{"id":"https://openalex.org/W3209260841","doi":"https://doi.org/10.4196/kjpp.2021.25.6.517","title":"Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia","display_name":"Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia","publication_year":2021,"publication_date":"2021-10-26","ids":{"openalex":"https://openalex.org/W3209260841","doi":"https://doi.org/10.4196/kjpp.2021.25.6.517","mag":"3209260841","pmid":"https://pubmed.ncbi.nlm.nih.gov/34697262","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8552820"},"language":"en","primary_location":{"id":"doi:10.4196/kjpp.2021.25.6.517","doi":"https://doi.org/10.4196/kjpp.2021.25.6.517","is_oa":true,"landing_page_url":"https://doi.org/10.4196/kjpp.2021.25.6.517","pdf_url":"https://www.kjpp.net/journal/download_pdf.php?doi=10.4196/kjpp.2021.25.6.517","source":{"id":"https://openalex.org/S126408025","display_name":"Korean Journal of Physiology and Pharmacology","issn_l":"1226-4512","issn":["1226-4512","2093-3827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","kci-registered","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4360969222","host_organization_name":"The Korean Society of Pharmacology","host_organization_lineage":["https://openalex.org/P4360969222"],"host_organization_lineage_names":["The Korean Society of Pharmacology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean Journal of Physiology & Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.kjpp.net/journal/download_pdf.php?doi=10.4196/kjpp.2021.25.6.517","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109804843","display_name":"Chuan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4405283000","display_name":"Medical Supplies Center","ror":"https://ror.org/00trsr683","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405283000"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chuan Zhao","raw_affiliation_strings":["Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, Beijing 100853, China","Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4405283000"]},{"raw_affiliation_string":"Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071293462","display_name":"Yushu Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4405283000","display_name":"Medical Supplies Center","ror":"https://ror.org/00trsr683","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405283000"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yushu Guo","raw_affiliation_strings":["Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, Beijing 100853, China","Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4405283000"]},{"raw_affiliation_string":"Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101902621","display_name":"Ruoxi Wang","orcid":"https://orcid.org/0000-0002-3988-3731","observed_orcids":["https://orcid.org/0000-0002-3988-3731"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4405283000","display_name":"Medical Supplies Center","ror":"https://ror.org/00trsr683","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405283000"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruoxi Wang","raw_affiliation_strings":["Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, Beijing 100853, China","Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4405283000"]},{"raw_affiliation_string":"Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349400","display_name":"Cheng Cheng","orcid":"https://orcid.org/0000-0002-2497-1712","observed_orcids":["https://orcid.org/0000-0002-2497-1712"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4405283000","display_name":"Medical Supplies Center","ror":"https://ror.org/00trsr683","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405283000"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Cheng","raw_affiliation_strings":["Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, Beijing 100853, China","Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4405283000"]},{"raw_affiliation_string":"Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101809859","display_name":"Xiangmei Chen","orcid":"https://orcid.org/0000-0001-8774-6021","observed_orcids":["https://orcid.org/0000-0001-8774-6021"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4405283000","display_name":"Medical Supplies Center","ror":"https://ror.org/00trsr683","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405283000"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangmei Chen","raw_affiliation_strings":["Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, Beijing 100853, China","Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Medical Supplies Center of Chinese PLA General Hospital, Beijing 100853, China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4405283000"]},{"raw_affiliation_string":"Department of Pharmacy, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109804843"],"corresponding_institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4405283000"],"apc_list":null,"apc_paid":null,"fwci":0.2349,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.54655184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"25","issue":"6","first_page":"517","last_page":"523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10736","display_name":"Hydrogen embrittlement and corrosion behaviors in metals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2506","display_name":"Metals and Alloys"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-rich-water","display_name":"hydrogen-rich water","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.8460000157356262},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7200000286102295},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/lactic-acidosis","display_name":"lactic acidosis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/lactic-acid","display_name":"lactic acid","score":0.7239999771118164},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8140000104904175},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.7059999704360962},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9079999923706055},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9079999923706055},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.925000011920929},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9399999976158142},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.953000009059906}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8725259304046631},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6813175678253174},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.669651985168457},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.633270263671875},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5696523189544678},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5686663389205933},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5445204377174377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