{"id":"https://openalex.org/W3209434682","doi":"https://doi.org/10.3390/cells10112891","title":"Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model","display_name":"Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model","publication_year":2021,"publication_date":"2021-10-26","ids":{"openalex":"https://openalex.org/W3209434682","doi":"https://doi.org/10.3390/cells10112891","mag":"3209434682","pmid":"https://pubmed.ncbi.nlm.nih.gov/34831118","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8616236"},"language":"en","primary_location":{"id":"doi:10.3390/cells10112891","doi":"https://doi.org/10.3390/cells10112891","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells10112891","pdf_url":"https://www.mdpi.com/2073-4409/10/11/2891/pdf?version=1635251506","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/10/11/2891/pdf?version=1635251506","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103012555","display_name":"Xiaonan Sun","orcid":"https://orcid.org/0000-0003-2207-4716","observed_orcids":["https://orcid.org/0000-0003-2207-4716"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaonan Sun","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084068635","display_name":"Ning Zhou","orcid":"https://orcid.org/0000-0003-0863-3091","observed_orcids":["https://orcid.org/0000-0003-0863-3091"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ning Zhou","raw_affiliation_strings":["Division of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92318, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92318, USA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110552903","display_name":"Ben Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Ma","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082993916","display_name":"Wenqian Wu","orcid":"https://orcid.org/0000-0002-0452-9273","observed_orcids":["https://orcid.org/0000-0002-0452-9273","https://orcid.org/0009-0007-4507-4889"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenqian Wu","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA"],"raw_orcid":"https://orcid.org/0000-0002-0452-9273","affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067846239","display_name":"Shaunrick Stoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaunrick Stoll","raw_affiliation_strings":["Division of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92318, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92318, USA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020184352","display_name":"Lo Lai","orcid":"https://orcid.org/0009-0004-4395-1364","observed_orcids":["https://orcid.org/0009-0004-4395-1364"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lo Lai","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002798288","display_name":"Gangjian Qin","orcid":"https://orcid.org/0000-0002-3135-7307","observed_orcids":["https://orcid.org/0000-0002-3135-7307"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gangjian Qin","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020701449","display_name":"Hongyu Qiu","orcid":"https://orcid.org/0000-0002-2436-8921","observed_orcids":["https://orcid.org/0000-0002-2436-8921"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hongyu Qiu","raw_affiliation_strings":["Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA","Division of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92318, USA"],"raw_orcid":"https://orcid.org/0000-0002-2436-8921","affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I181565077"]},{"raw_affiliation_string":"Division of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92318, USA","institution_ids":["https://openalex.org/I26347476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020701449"],"corresponding_institution_ids":["https://openalex.org/I181565077","https://openalex.org/I26347476"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":0.6276,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.62705346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"10","issue":"11","first_page":"2891","last_page":"2891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.384799987077713,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.384799987077713,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.2897999882698059,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.18979999423027039,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valosin-containing-protein","display_name":"VCP","score":0.972000002861023},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cardiac-dilation","display_name":"cardiac dilatation","score":0.902999997138977},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.9520000219345093},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.7720000147819519},{"id":"https://openalex.org/keywords/atpase-activity","display_name":"ATPase activity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5080000162124634},{"id":"https://openalex.org/keywords/nucleocytoplasmic-shuttling","display_name":"nucleocytoplasmic shuttling","score":0.6600000262260437},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6247135400772095},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5900633335113525},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5181987881660461},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5121209621429443},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4867253601551056},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4789469838142395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40287381410598755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3755248785018921},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3521937429904938},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.33765706419944763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.317268431186676},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29976898431777954},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23161303997039795},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.152028888463974},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0967845618724823}],"mesh":[{"descriptor_ui":"D000074405","descriptor_name":"Valosin Containing Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000074405","descriptor_name":"Valosin