{"id":"https://openalex.org/W320939438","doi":null,"title":"Up regulation of interleukin-8 expressions induced by mast cell tryptase via protease activated receptor-2 in endothelial cell line.","display_name":"Up regulation of interleukin-8 expressions induced by mast cell tryptase via protease activated receptor-2 in endothelial cell line.","publication_year":2005,"publication_date":"2005-11-20","ids":{"openalex":"https://openalex.org/W320939438","mag":"320939438","pmid":"https://pubmed.ncbi.nlm.nih.gov/16313845"},"language":"en","primary_location":{"id":"pmid:16313845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16313845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044847603","display_name":"Chao L\u00fc","orcid":"https://orcid.org/0000-0002-9484-6415","observed_orcids":["https://orcid.org/0000-0002-9484-6415"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Lu","raw_affiliation_strings":["Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113946826","display_name":"Fengdi Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng-di Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318764","display_name":"Xiaobo Li","orcid":"https://orcid.org/0000-0003-2554-4234","observed_orcids":["https://orcid.org/0000-0003-2554-4234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Bo Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Lian-Hua Yin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lian-Hua Yin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1498,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.78430578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"118","issue":"22","first_page":"1900","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.5562000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.5562000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.35569998621940613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.06040000170469284,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protease-activated-receptor-2","display_name":"protease-activated receptor 2","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tryptase","display_name":"tryptase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9819999933242798},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/ecv304-cells","display_name":"ECV304 cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/receptor-activation","display_name":"receptor activation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/protease-signaling","display_name":"protease signaling","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2781406822","wikidata":"https://www.wikidata.org/wiki/Q904140","display_name":"Tryptase","level":3,"score":0.9556645750999451},{"id":"https://openalex.org/C125268873","wikidata":"https://www.wikidata.org/wiki/Q17918484","display_name":"Protease-activated receptor 2","level":4,"score":0.834383487701416},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.7285022139549255},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6586791276931763},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5073522925376892},{"id":"https://openalex.org/C149577978","wikidata":"https://www.wikidata.org/wiki/Q24777577","display_name":"Protease-activated receptor","level":4,"score":0.48785996437072754},{"id":"https://openalex.org/C122862929","wikidata":"https://www.wikidata.org/wiki/Q18048437","display_name":"Interleukin 33","level":4,"score":0.47858452796936035},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.45160967111587524},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4159950315952301},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.41123417019844055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36528244614601135},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.23225948214530945},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19548609852790833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15719828009605408},{"id":"https://openalex.org/C75184817","wikidata":"https://www.wikidata.org/wiki/Q5381540","display_name":"Enzyme-linked receptor","level":3,"score":0.09135788679122925},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053802","descriptor_name":"Tryptases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16313845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16313845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:3150809260","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85656X/200522/20666434.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541197","display_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null},{"id":"mag:320939438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16313845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7023926085","https://openalex.org/W7096798777","https://openalex.org/W2069097967","https://openalex.org/W7098971827","https://openalex.org/W2029030860","https://openalex.org/W2018245020","https://openalex.org/W2371650128","https://openalex.org/W2372462022","https://openalex.org/W2276204843","https://openalex.org/W2912987259"],"abstract_inverted_index":{"BACKGROUND:":[0],"Protease":[1,60,182],"activated":[2,7,44,61,119,149,177,183],"receptor-2":[3,62,120,150,178,184],"is":[4,24],"cleaved":[5],"and":[6,14,49,78,93,115,127,137],"by":[8,45,72,83,91,102,146,159],"trypsin":[9],"or":[10],"mast":[11,46,86,188],"cell":[12,47,68,71,87,189],"tryptase":[13,48,52,88,128,169,190],"may":[15],"play":[16],"an":[17,147],"important":[18],"role":[19],"in":[20,56,66,124,195],"inflammation.":[21],"However,":[22],"it":[23],"unknown":[25],"whether":[26,39],"PAR-2":[27,40],"can":[28,185],"mediate":[29,186],"tryptase-induced":[30],"inflammatory":[31],"reaction.":[32],"This":[33],"study":[34,111],"was":[35,64,89,144,157,179],"conduct":[36],"to":[37],"investigate":[38],"could":[41,121],"be":[42,122],"the":[43,51,103,130,163,187],"medicated":[50],"induced":[53],"interleukin-8":[54,135,143,194],"expression":[55,63,131,141,192],"endothelial":[57,67],"cells.":[58],"METHODS:":[59],"found":[65],"lines":[69],"ECV304":[70,125,166,196],"reverse":[73],"transcription-polymerase":[74],"chain":[75],"reaction":[76],"(RT-PCR)":[77],"Western":[79,160],"blotting.":[80],"Interleukin-8":[81],"stimulated":[82,191],"purified":[84],"human":[85],"determined":[90],"RT-PCR":[92],"enzyme":[94],"linked":[95],"immunosorbent":[96],"assay":[97],"(ELISA).":[98],"Data":[99],"were":[100],"analysed":[101],"S-N-K":[104],"one-way":[105],"ANOVA":[106],"test.":[107],"RESULTS:":[108],"The":[109,139],"present":[110],"shows":[112],"that":[113,175],"mRNA":[114,136],"protein":[116],"of":[117,133,142,165,193],"protease":[118,176],"expressed":[123],"cells,":[126],"upregulated":[129],"levels":[132],"both":[134],"protein.":[138],"increased":[140],"inhibited":[145],"antiprotease":[148],"monoclonal":[151],"antibody,":[152],"SAM11.":[153],"An":[154],"additional":[155],"band":[156],"observed":[158],"blotting":[161],"after":[162],"incubation":[164],"cells":[167],"with":[168],"for":[170],"2":[171],"hours,":[172],"which":[173],"suggested":[174],"activated.":[180],"CONCLUSION:":[181],"cell.":[197]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
