{"id":"https://openalex.org/W3209129018","doi":"https://doi.org/10.1136/bmjopen-2021-052944","title":"Effect of preoperative duloxetine treatment on postoperative chronic residual pain after total hip or knee arthroplasty: a randomised controlled trial","display_name":"Effect of preoperative duloxetine treatment on postoperative chronic residual pain after total hip or knee arthroplasty: a randomised controlled trial","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W3209129018","doi":"https://doi.org/10.1136/bmjopen-2021-052944","mag":"3209129018","pmid":"https://pubmed.ncbi.nlm.nih.gov/34732491","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8572398"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2021-052944","doi":"https://doi.org/10.1136/bmjopen-2021-052944","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2021-052944","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/11/11/e052944.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopen.bmj.com/content/bmjopen/11/11/e052944.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042921040","display_name":"Wietske Rienstra","orcid":"https://orcid.org/0000-0001-6718-3129","observed_orcids":["https://orcid.org/0000-0001-6718-3129"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wietske Rienstra","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","Department of Rehabilitation Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-6718-3129","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Department of Rehabilitation Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061119049","display_name":"Tim Blikman","orcid":"https://orcid.org/0000-0002-6318-6450","observed_orcids":["https://orcid.org/0000-0002-6318-6450"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tim Blikman","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","Department of Rehabilitation Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-6318-6450","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Department of Rehabilitation Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Baukje Dijkstra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Baukje Dijkstra","raw_affiliation_strings":["Department of Orthopaedic Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035618530","display_name":"Roy E. Stewart","orcid":"https://orcid.org/0000-0001-9227-433X","observed_orcids":["https://orcid.org/0000-0001-9227-433X"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Roy Stewart","raw_affiliation_strings":["Department of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","University of Groningen/UMCG, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-9227-433X","affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"University of Groningen/UMCG, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036572424","display_name":"Wierd Pieter Zijlstra","orcid":"https://orcid.org/0000-0001-6410-3824","observed_orcids":["https://orcid.org/0000-0001-6410-3824"]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wierd Zijlstra","raw_affiliation_strings":["Department of Orthopaedic Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062185697","display_name":"Tom M. van Raaij","orcid":"https://orcid.org/0000-0002-1161-0432","observed_orcids":["https://orcid.org/0000-0002-1161-0432"]},"institutions":[{"id":"https://openalex.org/I4210110920","display_name":"Martini Ziekenhuis","ror":"https://ror.org/017b69w10","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210110920"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tom van Raaij","raw_affiliation_strings":["Department of Orthopaedic Surgery, Martini Hospital Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Martini Hospital Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I4210110920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027720546","display_name":"Anita ten Hagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110920","display_name":"Martini Ziekenhuis","ror":"https://ror.org/017b69w10","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210110920"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anita ten Hagen","raw_affiliation_strings":["Department of Anaesthesiology, Martini Hospital Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Martini Hospital Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I4210110920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032370681","display_name":"Sjoerd K. Bulstra","orcid":"https://orcid.org/0000-0002-0486-1786","observed_orcids":["https://orcid.org/0000-0002-0486-1786"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjoerd Bulstra","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064756231","display_name":"Martin J. Stevens","orcid":"https://orcid.org/0000-0001-8183-6894","observed_orcids":["https://orcid.org/0000-0001-8183-6894"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martin Stevens","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-8183-6894","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043872893","display_name":"Inge van den Akker\u2010Scheek","orcid":"https://orcid.org/0000-0002-1614-8419","observed_orcids":["https://orcid.org/0000-0002-1614-8419"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Inge van den Akker-Scheek","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-1614-8419","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043872893"],"corresponding_institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":6.4651,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.97663978,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"11","issue":"11","first_page":"e052944","last_page":"e052944"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10562","display_name":"Total