{"id":"https://openalex.org/W3209756798","doi":"https://doi.org/10.14309/ctg.0000000000000416","title":"Specific Plasma MicroRNA Signatures in Predicting and Confirming Crohn's Disease Recurrence: Role and Pathogenic Implications","display_name":"Specific Plasma MicroRNA Signatures in Predicting and Confirming Crohn's Disease Recurrence: Role and Pathogenic Implications","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3209756798","doi":"https://doi.org/10.14309/ctg.0000000000000416","mag":"3209756798","pmid":"https://pubmed.ncbi.nlm.nih.gov/34695034","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8547914"},"language":"en","primary_location":{"id":"doi:10.14309/ctg.0000000000000416","doi":"https://doi.org/10.14309/ctg.0000000000000416","is_oa":true,"landing_page_url":"https://doi.org/10.14309/ctg.0000000000000416","pdf_url":null,"source":{"id":"https://openalex.org/S2764670792","display_name":"Clinical and Translational Gastroenterology","issn_l":"2155-384X","issn":["2155-384X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.14309/ctg.0000000000000416","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090655982","display_name":"In\u00e9s Moret\u2010Tatay","orcid":"https://orcid.org/0000-0003-2086-1521","observed_orcids":["https://orcid.org/0000-0003-2086-1521"]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"In\u00e9s Moret-Tatay","raw_affiliation_strings":["Biomedical Research Centre, Hepatic and Digestive Diseases Network [Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)], Madrid, Spain;","Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;"],"raw_orcid":"https://orcid.org/0000-0003-2086-1521","affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, Hepatic and Digestive Diseases Network [Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)], Madrid, Spain;","institution_ids":["https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","institution_ids":["https://openalex.org/I4210166036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020843754","display_name":"Elena Cerrillo","orcid":"https://orcid.org/0000-0001-7623-7299","observed_orcids":["https://orcid.org/0000-0001-7623-7299"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]},{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Cerrillo","raw_affiliation_strings":["Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","institution_ids":["https://openalex.org/I4210166036"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005116367","display_name":"David Herv\u00e1s","orcid":"https://orcid.org/0000-0003-0635-4961","observed_orcids":["https://orcid.org/0000-0003-0635-4961"]},"institutions":[{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Herv\u00e1s","raw_affiliation_strings":["Biostatistics Unit, Health Research IIS La Fe, Valencia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Unit, Health Research IIS La Fe, Valencia, Spain;","institution_ids":["https://openalex.org/I4210166036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041654625","display_name":"Marisa Iborra","orcid":"https://orcid.org/0000-0001-7360-7581","observed_orcids":["https://orcid.org/0000-0001-7360-7581"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marisa Iborra","raw_affiliation_strings":["Biomedical Research Centre, Hepatic and Digestive Diseases Network [Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)], Madrid, Spain;","Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, Hepatic and Digestive Diseases Network [Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)], Madrid, Spain;","institution_ids":["https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","institution_ids":["https://openalex.org/I4210166036"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014674437","display_name":"Esteban S\u00e1ez Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-9042-2308","observed_orcids":["https://orcid.org/0000-0002-9042-2308"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]},{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esteban S\u00e1ez-Gonz\u00e1lez","raw_affiliation_strings":["Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","institution_ids":["https://openalex.org/I4210166036"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051218241","display_name":"Javier Forment","orcid":"https://orcid.org/0000-0002-1872-4061","observed_orcids":["https://orcid.org/0000-0002-1872-4061"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210164699","display_name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas","ror":"https://ror.org/04zdays56","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210164699","https://openalex.org/I60053951"]},{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Forment","raw_affiliation_strings":["The