4951914846897125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4923042058944702},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4728047251701355},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43698570132255554},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4153668284416199},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38655516505241394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37361156940460205},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2889006733894348},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.19214114546775818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1551130712032318},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12740036845207214},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07643070816993713},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4196/kjpp.2021.25.6.517","doi":"https://doi.org/10.4196/kjpp.2021.25.6.517","is_oa":true,"landing_page_url":"https://doi.org/10.4196/kjpp.2021.25.6.517","pdf_url":"https://www.kjpp.net/journal/download_pdf.php?doi=10.4196/kjpp.2021.25.6.517","source":{"id":"https://openalex.org/S126408025","display_name":"Korean Journal of Physiology and Pharmacology","issn_l":"1226-4512","issn":["1226-4512","2093-3827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","kci-registered","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4360969222","host_organization_name":"The Korean Society of Pharmacology","host_organization_lineage":["https://openalex.org/P4360969222"],"host_organization_lineage_names":["The Korean Society of Pharmacology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean Journal of Physiology & Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7466375","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8552820","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8552820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8552820","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean J Physiol Pharmacol","raw_type":"Text"},{"id":"pmid:34697262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34697262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4196/kjpp.2021.25.6.517","doi":"https://doi.org/10.4196/kjpp.2021.25.6.517","is_oa":true,"landing_page_url":"https://doi.org/10.4196/kjpp.2021.25.6.517","pdf_url":"https://www.kjpp.net/journal/download_pdf.php?doi=10.4196/kjpp.2021.25.6.517","source":{"id":"https://openalex.org/S126408025","display_name":"Korean Journal of Physiology and Pharmacology","issn_l":"1226-4512","issn":["1226-4512","2093-3827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","kci-registered","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4360969222","host_organization_name":"The Korean Society of Pharmacology","host_organization_lineage":["https://openalex.org/P4360969222"],"host_organization_lineage_names":["The Korean Society of Pharmacology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean Journal of Physiology & Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325891","display_name":"General Hospital of People\u2019s Liberation Army","ror":"https://ror.org/04gw3ra78"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3209260841.pdf","grobid_xml":"https://content.openalex.org/works/W3209260841.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W52410818","https://openalex.org/W1565979608","https://openalex.org/W1899747697","https://openalex.org/W1961192788","https://openalex.org/W1983890824","https://openalex.org/W1996482353","https://openalex.org/W2025144170","https://openalex.org/W2088012387","https://openalex.org/W2093838944","https://openalex.org/W2099420745","https://openalex.org/W2109179624","https://openalex.org/W2123472586","https://openalex.org/W2199417652","https://openalex.org/W2261579344","https://openalex.org/W2741027917","https://openalex.org/W2747491011","https://openalex.org/W2891957570","https://openalex.org/W2911574222","https://openalex.org/W2953822192","https://openalex.org/W2958310296","https://openalex.org/W2967960051"],"related_works":["https://openalex.org/W3144323690","https://openalex.org/W4210496052","https://openalex.org/W4411743986","https://openalex.org/W4230183452","https://openalex.org/W4220842838","https://openalex.org/W7208479604","https://openalex.org/W3186757216","https://openalex.org/W2090016809","https://openalex.org/W2419178168","https://openalex.org/W2973921692"],"abstract_inverted_index":{"The":[0],"present":[1],"study":[2],"aims":[3],"to":[4,202,220],"investigate":[5],"the":[6,12,62,75,152],"impact":[7],"of":[8,64,77,154],"hydrogen-rich":[9,99,121,161,175,188],"water":[10,56,100,122,162,176,189],"on":[11,156,166],"lactic":[13,65,222],"acid":[14],"level":[15],"in":[16,74,88,95,110,137,198],"metformin-treated":[17],"diabetic":[18,199],"rats":[19,24],"under":[20,169,181,228],"hypoxia.":[21,170,182],"Thirty":[22],"Sprague-Dawley":[23],"were":[25,71,92,108,135],"randomly":[26],"divided":[27],"into":[28],"five":[29],"groups,":[30],"including":[31],"normal":[32],"diet":[33],"group,":[34,39,45,117],"and":[35,52,68,85,90,104,140,160,194,224],"diabetes":[36,215],"model":[37,201],"(DM)":[38],"DM":[40,138],"+":[41,47,54],"metformin":[42,141,155,218],"treatment":[43,49,142,219],"(DMM)":[44],"DMM":[46],"hypoxia":[48],"(DMMH)":[50],"group":[51,79,97,112,139],"DMMH":[53,81,96,116],"hydrogenrich":[55],"(DMMHR)":[57],"group.":[58,82],"We":[59],"found":[60],"that":[61,120,130,131,174,187],"levels":[63,87,107],"acid,":[66],"pyruvate":[67],"lactate":[69,192],"dehydrogenase":[70],"significantly":[72,93],"lower":[73],"blood":[76],"DMMHR":[78,111],"than":[80],"Superoxide":[83],"dismutase":[84],"glutathione":[86,106],"liver":[89],"heart":[91],"higher":[94],"after":[98],"treatment,":[101],"while":[102],"malondialdehyde":[103],"oxidized":[105],"decreased":[109],"when":[113],"compared":[114],"with":[115,217],"which":[118],"indicates":[119],"could":[123,190,207],"reduce":[124,195,225],"oxidative":[125],"stress.":[126],"qPCR":[127],"analysis":[128],"demonstrated":[129],"pro-apoptotic":[132],"genes":[133,168],"Bax/Caspase-3":[134],"upregulated":[136],"suppressed":[143],"their":[144],"upregulation":[145],"(DMM":[146],"group).":[147],"However,":[148],"hypoxic":[149,229],"condition":[150],"reversed":[151],"effect":[153,165],"apoptotic":[157],"gene":[158],"expression,":[159],"showed":[163,173],"little":[164],"these":[167],"HE":[171],"staining":[172],"prevented":[177],"myocardial":[178,226],"fiber":[179],"damages":[180,227],"In":[183],"summary,":[184],"we":[185],"conclude":[186],"prevent":[191,203,221],"accumulation":[193],"oxidant":[196],"stress":[197],"rat":[200],"hypoxia-induced":[204],"damages.":[205],"It":[206],"be":[208],"served":[209],"as":[210],"a":[211],"potential":[212],"agent":[213],"for":[214],"patients":[216],"acidosis":[223],"conditions.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-11-08T00:00:00"}