Knee Arthroplasty Outcomes","score":0.1851000040769577,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0478999987244606,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/preoperative-analgesia","display_name":"preoperative analgesia","score":0.7260000109672546},{"id":"https://openalex.org/keywords/total-knee-arthroplasty","display_name":"total knee arthroplasty","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hip-arthroplasty","display_name":"total hip arthroplasty","score":1.0},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/central-sensitization","display_name":"central sensitization","score":0.7440000176429749},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.7879999876022339},{"id":"https://openalex.org/keywords/paindetect","display_name":"painDETECT","score":0.6819999814033508},{"id":"https://openalex.org/keywords/postoperative-pain-management","display_name":"postoperative pain management","score":0.4650000035762787},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.4749999940395355},{"id":"https://openalex.org/keywords/koos","display_name":"KOOS","score":0.37400001287460327},{"id":"https://openalex.org/keywords/hip-disability-and-osteoarthritis-outcome-score","display_name":"HOOS","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gabapentin","display_name":"gabapentin","score":0.33500000834465027},{"id":"https://openalex.org/keywords/pregabalin","display_name":"pregabalin","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9746605753898621},{"id":"https://openalex.org/C2780764818","wikidata":"https://www.wikidata.org/wiki/Q411932","display_name":"Duloxetine","level":3,"score":0.9266943335533142},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7127180099487305},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5996174812316895},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.5895543694496155},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.5621750950813293},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5113422274589539},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4911298453807831},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.44936880469322205},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4152362048625946},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.28901177644729614},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26489266753196716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15131086111068726},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068736","descriptor_name":"Duloxetine Hydrochloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015207","descriptor_name":"Osteoarthritis, Hip","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015207","descriptor_name":"Osteoarthritis, Hip","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019644","descriptor_name":"Arthroplasty, Replacement, Hip","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1136/bmjopen-2021-052944","doi":"https://doi.org/10.1136/bmjopen-2021-052944","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2021-052944","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/11/11/e052944.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8572398","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8572398","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmid:34732491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34732491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/e655cc91-f609-43bd-8650-103140e1f6e3","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/e655cc91-f609-43bd-8650-103140e1f6e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rienstra, W, Blikman, T, Dijkstra, B, Stewart, R, Zijlstra, W, van Raaij, T, Ten Hagen, A, Bulstra, S, Stevens, M & van den Akker-Scheek, I 2021, 'Effect of preoperative duloxetine treatment on postoperative chronic residual pain after total hip or knee arthroplasty : a randomised controlled trial', BMJ Open, vol. 11, no. 11, 052944, pp. e052944. https://doi.org/10.1136/bmjopen-2021-052944","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:94e886a6815841cf9ec608e80b92b6ff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/94e886a6815841cf9ec608e80b92b6ff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open, Vol 11, Iss 11 (2021)","raw_type":"article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/e655cc91-f609-43bd-8650-103140e1f6e3","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/e655cc91-f609-43bd-8650-103140e1f6e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open, 11(11):052944. BMJ PUBLISHING GROUP","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2021-052944","doi":"https://doi.org/10.1136/bmjopen-2021-052944","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2021-052944","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/11/11/e052944.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G8728806972","display_name":null,"funder_award_id":"BP 12-3-401","funder_id":"https://openalex.org/F4320331585","funder_display_name":"Dutch Arthritis Association"}],"funders":[{"id":"https://openalex.org/F4320323768","display_name":"ReumaNederland","ror":"https://ror.org/05dr3r825"},{"id":"https://openalex.org/F4320331585","display_name":"Dutch Arthritis Association","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3209129018.pdf","grobid_xml":"https://content.openalex.org/works/W3209129018.