Institute for Plant Molecular and Cellular Biology (IBMCP), Polytechnic University of Valencia- Spanish Research Council (CSIC), Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute for Plant Molecular and Cellular Biology (IBMCP), Polytechnic University of Valencia- Spanish Research Council (CSIC), Valencia, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210164699","https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007071345","display_name":"Lu\u00eds Tortosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Tortosa","raw_affiliation_strings":["Biomedical Research Centre, Hepatic and Digestive Diseases Network [Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)], Madrid, Spain;","Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, Hepatic and Digestive Diseases Network [Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)], Madrid, Spain;","institution_ids":["https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","institution_ids":["https://openalex.org/I4210166036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082466185","display_name":"Pilar Nos","orcid":"https://orcid.org/0000-0002-6619-1511","observed_orcids":["https://orcid.org/0000-0002-6619-1511"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Nos","raw_affiliation_strings":["Biomedical Research Centre, Hepatic and Digestive Diseases Network [Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)], Madrid, Spain;","Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, Hepatic and Digestive Diseases Network [Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)], Madrid, Spain;","institution_ids":["https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","institution_ids":["https://openalex.org/I4210166036"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049691691","display_name":"Jos\u00e9 Gadea","orcid":"https://orcid.org/0000-0002-3612-7914","observed_orcids":["https://orcid.org/0000-0002-3612-7914"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210164699","display_name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas","ror":"https://ror.org/04zdays56","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210164699","https://openalex.org/I60053951"]},{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jose Gadea","raw_affiliation_strings":["The Institute for Plant Molecular and Cellular Biology (IBMCP), Polytechnic University of Valencia- Spanish Research Council (CSIC), Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute for Plant Molecular and Cellular Biology (IBMCP), Polytechnic University of Valencia- Spanish Research Council (CSIC), Valencia, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210164699","https://openalex.org/I60053951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029279273","display_name":"Bel\u00e9n Beltr\u00e1n","orcid":"https://orcid.org/0000-0002-7063-6376","observed_orcids":["https://orcid.org/0000-0002-7063-6376"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Bel\u00e9n Beltr\u00e1n","raw_affiliation_strings":["Biomedical Research Centre, Hepatic and Digestive Diseases Network [Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)], Madrid, Spain;","Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre, Hepatic and Digestive Diseases Network [Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)], Madrid, Spain;","institution_ids":["https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Research Group, Health Research Institute, Hospital La Fe (IIS La Fe), Valencia, Spain;","institution_ids":["https://openalex.org/I4210166036"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, Valencia, Spain;","institution_ids":["https://openalex.org/I3019010403"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5029279273","https://openalex.org/A5049691691"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I3019010403","https://openalex.org/I4210132431","https://openalex.org/I4210164699","https://openalex.org/I4210166036","https://openalex.org/I60053951"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":1.1286,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.76636528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"12","issue":"10","first_page":"e00416","last_page":"e00416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.04019999876618385,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/postoperative-recurrence","display_name":"postoperative recurrence","score":0.9520000219345093},{"id":"https://openalex.org/keywords/plasma-mirna","display_name":"plasma microRNA","score":0.8119999766349792},{"id":"https://openalex.org/keywords/microrna-signature","display_name":"microRNA