_orcids":["https://orcid.org/0000-0002-7639-7441"]},"institutions":[{"id":"https://openalex.org/I2800477803","display_name":"Eijkman Institute for Molecular Biology","ror":"https://ror.org/0308s4091","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I2800477803","https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Dodi Safari","raw_affiliation_strings":["Eijkman Institute for Molecular Biology, Jakarta, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-7639-7441","affiliations":[{"raw_affiliation_string":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia","institution_ids":["https://openalex.org/I2800477803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058407204","display_name":"Hanifah Fajri Maharani Putri","orcid":"https://orcid.org/0000-0003-0137-2474","observed_orcids":["https://orcid.org/0000-0003-0137-2474"]},"institutions":[{"id":"https://openalex.org/I148277539","display_name":"Surya University","ror":"https://ror.org/0351zfv36","country_code":"ID","type":"education","lineage":["https://openalex.org/I148277539"]},{"id":"https://openalex.org/I2800477803","display_name":"Eijkman Institute for Molecular Biology","ror":"https://ror.org/0308s4091","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I2800477803","https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Hanifah Fajri Maharani Putri","raw_affiliation_strings":["Biology Program, Surya University, Tangerang, Indonesia","Eijkman Institute for Molecular Biology, Jakarta, Indonesia"],"raw_orcid":"https://orcid.org/0000-0003-0137-2474","affiliations":[{"raw_affiliation_string":"Biology Program, Surya University, Tangerang, Indonesia","institution_ids":["https://openalex.org/I148277539"]},{"raw_affiliation_string":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia","institution_ids":["https://openalex.org/I2800477803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052427077","display_name":"Arrayan Bimantari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Arrayan Bimantari","raw_affiliation_strings":["Faculty of Biology, Gajah Mada University, Jogjakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Gajah Mada University, Jogjakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071592829","display_name":"Wisiva Tofriska Paramaiswari","orcid":"https://orcid.org/0000-0003-2808-5248","observed_orcids":["https://orcid.org/0000-0003-2808-5248"]},"institutions":[{"id":"https://openalex.org/I2800477803","display_name":"Eijkman Institute for Molecular Biology","ror":"https://ror.org/0308s4091","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I2800477803","https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Wisiva Tofriska Paramaiswari","raw_affiliation_strings":["Eijkman Institute for Molecular Biology, Jakarta, Indonesia"],"raw_orcid":"https://orcid.org/0000-0003-2808-5248","affiliations":[{"raw_affiliation_string":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia","institution_ids":["https://openalex.org/I2800477803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038543312","display_name":"Wisnu Tafroji","orcid":"https://orcid.org/0000-0003-0622-7022","observed_orcids":["https://orcid.org/0000-0003-0622-7022"]},"institutions":[{"id":"https://openalex.org/I2800477803","display_name":"Eijkman Institute for Molecular Biology","ror":"https://ror.org/0308s4091","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I2800477803","https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Wisnu Tafroji","raw_affiliation_strings":["Eijkman Institute for Molecular Biology, Jakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia","institution_ids":["https://openalex.org/I2800477803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005052897","display_name":"Miftahuddin Majid Khoeri","orcid":"https://orcid.org/0000-0002-8862-6707","observed_orcids":["https://orcid.org/0000-0002-8862-6707"]},"institutions":[{"id":"https://openalex.org/I2800477803","display_name":"Eijkman Institute for Molecular Biology","ror":"https://ror.org/0308s4091","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I2800477803","https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Miftahuddin Majid Khoeri","raw_affiliation_strings":["Eijkman Institute for Molecular Biology, Jakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia","institution_ids":["https://openalex.org/I2800477803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003738496","display_name":"Korrie Salsabila","orcid":"https://orcid.org/0000-0003-2866-678X","observed_orcids":["https://orcid.org/0000-0003-2866-678X"]},"institutions":[{"id":"https://openalex.org/I2800477803","display_name":"Eijkman Institute for Molecular Biology","ror":"https://ror.org/0308s4091","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I2800477803","https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Korrie Salsabila","raw_affiliation_strings":["Eijkman Institute for Molecular Biology, Jakarta, Indonesia"],"raw_orcid":"https://orcid.org/0000-0003-2866-678X","affiliations":[{"raw_affiliation_string":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia","institution_ids":["https://openalex.org/I2800477803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083999961"],"corresponding_institution_ids":["https://openalex.org/I2800477803"],"apc_list":{"value":700,"currency":"GBP","value_usd":858},"apc_paid":{"value":700,"currency":"GBP","value_usd":858},"fwci":0.1191,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"3","issue":"10","first_page":"000271","last_page":"000271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.357699990272522,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":1.0},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole-resistance","display_name":"trimethoprim-sulfamethoxazole