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1856597536","https://openalex.org/W1924282669","https://openalex.org/W1964480324","https://openalex.org/W1966699568","https://openalex.org/W1970589761","https://openalex.org/W1970850418","https://openalex.org/W1974905386","https://openalex.org/W1990076794","https://openalex.org/W2017805692","https://openalex.org/W2051239218","https://openalex.org/W2059761199","https://openalex.org/W2068485217","https://openalex.org/W2075809557","https://openalex.org/W2083274218","https://openalex.org/W2094044265","https://openalex.org/W2100276898","https://openalex.org/W2108174506","https://openalex.org/W2113670619","https://openalex.org/W2128659393","https://openalex.org/W2129578138","https://openalex.org/W2129650714","https://openalex.org/W2133255767","https://openalex.org/W2134175790","https://openalex.org/W2154693681","https://openalex.org/W2163522693","https://openalex.org/W2164863281","https://openalex.org/W2167165853","https://openalex.org/W2167792025","https://openalex.org/W2208329680","https://openalex.org/W2288648624","https://openalex.org/W2307882414","https://openalex.org/W2562940003","https://openalex.org/W2613157051","https://openalex.org/W2767895838","https://openalex.org/W2774153899","https://openalex.org/W2911071869","https://openalex.org/W2914858358","https://openalex.org/W2922356949","https://openalex.org/W2944307193","https://openalex.org/W2944669133","https://openalex.org/W3106882649","https://openalex.org/W4211067786"],"related_works":["https://openalex.org/W2288648624","https://openalex.org/W3143124021","https://openalex.org/W2031964404","https://openalex.org/W2911071869","https://openalex.org/W3176759448","https://openalex.org/W3180769804","https://openalex.org/W4221065505","https://openalex.org/W4415284213","https://openalex.org/W4387478534","https://openalex.org/W7205010571"],"abstract_inverted_index":{"OBJECTIVES:":[0],"A":[1,67],"key":[2],"predictor":[3],"for":[4,93,114,163],"developing":[5],"chronic":[6,57,333],"residual":[7,58,334],"pain":[8,59,153,185,228,262,335],"after":[9,64,189,242,336],"total":[10],"knee":[11,49,322],"or":[12,127,205],"hip":[13,51,324],"arthroplasty":[14],"(TKA/THA)":[15],"is":[16,37],"sensitisation.":[17],"Sensitisation":[18],"can":[19],"be":[20,110],"defined":[21],"as":[22],"an":[23,125],"'increased":[24],"responsiveness":[25],"of":[26,34,42,169,196],"nociceptive":[27],"neurons":[28],"in":[29,47,76,81,259,272,280,290,320],"the":[30,40,82,98,137,193,197,206,231,260,273,281,297,304],"nervous":[31],"system'.":[32],"Aim":[33],"this":[35],"study":[36],"to":[38,61,124,149,311],"investigate":[39],"effects":[41],"preoperative":[43],"treatment":[44,145,162,317],"with":[45,86,151,166,173,192,214,318,327],"duloxetine":[46,135,170,243,309,319],"sensitised":[48],"and":[50,120,200,209,226,247,252,276,323],"osteoarthritis":[52],"(OA)":[53],"patients":[54,302,326],"on":[55],"postoperative":[56,332],"up":[60],"1":[62],"year":[63],"arthroplasty.":[65],"SETTING:":[66],"multicentre,":[68],"pragmatic,":[69],"prospective,":[70],"randomised":[71],"clinical":[72],"trial":[73],"was":[74,147,171,184,268,288],"conducted":[75],"three":[77],"secondary":[78],"care":[79],"hospitals":[80],"Netherlands.":[83],"PARTICIPANTS:":[84],"Patients":[85,102],"primary":[87],"knee/hip":[88],"OA":[89,325],"who":[90],"were":[91,95,112,118,156,221],"planned":[92],"TKA/THA":[94],"screened":[96],"using":[97,230],"modified":[99,232],"painDETECT":[100,104],"Questionnaire.":[101,234],"whose":[103],"score":[105,292],"indicated":[106],"that":[107],"sensitisation":[108,328],"may":[109],"present":[111],"eligible":[113],"participation.":[115],"111":[116],"participants":[117],"included":[119,238],"randomly":[121],"assigned":[122],"1:1":[123],"intervention":[126,131,274,305],"control":[128,138,282],"group.":[129,283],"The":[130],"group":[132,139,275,306],"received":[133],"additional":[134,144],"treatment,":[136,244],"did":[140],"not":[141,330],"receive":[142],"any":[143,152],"but":[146],"allowed":[148],"continue":[150],"medication":[154],"they":[155],"already":[157],"taking.":[158],"INTERVENTIONS:":[159],"Preoperative":[160,315],"oral":[161],"7":[164],"weeks":[165],"60":[167],"mg/day":[168],"compared":[172],"usual":[174],"care.":[175],"PRIMARY":[176],"AND":[177],"SECONDARY":[178],"OUTCOME":[179],"MEASURES:":[180],"Primary":[181],"outcome":[182,219],"measure":[183],"at":[186,264],"6":[187,248,250,265,293],"months":[188,251,254,266,294],"arthroplasty,":[190],"assessed":[191],"Pain":[194],"Subscale":[195],"Knee":[198],"injury":[199],"Osteoarthritis":[201,210],"Outcome":[202,211],"Score":[203,212],"(KOOS)":[204],"Hip":[207],"disability":[208],"(HOOS)":[213],"a":[215],"0-100":[216],"scale.":[217],"Secondary":[218],"measures":[220],"Visual":[222],"Analogue":[223],"Scale":[224],"(VAS),":[225],"neuropathic-like":[227],"measured":[229],"PainDETECT":[233],"Longitudinal":[235],"data":[236],"collection":[237],"time":[239],"points":[240],"directly":[241],"1-day":[245],"preoperatively,":[246],"weeks,":[249],"12":[253,301],"postoperatively.":[255],"RESULTS:":[256],"Mean":[257],"improvement":[258],"KOOS/HOOS":[261],"subscale":[263],"postoperatively":[267,295],"37":[269],"(SD":[270,278],"28.1)":[271],"43":[277],"26.5)":[279],"No":[284],"statistically":[285],"significant":[286],"difference":[287],"found":[289],"change":[291],"between":[296],"two":[298],"groups":[299],"(p=0.280).":[300],"from":[303],"(21%)":[307],"discontinued":[308],"due":[310],"adverse":[312],"effects.":[313],"CONCLUSIONS:":[314],"targeted":[316],"end-stage":[321],"does":[329],"influence":[331],"TKA/THA.":[337],"TRIAL":[338],"REGISTRATION":[339],"NUMBER:":[340],"NTR4744.":[341]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-11-08T00:00:00"}