signature","score":0.6549999713897705},{"id":"https://openalex.org/keywords/recurrence-prediction","display_name":"recurrence prediction","score":0.6840000152587891},{"id":"https://openalex.org/keywords/nomogram","display_name":"nomogram","score":0.5680000185966492},{"id":"https://openalex.org/keywords/mir-15b-5p","display_name":"miR-15b-5p","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mir-451a","display_name":"miR-451a","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mir-93-5p","display_name":"miR-93-5p","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mir-106b-5p","display_name":"miR-106b-5p","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mir-125b-5p","display_name":"miR-125b-5p","score":0.902999997138977},{"id":"https://openalex.org/keywords/mir-423-5p","display_name":"miR-423-5p","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mir-191-5p","display_name":"miR-191-5p","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cyclin-d2","display_name":"cyclin D2","score":0.6859999895095825},{"id":"https://openalex.org/keywords/bcl9l","display_name":"BCL9L","score":0.996999979019165},{"id":"https://openalex.org/keywords/senp5","display_name":"SENP5","score":0.9860000014305115},{"id":"https://openalex.org/keywords/akt3","display_name":"AKT3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/suv39h1","display_name":"SUV39H1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7229999899864197},{"id":"https://openalex.org/keywords/ileal-crohn-s-disease","display_name":"ileal Crohn's disease","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.8518136739730835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7957148551940918},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5234277248382568},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4590010643005371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3643167316913605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10739043354988098},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09171432256698608},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0860782265663147}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.14309/ctg.0000000000000416","doi":"https://doi.org/10.14309/ctg.0000000000000416","is_oa":true,"landing_page_url":"https://doi.org/10.14309/ctg.0000000000000416","pdf_url":null,"source":{"id":"https://openalex.org/S2764670792","display_name":"Clinical and Translational Gastroenterology","issn_l":"2155-384X","issn":["2155-384X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7437686","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8547914","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8547914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8547914","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Gastroenterol","raw_type":"Text"},{"id":"pmid:34695034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34695034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational gastroenterology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.14309/ctg.0000000000000416","doi":"https://doi.org/10.14309/ctg.0000000000000416","is_oa":true,"landing_page_url":"https://doi.org/10.14309/ctg.0000000000000416","pdf_url":null,"source":{"id":"https://openalex.org/S2764670792","display_name":"Clinical and Translational Gastroenterology","issn_l":"2155-384X","issn":["2155-384X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W993266572","https://openalex.org/W1497803007","https://openalex.org/W1579196248","https://openalex.org/W1713116667","https://openalex.org/W1877299465","https://openalex.org/W1963557963","https://openalex.org/W1965811760","https://openalex.org/W1996948576","https://openalex.org/W2000915117","https://openalex.org/W2001678644","https://openalex.org/W2021489180","https://openalex.org/W2021992979","https://openalex.org/W2027568683","https://openalex.org/W2031581992","https://openalex.org/W2041606152","https://openalex.org/W2043015183","https://openalex.org/W2055237453","https://openalex.org/W2061453779","https://openalex.org/W2066572073","https://openalex.org/W2074932800","https://openalex.org/W2086096279","https://openalex.org/W2098055602","https://openalex.org/W2099435096","https://openalex.org/W2104619111","https://openalex.org/W2108417458","https://openalex.org/W2116655875","https://openalex.org/W2120133117","https://openalex.org/W2121159565","https://openalex.org/W2126660615","https://openalex.org/W2149031002","https://openalex.org/W2151871253","https://openalex.org/W2154302514","https://openalex.org/W2158217645","https://openalex.org/W2397650599","https://openalex.org/W2408483783","https://openalex.org/W2412122553","https://openalex.org/W2418867279","https://openalex.org/W2633313719","https://openalex.org/W2776325