Containing Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/cells10112891","doi":"https://doi.org/10.3390/cells10112891","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells10112891","pdf_url":"https://www.mdpi.com/2073-4409/10/11/2891/pdf?version=1635251506","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8616236","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8616236","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmid:34831118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34831118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:edd7597b2f3f4e32b0397aa06d10e564","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/edd7597b2f3f4e32b0397aa06d10e564","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 10, Iss 11, p 2891 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells10112891","doi":"https://doi.org/10.3390/cells10112891","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells10112891","pdf_url":"https://www.mdpi.com/2073-4409/10/11/2891/pdf?version=1635251506","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1082706728","display_name":"Novel mechanisms mediating cardiac protection upon pressure overload","funder_award_id":"R56HL137962","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4954513350","display_name":"Novel mechanism mediating cardiac protection upon pressure overload","funder_award_id":"R01HL137962","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6622513991","display_name":"Role of VCP in coronary ischemic injury","funder_award_id":"R01HL142291","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7285413546","display_name":"Intrinsic stiffness of aortic vascular smooth muscle cell in the development of hypertension","funder_award_id":"R01HL115195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000136307","display_name":null,"funder_award_id":"HL137962","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3209434682.pdf","grobid_xml":"https://content.openalex.org/works/W3209434682.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W181982349","https://openalex.org/W1528145391","https://openalex.org/W1689039642","https://openalex.org/W1968731846","https://openalex.org/W1975403755","https://openalex.org/W1983160166","https://openalex.org/W2002330190","https://openalex.org/W2003079343","https://openalex.org/W2008219605","https://openalex.org/W2020960677","https://openalex.org/W2040551057","https://openalex.org/W2043345690","https://openalex.org/W2043997676","https://openalex.org/W2051152369","https://openalex.org/W2058786295","https://openalex.org/W2061673254","https://openalex.org/W2099208822","https://openalex.org/W2100599614","https://openalex.org/W2103959299","https://openalex.org/W2115064839","https://openalex.org/W2115378291","https://openalex.org/W2126753299","https://openalex.org/W2143514140","https://openalex.org/W2155537040","https://openalex.org/W2171862076","https://openalex.org/W2201659533","https://openalex.org/W2300083264","https://openalex.org/W2464814890","https://openalex.org/W2536564825","https://openalex.org/W2559362560","https://openalex.org/W2605749084","https://openalex.org/W2742501476","https://openalex.org/W2742837250","https://openalex.org/W2769061006","https://openalex.org/W2779928931","https://openalex.org/W2795200378","https://openalex.org/W2810410577","https://openalex.org/W2940379717","https://openalex.org/W2966555630","https://openalex.org/W2979586066","https://openalex.org/W3032263408","https://openalex.org/W3043781715","https://openalex.org/W3046218637","https://openalex.org/W3046932207","https://openalex.org/W3093962046","https://openalex.org/W3096222579","https://openalex.org/W3153966061","https://openalex.org/W6678597336"],"related_works":["https://openalex.org/W4399533872","https://openalex.org/W2584672410","https://openalex.org/W4242549959","https://openalex.org/W3176366892","https://openalex.org/W2395292855","https://openalex.org/W2757365300","https://openalex.org/W2912534619","https://openalex.org/W3093962046","https://openalex.org/W2605749084","https://openalex.org/W3046218637"],"abstract_inverted_index":{"Valosin-containing":[0],"protein":[1,149,152,154],"(VCP)":[2],"was":[3],"found":[4],"to":[5,58,164],"play":[6],"a":[7,50,79,115,183],"vital":[8],"protective":[9],"role":[10,27],"against":[11],"cardiac":[12,81,86,105],"stresses.":[13],"Genetic":[14],"mutations":[15],"of":[16,28,62,76,125,138,176],"VCP":[17,29,41,53,64,99,189],"are":[18],"associated":[19],"with":[20,168],"human":[21],"dilated":[22],"cardiomyopathy.":[23],"However,":[24],"the":[25,31,34,40,60,67,89,97,109,121,131,136,139,143,165,169,191],"essential":[26],"in":[30,43,108,130,173,190,193],"heart":[32,132,192],"during":[33,88],"physiological":[35,194],"condition":[36],"remains":[37],"unknown":[38],"since":[39],"knockout":[42],"mice":[44],"is":[45],"embryonically":[46],"lethal.":[47],"We":[48],"generated":[49],"cardiac-specific":[51,74],"dominant-negative":[52],"transgenic":[54],"(DN-VCP":[55],"TG)":[56],"mouse":[57,112,181],"determine":[59],"effects":[61],"impaired":[63,120],"activity":[65,107],"on":[66],"heart.":[68],"Using":[69],"echocardiography,":[70],"we":[71],"showed":[72],"that":[73],"overexpression":[75],"DN-VCP":[77,93,110,118,179],"induced":[78],"remarkable":[80],"dilation":[82],"and":[83,127,134,158,195],"progressively":[84],"declined":[85],"function":[87],"aging":[90],"transition.":[91],"Mechanistically,":[92],"did":[94],"not":[95],"affect":[96],"endogenous":[98],"(EN-VCP)":[100],"expression":[101],"but":[102],"significantly":[103,119],"reduced":[104],"ATPase":[106],"TG":[111,180],"hearts,":[113],"indicating":[114],"functional":[116,174],"inhibition.":[117],"aging-related":[122],"cytoplasmic/nuclear":[123],"shuffling":[124],"EN-VCP":[126],"its":[128,159],"co-factors":[129],"tissues":[133],"interrupted":[135],"balance":[137],"VCP-cofactors":[140],"interaction":[141],"between":[142],"activating":[144],"co-factors,":[145],"ubiquitin":[146],"fusion":[147],"degradation":[148],"1":[150],"(UFD-1)/nuclear":[151],"localization":[153],"4":[155],"(NPL-4)":[156],"complex,":[157],"inhibiting":[160],"co-factor":[161],"P47,":[162],"leading":[163],"binding":[166],"preference":[167],"inhibitory":[170],"co-factor,":[171],"resulting":[172],"repression":[175],"VCP.":[177],"This":[178],"provides":[182],"unique":[184],"functional-inactivation":[185],"model":[186],"for":[187],"investigating":[188],"pathological":[196],"conditions.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}