resistance","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dihydropteroate-synthase","display_name":"dihydropteroate synthase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dihydrofolate-reductase","display_name":"dihydrofolate reductase","score":1.0},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.8140000104904175},{"id":"https://openalex.org/keywords/antimicrobial-resistance-genes","display_name":"antimicrobial resistance genes","score":0.6449999809265137},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/indonesia","display_name":"Indonesia","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2780866276","wikidata":"https://www.wikidata.org/wiki/Q7761386","display_name":"DHPS","level":4,"score":0.949609100818634},{"id":"https://openalex.org/C2781320022","wikidata":"https://www.wikidata.org/wiki/Q417149","display_name":"Dihydrofolate reductase","level":3,"score":0.8457667231559753},{"id":"https://openalex.org/C2777234095","wikidata":"https://www.wikidata.org/wiki/Q5276443","display_name":"Dihydropteroate synthase","level":5,"score":0.8300217390060425},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.7481995820999146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5845023393630981},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5545993447303772},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5258859992027283},{"id":"https://openalex.org/C2779425571","wikidata":"https://www.wikidata.org/wiki/Q415843","display_name":"Sulfamethoxazole","level":3,"score":0.5240652561187744},{"id":"https://openalex.org/C2780728791","wikidata":"https://www.wikidata.org/wiki/Q422665","display_name":"Trimethoprim","level":3,"score":0.5095512866973877},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4278486371040344},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42604804039001465},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39547520875930786},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3319436311721802},{"id":"https://openalex.org/C2777035104","wikidata":"https://www.wikidata.org/wiki/Q421072","display_name":"Pyrimethamine","level":4,"score":0.24838018417358398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1319369077682495},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.12998515367507935},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.05584588646888733},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1099/acmi.0.000271","doi":"https://doi.org/10.1099/acmi.0.000271","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.000271","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8604174","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8604174/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8604174/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiol","raw_type":"Text"},{"id":"pmid:34816091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34816091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access microbiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1099/acmi.0.000271","doi":"https://doi.org/10.1099/acmi.0.000271","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.000271","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3209813652.pdf","grobid_xml":"https://content.openalex.org/works/W3209813652.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1970432557","https://openalex.org/W2013627465","https://openalex.org/W2042511011","https://openalex.org/W2088568279","https://openalex.org/W2117383615","https://openalex.org/W2147323935","https://openalex.org/W2157680592","https://openalex.org/W2165669844","https://openalex.org/W2171803398","https://openalex.org/W2341199367","https://openalex.org/W2473050910","https://openalex.org/W2476219336","https://openalex.org/W2707842792","https://openalex.org/W2930430085","https://openalex.org/W2964631544","https://openalex.org/W3041214367"],"related_works":["https://openalex.org/W2165669844","https://openalex.org/W2145469243","https://openalex.org/W2171803398","https://openalex.org/W2418519739","https://openalex.org/W1860509478","https://openalex.org/W2170555633","https://openalex.org/W1993583316","https://openalex.org/W2117952052","https://openalex.org/W7097570574","https://openalex.org/W2097456009"],"abstract_inverted_index":{"We":[0,53],"investigated":[1],"the":[2,27,37,47,69,89,101,105,109,114],"genetic":[3],"variation":[4],"of":[5,41,58,72,100],"folA":[6,42,122],"and":[7,14,39,43,76,92,108,123],"folP":[8,44,124],"genes":[9,45],"encoding":[10],"dihydropteroate":[11],"synthase":[12],"(DHPS)":[13],"dihydrofolate":[15],"reductase":[16],"(DHFR)":[17],"enzymes":[18],"amongst":[19],"trimethoprim/sulfamethoxazole":[20],"(co-trimoxazole)":[21],"non-susceptible":[22,60],"Streptococcus":[23],"pneumoniae":[24,32],"isolated":[25],"from":[26],"Indonesian":[28],"population.":[29],"Archived":[30],"S.":[31],"isolates":[33,61,119],"were":[34,79],"screened":[35],"for":[36],"presence":[38],"analysis":[40],"using":[46],"polymerase":[48],"chain":[49],"reaction":[50],"sequencing":[51],"method.":[52],"found":[54],"that":[55],"80":[56],"%":[57],"co-trimoxazole":[59],"(n=30/39)":[62],"showed":[63],"a":[64],"6":[65,110],"bp":[66,111],"insertion":[67,112],"in":[68],"sulphonamide-binding":[70],"site":[71],"DHPS.":[73],"The":[74,98],"Asp-92-Ala":[75],"Ile-100-Leu":[77],"substitutions":[78,94],"more":[80],"common":[81],"on":[82],"DHFR":[83,106],"(42":[84],"%;":[85,96],"22/53)":[86],"followed":[87],"by":[88],"Asp-92\u2013Ala,":[90],"Glu-94\u2013Asp":[91],"Ile-100\u2013Leu":[93,102],"(32":[95],"17/53).":[97],"combination":[99,117],"substitution":[103],"at":[104],"region":[107],"was":[113],"most":[115],"dominant":[116],"among":[118],"having":[120],"both":[121],"genes.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-11-08T00:00:00"}
