{"id":"https://openalex.org/W320933043","doi":"https://doi.org/10.1016/b978-0-08-023200-3.50024-1","title":"Aryl Hydrocarbon Hydroxylase. Evidence of Receptors for Induction Process in Cell Culture","display_name":"Aryl Hydrocarbon Hydroxylase. Evidence of Receptors for Induction Process in Cell Culture","publication_year":1979,"publication_date":"1979-01-01","ids":{"openalex":"https://openalex.org/W320933043","doi":"https://doi.org/10.1016/b978-0-08-023200-3.50024-1","mag":"320933043"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-08-023200-3.50024-1","doi":"https://doi.org/10.1016/b978-0-08-023200-3.50024-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-08-023200-3.50024-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4236065523","display_name":"Chemotherapy"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029237881","display_name":"Daniel W. Nebert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel W. Nebert","raw_affiliation_strings":["Developmental Pharmacology Branch, National Institute of Child, Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Pharmacology Branch, National Institute of Child, Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111431825","display_name":"Ida S. Owens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ida S. Owens","raw_affiliation_strings":["Developmental Pharmacology Branch, National Institute of Child, Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Pharmacology Branch, National Institute of Child, Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068435413","display_name":"Itsu Kano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Itsu Kano","raw_affiliation_strings":["Developmental Pharmacology Branch, National Institute of Child, Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Pharmacology Branch, National Institute of Child, Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024412867","display_name":"Thomas M. Guenthner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Guenthner","raw_affiliation_strings":["Developmental Pharmacology Branch, National Institute of Child, Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Pharmacology Branch, National Institute of Child, Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8543,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79136691,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"185","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.061799999326467514,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-hydroxylase","display_name":"aryl hydrocarbon hydroxylase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ah-locus","display_name":"Ah locus","score":0.9300000071525574},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.843999981880188},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.902999997138977},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9340000152587891},{"id":"https://openalex.org/keywords/liver-cell-culture","display_name":"liver cell culture","score":0.5509999990463257},{"id":"https://openalex.org/keywords/receptor-binding-sites","display_name":"receptor binding sites","score":0.7369999885559082},{"id":"https://openalex.org/keywords/monooxygenase-induction","display_name":"monooxygenase induction","score":0.7070000171661377},{"id":"https://openalex.org/keywords/drug-toxicity-screening","display_name":"drug toxicity testing","score":0.6110000014305115},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.8671265840530396},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5868227481842041},{"id":"https://openalex.org/C132154277","wikidata":"https://www.wikidata.org/wiki/Q5381545","display_name":"Enzyme inducer","level":3,"score":0.5761135220527649},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.49219074845314026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46877923607826233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4530470371246338},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4517554044723511},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4433363378047943},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4121585786342621},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40199682116508484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24520060420036316},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21411827206611633},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.17271512746810913}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-08-023200-3.50024-1","doi":"https://doi.org/10.1016/b978-0-08-023200-3.50024-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-08-023200-3.50024-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W300138568","https://openalex.org/W1483367799","https://openalex.org/W1493185365","https://openalex.org/W1499517824","https://openalex.org/W1503373722","https://openalex.org/W1505027132","https://openalex.org/W1561313304","https://openalex.org/W1577296862","https://openalex.org/W1581161429","https://openalex.org/W1591874105","https://openalex.org/W1748988711","https://openalex.org/W1982386536","https://openalex.org/W2007893268","https://openalex.org/W2012766496","https://openalex.org/W2016836146","https://openalex.org/W2072298267","https://openalex.org/W2523874784","https://openalex.org/W2565812033","https://openalex.org/W4406987760","https://openalex.org/W4406988605","https://openalex.org/W7096222436"],"related_works":["https://openalex.org/W1483367799","https://openalex.org/W1510693272","https://openalex.org/W2419374164","https://openalex.org/W1503972125","https://openalex.org/W1758839563","https://openalex.org/W1618068447","https://openalex.org/W4406987813","https://openalex.org/W1940747546","https://openalex.org/W1994800122","https://openalex.org/W4406988605"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}