971","https://openalex.org/W2793889788","https://openalex.org/W2810862053","https://openalex.org/W2897825874","https://openalex.org/W2898258923","https://openalex.org/W2900446244","https://openalex.org/W2909605413","https://openalex.org/W2911312028","https://openalex.org/W2926335505","https://openalex.org/W2929646270","https://openalex.org/W2930960951","https://openalex.org/W2935815935","https://openalex.org/W2942272856","https://openalex.org/W2944646376","https://openalex.org/W2972782324","https://openalex.org/W2982529478","https://openalex.org/W2985560234","https://openalex.org/W2994919485","https://openalex.org/W2995977351","https://openalex.org/W3003677250","https://openalex.org/W3018986011","https://openalex.org/W3025620559","https://openalex.org/W3062058726","https://openalex.org/W3080550661","https://openalex.org/W3082066461","https://openalex.org/W3096139129","https://openalex.org/W3147361233","https://openalex.org/W4236667303","https://openalex.org/W4287242918","https://openalex.org/W4294541781","https://openalex.org/W4310142178","https://openalex.org/W4403515349","https://openalex.org/W6783014551","https://openalex.org/W6793073447","https://openalex.org/W6840226119","https://openalex.org/W7075598231"],"related_works":["https://openalex.org/W3000322703","https://openalex.org/W2120133117","https://openalex.org/W2586836667","https://openalex.org/W993266572","https://openalex.org/W2909605413","https://openalex.org/W7120464516","https://openalex.org/W4318539735","https://openalex.org/W7100616747","https://openalex.org/W4386701711","https://openalex.org/W2510026681"],"abstract_inverted_index":{"INTRODUCTION:":[0],"MicroRNAs":[1],"(miRNAs)":[2],"are":[3],"important":[4],"epigenetic":[5],"regulators":[6],"in":[7,30,33,109,252],"Crohn's":[8],"disease":[9],"(CD);":[10],"however,":[11],"their":[12,40],"contribution":[13],"to":[14,23,38,73,196,206,217,240],"postoperative":[15],"recurrence":[16],"(POR)":[17],"is":[18],"still":[19],"unknown.":[20],"We":[21,182,237],"aimed":[22],"characterize":[24],"the":[25,74,136,147,173,242],"potential":[26],"role":[27],"of":[28,78,149,175,245],"miRNAs":[29,89,124,250],"predicting":[31],"POR":[32,79,103,187,229],"patients":[34,48,69,226],"with":[35,49,54,143,169],"CD":[36],"and":[37,65,100,117,129,162,191,201,208,211,213,259],"identify":[39,225],"pathogenic":[41],"implications.":[42],"METHODS:":[43],"Of":[44],"67":[45],"consecutively":[46],"operated":[47],"CD,":[50],"we":[51],"included":[52],"44":[53],"pure":[55],"ileal":[56],"CD.":[57],"Peripheral":[58],"blood":[59],"samples":[60],"were":[61,70,90,119,131,164,194,204,215],"taken":[62],"before":[63,98],"surgery":[64,99],"during":[66,101],"follow-up.":[67],"The":[68,88,248],"classified":[71],"according":[72],"presence":[75],"or":[76,83],"absence":[77],"assessed":[80],"by":[81,92],"ileocolonoscopy":[82],"magnetic":[84],"resonance":[85],"imaging":[86],"enterography.":[87],"profiled":[91],"reverse":[93],"transcription":[94],"polymerase":[95],"chain":[96],"reaction":[97],"morphological":[102],"or,":[104],"for":[105,133,166,186],"those":[106],"who":[107],"remained":[108],"remission,":[110],"1":[111,167,209,218],"year":[112],"after":[113],"surgery.":[114],"R":[115],"software":[116],"mirWalk":[118],"used.":[120],"RESULTS:":[121],"Five":[122],"human":[123],"(miR-191-5p,":[125],"miR-15b-5p,":[126],"miR-106b-5p,":[127],"miR-451a,":[128,159],"miR-93-5p)":[130],"selected":[132,165],"discriminating":[134],"between":[135],"2":[137],"patient":[138,235],"groups":[139],"at":[140,227],"presurgery":[141],"(PS),":[142],"an":[144,170],"area":[145,171],"under":[146,172],"curve":[148,174],"0.88":[150],"(95%":[151,177],"confidence":[152,178],"interval":[153,179],"[0.79,":[154],"0.98]).":[155],"Another":[156],"5":[157],"(miR-15b-5p,":[158],"miR-93-5p,":[160],"miR-423-5p,":[161],"miR-125b-5p)":[163],"year,":[168],"0.96":[176],"[0.91,":[180],"1.0]).":[181],"also":[183],"created":[184],"nomograms":[185,239],"risk":[188],"estimation.":[189],"CCND2":[190],"BCL9L":[192],"genes":[193,203],"related":[195,205,216],"PS":[197,207],"miRNA":[198,223],"profiles;":[199],"SENP5":[200],"AKT3":[202],"year;":[210],"SUV39H1":[212],"MAPK3K10":[214],"year.":[219],"DISCUSSION:":[220],"Different":[221],"plasma":[222],"signatures":[224],"high":[228],"risk,":[230],"which":[231],"could":[232],"help":[233],"optimize":[234],"outcomes.":[236],"developed":[238],"facilitate":[241],"clinical":[243],"use":[244],"these":[246],"results.":[247],"identified":[249],"participate":[251],"apoptosis,":[253],"autophagy,":[254],"proinflammatory":[255],"immunological":[256],"T-cell":[257],"clusters,":[258],"reactive":[260],"oxygen":[261],"species":[262],"metabolism.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}